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Protein

Nocturnin

Gene

NOCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).By similarity

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei195By similarity1
Metal bindingi195Magnesium 1By similarity1
Metal bindingi324Magnesium 2By similarity1
Metal bindingi326Magnesium 2By similarity1
Active sitei377By similarity1
Active sitei414By similarity1
Metal bindingi414Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
Biological processBiological rhythms, mRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
NocturninBy similarityImported (EC:3.1.13.4)
Alternative name(s):
Carbon catabolite repression 4-like protein
Circadian deadenylase NOC
Gene namesi
Name:NOCTImported
Synonyms:CCR4, CCRN4L, NOC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151014.5
HGNCiHGNC:14254 NOCT
MIMi608468 gene
neXtProtiNX_Q9UK39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25819
OpenTargetsiENSG00000151014
PharmGKBiPA26176

Polymorphism and mutation databases

DMDMi212276446

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185681 – 431NocturninAdd BLAST431

Proteomic databases

EPDiQ9UK39
MaxQBiQ9UK39
PaxDbiQ9UK39
PeptideAtlasiQ9UK39
PRIDEiQ9UK39
ProteomicsDBi84714

PTM databases

iPTMnetiQ9UK39
PhosphoSitePlusiQ9UK39

Expressioni

Tissue specificityi

Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000151014 Expressed in 127 organ(s), highest expression level in vagina
CleanExiHS_CCR4
HS_CCRN4L
ExpressionAtlasiQ9UK39 baseline and differential
GenevisibleiQ9UK39 HS

Organism-specific databases

HPAiHPA012287
HPA053714

Interactioni

Subunit structurei

Interacts with PPARG.By similarity

Protein-protein interaction databases

BioGridi117347, 34 interactors
IntActiQ9UK39, 2 interactors
STRINGi9606.ENSP00000280614

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UK39
SMRiQ9UK39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni343 – 353Interaction with PPARGBy similarityAdd BLAST11

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGiKOG0620 Eukaryota
COG5239 LUCA
GeneTreeiENSGT00550000074364
HOGENOMiHOG000237357
HOVERGENiHBG006512
InParanoidiQ9UK39
KOiK18764
OMAiRTDCPSS
OrthoDBiEOG091G0BF8
PhylomeDBiQ9UK39
TreeFamiTF323175

Family and domain databases

CDDicd09096 Deadenylase_nocturnin, 1 hit
Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR034965 Deadenylase_nocturnin
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UK39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFHSPRRLCS ALLQRDAPGL RRLPAPGLRR PLSPPAAVPR PASPRLLAAA
60 70 80 90 100
SAASGAARSC SRTVCSMGTG TSRLYSALAK TLNSSAASQH PEYLVSPDPE
110 120 130 140 150
HLEPIDPKEL LEECRAVLHT RPPRFQRDFV DLRTDCPSTH PPIRVMQWNI
160 170 180 190 200
LAQALGEGKD NFVQCPVEAL KWEERKCLIL EEILAYQPDI LCLQEVDHYF
210 220 230 240 250
DTFQPLLSRL GYQGTFFPKP WSPCLDVEHN NGPDGCALFF LQNRFKLVNS
260 270 280 290 300
ANIRLTAMTL KTNQVAIAQT LECKESGRQF CIAVTHLKAR TGWERFRSAQ
310 320 330 340 350
GCDLLQNLQN ITQGAKIPLI VCGDFNAEPT EEVYKHFASS SLNLNSAYKL
360 370 380 390 400
LSADGQSEPP YTTWKIRTSG ECRHTLDYIW YSKHALNVRS ALDLLTEEQI
410 420 430
GPNRLPSFNY PSDHLSLVCD FSFTEESDGL S
Length:431
Mass (Da):48,196
Last modified:November 4, 2008 - v2
Checksum:i5BDEFC43173B2D0C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WTX0Q8WTX0_HUMAN
CCR4 carbon catabolite repression 4...
NOCT CCRN4L, hCG_1735627
167Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16D → G in AAD56548 (PubMed:10521507).Curated1
Sequence conflicti69T → N in AAG01387 (Ref. 4) Curated1
Sequence conflicti77A → G in AAD56548 (PubMed:10521507).Curated1
Sequence conflicti266A → T in AAG01389 (Ref. 4) Curated1
Sequence conflicti341S → N in AAD56548 (PubMed:10521507).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047096140H → Y. Corresponds to variant dbSNP:rs2271777Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF183961 mRNA Translation: AAD56548.1
CH471056 Genomic DNA Translation: EAX05129.1
CH471056 Genomic DNA Translation: EAX05131.1
BC113494 mRNA Translation: AAI13495.1
BC113500 mRNA Translation: AAI13501.1
AF199492 Genomic DNA Translation: AAG01387.1
AF199493 mRNA Translation: AAG01388.1
AF199494 Transcribed RNA Translation: AAG01389.1
CCDSiCCDS3743.1
RefSeqiNP_036250.2, NM_012118.3
UniGeneiHs.639842
Hs.656047

Genome annotation databases

EnsembliENST00000280614; ENSP00000280614; ENSG00000151014
GeneIDi25819
KEGGihsa:25819
UCSCiuc003ihl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF183961 mRNA Translation: AAD56548.1
CH471056 Genomic DNA Translation: EAX05129.1
CH471056 Genomic DNA Translation: EAX05131.1
BC113494 mRNA Translation: AAI13495.1
BC113500 mRNA Translation: AAI13501.1
AF199492 Genomic DNA Translation: AAG01387.1
AF199493 mRNA Translation: AAG01388.1
AF199494 Transcribed RNA Translation: AAG01389.1
CCDSiCCDS3743.1
RefSeqiNP_036250.2, NM_012118.3
UniGeneiHs.639842
Hs.656047

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BT1X-ray1.48A120-431[»]
6BT2X-ray2.41A/B120-431[»]
6DIPX-ray2.60A122-426[»]
ProteinModelPortaliQ9UK39
SMRiQ9UK39
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117347, 34 interactors
IntActiQ9UK39, 2 interactors
STRINGi9606.ENSP00000280614

PTM databases

iPTMnetiQ9UK39
PhosphoSitePlusiQ9UK39

Polymorphism and mutation databases

DMDMi212276446

Proteomic databases

EPDiQ9UK39
MaxQBiQ9UK39
PaxDbiQ9UK39
PeptideAtlasiQ9UK39
PRIDEiQ9UK39
ProteomicsDBi84714

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280614; ENSP00000280614; ENSG00000151014
GeneIDi25819
KEGGihsa:25819
UCSCiuc003ihl.5 human

Organism-specific databases

CTDi25819
DisGeNETi25819
EuPathDBiHostDB:ENSG00000151014.5
GeneCardsiNOCT
H-InvDBiHIX0004503
HGNCiHGNC:14254 NOCT
HPAiHPA012287
HPA053714
MIMi608468 gene
neXtProtiNX_Q9UK39
OpenTargetsiENSG00000151014
PharmGKBiPA26176
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0620 Eukaryota
COG5239 LUCA
GeneTreeiENSGT00550000074364
HOGENOMiHOG000237357
HOVERGENiHBG006512
InParanoidiQ9UK39
KOiK18764
OMAiRTDCPSS
OrthoDBiEOG091G0BF8
PhylomeDBiQ9UK39
TreeFamiTF323175

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

Miscellaneous databases

ChiTaRSiNOCT human
GenomeRNAii25819
PROiPR:Q9UK39
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151014 Expressed in 127 organ(s), highest expression level in vagina
CleanExiHS_CCR4
HS_CCRN4L
ExpressionAtlasiQ9UK39 baseline and differential
GenevisibleiQ9UK39 HS

Family and domain databases

CDDicd09096 Deadenylase_nocturnin, 1 hit
Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR034965 Deadenylase_nocturnin
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOCT_HUMAN
AccessioniPrimary (citable) accession number: Q9UK39
Secondary accession number(s): D3DNY5
, Q14D51, Q9HD93, Q9HD94, Q9HD95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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