UniProtKB - Q9UK45 (LSM7_HUMAN)
U6 snRNA-associated Sm-like protein LSm7
LSM7
Functioni
GO - Molecular functioni
- U6 snRNA binding Source: UniProtKB
GO - Biological processi
- exonucleolytic catabolism of deadenylated mRNA Source: Reactome
- mRNA splicing, via spliceosome Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q9UK45 |
Reactomei | R-HSA-430039, mRNA decay by 5' to 3' exoribonuclease R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: U6 snRNA-associated Sm-like protein LSm7 |
Gene namesi | Name:LSM7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20470, LSM7 |
MIMi | 607287, gene |
neXtProti | NX_Q9UK45 |
VEuPathDBi | HostDB:ENSG00000130332.14 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Cytosol
- cytosol Source: Reactome
Nucleus
- catalytic step 2 spliceosome Source: GO_Central
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- spliceosomal tri-snRNP complex Source: GO_Central
- U12-type spliceosomal complex Source: GO_Central
- U2-type precatalytic spliceosome Source: UniProtKB
- U2-type prespliceosome Source: GO_Central
- U4/U6 x U5 tri-snRNP complex Source: UniProtKB
- U6 snRNP Source: GO_Central
Other locations
- Lsm1-7-Pat1 complex Source: GO_Central
- Lsm2-8 complex Source: UniProtKB
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 51690 |
OpenTargetsi | ENSG00000130332 |
PharmGKBi | PA134888612 |
Miscellaneous databases
Pharosi | Q9UK45, Tbio |
Genetic variation databases
BioMutai | LSM7 |
DMDMi | 10720075 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000125579 | 2 – 103 | U6 snRNA-associated Sm-like protein LSm7Add BLAST | 102 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9UK45 |
jPOSTi | Q9UK45 |
MassIVEi | Q9UK45 |
MaxQBi | Q9UK45 |
PaxDbi | Q9UK45 |
PeptideAtlasi | Q9UK45 |
PRIDEi | Q9UK45 |
ProteomicsDBi | 84717 |
TopDownProteomicsi | Q9UK45 |
PTM databases
iPTMneti | Q9UK45 |
MetOSitei | Q9UK45 |
PhosphoSitePlusi | Q9UK45 |
SwissPalmi | Q9UK45 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130332, Expressed in ectocervix and 237 other tissues |
ExpressionAtlasi | Q9UK45, baseline and differential |
Genevisiblei | Q9UK45, HS |
Organism-specific databases
HPAi | ENSG00000130332, Low tissue specificity |
Interactioni
Subunit structurei
Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166).
Interacts with TACC1 (PubMed:12165861).
4 PublicationsBinary interactionsi
Hide detailsQ9UK45
Protein-protein interaction databases
BioGRIDi | 119678, 69 interactors |
CORUMi | Q9UK45 |
DIPi | DIP-31129N |
IntActi | Q9UK45, 26 interactors |
MINTi | Q9UK45 |
STRINGi | 9606.ENSP00000252622 |
Miscellaneous databases
RNActi | Q9UK45, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1781, Eukaryota |
GeneTreei | ENSGT00510000047872 |
HOGENOMi | CLU_076902_3_1_1 |
InParanoidi | Q9UK45 |
OMAi | DDPYKLT |
OrthoDBi | 1593201at2759 |
PhylomeDBi | Q9UK45 |
TreeFami | TF314385 |
Family and domain databases
CDDi | cd01729, LSm7, 1 hit |
InterProi | View protein in InterPro IPR017132, Lsm7 IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG
60 70 80 90 100
TIEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ
QDA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2I5 | A0A087X2I5_HUMAN | U6 snRNA-associated Sm-like protein... | LSM7 | 49 | Annotation score: | ||
K7ENY5 | K7ENY5_HUMAN | U6 snRNA-associated Sm-like protein... | LSM7 | 35 | Annotation score: | ||
K7EML7 | K7EML7_HUMAN | U6 snRNA-associated Sm-like protein... | LSM7 | 60 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182293 mRNA Translation: AAD56231.1 AC005258 Genomic DNA Translation: AAG45442.1 BC018621 mRNA Translation: AAH18621.1 |
CCDSi | CCDS45907.1 |
RefSeqi | NP_057283.1, NM_016199.2 |
Genome annotation databases
Ensembli | ENST00000252622; ENSP00000252622; ENSG00000130332 |
GeneIDi | 51690 |
KEGGi | hsa:51690 |
UCSCi | uc002lvp.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182293 mRNA Translation: AAD56231.1 AC005258 Genomic DNA Translation: AAG45442.1 BC018621 mRNA Translation: AAH18621.1 |
CCDSi | CCDS45907.1 |
RefSeqi | NP_057283.1, NM_016199.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3JCR | electron microscopy | 7.00 | 7 | 1-103 | [»] | |
5O9Z | electron microscopy | 4.50 | t | 1-103 | [»] | |
6AH0 | electron microscopy | 5.70 | y | 1-103 | [»] | |
6AHD | electron microscopy | 3.80 | y | 1-103 | [»] | |
6QW6 | electron microscopy | 2.92 | 67 | 1-103 | [»] | |
6QX9 | electron microscopy | 3.28 | 67 | 1-103 | [»] | |
SMRi | Q9UK45 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119678, 69 interactors |
CORUMi | Q9UK45 |
DIPi | DIP-31129N |
IntActi | Q9UK45, 26 interactors |
MINTi | Q9UK45 |
STRINGi | 9606.ENSP00000252622 |
PTM databases
iPTMneti | Q9UK45 |
MetOSitei | Q9UK45 |
PhosphoSitePlusi | Q9UK45 |
SwissPalmi | Q9UK45 |
Genetic variation databases
BioMutai | LSM7 |
DMDMi | 10720075 |
Proteomic databases
EPDi | Q9UK45 |
jPOSTi | Q9UK45 |
MassIVEi | Q9UK45 |
MaxQBi | Q9UK45 |
PaxDbi | Q9UK45 |
PeptideAtlasi | Q9UK45 |
PRIDEi | Q9UK45 |
ProteomicsDBi | 84717 |
TopDownProteomicsi | Q9UK45 |
Protocols and materials databases
Antibodypediai | 42295, 131 antibodies |
DNASUi | 51690 |
Genome annotation databases
Ensembli | ENST00000252622; ENSP00000252622; ENSG00000130332 |
GeneIDi | 51690 |
KEGGi | hsa:51690 |
UCSCi | uc002lvp.5, human |
Organism-specific databases
CTDi | 51690 |
DisGeNETi | 51690 |
GeneCardsi | LSM7 |
HGNCi | HGNC:20470, LSM7 |
HPAi | ENSG00000130332, Low tissue specificity |
MIMi | 607287, gene |
neXtProti | NX_Q9UK45 |
OpenTargetsi | ENSG00000130332 |
PharmGKBi | PA134888612 |
VEuPathDBi | HostDB:ENSG00000130332.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1781, Eukaryota |
GeneTreei | ENSGT00510000047872 |
HOGENOMi | CLU_076902_3_1_1 |
InParanoidi | Q9UK45 |
OMAi | DDPYKLT |
OrthoDBi | 1593201at2759 |
PhylomeDBi | Q9UK45 |
TreeFami | TF314385 |
Enzyme and pathway databases
PathwayCommonsi | Q9UK45 |
Reactomei | R-HSA-430039, mRNA decay by 5' to 3' exoribonuclease R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 51690, 767 hits in 876 CRISPR screens |
ChiTaRSi | LSM7, human |
GeneWikii | LSM7 |
GenomeRNAii | 51690 |
Pharosi | Q9UK45, Tbio |
PROi | PR:Q9UK45 |
RNActi | Q9UK45, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130332, Expressed in ectocervix and 237 other tissues |
ExpressionAtlasi | Q9UK45, baseline and differential |
Genevisiblei | Q9UK45, HS |
Family and domain databases
CDDi | cd01729, LSm7, 1 hit |
InterProi | View protein in InterPro IPR017132, Lsm7 IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LSM7_HUMAN | |
Accessioni | Q9UK45Primary (citable) accession number: Q9UK45 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families