ING1

Functionⁱ

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	355	Histone H3K4me3Combined sources1 Publication	1
Metal bindingⁱ	356	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	358	Zinc 1Combined sources1 Publication	1
Binding siteⁱ	366	Histone H3K4me3Combined sources1 Publication	1
Metal bindingⁱ	369	Zinc 2Combined sources1 Publication	1
Binding siteⁱ	370	Histone H3K4me3Combined sources1 Publication	1
Metal bindingⁱ	374	Zinc 2Combined sources1 Publication	1
Binding siteⁱ	378	Histone H3K4me3Combined sources1 Publication	1
Metal bindingⁱ	380	Zinc 1; via pros nitrogenCombined sources1 Publication	1
Metal bindingⁱ	383	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	396	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	399	Zinc 2Combined sources1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	353 – 402	PHD-typePROSITE-ProRule annotationAdd BLAST		50

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16728974

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
negative regulation of cell growth
Source: UniProtKB
Non-traceable author statementⁱ
- 8944021
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8944021
regulation of cell death Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q9UK53

SIGNORⁱ

Q9UK53

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Inhibitor of growth protein 1
Gene namesⁱ	Name:ING1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153487.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6062 ING1
MIMⁱ	601566 gene
neXtProtⁱ	NX_Q9UK53

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Squamous cell carcinoma of the head and neck (HNSCC)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017420	335	A → D in HNSCC. 1 Publication	1
Natural variantⁱVAR_017421	358	C → S in HNSCC. 1 Publication	1
Natural variantⁱVAR_017422	359	N → S in HNSCC. 1 Publication	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	378	W → A: Unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3621
MalaCards human disease database More...MalaCardsⁱ	ING1
MIMⁱ	275355 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000153487
Orphanetⁱ	500481 Squamous cell carcinoma of salivary glands 494547 Squamous cell carcinoma of the hypopharynx 494550 Squamous cell carcinoma of the larynx 502366 Squamous cell carcinoma of the lip 500464 Squamous cell carcinoma of the nasal cavity and paranasal sinuses 502363 Squamous cell carcinoma of the oral cavity 500478 Squamous cell carcinoma of the oropharynx
PharmGKBⁱ	PA29872

Polymorphism and mutation databases

BioMutaⁱ	ING1
DMDMⁱ	212276438

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000212661	1 – 422	Inhibitor of growth protein 1Add BLAST		422

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	278	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UK53
PaxDbⁱ	Q9UK53
PeptideAtlas More...PeptideAtlasⁱ	Q9UK53
PRIDEⁱ	Q9UK53
ProteomicsDBⁱ	84718 84719 [Q9UK53-2] 84720 [Q9UK53-3] 84721 [Q9UK53-4] 84722 [Q9UK53-5]

PTM databases

iPTMnetⁱ	Q9UK53
PhosphoSitePlusⁱ	Q9UK53

Expressionⁱ

Tissue specificityⁱ

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000153487 Expressed in 207 organ(s), highest expression level in decidua
ExpressionAtlasⁱ	Q9UK53 baseline and differential
Genevisibleⁱ	Q9UK53 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016136 CAB017773 HPA052591

HPAⁱ

CAB016136
CAB017773
HPA052591

Interactionⁱ

Subunit structureⁱ

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53. Isoform 2 interacts with RSL1D1.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NQO1	P15559	3	EBI-399198,EBI-3989435

With

Entry

#Exp.

IntAct

Notes

NQO1

P15559

3

EBI-399198,EBI-3989435

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16728974

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109833, 80 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9UK53
Database of interacting proteins More...DIPⁱ	DIP-24256N DIP-24257N DIP-24258N
IntActⁱ	Q9UK53, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q9UK53
STRINGⁱ	9606.ENSP00000364929

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	356 – 359	Combined sources	4
Beta strandⁱ	364 – 368	Combined sources	5
Beta strandⁱ	378 – 380	Combined sources	3
Helixⁱ	382 – 384	Combined sources	3
Helixⁱ	397 – 400	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UK53
SMRⁱ	Q9UK53
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UK53

EvolutionaryTraceⁱ

Q9UK53

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	405 – 422	PBRBy similarityAdd BLAST		18

Domainⁱ

The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns₅P).By similarity

Sequence similaritiesⁱ

Belongs to the ING family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	353 – 402	PHD-typePROSITE-ProRule annotationAdd BLAST		50

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1973 Eukaryota COG5034 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074538
HOGENOMⁱ	HOG000239724
HOVERGENⁱ	HBG006607
InParanoidⁱ	Q9UK53
KEGG Orthology (KO) More...KOⁱ	K19197
OMAⁱ	YCVCNQI
PhylomeDBⁱ	Q9UK53
TreeFamⁱ	TF352014

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR028643 ING1 IPR024610 ING_N_histone_binding IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR10333:SF85 PTHR10333:SF85, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12998 ING, 1 hit
SMARTⁱ	View protein in SMART SM01408 ING, 1 hit SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UK53-1) [UniParc]FASTA Add to basket

Also known as: p47ING1a, ING1-ALT2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG 
        60         70         80         90        100
RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG 
       110        120        130        140        150
GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA 
       160        170        180        190        200
RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER 
       210        220        230        240        250
FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD 
       260        270        280        290        300
SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 
       310        320        330        340        350
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP 
       360        370        380        390        400
NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR 
       410        420 
GENEKTMDKA LEKSKKERAY NR

Length:422

Mass (Da):46,738

Last modified:November 4, 2008 - v2

Checksum:ⁱ03D6AEEAA6E39090

GO

Isoform 2 (identifier: Q9UK53-2) [UniParc]FASTA Add to basket

Also known as: p33ING1b, Variant A

The sequence of this isoform differs from the canonical sequence as follows:
1-189: MSFVECPYHS...GWGRAWPWKQ → MLSPANGEQL...MREIDAKYQE

« Hide

        10         20         30         40         50
MLSPANGEQL HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE 
        60         70         80         90        100
LDECYERFSR ETDGAQKRRM LHCVQRALIR SQELGDEKIQ IVSQMVELVE 
       110        120        130        140        150
NRTRQVDSHV ELFEAQQELG DTAGNSGKAG ADRPKGEAAA QADKPNSKRS 
       160        170        180        190        200
RRQRNNENRE NASSNHDHDD GASGTPKEKK AKTSKKKKRS KAKAEREASP 
       210        220        230        240        250
ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC VGLNHKPKGK 
       260        270 
WYCPKCRGEN EKTMDKALEK SKKERAYNR

Show »

Length:279

Mass (Da):31,864

Checksum:ⁱ6DA3F3F892B35810

GO

Isoform 3 (identifier: Q9UK53-3) [UniParc]FASTA Add to basket

Also known as: p24ING1c, ING1-ALT1, Variant B

The sequence of this isoform differs from the canonical sequence as follows:
1-212: Missing.

« Hide

        10         20         30         40         50
MLHCVQRALI RSQELGDEKI QIVSQMVELV ENRTRQVDSH VELFEAQQEL 
        60         70         80         90        100
GDTAGNSGKA GADRPKGEAA AQADKPNSKR SRRQRNNENR ENASSNHDHD 
       110        120        130        140        150
DGASGTPKEK KAKTSKKKKR SKAKAEREAS PADLPIDPNE PTYCLCNQVS 
       160        170        180        190        200
YGEMIGCDND ECPIEWFHFS CVGLNHKPKG KWYCPKCRGE NEKTMDKALE 
       210
KSKKERAYNR

Show »

Length:210

Mass (Da):23,671

Checksum:ⁱ98961A2886E319FC

GO

Isoform 4 (identifier: Q9UK53-4) [UniParc]FASTA Add to basket

Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
1-189: MSFVECPYHS...GWGRAWPWKQ → ME

« Hide

        10         20         30         40         50
MEILKELDEC YERFSRETDG AQKRRMLHCV QRALIRSQEL GDEKIQIVSQ 
        60         70         80         90        100
MVELVENRTR QVDSHVELFE AQQELGDTAG NSGKAGADRP KGEAAAQADK 
       110        120        130        140        150
PNSKRSRRQR NNENRENASS NHDHDDGASG TPKEKKAKTS KKKKRSKAKA 
       160        170        180        190        200
EREASPADLP IDPNEPTYCL CNQVSYGEMI GCDNDECPIE WFHFSCVGLN 
       210        220        230 
HKPKGKWYCP KCRGENEKTM DKALEKSKKE RAYNR

Show »

Length:235

Mass (Da):26,757

Checksum:ⁱ0422C638B9AB741C

GO

Isoform 5 (identifier: Q9UK53-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-189: MSFVECPYHS...GWGRAWPWKQ → MSFVECPYHSPAERLVAEADEGGPSAITE

« Hide

        10         20         30         40         50
MSFVECPYHS PAERLVAEAD EGGPSAITEI LKELDECYER FSRETDGAQK 
        60         70         80         90        100
RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD SHVELFEAQQ 
       110        120        130        140        150
ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE NRENASSNHD 
       160        170        180        190        200
HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ 
       210        220        230        240        250
VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA 
       260 
LEKSKKERAY NR

Show »

Length:262

Mass (Da):29,572

Checksum:ⁱ7C1A910F8B850C59

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DFW2	A0A0C4DFW2_HUMAN	Inhibitor of growth protein Inhibitor of growth protein	ING1 hCG_1774813	422	Annotation score:
A0A087WXF7	A0A087WXF7_HUMAN	Inhibitor of growth protein 1 Inhibitor of growth protein 1	ING1	111	Annotation score:

Sequence cautionⁱ

The sequence AAB60879 differs from that shown. Reason: Frameshift at position 149.Curated

The sequence AAG02579 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	266	A → V in AAC00501 (PubMed:8944021).Curated	1
Sequence conflictⁱ	266	A → V in AAB60879 (PubMed:8944021).Curated	1
Sequence conflictⁱ	266	A → V (PubMed:10626813).Curated	1
Sequence conflictⁱ	266	A → V (PubMed:10807544).Curated	1
Sequence conflictⁱ	272	A → V in AAC00501 (PubMed:8944021).Curated	1
Sequence conflictⁱ	272	A → V in AAB60879 (PubMed:8944021).Curated	1
Sequence conflictⁱ	272	A → V (PubMed:10626813).Curated	1
Sequence conflictⁱ	272	A → V (PubMed:10807544).Curated	1
Sequence conflictⁱ	278	K → N in AAC00501 (PubMed:8944021).Curated	1
Sequence conflictⁱ	278	K → N in AAB60879 (PubMed:8944021).Curated	1
Sequence conflictⁱ	278	K → N (PubMed:10626813).Curated	1
Sequence conflictⁱ	278	K → N (PubMed:10807544).Curated	1
Sequence conflictⁱ	280	E → D in AAC00501 (PubMed:8944021).Curated	1
Sequence conflictⁱ	280	E → D in AAB60879 (PubMed:8944021).Curated	1
Sequence conflictⁱ	280	E → D (PubMed:10626813).Curated	1
Sequence conflictⁱ	280	E → D (PubMed:10807544).Curated	1
Sequence conflictⁱ	282	A → V in AAC00501 (PubMed:8944021).Curated	1
Sequence conflictⁱ	282	A → V in AAB60879 (PubMed:8944021).Curated	1
Sequence conflictⁱ	282	A → V (PubMed:10626813).Curated	1
Sequence conflictⁱ	282	A → V (PubMed:10807544).Curated	1
Sequence conflictⁱ	285	A → S in AAC00501 (PubMed:8944021).Curated	1
Sequence conflictⁱ	285	A → S in AAB60879 (PubMed:8944021).Curated	1
Sequence conflictⁱ	285	A → S (PubMed:10626813).Curated	1
Sequence conflictⁱ	285	A → S (PubMed:10807544).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047097	125	L → R3 PublicationsCorresponds to variant dbSNP:rs7338333Ensembl.	1
Natural variantⁱVAR_017420	335	A → D in HNSCC. 1 Publication	1
Natural variantⁱVAR_017421	358	C → S in HNSCC. 1 Publication	1
Natural variantⁱVAR_017422	359	N → S in HNSCC. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_009129	1 – 212	Missing in isoform 3. 2 PublicationsAdd BLAST	212
Alternative sequenceⁱVSP_009126	1 – 189	MSFVE…WPWKQ → MLSPANGEQLHLVNYVEDYL DSIESLPFDLQRNVSLMREI DAKYQE in isoform 2. 5 PublicationsAdd BLAST	189
Alternative sequenceⁱVSP_009127	1 – 189	MSFVE…WPWKQ → ME in isoform 4. 2 PublicationsAdd BLAST	189
Alternative sequenceⁱVSP_009128	1 – 189	MSFVE…WPWKQ → MSFVECPYHSPAERLVAEAD EGGPSAITE in isoform 5. CuratedAdd BLAST	189

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF181849 mRNA Translation: AAF07920.1 AF181850 mRNA Translation: AAF07921.1 AF001954 mRNA Translation: AAB60879.1 Frameshift. AF044076 mRNA Translation: AAC00501.1 AF149721 mRNA Translation: AAF37421.1 AF149722 mRNA Translation: AAF37422.1 AF149723 mRNA Translation: AAF37423.1 AF167551, AF167550 Genomic DNA Translation: AAG02578.1 AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems. AB037387 Genomic DNA Translation: BAB08101.1 AB037387 Genomic DNA Translation: BAB08102.1 AB037387 Genomic DNA Translation: BAB08103.1 AB037594 mRNA Translation: BAB20992.2 AB031269 mRNA Translation: BAA83496.1 AB024401 mRNA Translation: BAA82886.1 AB024402 mRNA Translation: BAA82887.1 AB024403 Genomic DNA Translation: BAA82888.1 AB024404 Genomic DNA Translation: BAA82889.1 AB024404 Genomic DNA Translation: BAA83462.1 AB024405 Genomic DNA Translation: BAA82890.1 AJ310392 mRNA Translation: CAC38067.1 AF078835 mRNA Translation: AAG12174.1 AF078837, AF078836 Genomic DNA Translation: AAG12175.1 AK302353 mRNA Translation: BAG63679.1 AL157820 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09127.1 CH471085 Genomic DNA Translation: EAX09130.1 BC093942 mRNA Translation: AAH93942.1 BC093944 mRNA Translation: AAH93944.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9515.1 [Q9UK53-4] CCDS9516.1 [Q9UK53-2] CCDS9517.1 [Q9UK53-1] CCDS9518.1 [Q9UK53-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001254657.1, NM_001267728.1 [Q9UK53-5] NP_005528.4, NM_005537.5 NP_937860.1, NM_198217.2 [Q9UK53-4] NP_937861.1, NM_198218.2 [Q9UK53-3] NP_937862.1, NM_198219.2 [Q9UK53-2]
UniGeneⁱ	Hs.46700 Hs.508725

Genome annotation databases

Ensemblⁱ	ENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2] ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4] ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3]
GeneIDⁱ	3621
KEGGⁱ	hsa:3621
UCSC genome browser More...UCSCⁱ	uc001vrf.5 human [Q9UK53-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK53	Inhibitor of growth protein		PANTR		210	UniRef100_Q9UK53
Isoform 3 of Inhibitor of growth protein 1		HUMAN		210
Q9UK53-2	Inhibitor of growth protein		PANTR		279	UniRef100_H2Q7T1
Inhibitor of growth protein		GORGO		279
Q9UK53-4	Inhibitor of growth protein		PANTR		235	UniRef100_A0A2I3RM45
Inhibitor of growth protein		PANPA		235
Inhibitor of growth protein		GORGO		235
Q9UK53-5	Inhibitor of growth protein 1 (Fragment)		HUMAN		111	UniRef100_Q9UK53-5
ING1 isoform 5 (Fragment)		PANTR		111

Protein	Similar proteins		Species	Score	Length	Source
Q9UK53	Inhibitor of growth protein		PANTR		210	UniRef90_Q9UK53
Isoform 3 of Inhibitor of growth protein 1		HUMAN		210
Inhibitor of growth protein		GORGO		421
Inhibitor of growth protein		COLAP		419
Inhibitor of growth protein		PAPAN		419
+22
Q9UK53-2	Inhibitor of growth protein		PONAB		279	UniRef90_H2NKB7
Inhibitor of growth protein		MACMU		279
Inhibitor of growth protein		MACFA		279
Inhibitor of growth protein		MACNE		279
Inhibitor of growth protein		PANTR		279
+32
Q9UK53-4	Inhibitor of growth protein		PONAB		279	UniRef90_H2NKB7
Inhibitor of growth protein		MACMU		279
Inhibitor of growth protein		MACFA		279
Inhibitor of growth protein		MACNE		279
Inhibitor of growth protein		PANTR		279
+32
Q9UK53-5	Inhibitor of growth protein 1 (Fragment)		HUMAN		111	UniRef90_Q9UK53-5
ING1 isoform 5 (Fragment)		PANTR		111
UPI000C29E2E7		Ugandan red Colobus		322
UPI00045DED2D		CHLSB		283
UPI000DC16618		THEGE		283
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9UK53	Inhibitor of growth protein		PANTR		210	UniRef50_Q9UK53
Isoform 3 of Inhibitor of growth protein 1		HUMAN		210
Inhibitor of growth protein		GORGO		421
Inhibitor of growth protein		PAPAN		419
Inhibitor of growth protein		MANLE		419
+44
Q9UK53-2	Isoform 5 of Inhibitor of growth protein 1		HUMAN		262	UniRef50_Q9UK53-5
ING1 isoform 5 (Fragment)		PANTR		111
Inhibitor of growth protein		ASTMX		290
Inhibitor of growth protein		SHEEP		278
Inhibitor of growth protein (Fragment)		wild yak		272
+152
Q9UK53-4	Isoform 5 of Inhibitor of growth protein 1		HUMAN		262	UniRef50_Q9UK53-5
ING1 isoform 5 (Fragment)		PANTR		111
Inhibitor of growth protein		ASTMX		290
Inhibitor of growth protein		SHEEP		278
Inhibitor of growth protein (Fragment)		wild yak		272
+152
Q9UK53-5	Inhibitor of growth protein 1 (Fragment)		HUMAN		111	UniRef50_Q9UK53-5
ING1 isoform 5 (Fragment)		PANTR		111
Inhibitor of growth protein		ASTMX		290
Inhibitor of growth protein		SHEEP		278
Inhibitor of growth protein (Fragment)		wild yak		272
+152

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF181849 mRNA Translation: AAF07920.1 AF181850 mRNA Translation: AAF07921.1 AF001954 mRNA Translation: AAB60879.1 Frameshift. AF044076 mRNA Translation: AAC00501.1 AF149721 mRNA Translation: AAF37421.1 AF149722 mRNA Translation: AAF37422.1 AF149723 mRNA Translation: AAF37423.1 AF167551, AF167550 Genomic DNA Translation: AAG02578.1 AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems. AB037387 Genomic DNA Translation: BAB08101.1 AB037387 Genomic DNA Translation: BAB08102.1 AB037387 Genomic DNA Translation: BAB08103.1 AB037594 mRNA Translation: BAB20992.2 AB031269 mRNA Translation: BAA83496.1 AB024401 mRNA Translation: BAA82886.1 AB024402 mRNA Translation: BAA82887.1 AB024403 Genomic DNA Translation: BAA82888.1 AB024404 Genomic DNA Translation: BAA82889.1 AB024404 Genomic DNA Translation: BAA83462.1 AB024405 Genomic DNA Translation: BAA82890.1 AJ310392 mRNA Translation: CAC38067.1 AF078835 mRNA Translation: AAG12174.1 AF078837, AF078836 Genomic DNA Translation: AAG12175.1 AK302353 mRNA Translation: BAG63679.1 AL157820 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09127.1 CH471085 Genomic DNA Translation: EAX09130.1 BC093942 mRNA Translation: AAH93942.1 BC093944 mRNA Translation: AAH93944.1
CCDSⁱ	CCDS9515.1 [Q9UK53-4] CCDS9516.1 [Q9UK53-2] CCDS9517.1 [Q9UK53-1] CCDS9518.1 [Q9UK53-3]
RefSeqⁱ	NP_001254657.1, NM_001267728.1 [Q9UK53-5] NP_005528.4, NM_005537.5 NP_937860.1, NM_198217.2 [Q9UK53-4] NP_937861.1, NM_198218.2 [Q9UK53-3] NP_937862.1, NM_198219.2 [Q9UK53-2]
UniGeneⁱ	Hs.46700 Hs.508725

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2QIC	X-ray	2.10	A	345-404	[»]
ProteinModelPortalⁱ	Q9UK53
SMRⁱ	Q9UK53
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109833, 80 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9UK53
DIPⁱ	DIP-24256N DIP-24257N DIP-24258N
IntActⁱ	Q9UK53, 19 interactors
MINTⁱ	Q9UK53
STRINGⁱ	9606.ENSP00000364929

PTM databases

iPTMnetⁱ	Q9UK53
PhosphoSitePlusⁱ	Q9UK53

Polymorphism and mutation databases

BioMutaⁱ	ING1
DMDMⁱ	212276438

Proteomic databases

EPDⁱ	Q9UK53
PaxDbⁱ	Q9UK53
PeptideAtlasⁱ	Q9UK53
PRIDEⁱ	Q9UK53
ProteomicsDBⁱ	84718 84719 [Q9UK53-2] 84720 [Q9UK53-3] 84721 [Q9UK53-4] 84722 [Q9UK53-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2] ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4] ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3]
GeneIDⁱ	3621
KEGGⁱ	hsa:3621
UCSCⁱ	uc001vrf.5 human [Q9UK53-1]

Organism-specific databases

CTDⁱ	3621
DisGeNETⁱ	3621
EuPathDBⁱ	HostDB:ENSG00000153487.12
GeneCardsⁱ	ING1
H-InvDBⁱ	HIX0056146
HGNCⁱ	HGNC:6062 ING1
HPAⁱ	CAB016136 CAB017773 HPA052591
MalaCardsⁱ	ING1
MIMⁱ	275355 phenotype 601566 gene
neXtProtⁱ	NX_Q9UK53
OpenTargetsⁱ	ENSG00000153487
Orphanetⁱ	500481 Squamous cell carcinoma of salivary glands 494547 Squamous cell carcinoma of the hypopharynx 494550 Squamous cell carcinoma of the larynx 502366 Squamous cell carcinoma of the lip 500464 Squamous cell carcinoma of the nasal cavity and paranasal sinuses 502363 Squamous cell carcinoma of the oral cavity 500478 Squamous cell carcinoma of the oropharynx
PharmGKBⁱ	PA29872
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1973 Eukaryota COG5034 LUCA
GeneTreeⁱ	ENSGT00550000074538
HOGENOMⁱ	HOG000239724
HOVERGENⁱ	HBG006607
InParanoidⁱ	Q9UK53
KOⁱ	K19197
OMAⁱ	YCVCNQI
PhylomeDBⁱ	Q9UK53
TreeFamⁱ	TF352014

Enzyme and pathway databases

SIGNORⁱ	Q9UK53

SIGNORⁱ

Q9UK53

Miscellaneous databases

ChiTaRSⁱ	ING1 human
EvolutionaryTraceⁱ	Q9UK53
GeneWikiⁱ	ING1
GenomeRNAiⁱ	3621
Protein Ontology More...PROⁱ	PR:Q9UK53
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153487 Expressed in 207 organ(s), highest expression level in decidua
ExpressionAtlasⁱ	Q9UK53 baseline and differential
Genevisibleⁱ	Q9UK53 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR028643 ING1 IPR024610 ING_N_histone_binding IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR10333:SF85 PTHR10333:SF85, 1 hit
Pfamⁱ	View protein in Pfam PF12998 ING, 1 hit
SMARTⁱ	View protein in SMART SM01408 ING, 1 hit SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ING1_HUMAN
Accessionⁱ	Q9UK53Primary (citable) accession number: Q9UK53 Secondary accession number(s): O00532 Q9UK52
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	November 4, 2008
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - Q9UK53 (ING1_HUMAN)

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Inhibitor of growth protein 1

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Zinc finger

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ