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Protein

U6 snRNA-associated Sm-like protein LSm7

Gene

LSM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).2 Publications

GO - Molecular functioni

  • U6 snRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm7
Gene namesi
Name:LSM7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130332.14
HGNCiHGNC:20470 LSM7
MIMi607287 gene
neXtProtiNX_Q9UK45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130332
PharmGKBiPA134888612

Polymorphism and mutation databases

BioMutaiLSM7
DMDMi10720075

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001255792 – 103U6 snRNA-associated Sm-like protein LSm7Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UK45
MaxQBiQ9UK45
PaxDbiQ9UK45
PeptideAtlasiQ9UK45
PRIDEiQ9UK45
ProteomicsDBi84717
TopDownProteomicsiQ9UK45

PTM databases

iPTMnetiQ9UK45
PhosphoSitePlusiQ9UK45

Expressioni

Gene expression databases

BgeeiENSG00000130332 Expressed in 226 organ(s), highest expression level in ectocervix
CleanExiHS_LSM7
ExpressionAtlasiQ9UK45 baseline and differential
GenevisibleiQ9UK45 HS

Organism-specific databases

HPAiHPA041850

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166). Interacts with TACC1 (PubMed:12165861).4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi119678, 59 interactors
CORUMiQ9UK45
DIPiDIP-31129N
IntActiQ9UK45, 25 interactors
MINTiQ9UK45
STRINGi9606.ENSP00000252622

Structurei

3D structure databases

ProteinModelPortaliQ9UK45
SMRiQ9UK45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1781 Eukaryota
ENOG4111VMJ LUCA
GeneTreeiENSGT00510000047872
HOGENOMiHOG000223548
HOVERGENiHBG000513
InParanoidiQ9UK45
KOiK12626
OMAiGPKREAI
OrthoDBiEOG091G14J2
PhylomeDBiQ9UK45
TreeFamiTF314385

Family and domain databases

CDDicd01729 LSm7, 1 hit
InterProiView protein in InterPro
IPR017132 Lsm7
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UK45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG
60 70 80 90 100
TIEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ

QDA
Length:103
Mass (Da):11,602
Last modified:May 1, 2000 - v1
Checksum:i7429DC0FB365C9C8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X2I5A0A087X2I5_HUMAN
U6 snRNA-associated Sm-like protein...
LSM7
49Annotation score:
K7ENY5K7ENY5_HUMAN
U6 snRNA-associated Sm-like protein...
LSM7
35Annotation score:
K7EML7K7EML7_HUMAN
U6 snRNA-associated Sm-like protein...
LSM7
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182293 mRNA Translation: AAD56231.1
AC005258 Genomic DNA Translation: AAG45442.1
BC018621 mRNA Translation: AAH18621.1
CCDSiCCDS45907.1
RefSeqiNP_057283.1, NM_016199.2
UniGeneiHs.512610

Genome annotation databases

EnsembliENST00000252622; ENSP00000252622; ENSG00000130332
GeneIDi51690
KEGGihsa:51690
UCSCiuc002lvp.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182293 mRNA Translation: AAD56231.1
AC005258 Genomic DNA Translation: AAG45442.1
BC018621 mRNA Translation: AAH18621.1
CCDSiCCDS45907.1
RefSeqiNP_057283.1, NM_016199.2
UniGeneiHs.512610

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0071-103[»]
5O9Zelectron microscopy4.50t1-103[»]
ProteinModelPortaliQ9UK45
SMRiQ9UK45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119678, 59 interactors
CORUMiQ9UK45
DIPiDIP-31129N
IntActiQ9UK45, 25 interactors
MINTiQ9UK45
STRINGi9606.ENSP00000252622

PTM databases

iPTMnetiQ9UK45
PhosphoSitePlusiQ9UK45

Polymorphism and mutation databases

BioMutaiLSM7
DMDMi10720075

Proteomic databases

EPDiQ9UK45
MaxQBiQ9UK45
PaxDbiQ9UK45
PeptideAtlasiQ9UK45
PRIDEiQ9UK45
ProteomicsDBi84717
TopDownProteomicsiQ9UK45

Protocols and materials databases

DNASUi51690
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252622; ENSP00000252622; ENSG00000130332
GeneIDi51690
KEGGihsa:51690
UCSCiuc002lvp.5 human

Organism-specific databases

CTDi51690
EuPathDBiHostDB:ENSG00000130332.14
GeneCardsiLSM7
HGNCiHGNC:20470 LSM7
HPAiHPA041850
MIMi607287 gene
neXtProtiNX_Q9UK45
OpenTargetsiENSG00000130332
PharmGKBiPA134888612
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1781 Eukaryota
ENOG4111VMJ LUCA
GeneTreeiENSGT00510000047872
HOGENOMiHOG000223548
HOVERGENiHBG000513
InParanoidiQ9UK45
KOiK12626
OMAiGPKREAI
OrthoDBiEOG091G14J2
PhylomeDBiQ9UK45
TreeFamiTF314385

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

GeneWikiiLSM7
GenomeRNAii51690
PROiPR:Q9UK45
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130332 Expressed in 226 organ(s), highest expression level in ectocervix
CleanExiHS_LSM7
ExpressionAtlasiQ9UK45 baseline and differential
GenevisibleiQ9UK45 HS

Family and domain databases

CDDicd01729 LSm7, 1 hit
InterProiView protein in InterPro
IPR017132 Lsm7
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM7_HUMAN
AccessioniPrimary (citable) accession number: Q9UK45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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