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UniProtKB - Q9UK55 (ZPI_HUMAN)
Protein
Protein Z-dependent protease inhibitor
Gene
SERPINA10
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
1 PublicationMiscellaneous
Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 261 | Essential for interaction with PROZBy similarity | 1 | |
Sitei | 314 | Essential for interaction with PROZBy similarity | 1 | |
Sitei | 408 – 409 | Reactive bondBy similarity | 2 |
GO - Molecular functioni
- heparin binding Source: UniProtKB-KW
- serine-type endopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
- liver regeneration Source: Ensembl
- negative regulation of endopeptidase activity Source: GO_Central
Keywordsi
Molecular function | Heparin-binding, Protease inhibitor, Serine protease inhibitor |
Biological process | Blood coagulation, Hemostasis |
Enzyme and pathway databases
PathwayCommonsi | Q9UK55 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q9UK55 |
Protein family/group databases
MEROPSi | I04.005 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Z-dependent protease inhibitorShort name: PZ-dependent protease inhibitor Short name: PZI Alternative name(s): Serpin A10 |
Gene namesi | Name:SERPINA10 Synonyms:ZPI ORF Names:UNQ707/PRO1358 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15996, SERPINA10 |
MIMi | 602455, gene 605271, gene+phenotype |
neXtProti | NX_Q9UK55 |
VEuPathDBi | HostDB:ENSG00000140093 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 408 | Y → A: Loss of inhibitory activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51156 |
MIMi | 605271, gene+phenotype |
OpenTargetsi | ENSG00000140093 |
Orphaneti | 64738, NON RARE IN EUROPE: Non rare thrombophilia |
PharmGKBi | PA38078 |
Miscellaneous databases
Pharosi | Q9UK55, Tbio |
Genetic variation databases
BioMutai | SERPINA10 |
DMDMi | 12585541 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000032482 | 22 – 444 | Protein Z-dependent protease inhibitorAdd BLAST | 423 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 56 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 295 | N-linked (GlcNAc...) asparagine2 Publications | 1 |
Post-translational modificationi
Phosphorylated by FAM20C in the extracellular medium.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-2690 |
jPOSTi | Q9UK55 |
MassIVEi | Q9UK55 |
PaxDbi | Q9UK55 |
PeptideAtlasi | Q9UK55 |
PRIDEi | Q9UK55 |
ProteomicsDBi | 84723 |
PTM databases
GlyConnecti | 1673, 8 N-Linked glycans (3 sites) |
GlyGeni | Q9UK55, 4 sites, 10 N-linked glycans (3 sites) |
iPTMneti | Q9UK55 |
PhosphoSitePlusi | Q9UK55 |
Expressioni
Tissue specificityi
Expressed by the liver and secreted in plasma.
Gene expression databases
Bgeei | ENSG00000140093, Expressed in liver and 118 other tissues |
ExpressionAtlasi | Q9UK55, baseline and differential |
Genevisiblei | Q9UK55, HS |
Organism-specific databases
HPAi | ENSG00000140093, Tissue enriched (liver) |
Interactioni
Subunit structurei
Interacts with PROZ.
3 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 119339, 16 interactors |
IntActi | Q9UK55, 9 interactors |
STRINGi | 9606.ENSP00000261994 |
Miscellaneous databases
RNActi | Q9UK55, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9UK55 |
SMRi | Q9UK55 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UK55 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 65 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 136 – 153 | Heparin-bindingAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000159462 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | Q9UK55 |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q9UK55 |
TreeFami | TF343094 |
Family and domain databases
CDDi | cd02055, serpinA10_PZI, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR033835, PZI_serpin_dom IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UK55-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVVPSLLLS VLLAQVWLVP GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE
60 70 80 90 100
DEQEASEEKA SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF
110 120 130 140 150
SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL LPSLFKGLRE
160 170 180 190 200
TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ
210 220 230 240 250
AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF
260 270 280 290 300
TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV
310 320 330 340 350
VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE
360 370 380 390 400
LLRQMGIRRI FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG
410 420 430 440
ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN PTLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V2W1 | G3V2W1_HUMAN | Protein Z-dependent protease inhibi... | SERPINA10 hCG_22331 | 484 | Annotation score: |
Sequence cautioni
The sequence CAD62339 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020325 | 46 | K → R2 PublicationsCorresponds to variant dbSNP:rs941590Ensembl. | 1 | |
Natural variantiVAR_020326 | 61 | S → G2 PublicationsCorresponds to variant dbSNP:rs941591Ensembl. | 1 | |
Natural variantiVAR_038833 | 139 | G → R1 PublicationCorresponds to variant dbSNP:rs56137907Ensembl. | 1 | |
Natural variantiVAR_051940 | 158 | L → Q. Corresponds to variant dbSNP:rs2232699Ensembl. | 1 | |
Natural variantiVAR_020327 | 161 | T → S2 PublicationsCorresponds to variant dbSNP:rs2232700Ensembl. | 1 | |
Natural variantiVAR_051941 | 196 | R → H. Corresponds to variant dbSNP:rs2232701Ensembl. | 1 | |
Natural variantiVAR_038834 | 271 | G → S1 PublicationCorresponds to variant dbSNP:rs2232708Ensembl. | 1 | |
Natural variantiVAR_038835 | 384 | Q → P1 Publication | 1 | |
Natural variantiVAR_051942 | 384 | Q → R1 PublicationCorresponds to variant dbSNP:rs2232710Ensembl. | 1 | |
Natural variantiVAR_070192 | 420 | F → L1 PublicationCorresponds to variant dbSNP:rs546304706Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181467 mRNA Translation: AAD53962.1 AY358597 mRNA Translation: AAQ88960.1 BX248011 mRNA Translation: CAD62339.1 Different initiation. EF621762 Genomic DNA Translation: ABR09269.1 BC022261 mRNA Translation: AAH22261.1 |
CCDSi | CCDS9923.1 |
RefSeqi | NP_001094077.1, NM_001100607.2 NP_057270.1, NM_016186.2 XP_005267790.1, XM_005267733.4 |
Genome annotation databases
Ensembli | ENST00000261994.9; ENSP00000261994.4; ENSG00000140093.10 ENST00000393096.5; ENSP00000376809.1; ENSG00000140093.10 ENST00000554173.1; ENSP00000450971.1; ENSG00000140093.10 ENST00000614630.4; ENSP00000484632.1; ENSG00000278767.4 |
GeneIDi | 51156 |
KEGGi | hsa:51156 |
MANE-Selecti | ENST00000261994.9; ENSP00000261994.4; NM_001100607.3; NP_001094077.1 |
UCSCi | uc001ycu.6, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181467 mRNA Translation: AAD53962.1 AY358597 mRNA Translation: AAQ88960.1 BX248011 mRNA Translation: CAD62339.1 Different initiation. EF621762 Genomic DNA Translation: ABR09269.1 BC022261 mRNA Translation: AAH22261.1 |
CCDSi | CCDS9923.1 |
RefSeqi | NP_001094077.1, NM_001100607.2 NP_057270.1, NM_016186.2 XP_005267790.1, XM_005267733.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3F1S | X-ray | 2.30 | A | 60-444 | [»] | |
3H5C | X-ray | 3.26 | A | 22-444 | [»] | |
4AFX | X-ray | 2.09 | A | 23-408 | [»] | |
B | 409-444 | [»] | ||||
4AJU | X-ray | 2.65 | A | 23-408 | [»] | |
B | 409-444 | [»] | ||||
AlphaFoldDBi | Q9UK55 | |||||
SMRi | Q9UK55 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119339, 16 interactors |
IntActi | Q9UK55, 9 interactors |
STRINGi | 9606.ENSP00000261994 |
Protein family/group databases
MEROPSi | I04.005 |
PTM databases
GlyConnecti | 1673, 8 N-Linked glycans (3 sites) |
GlyGeni | Q9UK55, 4 sites, 10 N-linked glycans (3 sites) |
iPTMneti | Q9UK55 |
PhosphoSitePlusi | Q9UK55 |
Genetic variation databases
BioMutai | SERPINA10 |
DMDMi | 12585541 |
Proteomic databases
CPTACi | non-CPTAC-2690 |
jPOSTi | Q9UK55 |
MassIVEi | Q9UK55 |
PaxDbi | Q9UK55 |
PeptideAtlasi | Q9UK55 |
PRIDEi | Q9UK55 |
ProteomicsDBi | 84723 |
Protocols and materials databases
Antibodypediai | 27029, 347 antibodies from 39 providers |
DNASUi | 51156 |
Genome annotation databases
Ensembli | ENST00000261994.9; ENSP00000261994.4; ENSG00000140093.10 ENST00000393096.5; ENSP00000376809.1; ENSG00000140093.10 ENST00000554173.1; ENSP00000450971.1; ENSG00000140093.10 ENST00000614630.4; ENSP00000484632.1; ENSG00000278767.4 |
GeneIDi | 51156 |
KEGGi | hsa:51156 |
MANE-Selecti | ENST00000261994.9; ENSP00000261994.4; NM_001100607.3; NP_001094077.1 |
UCSCi | uc001ycu.6, human |
Organism-specific databases
CTDi | 51156 |
DisGeNETi | 51156 |
GeneCardsi | SERPINA10 |
HGNCi | HGNC:15996, SERPINA10 |
HPAi | ENSG00000140093, Tissue enriched (liver) |
MIMi | 602455, gene 605271, gene+phenotype |
neXtProti | NX_Q9UK55 |
OpenTargetsi | ENSG00000140093 |
Orphaneti | 64738, NON RARE IN EUROPE: Non rare thrombophilia |
PharmGKBi | PA38078 |
VEuPathDBi | HostDB:ENSG00000140093 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000159462 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | Q9UK55 |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q9UK55 |
TreeFami | TF343094 |
Enzyme and pathway databases
PathwayCommonsi | Q9UK55 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | Q9UK55 |
Miscellaneous databases
BioGRID-ORCSi | 51156, 10 hits in 1061 CRISPR screens |
EvolutionaryTracei | Q9UK55 |
GenomeRNAii | 51156 |
Pharosi | Q9UK55, Tbio |
PROi | PR:Q9UK55 |
RNActi | Q9UK55, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140093, Expressed in liver and 118 other tissues |
ExpressionAtlasi | Q9UK55, baseline and differential |
Genevisiblei | Q9UK55, HS |
Family and domain databases
CDDi | cd02055, serpinA10_PZI, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR033835, PZI_serpin_dom IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZPI_HUMAN | |
Accessioni | Q9UK55Primary (citable) accession number: Q9UK55 Secondary accession number(s): A5Z2A5, Q6UWX9, Q86U20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families