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UniProtKB - Q9UK39 (NOCT_HUMAN)

Entry version 162 (23 Feb 2022)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
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Protein

Nocturnin

Gene

NOCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase which catalyzes the conversion of NADP+ to NAD+ and of NADPH to NADH (PubMed:31147539).

Shows a small preference for NADPH over NADP+ (PubMed:31147539).

Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338).

Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity).

Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity).

Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity).

Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity).

Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity).

Critical for proper development of early embryos (By similarity).

By similarity2 Publications

Caution

Was initially shown to have low deadenylase activity that was lost when the metal-binding Glu was mutated (By similarity). Later studies showed that the purified protein lacked deadenylase activity (PubMed:29860338, PubMed:30389976). Was subsequently shown to act as a phosphatase (PubMed:31147539).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Binds 2 magnesium ions, but the ions are only loosely bound to the protein.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=173 µM for NADPH1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi195MagnesiumCombined sources3 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei195Substrate1 Publication1
Binding sitei263Substrate1 Publication1
Binding sitei414Substrate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Repressor, RNA-binding
Biological processBiological rhythms
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.108, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UK39

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UK39

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NocturninImported (EC:3.1.3.1081 Publication)
Alternative name(s):
Carbon catabolite repression 4-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOCTImported
Synonyms:CCR4, CCRN4L, NOC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14254, NOCT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608468, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UK39

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151014

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149N → A: Slightly decreased activity as transcriptional repressor. 1 Publication1
Mutagenesisi160D → A: Lack of catalytic activity. 1 Publication1
Mutagenesisi195E → A: Slightly increased activity as transcriptional repressor. Lack of catalytic activity. 2 Publications1
Mutagenesisi219K → A: Reduced catalytic activity. 1 Publication1
Mutagenesisi286H → A: No effect on activity as transcriptional repressor. 1 Publication1
Mutagenesisi286H → N: Lack of catalytic activity. 1 Publication1
Mutagenesisi288K → A: Reduced catalytic activity. 1 Publication1
Mutagenesisi290R → A: Lack of catalytic activity. 1 Publication1
Mutagenesisi324D → A: No effect on activity as transcriptional repressor. 1 Publication1
Mutagenesisi326N → A: No effect on activity as transcriptional repressor. 1 Publication1
Mutagenesisi365K → A: No effect on catalytic activity. 1 Publication1
Mutagenesisi367R → A: Reduced catalytic activity. 1 Publication1
Mutagenesisi377D → A: Slightly decreased activity as transcriptional repressor. 1 Publication1
Mutagenesisi414H → A or N: Decreased activity as transcriptional repressor. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		25819

Open Targets

More...OpenTargetsi		ENSG00000151014

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26176

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UK39, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NOCT

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 75MitochondrionSequence analysisAdd BLAST75
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000021856876 – 431NocturninSequence analysisAdd BLAST356

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UK39

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UK39

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UK39

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UK39

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UK39

PeptideAtlas

More...PeptideAtlasi		Q9UK39

PRoteomics IDEntifications database

More...PRIDEi		Q9UK39

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84714

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UK39

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UK39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151014, Expressed in bone marrow and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UK39, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UK39, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151014, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PPARG.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117347, 48 interactors

Protein interaction database and analysis system

More...IntActi		Q9UK39, 28 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000280614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UK39, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UK39

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 41DisorderedSequence analysisAdd BLAST22
Regioni219 – 221Substrate binding1 Publication3
Regioni286 – 289Substrate binding1 Publication4
Regioni324 – 326Substrate binding1 Publication3
Regioni343 – 353Interaction with PPARGBy similarityAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0620, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155249

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016428_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UK39

Identification of Orthologs from Complete Genome Data

More...OMAi		FEADLMC

Database of Orthologous Groups

More...OrthoDBi		1387401at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UK39

TreeFam database of animal gene trees

More...TreeFami		TF323175

Family and domain databases

Conserved Domains Database

More...CDDi		cd09096, Deadenylase_nocturnin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034965, Deadenylase_nocturnin
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR040109, Nocturnin

The PANTHER Classification System

More...PANTHERi		PTHR12121:SF45, PTHR12121:SF45, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03372, Exo_endo_phos, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56219, SSF56219, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UK39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFHSPRRLCS ALLQRDAPGL RRLPAPGLRR PLSPPAAVPR PASPRLLAAA 
        60         70         80         90        100
SAASGAARSC SRTVCSMGTG TSRLYSALAK TLNSSAASQH PEYLVSPDPE 
       110        120        130        140        150
HLEPIDPKEL LEECRAVLHT RPPRFQRDFV DLRTDCPSTH PPIRVMQWNI 
       160        170        180        190        200
LAQALGEGKD NFVQCPVEAL KWEERKCLIL EEILAYQPDI LCLQEVDHYF 
       210        220        230        240        250
DTFQPLLSRL GYQGTFFPKP WSPCLDVEHN NGPDGCALFF LQNRFKLVNS 
       260        270        280        290        300
ANIRLTAMTL KTNQVAIAQT LECKESGRQF CIAVTHLKAR TGWERFRSAQ 
       310        320        330        340        350
GCDLLQNLQN ITQGAKIPLI VCGDFNAEPT EEVYKHFASS SLNLNSAYKL 
       360        370        380        390        400
LSADGQSEPP YTTWKIRTSG ECRHTLDYIW YSKHALNVRS ALDLLTEEQI 
       410        420        430 
GPNRLPSFNY PSDHLSLVCD FSFTEESDGL S
Length:431
Mass (Da):48,196
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BDEFC43173B2D0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WTX0Q8WTX0_HUMAN
CCR4 carbon catabolite repression 4...
NOCT CCRN4L, hCG_1735627
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16D → G in AAD56548 (PubMed:10521507).Curated1
Sequence conflicti69T → N in AAG01387 (Ref. 4) Curated1
Sequence conflicti77A → G in AAD56548 (PubMed:10521507).Curated1
Sequence conflicti266A → T in AAG01389 (Ref. 4) Curated1
Sequence conflicti341S → N in AAD56548 (PubMed:10521507).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047096140H → Y. Corresponds to variant dbSNP:rs2271777Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF183961 mRNA Translation: AAD56548.1
CH471056 Genomic DNA Translation: EAX05129.1
CH471056 Genomic DNA Translation: EAX05131.1
BC113494 mRNA Translation: AAI13495.1
BC113500 mRNA Translation: AAI13501.1
AF199492 Genomic DNA Translation: AAG01387.1
AF199493 mRNA Translation: AAG01388.1
AF199494 Transcribed RNA Translation: AAG01389.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3743.1

NCBI Reference Sequences

More...RefSeqi		NP_036250.2, NM_012118.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000280614; ENSP00000280614; ENSG00000151014

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25819

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25819

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000280614.4; ENSP00000280614.2; NM_012118.4; NP_036250.2

UCSC genome browser

More...UCSCi		uc003ihl.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF183961 mRNA Translation: AAD56548.1
CH471056 Genomic DNA Translation: EAX05129.1
CH471056 Genomic DNA Translation: EAX05131.1
BC113494 mRNA Translation: AAI13495.1
BC113500 mRNA Translation: AAI13501.1
AF199492 Genomic DNA Translation: AAG01387.1
AF199493 mRNA Translation: AAG01388.1
AF199494 Transcribed RNA Translation: AAG01389.1
CCDSiCCDS3743.1
RefSeqiNP_036250.2, NM_012118.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BT1X-ray1.48A120-431[»]
6BT2X-ray2.41A/B120-431[»]
6MALX-ray2.60A122-431[»]
6NF0X-ray2.70A122-431[»]
SMRiQ9UK39
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117347, 48 interactors
IntActiQ9UK39, 28 interactors
STRINGi9606.ENSP00000280614

PTM databases

iPTMnetiQ9UK39
PhosphoSitePlusiQ9UK39

Genetic variation databases

BioMutaiNOCT
DMDMi212276446

Proteomic databases

EPDiQ9UK39
jPOSTiQ9UK39
MassIVEiQ9UK39
MaxQBiQ9UK39
PaxDbiQ9UK39
PeptideAtlasiQ9UK39
PRIDEiQ9UK39
ProteomicsDBi84714

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16153, 127 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		25819

Genome annotation databases

EnsembliENST00000280614; ENSP00000280614; ENSG00000151014
GeneIDi25819
KEGGihsa:25819
MANE-SelectiENST00000280614.4; ENSP00000280614.2; NM_012118.4; NP_036250.2
UCSCiuc003ihl.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25819
DisGeNETi25819

GeneCards: human genes, protein and diseases

More...GeneCardsi		NOCT
HGNCiHGNC:14254, NOCT
HPAiENSG00000151014, Tissue enhanced (bone)
MIMi608468, gene
neXtProtiNX_Q9UK39
OpenTargetsiENSG00000151014
PharmGKBiPA26176
VEuPathDBiHostDB:ENSG00000151014

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0620, Eukaryota
GeneTreeiENSGT00940000155249
HOGENOMiCLU_016428_1_2_1
InParanoidiQ9UK39
OMAiFEADLMC
OrthoDBi1387401at2759
PhylomeDBiQ9UK39
TreeFamiTF323175

Enzyme and pathway databases

BRENDAi3.1.3.108, 2681
PathwayCommonsiQ9UK39
ReactomeiR-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression
SignaLinkiQ9UK39

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25819, 13 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NOCT, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25819
PharosiQ9UK39, Tbio

Protein Ontology

More...PROi		PR:Q9UK39
RNActiQ9UK39, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151014, Expressed in bone marrow and 148 other tissues
ExpressionAtlasiQ9UK39, baseline and differential
GenevisibleiQ9UK39, HS

Family and domain databases

CDDicd09096, Deadenylase_nocturnin, 1 hit
Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR034965, Deadenylase_nocturnin
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR040109, Nocturnin
PANTHERiPTHR12121:SF45, PTHR12121:SF45, 1 hit
PfamiView protein in Pfam
PF03372, Exo_endo_phos, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOCT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK39
Secondary accession number(s): D3DNY5
, Q14D51, Q9HD93, Q9HD94, Q9HD95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 4, 2008
Last modified: February 23, 2022
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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