UniProtKB - Q9UK53 (ING1_HUMAN)
Inhibitor of growth protein 1
ING1
Functioni
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 355 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 356 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 358 | Zinc 1Combined sources1 Publication | 1 | |
Sitei | 366 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 369 | Zinc 2Combined sources1 Publication | 1 | |
Sitei | 370 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 374 | Zinc 2Combined sources1 Publication | 1 | |
Sitei | 378 | Histone H3K4me3 bindingCombined sources1 Publication | 1 | |
Metal bindingi | 380 | Zinc 1; via pros nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 383 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 396 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 399 | Zinc 2Combined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 353 – 402 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell population proliferation Source: ProtInc
- positive regulation of transcription, DNA-templated Source: GO_Central
- protein import into nucleus Source: Ensembl
- regulation of cell death Source: Ensembl
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Biological process | Cell cycle |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UK53 |
SignaLinki | Q9UK53 |
SIGNORi | Q9UK53 |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibitor of growth protein 1 |
Gene namesi | Name:ING1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6062, ING1 |
MIMi | 601566, gene |
neXtProti | NX_Q9UK53 |
VEuPathDBi | HostDB:ENSG00000153487 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Squamous cell carcinoma of the head and neck (HNSCC)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017420 | 335 | A → D in HNSCC. 1 Publication | 1 | |
Natural variantiVAR_017421 | 358 | C → S in HNSCC. 1 Publication | 1 | |
Natural variantiVAR_017422 | 359 | N → S in HNSCC. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 378 | W → A: Unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Tumor suppressorOrganism-specific databases
DisGeNETi | 3621 |
MalaCardsi | ING1 |
MIMi | 275355, phenotype |
OpenTargetsi | ENSG00000153487 |
Orphaneti | 500481, Squamous cell carcinoma of salivary glands 494547, Squamous cell carcinoma of the hypopharynx 494550, Squamous cell carcinoma of the larynx 502366, Squamous cell carcinoma of the lip 500464, Squamous cell carcinoma of the nasal cavity and paranasal sinuses 502363, Squamous cell carcinoma of the oral cavity 500478, Squamous cell carcinoma of the oropharynx |
PharmGKBi | PA29872 |
Miscellaneous databases
Pharosi | Q9UK53, Tbio |
Genetic variation databases
BioMutai | ING1 |
DMDMi | 212276438 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212661 | 1 – 422 | Inhibitor of growth protein 1Add BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 278 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9UK53 |
jPOSTi | Q9UK53 |
MassIVEi | Q9UK53 |
MaxQBi | Q9UK53 |
PaxDbi | Q9UK53 |
PeptideAtlasi | Q9UK53 |
PRIDEi | Q9UK53 |
ProteomicsDBi | 84718 [Q9UK53-1] 84719 [Q9UK53-2] 84720 [Q9UK53-3] 84721 [Q9UK53-4] 84722 [Q9UK53-5] |
PTM databases
GlyGeni | Q9UK53, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UK53 |
PhosphoSitePlusi | Q9UK53 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000153487, Expressed in decidua and 217 other tissues |
ExpressionAtlasi | Q9UK53, baseline and differential |
Genevisiblei | Q9UK53, HS |
Organism-specific databases
HPAi | ENSG00000153487, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with H3K4me3 and to a lesser extent with H3K4me2.
Interacts with TP53.
Isoform 2 interacts with RSL1D1.
4 PublicationsBinary interactionsi
Q9UK53
With | #Exp. | IntAct |
---|---|---|
NQO1 [P15559] | 3 | EBI-399198,EBI-3989435 |
Isoform 2 [Q9UK53-2]
With | #Exp. | IntAct |
---|---|---|
EXOC4 - isoform 2 [Q96A65-2] | 3 | EBI-8068204,EBI-17869840 |
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109833, 88 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9UK53 |
DIPi | DIP-24256N DIP-24257N DIP-24258N |
IntActi | Q9UK53, 24 interactors |
MINTi | Q9UK53 |
STRINGi | 9606.ENSP00000364929 |
Miscellaneous databases
RNActi | Q9UK53, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UK53 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UK53 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 261 – 349 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 405 – 422 | PBRBy similarityAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 280 – 322 | Basic and acidic residuesSequence analysisAdd BLAST | 43 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 353 – 402 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000155401 |
HOGENOMi | CLU_031900_5_1_1 |
InParanoidi | Q9UK53 |
OMAi | KMQIVNH |
OrthoDBi | 1434088at2759 |
PhylomeDBi | Q9UK53 |
TreeFami | TF352014 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028643, ING1 IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF85, PTHR10333:SF85, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG
60 70 80 90 100
RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG
110 120 130 140 150
GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA
160 170 180 190 200
RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER
210 220 230 240 250
FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD
260 270 280 290 300
SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE
310 320 330 340 350
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP
360 370 380 390 400
NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR
410 420
GENEKTMDKA LEKSKKERAY NR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFW2 | A0A0C4DFW2_HUMAN | Inhibitor of growth protein | ING1 hCG_1774813 | 422 | Annotation score: | ||
A0A087WXF7 | A0A087WXF7_HUMAN | Inhibitor of growth protein 1 | ING1 | 111 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 266 | A → V in AAC00501 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 266 | A → V in AAB60879 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 266 | A → V (PubMed:10626813).Curated | 1 | |
Sequence conflicti | 266 | A → V (PubMed:10807544).Curated | 1 | |
Sequence conflicti | 272 | A → V in AAC00501 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 272 | A → V in AAB60879 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 272 | A → V (PubMed:10626813).Curated | 1 | |
Sequence conflicti | 272 | A → V (PubMed:10807544).Curated | 1 | |
Sequence conflicti | 278 | K → N in AAC00501 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 278 | K → N in AAB60879 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 278 | K → N (PubMed:10626813).Curated | 1 | |
Sequence conflicti | 278 | K → N (PubMed:10807544).Curated | 1 | |
Sequence conflicti | 280 | E → D in AAC00501 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 280 | E → D in AAB60879 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 280 | E → D (PubMed:10626813).Curated | 1 | |
Sequence conflicti | 280 | E → D (PubMed:10807544).Curated | 1 | |
Sequence conflicti | 282 | A → V in AAC00501 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 282 | A → V in AAB60879 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 282 | A → V (PubMed:10626813).Curated | 1 | |
Sequence conflicti | 282 | A → V (PubMed:10807544).Curated | 1 | |
Sequence conflicti | 285 | A → S in AAC00501 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 285 | A → S in AAB60879 (PubMed:8944021).Curated | 1 | |
Sequence conflicti | 285 | A → S (PubMed:10626813).Curated | 1 | |
Sequence conflicti | 285 | A → S (PubMed:10807544).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047097 | 125 | L → R3 PublicationsCorresponds to variant dbSNP:rs7338333Ensembl. | 1 | |
Natural variantiVAR_017420 | 335 | A → D in HNSCC. 1 Publication | 1 | |
Natural variantiVAR_017421 | 358 | C → S in HNSCC. 1 Publication | 1 | |
Natural variantiVAR_017422 | 359 | N → S in HNSCC. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009129 | 1 – 212 | Missing in isoform 3. 2 PublicationsAdd BLAST | 212 | |
Alternative sequenceiVSP_009126 | 1 – 189 | MSFVE…WPWKQ → MLSPANGEQLHLVNYVEDYL DSIESLPFDLQRNVSLMREI DAKYQE in isoform 2. 5 PublicationsAdd BLAST | 189 | |
Alternative sequenceiVSP_009127 | 1 – 189 | MSFVE…WPWKQ → ME in isoform 4. 2 PublicationsAdd BLAST | 189 | |
Alternative sequenceiVSP_009128 | 1 – 189 | MSFVE…WPWKQ → MSFVECPYHSPAERLVAEAD EGGPSAITE in isoform 5. CuratedAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181849 mRNA Translation: AAF07920.1 AF181850 mRNA Translation: AAF07921.1 AF001954 mRNA Translation: AAB60879.1 Frameshift. AF044076 mRNA Translation: AAC00501.1 AF149721 mRNA Translation: AAF37421.1 AF149722 mRNA Translation: AAF37422.1 AF149723 mRNA Translation: AAF37423.1 AF167551, AF167550 Genomic DNA Translation: AAG02578.1 AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems. AB037387 Genomic DNA Translation: BAB08101.1 AB037387 Genomic DNA Translation: BAB08102.1 AB037387 Genomic DNA Translation: BAB08103.1 AB037594 mRNA Translation: BAB20992.2 AB031269 mRNA Translation: BAA83496.1 AB024401 mRNA Translation: BAA82886.1 AB024402 mRNA Translation: BAA82887.1 AB024403 Genomic DNA Translation: BAA82888.1 AB024404 Genomic DNA Translation: BAA82889.1 AB024404 Genomic DNA Translation: BAA83462.1 AB024405 Genomic DNA Translation: BAA82890.1 AJ310392 mRNA Translation: CAC38067.1 AF078835 mRNA Translation: AAG12174.1 AF078837, AF078836 Genomic DNA Translation: AAG12175.1 AK302353 mRNA Translation: BAG63679.1 AL157820 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09127.1 CH471085 Genomic DNA Translation: EAX09130.1 BC093942 mRNA Translation: AAH93942.1 BC093944 mRNA Translation: AAH93944.1 |
CCDSi | CCDS9515.1 [Q9UK53-4] CCDS9516.1 [Q9UK53-2] CCDS9517.1 [Q9UK53-1] CCDS9518.1 [Q9UK53-3] |
RefSeqi | NP_001254657.1, NM_001267728.1 [Q9UK53-5] NP_005528.4, NM_005537.5 NP_937860.1, NM_198217.2 [Q9UK53-4] NP_937861.1, NM_198218.2 [Q9UK53-3] NP_937862.1, NM_198219.2 [Q9UK53-2] |
Genome annotation databases
Ensembli | ENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2] ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4] ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3] |
GeneIDi | 3621 |
KEGGi | hsa:3621 |
MANE-Selecti | ENST00000333219.9; ENSP00000328436.8; NM_198219.3; NP_937862.1 [Q9UK53-2] |
UCSCi | uc001vrf.5, human [Q9UK53-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181849 mRNA Translation: AAF07920.1 AF181850 mRNA Translation: AAF07921.1 AF001954 mRNA Translation: AAB60879.1 Frameshift. AF044076 mRNA Translation: AAC00501.1 AF149721 mRNA Translation: AAF37421.1 AF149722 mRNA Translation: AAF37422.1 AF149723 mRNA Translation: AAF37423.1 AF167551, AF167550 Genomic DNA Translation: AAG02578.1 AF167551, AF167549 Genomic DNA Translation: AAG02579.1 Sequence problems. AB037387 Genomic DNA Translation: BAB08101.1 AB037387 Genomic DNA Translation: BAB08102.1 AB037387 Genomic DNA Translation: BAB08103.1 AB037594 mRNA Translation: BAB20992.2 AB031269 mRNA Translation: BAA83496.1 AB024401 mRNA Translation: BAA82886.1 AB024402 mRNA Translation: BAA82887.1 AB024403 Genomic DNA Translation: BAA82888.1 AB024404 Genomic DNA Translation: BAA82889.1 AB024404 Genomic DNA Translation: BAA83462.1 AB024405 Genomic DNA Translation: BAA82890.1 AJ310392 mRNA Translation: CAC38067.1 AF078835 mRNA Translation: AAG12174.1 AF078837, AF078836 Genomic DNA Translation: AAG12175.1 AK302353 mRNA Translation: BAG63679.1 AL157820 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09127.1 CH471085 Genomic DNA Translation: EAX09130.1 BC093942 mRNA Translation: AAH93942.1 BC093944 mRNA Translation: AAH93944.1 |
CCDSi | CCDS9515.1 [Q9UK53-4] CCDS9516.1 [Q9UK53-2] CCDS9517.1 [Q9UK53-1] CCDS9518.1 [Q9UK53-3] |
RefSeqi | NP_001254657.1, NM_001267728.1 [Q9UK53-5] NP_005528.4, NM_005537.5 NP_937860.1, NM_198217.2 [Q9UK53-4] NP_937861.1, NM_198218.2 [Q9UK53-3] NP_937862.1, NM_198219.2 [Q9UK53-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QIC | X-ray | 2.10 | A | 345-404 | [»] | |
SMRi | Q9UK53 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109833, 88 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9UK53 |
DIPi | DIP-24256N DIP-24257N DIP-24258N |
IntActi | Q9UK53, 24 interactors |
MINTi | Q9UK53 |
STRINGi | 9606.ENSP00000364929 |
PTM databases
GlyGeni | Q9UK53, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UK53 |
PhosphoSitePlusi | Q9UK53 |
Genetic variation databases
BioMutai | ING1 |
DMDMi | 212276438 |
Proteomic databases
EPDi | Q9UK53 |
jPOSTi | Q9UK53 |
MassIVEi | Q9UK53 |
MaxQBi | Q9UK53 |
PaxDbi | Q9UK53 |
PeptideAtlasi | Q9UK53 |
PRIDEi | Q9UK53 |
ProteomicsDBi | 84718 [Q9UK53-1] 84719 [Q9UK53-2] 84720 [Q9UK53-3] 84721 [Q9UK53-4] 84722 [Q9UK53-5] |
Protocols and materials databases
Antibodypediai | 4248, 512 antibodies from 38 providers |
DNASUi | 3621 |
Genome annotation databases
Ensembli | ENST00000333219; ENSP00000328436; ENSG00000153487 [Q9UK53-2] ENST00000338450; ENSP00000345202; ENSG00000153487 [Q9UK53-4] ENST00000375775; ENSP00000364930; ENSG00000153487 [Q9UK53-3] |
GeneIDi | 3621 |
KEGGi | hsa:3621 |
MANE-Selecti | ENST00000333219.9; ENSP00000328436.8; NM_198219.3; NP_937862.1 [Q9UK53-2] |
UCSCi | uc001vrf.5, human [Q9UK53-1] |
Organism-specific databases
CTDi | 3621 |
DisGeNETi | 3621 |
GeneCardsi | ING1 |
HGNCi | HGNC:6062, ING1 |
HPAi | ENSG00000153487, Low tissue specificity |
MalaCardsi | ING1 |
MIMi | 275355, phenotype 601566, gene |
neXtProti | NX_Q9UK53 |
OpenTargetsi | ENSG00000153487 |
Orphaneti | 500481, Squamous cell carcinoma of salivary glands 494547, Squamous cell carcinoma of the hypopharynx 494550, Squamous cell carcinoma of the larynx 502366, Squamous cell carcinoma of the lip 500464, Squamous cell carcinoma of the nasal cavity and paranasal sinuses 502363, Squamous cell carcinoma of the oral cavity 500478, Squamous cell carcinoma of the oropharynx |
PharmGKBi | PA29872 |
VEuPathDBi | HostDB:ENSG00000153487 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000155401 |
HOGENOMi | CLU_031900_5_1_1 |
InParanoidi | Q9UK53 |
OMAi | KMQIVNH |
OrthoDBi | 1434088at2759 |
PhylomeDBi | Q9UK53 |
TreeFami | TF352014 |
Enzyme and pathway databases
PathwayCommonsi | Q9UK53 |
SignaLinki | Q9UK53 |
SIGNORi | Q9UK53 |
Miscellaneous databases
BioGRID-ORCSi | 3621, 8 hits in 1062 CRISPR screens |
ChiTaRSi | ING1, human |
EvolutionaryTracei | Q9UK53 |
GeneWikii | ING1 |
GenomeRNAii | 3621 |
Pharosi | Q9UK53, Tbio |
PROi | PR:Q9UK53 |
RNActi | Q9UK53, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153487, Expressed in decidua and 217 other tissues |
ExpressionAtlasi | Q9UK53, baseline and differential |
Genevisiblei | Q9UK53, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028643, ING1 IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF85, PTHR10333:SF85, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ING1_HUMAN | |
Accessioni | Q9UK53Primary (citable) accession number: Q9UK53 Secondary accession number(s): O00532 Q9UK52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families