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UniProtKB - Q9UK53 (ING1_HUMAN)

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Protein

Inhibitor of growth protein 1

Gene

ING1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei355Histone H3K4me3Combined sources1 Publication1
Metal bindingi356Zinc 1Combined sources1 Publication1
Metal bindingi358Zinc 1Combined sources1 Publication1
Binding sitei366Histone H3K4me3Combined sources1 Publication1
Metal bindingi369Zinc 2Combined sources1 Publication1
Binding sitei370Histone H3K4me3Combined sources1 Publication1
Metal bindingi374Zinc 2Combined sources1 Publication1
Binding sitei378Histone H3K4me3Combined sources1 Publication1
Metal bindingi380Zinc 1; via pros nitrogenCombined sources1 Publication1
Metal bindingi383Zinc 1Combined sources1 Publication1
Metal bindingi396Zinc 2Combined sources1 Publication1
Metal bindingi399Zinc 2Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 402PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell proliferation Source: ProtInc
  • regulation of cell death Source: InterPro
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9UK53

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 1
Gene namesi
Name:ING1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000153487.12
HGNCiHGNC:6062 ING1
MIMi601566 gene
neXtProtiNX_Q9UK53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Squamous cell carcinoma of the head and neck (HNSCC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
See also OMIM:275355
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017420335A → D in HNSCC. 1 Publication1
Natural variantiVAR_017421358C → S in HNSCC. 1 Publication1
Natural variantiVAR_017422359N → S in HNSCC. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi378W → A: Unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis. 1 Publication1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi3621
MalaCardsiING1
MIMi275355 phenotype
OpenTargetsiENSG00000153487
Orphaneti67037 Squamous cell carcinoma of head and neck
PharmGKBiPA29872

Polymorphism and mutation databases

BioMutaiING1
DMDMi212276438

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126611 – 422Inhibitor of growth protein 1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UK53
PaxDbiQ9UK53
PeptideAtlasiQ9UK53
PRIDEiQ9UK53
ProteomicsDBi84718
84719 [Q9UK53-2]
84720 [Q9UK53-3]
84721 [Q9UK53-4]
84722 [Q9UK53-5]

PTM databases

iPTMnetiQ9UK53
PhosphoSitePlusiQ9UK53

Expressioni

Tissue specificityi

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000153487
ExpressionAtlasiQ9UK53 baseline and differential
GenevisibleiQ9UK53 HS

Organism-specific databases

HPAiCAB016136
CAB017773
HPA052591

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53. Isoform 2 interacts with RSL1D1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NQO1P155593EBI-399198,EBI-3989435

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi109833, 80 interactors
CORUMiQ9UK53
DIPiDIP-24256N
DIP-24257N
DIP-24258N
IntActiQ9UK53, 19 interactors
MINTiQ9UK53
STRINGi9606.ENSP00000364929

Structurei

Secondary structure

1422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni356 – 359Combined sources4
Beta strandi364 – 368Combined sources5
Beta strandi378 – 380Combined sources3
Helixi382 – 384Combined sources3
Helixi397 – 400Combined sources4

3D structure databases

ProteinModelPortaliQ9UK53
SMRiQ9UK53
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UK53

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni405 – 422PBRBy similarityAdd BLAST18

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 402PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1973 Eukaryota
COG5034 LUCA
GeneTreeiENSGT00550000074538
HOGENOMiHOG000239724
HOVERGENiHBG006607
InParanoidiQ9UK53
KOiK19197
OMAiYCVCNQI
PhylomeDBiQ9UK53
TreeFamiTF352014

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028643 ING1
IPR024610 ING_N_histone_binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF85 PTHR10333:SF85, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UK53-1) [UniParc]FASTAAdd to basket
Also known as: p47ING1a, ING1-ALT2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG 
        60         70         80         90        100
RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG 
       110        120        130        140        150
GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA 
       160        170        180        190        200
RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER 
       210        220        230        240        250
FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD 
       260        270        280        290        300
SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 
       310        320        330        340        350
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP 
       360        370        380        390        400
NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR 
       410        420 
GENEKTMDKA LEKSKKERAY NR
Length:422
Mass (Da):46,738
Last modified:November 4, 2008 - v2
Checksum:i03D6AEEAA6E39090
GO
Isoform 2 (identifier: Q9UK53-2) [UniParc]FASTAAdd to basket
Also known as: p33ING1b, Variant A

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → MLSPANGEQL...MREIDAKYQE

Show »
Length:279
Mass (Da):31,864
Checksum:i6DA3F3F892B35810
GO
Isoform 3 (identifier: Q9UK53-3) [UniParc]FASTAAdd to basket
Also known as: p24ING1c, ING1-ALT1, Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:210
Mass (Da):23,671
Checksum:i98961A2886E319FC
GO
Isoform 4 (identifier: Q9UK53-4) [UniParc]FASTAAdd to basket
Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → ME

Show »
Length:235
Mass (Da):26,757
Checksum:i0422C638B9AB741C
GO
Isoform 5 (identifier: Q9UK53-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → MSFVECPYHSPAERLVAEADEGGPSAITE

Show »
Length:262
Mass (Da):29,572
Checksum:i7C1A910F8B850C59
GO

Sequence cautioni

The sequence AAB60879 differs from that shown. Reason: Frameshift at position 149.Curated
The sequence AAG02579 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti266A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti266A → V (PubMed:10626813).Curated1
Sequence conflicti266A → V (PubMed:10807544).Curated1
Sequence conflicti272A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti272A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti272A → V (PubMed:10626813).Curated1
Sequence conflicti272A → V (PubMed:10807544).Curated1
Sequence conflicti278K → N in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti278K → N in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti278K → N (PubMed:10626813).Curated1
Sequence conflicti278K → N (PubMed:10807544).Curated1
Sequence conflicti280E → D in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti280E → D in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti280E → D (PubMed:10626813).Curated1
Sequence conflicti280E → D (PubMed:10807544).Curated1
Sequence conflicti282A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti282A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti282A → V (PubMed:10626813).Curated1
Sequence conflicti282A → V (PubMed:10807544).Curated1
Sequence conflicti285A → S in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti285A → S in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti285A → S (PubMed:10626813).Curated1
Sequence conflicti285A → S (PubMed:10807544).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047097125L → R3 PublicationsCorresponds to variant dbSNP:rs7338333Ensembl.1
Natural variantiVAR_017420335A → D in HNSCC. 1 Publication1
Natural variantiVAR_017421358C → S in HNSCC. 1 Publication1
Natural variantiVAR_017422359N → S in HNSCC. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0091291 – 212Missing in isoform 3. 2 PublicationsAdd BLAST212
Alternative sequenceiVSP_0091261 – 189MSFVE…WPWKQ → MLSPANGEQLHLVNYVEDYL DSIESLPFDLQRNVSLMREI DAKYQE in isoform 2. 5 PublicationsAdd BLAST189
Alternative sequenceiVSP_0091271 – 189MSFVE…WPWKQ → ME in isoform 4. 2 PublicationsAdd BLAST189
Alternative sequenceiVSP_0091281 – 189MSFVE…WPWKQ → MSFVECPYHSPAERLVAEAD EGGPSAITE in isoform 5. CuratedAdd BLAST189

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181849 mRNA Translation: AAF07920.1
AF181850 mRNA Translation: AAF07921.1
AF001954 mRNA Translation: AAB60879.1 Frameshift.
AF044076 mRNA Translation: AAC00501.1
AF149721 mRNA Translation: AAF37421.1
AF149722 mRNA Translation: AAF37422.1
AF149723 mRNA Translation: AAF37423.1
AF167551, AF167550 Genomic DNA Translation: AAG02578.1
AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems.
AB037387 Genomic DNA Translation: BAB08101.1
AB037387 Genomic DNA Translation: BAB08102.1
AB037387 Genomic DNA Translation: BAB08103.1
AB037594 mRNA Translation: BAB20992.2
AB031269 mRNA Translation: BAA83496.1
AB024401 mRNA Translation: BAA82886.1
AB024402 mRNA Translation: BAA82887.1
AB024403 Genomic DNA Translation: BAA82888.1
AB024404 Genomic DNA Translation: BAA82889.1
AB024404 Genomic DNA Translation: BAA83462.1
AB024405 Genomic DNA Translation: BAA82890.1
AJ310392 mRNA Translation: CAC38067.1
AF078835 mRNA Translation: AAG12174.1
AF078837, AF078836 Genomic DNA Translation: AAG12175.1
AK302353 mRNA Translation: BAG63679.1
AL157820 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09127.1
CH471085 Genomic DNA Translation: EAX09130.1
BC093942 mRNA Translation: AAH93942.1
BC093944 mRNA Translation: AAH93944.1
CCDSiCCDS9515.1 [Q9UK53-4]
CCDS9516.1 [Q9UK53-2]
CCDS9517.1 [Q9UK53-1]
CCDS9518.1 [Q9UK53-3]
RefSeqiNP_001254657.1, NM_001267728.1 [Q9UK53-5]
NP_005528.4, NM_005537.5
NP_937860.1, NM_198217.2 [Q9UK53-4]
NP_937861.1, NM_198218.2 [Q9UK53-3]
NP_937862.1, NM_198219.2 [Q9UK53-2]
UniGeneiHs.46700
Hs.508725

Genome annotation databases

EnsembliENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2]
ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4]
ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3]
GeneIDi3621
KEGGihsa:3621
UCSCiuc001vrf.5 human [Q9UK53-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiING1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK53
Secondary accession number(s): O00532
, O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0, Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, Q9P0U6, Q9UBC6, Q9UIJ1, Q9UIJ2, Q9UIJ3, Q9UIJ4, Q9UK52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 4, 2008
Last modified: July 18, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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