UniProtKB - Q9UK55 (ZPI_HUMAN)

BLAST

>sp|Q9UK55|ZPI_HUMAN Protein Z-dependent protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA10 PE=1 SV=1
MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA
SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT
ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN
LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG
KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV
VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI
FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF
HFMIYEETSGMLLFLGRVVNPTLL

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History
Entry version 173 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

Protein Z-dependent protease inhibitor

Gene

SERPINA10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.1 Publication

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	261	Essential for interaction with PROZBy similarity	1
Siteⁱ	314	Essential for interaction with PROZBy similarity	1
Siteⁱ	408 – 409	Reactive bondBy similarity	2

GO - Molecular functionⁱ

heparin binding Source: UniProtKB-KW
serine-type endopeptidase inhibitor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: UniProtKB-KW
cellular protein metabolic process Source: Reactome
negative regulation of endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
post-translational protein modification Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding, Protease inhibitor, Serine protease inhibitor
Biological process	Blood coagulation, Hemostasis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.005

MEROPSⁱ

I04.005

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Z-dependent protease inhibitor Short name: PZ-dependent protease inhibitor Short name: PZI Alternative name(s): Serpin A10
Gene namesⁱ	Name:SERPINA10 Synonyms:ZPI ORF Names:UNQ707/PRO1358
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140093.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15996 SERPINA10
MIMⁱ	602455 gene 605271 gene+phenotype
neXtProtⁱ	NX_Q9UK55

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	408	Y → A: Loss of inhibitory activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51156
MIMⁱ	605271 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000140093
Orphanetⁱ	64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBⁱ	PA38078

Polymorphism and mutation databases

BioMutaⁱ	SERPINA10
DMDMⁱ	12585541

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000032482	22 – 444	Protein Z-dependent protease inhibitorAdd BLAST		423

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	36	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	56	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	197	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	295	N-linked (GlcNAc...) asparagine2 Publications	1

Post-translational modificationⁱ

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9UK55
PeptideAtlas More...PeptideAtlasⁱ	Q9UK55
PRIDEⁱ	Q9UK55
ProteomicsDBⁱ	84723

PTM databases

GlyConnectⁱ	1673
iPTMnetⁱ	Q9UK55
PhosphoSitePlusⁱ	Q9UK55

Expressionⁱ

Tissue specificityⁱ

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgeeⁱ	ENSG00000140093 Expressed in 97 organ(s), highest expression level in liver
CleanExⁱ	HS_SERPINA10
ExpressionAtlasⁱ	Q9UK55 baseline and differential
Genevisibleⁱ	Q9UK55 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048739

HPAⁱ

HPA048739

Interactionⁱ

Subunit structureⁱ

Interacts with PROZ.3 Publications

Protein-protein interaction databases

BioGridⁱ	119339, 12 interactors
IntActⁱ	Q9UK55, 2 interactors
STRINGⁱ	9606.ENSP00000261994

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	62 – 93	Combined sources	32
Beta strandⁱ	98 – 100	Combined sources	3
Helixⁱ	102 – 113	Combined sources	12
Helixⁱ	119 – 127	Combined sources	9
Helixⁱ	137 – 139	Combined sources	3
Helixⁱ	140 – 154	Combined sources	15
Helixⁱ	156 – 158	Combined sources	3
Beta strandⁱ	160 – 169	Combined sources	10
Helixⁱ	176 – 186	Combined sources	11
Beta strandⁱ	189 – 193	Combined sources	5
Beta strandⁱ	195 – 197	Combined sources	3
Helixⁱ	198 – 212	Combined sources	15
Turnⁱ	213 – 215	Combined sources	3
Beta strandⁱ	216 – 218	Combined sources	3
Beta strandⁱ	228 – 244	Combined sources	17
Helixⁱ	248 – 250	Combined sources	3
Beta strandⁱ	252 – 261	Combined sources	10
Beta strandⁱ	263 – 280	Combined sources	18
Turnⁱ	281 – 284	Combined sources	4
Beta strandⁱ	285 – 292	Combined sources	8
Beta strandⁱ	295 – 304	Combined sources	10
Beta strandⁱ	305 – 307	Combined sources	3
Helixⁱ	312 – 314	Combined sources	3
Helixⁱ	318 – 326	Combined sources	9
Beta strandⁱ	329 – 338	Combined sources	10
Beta strandⁱ	340 – 347	Combined sources	8
Helixⁱ	349 – 354	Combined sources	6
Helixⁱ	359 – 361	Combined sources	3
Turnⁱ	368 – 370	Combined sources	3
Beta strandⁱ	371 – 373	Combined sources	3
Beta strandⁱ	378 – 390	Combined sources	13
Beta strandⁱ	392 – 406	Combined sources	15
Beta strandⁱ	413 – 415	Combined sources	3
Beta strandⁱ	420 – 426	Combined sources	7
Turnⁱ	427 – 430	Combined sources	4
Beta strandⁱ	431 – 439	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UK55
SMRⁱ	Q9UK55
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9UK55

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	136 – 153	Heparin-bindingAdd BLAST		18

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118839
HOGENOMⁱ	HOG000238519
HOVERGENⁱ	HBG101138
InParanoidⁱ	Q9UK55
KEGG Orthology (KO) More...KOⁱ	K04525
PhylomeDBⁱ	Q9UK55
TreeFamⁱ	TF343094

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02055 PZI, 1 hit
InterProⁱ	View protein in InterPro IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf IPR033835 SERPINA10
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9UK55-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKVVPSLLLS VLLAQVWLVP GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE 
        60         70         80         90        100
DEQEASEEKA SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF 
       110        120        130        140        150
SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL LPSLFKGLRE 
       160        170        180        190        200
TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ 
       210        220        230        240        250
AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF 
       260        270        280        290        300
TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV 
       310        320        330        340        350
VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE 
       360        370        380        390        400
LLRQMGIRRI FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG 
       410        420        430        440 
ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN PTLL

Length:444

Mass (Da):50,707

Last modified:May 1, 2000 - v1

Checksum:ⁱ06BD47C97BBDD700

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V2W1	G3V2W1_HUMAN		Protein Z-dependent protease inhibi... Protein Z-dependent protease inhibitor (Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 10, isoform CRA_a)	SERPINA10 hCG_22331	484	Annotation score:

Sequence cautionⁱ

The sequence CAD62339 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020325	46	K → R2 PublicationsCorresponds to variant dbSNP:rs941590Ensembl.	1
Natural variantⁱVAR_020326	61	S → G2 PublicationsCorresponds to variant dbSNP:rs941591Ensembl.	1
Natural variantⁱVAR_038833	139	G → R1 PublicationCorresponds to variant dbSNP:rs56137907Ensembl.	1
Natural variantⁱVAR_051940	158	L → Q. Corresponds to variant dbSNP:rs2232699Ensembl.	1
Natural variantⁱVAR_020327	161	T → S2 PublicationsCorresponds to variant dbSNP:rs2232700Ensembl.	1
Natural variantⁱVAR_051941	196	R → H. Corresponds to variant dbSNP:rs2232701Ensembl.	1
Natural variantⁱVAR_038834	271	G → S1 PublicationCorresponds to variant dbSNP:rs2232708Ensembl.	1
Natural variantⁱVAR_038835	384	Q → P1 Publication	1
Natural variantⁱVAR_051942	384	Q → R1 PublicationCorresponds to variant dbSNP:rs2232710Ensembl.	1
Natural variantⁱVAR_070192	420	F → L1 PublicationCorresponds to variant dbSNP:rs546304706Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF181467 mRNA Translation: AAD53962.1 AY358597 mRNA Translation: AAQ88960.1 BX248011 mRNA Translation: CAD62339.1 Different initiation. EF621762 Genomic DNA Translation: ABR09269.1 BC022261 mRNA Translation: AAH22261.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9923.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001094077.1, NM_001100607.2 NP_057270.1, NM_016186.2 XP_005267790.1, XM_005267733.4
UniGeneⁱ	Hs.118620

Genome annotation databases

Ensemblⁱ	ENST00000261994; ENSP00000261994; ENSG00000140093 ENST00000393096; ENSP00000376809; ENSG00000140093 ENST00000554173; ENSP00000450971; ENSG00000140093 ENST00000614630; ENSP00000484632; ENSG00000278767
GeneIDⁱ	51156
KEGGⁱ	hsa:51156
UCSC genome browser More...UCSCⁱ	uc001ycu.6 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK55	Protein Z-dependent protease inhibitor		HUMAN		484	UniRef100_Q9UK55
Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 10, isoform CRA_b		HUMAN		444
UPI0001AB29A1		HUMAN		385
UPI0001D14850		HUMAN		423

Protein	Similar proteins		Species	Score	Length	Source
Q9UK55	Protein Z-dependent protease inhibitor		PONAB		443	UniRef90_Q9UK55
Protein Z-dependent protease inhibitor		HUMAN		484
Serpin family A member 10		PANTR		484
Uncharacterized protein		PANPA		484
Uncharacterized protein		NOMLE		484
+38

Protein	Similar proteins		Species	Score	Length	Source
Q9UK55	Protein Z-dependent protease inhibitor		PONAB		443	UniRef50_Q9UK55
Protein Z-dependent protease inhibitor		HUMAN		484
Uncharacterized protein		PANPA		484
Serpin family A member 10		GORGO		484
Uncharacterized protein		NOMLE		484
+60

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF181467 mRNA Translation: AAD53962.1 AY358597 mRNA Translation: AAQ88960.1 BX248011 mRNA Translation: CAD62339.1 Different initiation. EF621762 Genomic DNA Translation: ABR09269.1 BC022261 mRNA Translation: AAH22261.1
CCDSⁱ	CCDS9923.1
RefSeqⁱ	NP_001094077.1, NM_001100607.2 NP_057270.1, NM_016186.2 XP_005267790.1, XM_005267733.4
UniGeneⁱ	Hs.118620

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3F1S	X-ray	2.30	A	60-444	[»]
	3H5C	X-ray	3.26	A	22-444	[»]
	4AFX	X-ray	2.09	A	23-408	[»]
				B	409-444	[»]
	4AJU	X-ray	2.65	A	23-408	[»]
				B	409-444	[»]
ProteinModelPortalⁱ	Q9UK55
SMRⁱ	Q9UK55
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119339, 12 interactors
IntActⁱ	Q9UK55, 2 interactors
STRINGⁱ	9606.ENSP00000261994

Protein family/group databases

MEROPSⁱ	I04.005

MEROPSⁱ

I04.005

PTM databases

GlyConnectⁱ	1673
iPTMnetⁱ	Q9UK55
PhosphoSitePlusⁱ	Q9UK55

Polymorphism and mutation databases

BioMutaⁱ	SERPINA10
DMDMⁱ	12585541

Proteomic databases

PaxDbⁱ	Q9UK55
PeptideAtlasⁱ	Q9UK55
PRIDEⁱ	Q9UK55
ProteomicsDBⁱ	84723

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51156
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261994; ENSP00000261994; ENSG00000140093 ENST00000393096; ENSP00000376809; ENSG00000140093 ENST00000554173; ENSP00000450971; ENSG00000140093 ENST00000614630; ENSP00000484632; ENSG00000278767
GeneIDⁱ	51156
KEGGⁱ	hsa:51156
UCSCⁱ	uc001ycu.6 human

Organism-specific databases

CTDⁱ	51156
DisGeNETⁱ	51156
EuPathDBⁱ	HostDB:ENSG00000140093.9
GeneCardsⁱ	SERPINA10
HGNCⁱ	HGNC:15996 SERPINA10
HPAⁱ	HPA048739
MIMⁱ	602455 gene 605271 gene+phenotype
neXtProtⁱ	NX_Q9UK55
OpenTargetsⁱ	ENSG00000140093
Orphanetⁱ	64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBⁱ	PA38078
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00760000118839
HOGENOMⁱ	HOG000238519
HOVERGENⁱ	HBG101138
InParanoidⁱ	Q9UK55
KOⁱ	K04525
PhylomeDBⁱ	Q9UK55
TreeFamⁱ	TF343094

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UK55
GenomeRNAiⁱ	51156
Protein Ontology More...PROⁱ	PR:Q9UK55
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140093 Expressed in 97 organ(s), highest expression level in liver
CleanExⁱ	HS_SERPINA10
ExpressionAtlasⁱ	Q9UK55 baseline and differential
Genevisibleⁱ	Q9UK55 HS

Family and domain databases

CDDⁱ	cd02055 PZI, 1 hit
InterProⁱ	View protein in InterPro IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf IPR033835 SERPINA10
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZPI_HUMAN
Accessionⁱ	Q9UK55Primary (citable) accession number: Q9UK55 Secondary accession number(s): A5Z2A5, Q6UWX9, Q86U20
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q9UK55 (ZPI_HUMAN)

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Protein Z-dependent protease inhibitor

SERPINA10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ