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UniProtKB - Q9UK53 (ING1_HUMAN)

Entry version 173 (07 Oct 2020)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
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Protein

Inhibitor of growth protein 1

Gene

ING1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei355Histone H3K4me3Combined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi356Zinc 1Combined sources1 Publication1
Metal bindingi358Zinc 1Combined sources1 Publication1
Binding sitei366Histone H3K4me3Combined sources1 Publication1
Metal bindingi369Zinc 2Combined sources1 Publication1
Binding sitei370Histone H3K4me3Combined sources1 Publication1
Metal bindingi374Zinc 2Combined sources1 Publication1
Binding sitei378Histone H3K4me3Combined sources1 Publication1
Metal bindingi380Zinc 1; via pros nitrogenCombined sources1 Publication1
Metal bindingi383Zinc 1Combined sources1 Publication1
Metal bindingi396Zinc 2Combined sources1 Publication1
Metal bindingi399Zinc 2Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri353 – 402PHD-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UK53

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UK53

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibitor of growth protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ING1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000153487.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:6062, ING1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601566, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UK53

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Squamous cell carcinoma of the head and neck (HNSCC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017420335A → D in HNSCC. 1 Publication1
Natural variantiVAR_017421358C → S in HNSCC. 1 Publication1
Natural variantiVAR_017422359N → S in HNSCC. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi378W → A: Unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis. 1 Publication1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		3621

MalaCards human disease database

More...MalaCardsi		ING1
MIMi275355, phenotype

Open Targets

More...OpenTargetsi		ENSG00000153487

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		500481, Squamous cell carcinoma of salivary glands
494547, Squamous cell carcinoma of the hypopharynx
494550, Squamous cell carcinoma of the larynx
502366, Squamous cell carcinoma of the lip
500464, Squamous cell carcinoma of the nasal cavity and paranasal sinuses
502363, Squamous cell carcinoma of the oral cavity
500478, Squamous cell carcinoma of the oropharynx

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29872

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UK53, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ING1

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126611 – 422Inhibitor of growth protein 1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UK53

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UK53

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UK53

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UK53

PeptideAtlas

More...PeptideAtlasi		Q9UK53

PRoteomics IDEntifications database

More...PRIDEi		Q9UK53

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84718 [Q9UK53-1]
84719 [Q9UK53-2]
84720 [Q9UK53-3]
84721 [Q9UK53-4]
84722 [Q9UK53-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UK53

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UK53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000153487, Expressed in decidua and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UK53, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UK53, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000153487, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2.

Interacts with TP53.

Isoform 2 interacts with RSL1D1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109833, 84 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3321, SIN3A histone deacetylase complex
CPX-3322, SIN3B histone deacetylase complex
CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UK53

Database of interacting proteins

More...DIPi		DIP-24256N
DIP-24257N
DIP-24258N

Protein interaction database and analysis system

More...IntActi		Q9UK53, 21 interactors

Molecular INTeraction database

More...MINTi		Q9UK53

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364929

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UK53, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UK53

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UK53

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni405 – 422PBRBy similarityAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 402PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1973, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155401

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031900_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UK53

KEGG Orthology (KO)

More...KOi		K19197

Identification of Orthologs from Complete Genome Data

More...OMAi		YCVCNQI

Database of Orthologous Groups

More...OrthoDBi		1434088at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UK53

TreeFam database of animal gene trees

More...TreeFami		TF352014

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028643, ING1
IPR028651, ING_fam
IPR024610, ING_N_histone-binding
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR10333, PTHR10333, 1 hit
PTHR10333:SF85, PTHR10333:SF85, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12998, ING, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01408, ING, 1 hit
SM00249, PHD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UK53-1) [UniParc]FASTAAdd to basket
Also known as: p47ING1a, ING1-ALT2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG 
        60         70         80         90        100
RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG 
       110        120        130        140        150
GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA 
       160        170        180        190        200
RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER 
       210        220        230        240        250
FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD 
       260        270        280        290        300
SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 
       310        320        330        340        350
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP 
       360        370        380        390        400
NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR 
       410        420 
GENEKTMDKA LEKSKKERAY NR
Length:422
Mass (Da):46,738
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03D6AEEAA6E39090
GO
Isoform 2 (identifier: Q9UK53-2) [UniParc]FASTAAdd to basket
Also known as: p33ING1b, Variant A

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → MLSPANGEQL...MREIDAKYQE

Show »
Length:279
Mass (Da):31,864
Checksum:i6DA3F3F892B35810
GO
Isoform 3 (identifier: Q9UK53-3) [UniParc]FASTAAdd to basket
Also known as: p24ING1c, ING1-ALT1, Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:210
Mass (Da):23,671
Checksum:i98961A2886E319FC
GO
Isoform 4 (identifier: Q9UK53-4) [UniParc]FASTAAdd to basket
Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → ME

Show »
Length:235
Mass (Da):26,757
Checksum:i0422C638B9AB741C
GO
Isoform 5 (identifier: Q9UK53-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → MSFVECPYHSPAERLVAEADEGGPSAITE

Show »
Length:262
Mass (Da):29,572
Checksum:i7C1A910F8B850C59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFW2A0A0C4DFW2_HUMAN
Inhibitor of growth protein
ING1 hCG_1774813
422Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXF7A0A087WXF7_HUMAN
Inhibitor of growth protein 1
ING1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60879 differs from that shown. Reason: Frameshift.Curated
The sequence AAG02579 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti266A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti266A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti266A → V (PubMed:10626813).Curated1
Sequence conflicti266A → V (PubMed:10807544).Curated1
Sequence conflicti272A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti272A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti272A → V (PubMed:10626813).Curated1
Sequence conflicti272A → V (PubMed:10807544).Curated1
Sequence conflicti278K → N in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti278K → N in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti278K → N (PubMed:10626813).Curated1
Sequence conflicti278K → N (PubMed:10807544).Curated1
Sequence conflicti280E → D in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti280E → D in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti280E → D (PubMed:10626813).Curated1
Sequence conflicti280E → D (PubMed:10807544).Curated1
Sequence conflicti282A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti282A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti282A → V (PubMed:10626813).Curated1
Sequence conflicti282A → V (PubMed:10807544).Curated1
Sequence conflicti285A → S in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti285A → S in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti285A → S (PubMed:10626813).Curated1
Sequence conflicti285A → S (PubMed:10807544).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047097125L → R3 PublicationsCorresponds to variant dbSNP:rs7338333Ensembl.1
Natural variantiVAR_017420335A → D in HNSCC. 1 Publication1
Natural variantiVAR_017421358C → S in HNSCC. 1 Publication1
Natural variantiVAR_017422359N → S in HNSCC. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0091291 – 212Missing in isoform 3. 2 PublicationsAdd BLAST212
Alternative sequenceiVSP_0091261 – 189MSFVE…WPWKQ → MLSPANGEQLHLVNYVEDYL DSIESLPFDLQRNVSLMREI DAKYQE in isoform 2. 5 PublicationsAdd BLAST189
Alternative sequenceiVSP_0091271 – 189MSFVE…WPWKQ → ME in isoform 4. 2 PublicationsAdd BLAST189
Alternative sequenceiVSP_0091281 – 189MSFVE…WPWKQ → MSFVECPYHSPAERLVAEAD EGGPSAITE in isoform 5. CuratedAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF181849 mRNA Translation: AAF07920.1
AF181850 mRNA Translation: AAF07921.1
AF001954 mRNA Translation: AAB60879.1 Frameshift.
AF044076 mRNA Translation: AAC00501.1
AF149721 mRNA Translation: AAF37421.1
AF149722 mRNA Translation: AAF37422.1
AF149723 mRNA Translation: AAF37423.1
AF167551, AF167550 Genomic DNA Translation: AAG02578.1
AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems.
AB037387 Genomic DNA Translation: BAB08101.1
AB037387 Genomic DNA Translation: BAB08102.1
AB037387 Genomic DNA Translation: BAB08103.1
AB037594 mRNA Translation: BAB20992.2
AB031269 mRNA Translation: BAA83496.1
AB024401 mRNA Translation: BAA82886.1
AB024402 mRNA Translation: BAA82887.1
AB024403 Genomic DNA Translation: BAA82888.1
AB024404 Genomic DNA Translation: BAA82889.1
AB024404 Genomic DNA Translation: BAA83462.1
AB024405 Genomic DNA Translation: BAA82890.1
AJ310392 mRNA Translation: CAC38067.1
AF078835 mRNA Translation: AAG12174.1
AF078837, AF078836 Genomic DNA Translation: AAG12175.1
AK302353 mRNA Translation: BAG63679.1
AL157820 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09127.1
CH471085 Genomic DNA Translation: EAX09130.1
BC093942 mRNA Translation: AAH93942.1
BC093944 mRNA Translation: AAH93944.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9515.1 [Q9UK53-4]
CCDS9516.1 [Q9UK53-2]
CCDS9517.1 [Q9UK53-1]
CCDS9518.1 [Q9UK53-3]

NCBI Reference Sequences

More...RefSeqi		NP_001254657.1, NM_001267728.1 [Q9UK53-5]
NP_005528.4, NM_005537.5
NP_937860.1, NM_198217.2 [Q9UK53-4]
NP_937861.1, NM_198218.2 [Q9UK53-3]
NP_937862.1, NM_198219.2 [Q9UK53-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2]
ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4]
ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3621

UCSC genome browser

More...UCSCi		uc001vrf.5, human [Q9UK53-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181849 mRNA Translation: AAF07920.1
AF181850 mRNA Translation: AAF07921.1
AF001954 mRNA Translation: AAB60879.1 Frameshift.
AF044076 mRNA Translation: AAC00501.1
AF149721 mRNA Translation: AAF37421.1
AF149722 mRNA Translation: AAF37422.1
AF149723 mRNA Translation: AAF37423.1
AF167551, AF167550 Genomic DNA Translation: AAG02578.1
AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems.
AB037387 Genomic DNA Translation: BAB08101.1
AB037387 Genomic DNA Translation: BAB08102.1
AB037387 Genomic DNA Translation: BAB08103.1
AB037594 mRNA Translation: BAB20992.2
AB031269 mRNA Translation: BAA83496.1
AB024401 mRNA Translation: BAA82886.1
AB024402 mRNA Translation: BAA82887.1
AB024403 Genomic DNA Translation: BAA82888.1
AB024404 Genomic DNA Translation: BAA82889.1
AB024404 Genomic DNA Translation: BAA83462.1
AB024405 Genomic DNA Translation: BAA82890.1
AJ310392 mRNA Translation: CAC38067.1
AF078835 mRNA Translation: AAG12174.1
AF078837, AF078836 Genomic DNA Translation: AAG12175.1
AK302353 mRNA Translation: BAG63679.1
AL157820 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09127.1
CH471085 Genomic DNA Translation: EAX09130.1
BC093942 mRNA Translation: AAH93942.1
BC093944 mRNA Translation: AAH93944.1
CCDSiCCDS9515.1 [Q9UK53-4]
CCDS9516.1 [Q9UK53-2]
CCDS9517.1 [Q9UK53-1]
CCDS9518.1 [Q9UK53-3]
RefSeqiNP_001254657.1, NM_001267728.1 [Q9UK53-5]
NP_005528.4, NM_005537.5
NP_937860.1, NM_198217.2 [Q9UK53-4]
NP_937861.1, NM_198218.2 [Q9UK53-3]
NP_937862.1, NM_198219.2 [Q9UK53-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QICX-ray2.10A345-404[»]
SMRiQ9UK53
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109833, 84 interactors
ComplexPortaliCPX-3321, SIN3A histone deacetylase complex
CPX-3322, SIN3B histone deacetylase complex
CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ9UK53
DIPiDIP-24256N
DIP-24257N
DIP-24258N
IntActiQ9UK53, 21 interactors
MINTiQ9UK53
STRINGi9606.ENSP00000364929

PTM databases

iPTMnetiQ9UK53
PhosphoSitePlusiQ9UK53

Polymorphism and mutation databases

BioMutaiING1
DMDMi212276438

Proteomic databases

EPDiQ9UK53
jPOSTiQ9UK53
MassIVEiQ9UK53
PaxDbiQ9UK53
PeptideAtlasiQ9UK53
PRIDEiQ9UK53
ProteomicsDBi84718 [Q9UK53-1]
84719 [Q9UK53-2]
84720 [Q9UK53-3]
84721 [Q9UK53-4]
84722 [Q9UK53-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4248, 480 antibodies

Genome annotation databases

EnsembliENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2]
ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4]
ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3]
GeneIDi3621
KEGGihsa:3621
UCSCiuc001vrf.5, human [Q9UK53-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3621
DisGeNETi3621
EuPathDBiHostDB:ENSG00000153487.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ING1
HGNCiHGNC:6062, ING1
HPAiENSG00000153487, Low tissue specificity
MalaCardsiING1
MIMi275355, phenotype
601566, gene
neXtProtiNX_Q9UK53
OpenTargetsiENSG00000153487
Orphaneti500481, Squamous cell carcinoma of salivary glands
494547, Squamous cell carcinoma of the hypopharynx
494550, Squamous cell carcinoma of the larynx
502366, Squamous cell carcinoma of the lip
500464, Squamous cell carcinoma of the nasal cavity and paranasal sinuses
502363, Squamous cell carcinoma of the oral cavity
500478, Squamous cell carcinoma of the oropharynx
PharmGKBiPA29872

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1973, Eukaryota
GeneTreeiENSGT00940000155401
HOGENOMiCLU_031900_5_1_1
InParanoidiQ9UK53
KOiK19197
OMAiYCVCNQI
OrthoDBi1434088at2759
PhylomeDBiQ9UK53
TreeFamiTF352014

Enzyme and pathway databases

PathwayCommonsiQ9UK53
SIGNORiQ9UK53

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3621, 7 hits in 885 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ING1, human
EvolutionaryTraceiQ9UK53

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ING1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3621
PharosiQ9UK53, Tbio

Protein Ontology

More...PROi		PR:Q9UK53
RNActiQ9UK53, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000153487, Expressed in decidua and 217 other tissues
ExpressionAtlasiQ9UK53, baseline and differential
GenevisibleiQ9UK53, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028643, ING1
IPR028651, ING_fam
IPR024610, ING_N_histone-binding
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR10333, PTHR10333, 1 hit
PTHR10333:SF85, PTHR10333:SF85, 1 hit
PfamiView protein in Pfam
PF12998, ING, 1 hit
SMARTiView protein in SMART
SM01408, ING, 1 hit
SM00249, PHD, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiING1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK53
Secondary accession number(s): O00532
, O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0, Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, Q9P0U6, Q9UBC6, Q9UIJ1, Q9UIJ2, Q9UIJ3, Q9UIJ4, Q9UK52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 4, 2008
Last modified: October 7, 2020
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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