Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9UK39 (NOCT_HUMAN)

Entry version 153 (22 Apr 2020)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nocturnin

Gene

NOCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP+ (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).By similarity2 Publications

Caution

Was initially shown to have low deadenylase activity that was lost when the metal-binding Glu was mutated (By similarity). Later studies showed that the purified protein lacked deadenylase activity (PubMed:29860338, PubMed:30389976). Was subsequently shown to act as a phosphatase (PubMed:31147539).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Binds 2 magnesium ions, but the ions are only loosely bound to the protein.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=173 µM for NADPH1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi195MagnesiumCombined sources3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei195Substrate1 Publication1
    Binding sitei263Substrate1 Publication1
    Binding sitei414Substrate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Repressor, RNA-binding
    Biological processBiological rhythms
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    NocturninImported (EC:3.1.3.-1 Publication)
    Alternative name(s):
    Carbon catabolite repression 4-like protein
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NOCTImported
    Synonyms:CCR4, CCRN4L, NOC
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:14254 NOCT

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		608468 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9UK39

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149N → A: Slightly decreased activity as transcriptional repressor. 1 Publication1
    Mutagenesisi160D → A: Lack of catalytic activity. 1 Publication1
    Mutagenesisi195E → A: Slightly increased activity as transcriptional repressor. Lack of catalytic activity. 2 Publications1
    Mutagenesisi219K → A: Reduced catalytic activity. 1 Publication1
    Mutagenesisi286H → A: No effect on activity as transcriptional repressor. 1 Publication1
    Mutagenesisi286H → N: Lack of catalytic activity. 1 Publication1
    Mutagenesisi288K → A: Reduced catalytic activity. 1 Publication1
    Mutagenesisi290R → A: Lack of catalytic activity. 1 Publication1
    Mutagenesisi324D → A: No effect on activity as transcriptional repressor. 1 Publication1
    Mutagenesisi326N → A: No effect on activity as transcriptional repressor. 1 Publication1
    Mutagenesisi365K → A: No effect on catalytic activity. 1 Publication1
    Mutagenesisi367R → A: Reduced catalytic activity. 1 Publication1
    Mutagenesisi377D → A: Slightly decreased activity as transcriptional repressor. 1 Publication1
    Mutagenesisi414H → A or N: Decreased activity as transcriptional repressor. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		25819

    Open Targets

    More...    OpenTargetsi    		ENSG00000151014

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA26176

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9UK39 Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		NOCT

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		212276446

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 75MitochondrionSequence analysisAdd BLAST75
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000021856876 – 431NocturninSequence analysisAdd BLAST356

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9UK39

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9UK39

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9UK39

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9UK39

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9UK39

    PeptideAtlas

    More...    PeptideAtlasi    		Q9UK39

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9UK39

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		84714

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9UK39

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9UK39

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000151014 Expressed in vagina and 126 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9UK39 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9UK39 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000151014 Tissue enhanced (bone)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with PPARG.

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		117347, 34 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9UK39, 28 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000280614

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9UK39 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1431
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9UK39

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 221Substrate binding1 Publication3
    Regioni286 – 289Substrate binding1 Publication4
    Regioni324 – 326Substrate binding1 Publication3
    Regioni343 – 353Interaction with PPARGBy similarityAdd BLAST11

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the CCR4/nocturin family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0620 Eukaryota
    COG5239 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155249

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_016428_1_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9UK39

    KEGG Orthology (KO)

    More...    KOi    		K18764

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		SCSRTVC

    Database of Orthologous Groups

    More...    OrthoDBi    		1387401at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9UK39

    TreeFam database of animal gene trees

    More...    TreeFami    		TF323175

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd09096 Deadenylase_nocturnin, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.60.10.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR034965 Deadenylase_nocturnin
    IPR036691 Endo/exonu/phosph_ase_sf
    IPR005135 Endo/exonuclease/phosphatase
    IPR040109 Nocturnin

    The PANTHER Classification System

    More...    PANTHERi    		PTHR12121:SF69 PTHR12121:SF69, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF03372 Exo_endo_phos, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF56219 SSF56219, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9UK39-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MFHSPRRLCS ALLQRDAPGL RRLPAPGLRR PLSPPAAVPR PASPRLLAAA 
            60         70         80         90        100
    SAASGAARSC SRTVCSMGTG TSRLYSALAK TLNSSAASQH PEYLVSPDPE 
           110        120        130        140        150
    HLEPIDPKEL LEECRAVLHT RPPRFQRDFV DLRTDCPSTH PPIRVMQWNI 
           160        170        180        190        200
    LAQALGEGKD NFVQCPVEAL KWEERKCLIL EEILAYQPDI LCLQEVDHYF 
           210        220        230        240        250
    DTFQPLLSRL GYQGTFFPKP WSPCLDVEHN NGPDGCALFF LQNRFKLVNS 
           260        270        280        290        300
    ANIRLTAMTL KTNQVAIAQT LECKESGRQF CIAVTHLKAR TGWERFRSAQ 
           310        320        330        340        350
    GCDLLQNLQN ITQGAKIPLI VCGDFNAEPT EEVYKHFASS SLNLNSAYKL 
           360        370        380        390        400
    LSADGQSEPP YTTWKIRTSG ECRHTLDYIW YSKHALNVRS ALDLLTEEQI 
           410        420        430 
    GPNRLPSFNY PSDHLSLVCD FSFTEESDGL S
    Length:431
    Mass (Da):48,196
    Last modified:November 4, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BDEFC43173B2D0C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    Q8WTX0Q8WTX0_HUMAN
    CCR4 carbon catabolite repression 4...
    NOCT CCRN4L, hCG_1735627
    		167Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16D → G in AAD56548 (PubMed:10521507).Curated1
    Sequence conflicti69T → N in AAG01387 (Ref. 4) Curated1
    Sequence conflicti77A → G in AAD56548 (PubMed:10521507).Curated1
    Sequence conflicti266A → T in AAG01389 (Ref. 4) Curated1
    Sequence conflicti341S → N in AAD56548 (PubMed:10521507).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047096140H → Y. Corresponds to variant dbSNP:rs2271777Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF183961 mRNA Translation: AAD56548.1
    CH471056 Genomic DNA Translation: EAX05129.1
    CH471056 Genomic DNA Translation: EAX05131.1
    BC113494 mRNA Translation: AAI13495.1
    BC113500 mRNA Translation: AAI13501.1
    AF199492 Genomic DNA Translation: AAG01387.1
    AF199493 mRNA Translation: AAG01388.1
    AF199494 Transcribed RNA Translation: AAG01389.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS3743.1

    NCBI Reference Sequences

    More...    RefSeqi    		NP_036250.2, NM_012118.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000280614; ENSP00000280614; ENSG00000151014

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		25819

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:25819

    UCSC genome browser

    More...    UCSCi    		uc003ihl.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF183961 mRNA Translation: AAD56548.1
    CH471056 Genomic DNA Translation: EAX05129.1
    CH471056 Genomic DNA Translation: EAX05131.1
    BC113494 mRNA Translation: AAI13495.1
    BC113500 mRNA Translation: AAI13501.1
    AF199492 Genomic DNA Translation: AAG01387.1
    AF199493 mRNA Translation: AAG01388.1
    AF199494 Transcribed RNA Translation: AAG01389.1
    CCDSiCCDS3743.1
    RefSeqiNP_036250.2, NM_012118.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6BT1X-ray1.48A120-431[»]
    6BT2X-ray2.41A/B120-431[»]
    6MALX-ray2.60A122-431[»]
    6NF0X-ray2.70A122-431[»]
    SMRiQ9UK39
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi117347, 34 interactors
    IntActiQ9UK39, 28 interactors
    STRINGi9606.ENSP00000280614

    PTM databases

    iPTMnetiQ9UK39
    PhosphoSitePlusiQ9UK39

    Polymorphism and mutation databases

    BioMutaiNOCT
    DMDMi212276446

    Proteomic databases

    EPDiQ9UK39
    jPOSTiQ9UK39
    MassIVEiQ9UK39
    MaxQBiQ9UK39
    PaxDbiQ9UK39
    PeptideAtlasiQ9UK39
    PRIDEiQ9UK39
    ProteomicsDBi84714

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		16153 121 antibodies

    Genome annotation databases

    EnsembliENST00000280614; ENSP00000280614; ENSG00000151014
    GeneIDi25819
    KEGGihsa:25819
    UCSCiuc003ihl.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		25819
    DisGeNETi25819

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		NOCT
    HGNCiHGNC:14254 NOCT
    HPAiENSG00000151014 Tissue enhanced (bone)
    MIMi608468 gene
    neXtProtiNX_Q9UK39
    OpenTargetsiENSG00000151014
    PharmGKBiPA26176

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0620 Eukaryota
    COG5239 LUCA
    GeneTreeiENSGT00940000155249
    HOGENOMiCLU_016428_1_2_1
    InParanoidiQ9UK39
    KOiK18764
    OMAiSCSRTVC
    OrthoDBi1387401at2759
    PhylomeDBiQ9UK39
    TreeFamiTF323175

    Enzyme and pathway databases

    ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		NOCT human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		25819
    PharosiQ9UK39 Tbio

    Protein Ontology

    More...    PROi    		PR:Q9UK39
    RNActiQ9UK39 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000151014 Expressed in vagina and 126 other tissues
    ExpressionAtlasiQ9UK39 baseline and differential
    GenevisibleiQ9UK39 HS

    Family and domain databases

    CDDicd09096 Deadenylase_nocturnin, 1 hit
    Gene3Di3.60.10.10, 1 hit
    InterProiView protein in InterPro
    IPR034965 Deadenylase_nocturnin
    IPR036691 Endo/exonu/phosph_ase_sf
    IPR005135 Endo/exonuclease/phosphatase
    IPR040109 Nocturnin
    PANTHERiPTHR12121:SF69 PTHR12121:SF69, 1 hit
    PfamiView protein in Pfam
    PF03372 Exo_endo_phos, 1 hit
    SUPFAMiSSF56219 SSF56219, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOCT_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK39
    Secondary accession number(s): D3DNY5
    , Q14D51, Q9HD93, Q9HD94, Q9HD95
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: November 4, 2008
    Last modified: April 22, 2020
    This is version 153 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again