LSM7

Functionⁱ

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).2 Publications

GO - Molecular functionⁱ

U6 snRNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10523320

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Source: Reactome
mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 28781166

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U6 snRNA-associated Sm-like protein LSm7
Gene namesⁱ	Name:LSM7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130332.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20470 LSM7
MIMⁱ	607287 gene
neXtProtⁱ	NX_Q9UK45

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000130332
PharmGKBⁱ	PA134888612

Polymorphism and mutation databases

BioMutaⁱ	LSM7
DMDMⁱ	10720075

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000125579	2 – 103	U6 snRNA-associated Sm-like protein LSm7Add BLAST		102

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9UK45
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UK45
PaxDbⁱ	Q9UK45
PeptideAtlas More...PeptideAtlasⁱ	Q9UK45
PRIDEⁱ	Q9UK45
ProteomicsDBⁱ	84717
TopDownProteomicsⁱ	Q9UK45

PTM databases

iPTMnetⁱ	Q9UK45
PhosphoSitePlusⁱ	Q9UK45

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130332 Expressed in 226 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_LSM7
ExpressionAtlasⁱ	Q9UK45 baseline and differential
Genevisibleⁱ	Q9UK45 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041850

HPAⁱ

HPA041850

Interactionⁱ

Subunit structureⁱ

Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:28781166, PubMed:26912367). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166). Interacts with TACC1 (PubMed:12165861).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DDIT4L	Q96D03	7	EBI-348372,EBI-742054
LSM2	Q9Y333	11	EBI-348372,EBI-347416
LSM3	P62310	6	EBI-348372,EBI-348239
LSM4	Q9Y4Z0	8	EBI-348372,EBI-372521
LSM5	Q9Y4Y9	14	EBI-348372,EBI-373007
LSM6	P62312	4	EBI-348372,EBI-373310
SNRPD3	P62318	3	EBI-348372,EBI-372789
SNRPF	P62306	3	EBI-348372,EBI-356900
TACC1	O75410-1	4	EBI-348372,EBI-624252
TACC1	O75410-6	2	EBI-348372,EBI-624278

Protein-protein interaction databases

BioGridⁱ	119678, 59 interactors
CORUMⁱ	Q9UK45
Database of interacting proteins More...DIPⁱ	DIP-31129N
IntActⁱ	Q9UK45, 25 interactors
Molecular INTeraction database More...MINTⁱ	Q9UK45
STRINGⁱ	9606.ENSP00000252622

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UK45
SMRⁱ	Q9UK45
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1781 Eukaryota ENOG4111VMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047872
HOGENOMⁱ	HOG000223548
HOVERGENⁱ	HBG000513
InParanoidⁱ	Q9UK45
KEGG Orthology (KO) More...KOⁱ	K12626
OMAⁱ	GPKREAI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14J2
PhylomeDBⁱ	Q9UK45
TreeFamⁱ	TF314385

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01729 LSm7, 1 hit
InterProⁱ	View protein in InterPro IPR017132 Lsm7 IPR001163 LSM_dom_euk/arc IPR010920 LSM_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01423 LSM, 1 hit
SMARTⁱ	View protein in SMART SM00651 Sm, 1 hit
SUPFAMⁱ	SSF50182 SSF50182, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9UK45-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG 
        60         70         80         90        100
TIEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ 

QDA

Length:103

Mass (Da):11,602

Last modified:May 1, 2000 - v1

Checksum:ⁱ7429DC0FB365C9C8

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X2I5	A0A087X2I5_HUMAN	U6 snRNA-associated Sm-like protein... U6 snRNA-associated Sm-like protein LSm7	LSM7	49	Annotation score:
K7ENY5	K7ENY5_HUMAN	U6 snRNA-associated Sm-like protein... U6 snRNA-associated Sm-like protein LSm7	LSM7	35	Annotation score:
K7EML7	K7EML7_HUMAN	U6 snRNA-associated Sm-like protein... U6 snRNA-associated Sm-like protein LSm7	LSM7	60	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF182293 mRNA Translation: AAD56231.1 AC005258 Genomic DNA Translation: AAG45442.1 BC018621 mRNA Translation: AAH18621.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45907.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057283.1, NM_016199.2
UniGeneⁱ	Hs.512610

Genome annotation databases

Ensemblⁱ	ENST00000252622; ENSP00000252622; ENSG00000130332
GeneIDⁱ	51690
KEGGⁱ	hsa:51690
UCSC genome browser More...UCSCⁱ	uc002lvp.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK45	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		MACMU		103	UniRef100_Q9UK45
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		PANTR		103
U6 snRNA-associated Sm-like protein LSm7		CALJA		103
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		GORGO		103
Uncharacterized protein		PANPA		103
+21

Protein	Similar proteins		Species	Score	Length	Source
Q9UK45	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		MACMU		103	UniRef90_Q9UK45
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		PANTR		103
U6 snRNA-associated Sm-like protein LSm7		CALJA		103
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		GORGO		103
Uncharacterized protein		PANPA		103
+21

Protein	Similar proteins		Species	Score	Length	Source
Q9UK45	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		MACMU		103	UniRef50_Q9UK45
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		PANTR		103
U6 snRNA-associated Sm-like protein LSm7		CALJA		103
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated		GORGO		103
Uncharacterized protein		PANPA		103
+89

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF182293 mRNA Translation: AAD56231.1 AC005258 Genomic DNA Translation: AAG45442.1 BC018621 mRNA Translation: AAH18621.1
CCDSⁱ	CCDS45907.1
RefSeqⁱ	NP_057283.1, NM_016199.2
UniGeneⁱ	Hs.512610

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3JCR	electron microscopy	7.00	7	1-103	[»]
	5O9Z	electron microscopy	4.50	t	1-103	[»]
ProteinModelPortalⁱ	Q9UK45
SMRⁱ	Q9UK45
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119678, 59 interactors
CORUMⁱ	Q9UK45
DIPⁱ	DIP-31129N
IntActⁱ	Q9UK45, 25 interactors
MINTⁱ	Q9UK45
STRINGⁱ	9606.ENSP00000252622

PTM databases

iPTMnetⁱ	Q9UK45
PhosphoSitePlusⁱ	Q9UK45

Polymorphism and mutation databases

BioMutaⁱ	LSM7
DMDMⁱ	10720075

Proteomic databases

EPDⁱ	Q9UK45
MaxQBⁱ	Q9UK45
PaxDbⁱ	Q9UK45
PeptideAtlasⁱ	Q9UK45
PRIDEⁱ	Q9UK45
ProteomicsDBⁱ	84717
TopDownProteomicsⁱ	Q9UK45

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51690
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000252622; ENSP00000252622; ENSG00000130332
GeneIDⁱ	51690
KEGGⁱ	hsa:51690
UCSCⁱ	uc002lvp.5 human

Organism-specific databases

CTDⁱ	51690
EuPathDBⁱ	HostDB:ENSG00000130332.14
GeneCardsⁱ	LSM7
HGNCⁱ	HGNC:20470 LSM7
HPAⁱ	HPA041850
MIMⁱ	607287 gene
neXtProtⁱ	NX_Q9UK45
OpenTargetsⁱ	ENSG00000130332
PharmGKBⁱ	PA134888612
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1781 Eukaryota ENOG4111VMJ LUCA
GeneTreeⁱ	ENSGT00510000047872
HOGENOMⁱ	HOG000223548
HOVERGENⁱ	HBG000513
InParanoidⁱ	Q9UK45
KOⁱ	K12626
OMAⁱ	GPKREAI
OrthoDBⁱ	EOG091G14J2
PhylomeDBⁱ	Q9UK45
TreeFamⁱ	TF314385

Enzyme and pathway databases

Reactomeⁱ	R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

GeneWikiⁱ	LSM7
GenomeRNAiⁱ	51690
Protein Ontology More...PROⁱ	PR:Q9UK45
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130332 Expressed in 226 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_LSM7
ExpressionAtlasⁱ	Q9UK45 baseline and differential
Genevisibleⁱ	Q9UK45 HS

Family and domain databases

CDDⁱ	cd01729 LSm7, 1 hit
InterProⁱ	View protein in InterPro IPR017132 Lsm7 IPR001163 LSM_dom_euk/arc IPR010920 LSM_dom_sf
Pfamⁱ	View protein in Pfam PF01423 LSM, 1 hit
SMARTⁱ	View protein in SMART SM00651 Sm, 1 hit
SUPFAMⁱ	SSF50182 SSF50182, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LSM7_HUMAN
Accessionⁱ	Q9UK45Primary (citable) accession number: Q9UK45
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UK45 (LSM7_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

U6 snRNA-associated Sm-like protein LSm7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ