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Protein

Protein Z-dependent protease inhibitor

Gene

SERPINA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.1 Publication

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei261Essential for interaction with PROZBy similarity1
Sitei314Essential for interaction with PROZBy similarity1
Sitei408 – 409Reactive bondBy similarity2

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI04.005

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Z-dependent protease inhibitor
Short name:
PZ-dependent protease inhibitor
Short name:
PZI
Alternative name(s):
Serpin A10
Gene namesi
Name:SERPINA10
Synonyms:ZPI
ORF Names:UNQ707/PRO1358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140093.9
HGNCiHGNC:15996 SERPINA10
MIMi602455 gene
605271 gene+phenotype
neXtProtiNX_Q9UK55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi408Y → A: Loss of inhibitory activity. 1 Publication1

Organism-specific databases

DisGeNETi51156
MIMi605271 gene+phenotype
OpenTargetsiENSG00000140093
Orphaneti64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBiPA38078

Polymorphism and mutation databases

BioMutaiSERPINA10
DMDMi12585541

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003248222 – 444Protein Z-dependent protease inhibitorAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei56Phosphoserine; by FAM20C1 Publication1
Glycosylationi180N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi197N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi295N-linked (GlcNAc...) asparagine2 Publications1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UK55
PeptideAtlasiQ9UK55
PRIDEiQ9UK55
ProteomicsDBi84723

PTM databases

GlyConnecti1673
iPTMnetiQ9UK55
PhosphoSitePlusiQ9UK55

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000140093 Expressed in 97 organ(s), highest expression level in liver
CleanExiHS_SERPINA10
ExpressionAtlasiQ9UK55 baseline and differential
GenevisibleiQ9UK55 HS

Organism-specific databases

HPAiHPA048739

Interactioni

Subunit structurei

Interacts with PROZ.3 Publications

Protein-protein interaction databases

BioGridi119339, 12 interactors
IntActiQ9UK55, 2 interactors
STRINGi9606.ENSP00000261994

Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UK55
SMRiQ9UK55
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UK55

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 153Heparin-bindingAdd BLAST18

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238519
HOVERGENiHBG101138
InParanoidiQ9UK55
KOiK04525
PhylomeDBiQ9UK55
TreeFamiTF343094

Family and domain databases

CDDicd02055 PZI, 1 hit
InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR033835 SERPINA10
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UK55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVVPSLLLS VLLAQVWLVP GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE
60 70 80 90 100
DEQEASEEKA SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF
110 120 130 140 150
SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL LPSLFKGLRE
160 170 180 190 200
TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ
210 220 230 240 250
AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF
260 270 280 290 300
TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV
310 320 330 340 350
VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE
360 370 380 390 400
LLRQMGIRRI FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG
410 420 430 440
ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN PTLL
Length:444
Mass (Da):50,707
Last modified:May 1, 2000 - v1
Checksum:i06BD47C97BBDD700
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2W1G3V2W1_HUMAN
Protein Z-dependent protease inhibi...
SERPINA10 hCG_22331
484Annotation score:

Sequence cautioni

The sequence CAD62339 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02032546K → R2 PublicationsCorresponds to variant dbSNP:rs941590Ensembl.1
Natural variantiVAR_02032661S → G2 PublicationsCorresponds to variant dbSNP:rs941591Ensembl.1
Natural variantiVAR_038833139G → R1 PublicationCorresponds to variant dbSNP:rs56137907Ensembl.1
Natural variantiVAR_051940158L → Q. Corresponds to variant dbSNP:rs2232699Ensembl.1
Natural variantiVAR_020327161T → S2 PublicationsCorresponds to variant dbSNP:rs2232700Ensembl.1
Natural variantiVAR_051941196R → H. Corresponds to variant dbSNP:rs2232701Ensembl.1
Natural variantiVAR_038834271G → S1 PublicationCorresponds to variant dbSNP:rs2232708Ensembl.1
Natural variantiVAR_038835384Q → P1 Publication1
Natural variantiVAR_051942384Q → R1 PublicationCorresponds to variant dbSNP:rs2232710Ensembl.1
Natural variantiVAR_070192420F → L1 PublicationCorresponds to variant dbSNP:rs546304706Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181467 mRNA Translation: AAD53962.1
AY358597 mRNA Translation: AAQ88960.1
BX248011 mRNA Translation: CAD62339.1 Different initiation.
EF621762 Genomic DNA Translation: ABR09269.1
BC022261 mRNA Translation: AAH22261.1
CCDSiCCDS9923.1
RefSeqiNP_001094077.1, NM_001100607.2
NP_057270.1, NM_016186.2
XP_005267790.1, XM_005267733.4
UniGeneiHs.118620

Genome annotation databases

EnsembliENST00000261994; ENSP00000261994; ENSG00000140093
ENST00000393096; ENSP00000376809; ENSG00000140093
ENST00000554173; ENSP00000450971; ENSG00000140093
ENST00000614630; ENSP00000484632; ENSG00000278767
GeneIDi51156
KEGGihsa:51156
UCSCiuc001ycu.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181467 mRNA Translation: AAD53962.1
AY358597 mRNA Translation: AAQ88960.1
BX248011 mRNA Translation: CAD62339.1 Different initiation.
EF621762 Genomic DNA Translation: ABR09269.1
BC022261 mRNA Translation: AAH22261.1
CCDSiCCDS9923.1
RefSeqiNP_001094077.1, NM_001100607.2
NP_057270.1, NM_016186.2
XP_005267790.1, XM_005267733.4
UniGeneiHs.118620

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F1SX-ray2.30A60-444[»]
3H5CX-ray3.26A22-444[»]
4AFXX-ray2.09A23-408[»]
B409-444[»]
4AJUX-ray2.65A23-408[»]
B409-444[»]
ProteinModelPortaliQ9UK55
SMRiQ9UK55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119339, 12 interactors
IntActiQ9UK55, 2 interactors
STRINGi9606.ENSP00000261994

Protein family/group databases

MEROPSiI04.005

PTM databases

GlyConnecti1673
iPTMnetiQ9UK55
PhosphoSitePlusiQ9UK55

Polymorphism and mutation databases

BioMutaiSERPINA10
DMDMi12585541

Proteomic databases

PaxDbiQ9UK55
PeptideAtlasiQ9UK55
PRIDEiQ9UK55
ProteomicsDBi84723

Protocols and materials databases

DNASUi51156
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261994; ENSP00000261994; ENSG00000140093
ENST00000393096; ENSP00000376809; ENSG00000140093
ENST00000554173; ENSP00000450971; ENSG00000140093
ENST00000614630; ENSP00000484632; ENSG00000278767
GeneIDi51156
KEGGihsa:51156
UCSCiuc001ycu.6 human

Organism-specific databases

CTDi51156
DisGeNETi51156
EuPathDBiHostDB:ENSG00000140093.9
GeneCardsiSERPINA10
HGNCiHGNC:15996 SERPINA10
HPAiHPA048739
MIMi602455 gene
605271 gene+phenotype
neXtProtiNX_Q9UK55
OpenTargetsiENSG00000140093
Orphaneti64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBiPA38078
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238519
HOVERGENiHBG101138
InParanoidiQ9UK55
KOiK04525
PhylomeDBiQ9UK55
TreeFamiTF343094

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

EvolutionaryTraceiQ9UK55
GenomeRNAii51156
PROiPR:Q9UK55
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140093 Expressed in 97 organ(s), highest expression level in liver
CleanExiHS_SERPINA10
ExpressionAtlasiQ9UK55 baseline and differential
GenevisibleiQ9UK55 HS

Family and domain databases

CDDicd02055 PZI, 1 hit
InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR033835 SERPINA10
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZPI_HUMAN
AccessioniPrimary (citable) accession number: Q9UK55
Secondary accession number(s): A5Z2A5, Q6UWX9, Q86U20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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