UniProtKB - Q9UK39 (NOCT_HUMAN)

BLAST

>sp|Q9UK39|NOCT_HUMAN Nocturnin OS=Homo sapiens OX=9606 GN=NOCT PE=1 SV=2
MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSC
SRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHT
RPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLIL
EEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFF
LQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQ
GCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPP
YTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCD
FSFTEESDGLS

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History
Entry version 140 (12 Sep 2018)
Sequence version 2 (04 Nov 2008)
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Protein

Nocturnin

Gene

NOCT

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).By similarity

Catalytic activityⁱ

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactorⁱ

Mg²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	195	By similarity	1
Metal bindingⁱ	195	Magnesium 1By similarity	1
Metal bindingⁱ	324	Magnesium 2By similarity	1
Metal bindingⁱ	326	Magnesium 2By similarity	1
Active siteⁱ	377	By similarity	1
Active siteⁱ	414	By similarity	1
Metal bindingⁱ	414	Magnesium 2By similarity	1

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 10521507
metal ion binding Source: UniProtKB-KW
mRNA binding Source: UniProtKB
poly(A)-specific ribonuclease activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian regulation of gene expression Source: UniProtKB
circadian rhythm Source: Reactome
cytoplasmic mRNA processing body assembly Source: Ensembl
deadenylation-dependent decapping of nuclear-transcribed mRNA Source: Ensembl
mRNA processing Source: UniProtKB-KW
mRNA stabilization Source: UniProtKB
negative regulation of gene expression Source: UniProtKB
negative regulation of osteoblast differentiation Source: UniProtKB
positive regulation of fat cell differentiation Source: UniProtKB
regulation of circadian rhythm Source: UniProtKB
regulation of embryonic development Source: Ensembl
response to extracellular stimulus Source: UniProtKB
response to lipopolysaccharide Source: UniProtKB
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 10521507

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Exonuclease, Hydrolase, Nuclease, RNA-binding
Biological process	Biological rhythms, mRNA processing
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

Reactomeⁱ

R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NocturninBy similarityImported (EC:3.1.13.4) Alternative name(s): Carbon catabolite repression 4-like protein Circadian deadenylase NOC
Gene namesⁱ	Name:NOCTImported Synonyms:CCR4, CCRN4L, NOC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151014.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14254 NOCT
MIMⁱ	608468 gene
neXtProtⁱ	NX_Q9UK39

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25819
Open Targets More...OpenTargetsⁱ	ENSG00000151014
PharmGKBⁱ	PA26176

Polymorphism and mutation databases

DMDMⁱ	212276446

DMDMⁱ

212276446

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218568	1 – 431	NocturninAdd BLAST		431

Proteomic databases

EPDⁱ	Q9UK39
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UK39
PaxDbⁱ	Q9UK39
PeptideAtlas More...PeptideAtlasⁱ	Q9UK39
PRIDEⁱ	Q9UK39
ProteomicsDBⁱ	84714

PTM databases

iPTMnetⁱ	Q9UK39
PhosphoSitePlusⁱ	Q9UK39

Expressionⁱ

Tissue specificityⁱ

Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151014 Expressed in 127 organ(s), highest expression level in vagina
CleanExⁱ	HS_CCR4 HS_CCRN4L
ExpressionAtlasⁱ	Q9UK39 baseline and differential
Genevisibleⁱ	Q9UK39 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012287 HPA053714

HPAⁱ

HPA012287
HPA053714

Interactionⁱ

Subunit structureⁱ

Interacts with PPARG.By similarity

Protein-protein interaction databases

BioGridⁱ	117347, 34 interactors
IntActⁱ	Q9UK39, 2 interactors
STRINGⁱ	9606.ENSP00000280614

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	123 – 125	Combined sources	3
Beta strandⁱ	129 – 131	Combined sources	3
Beta strandⁱ	143 – 149	Combined sources	7
Helixⁱ	153 – 158	Combined sources	6
Beta strandⁱ	163 – 165	Combined sources	3
Helixⁱ	167 – 170	Combined sources	4
Helixⁱ	172 – 186	Combined sources	15
Beta strandⁱ	189 – 195	Combined sources	7
Turnⁱ	199 – 202	Combined sources	4
Helixⁱ	203 – 209	Combined sources	7
Beta strandⁱ	212 – 218	Combined sources	7
Helixⁱ	223 – 226	Combined sources	4
Beta strandⁱ	235 – 241	Combined sources	7
Turnⁱ	242 – 244	Combined sources	3
Beta strandⁱ	245 – 257	Combined sources	13
Beta strandⁱ	260 – 273	Combined sources	14
Turnⁱ	274 – 276	Combined sources	3
Beta strandⁱ	279 – 286	Combined sources	8
Helixⁱ	294 – 311	Combined sources	18
Turnⁱ	312 – 316	Combined sources	5
Beta strandⁱ	319 – 324	Combined sources	6
Helixⁱ	332 – 339	Combined sources	8
Beta strandⁱ	344 – 346	Combined sources	3
Helixⁱ	347 – 351	Combined sources	5
Beta strandⁱ	352 – 355	Combined sources	4
Beta strandⁱ	362 – 367	Combined sources	6
Beta strandⁱ	370 – 374	Combined sources	5
Beta strandⁱ	377 – 382	Combined sources	6
Turnⁱ	383 – 385	Combined sources	3
Beta strandⁱ	386 – 392	Combined sources	7
Helixⁱ	397 – 400	Combined sources	4
Beta strandⁱ	405 – 407	Combined sources	3
Beta strandⁱ	411 – 414	Combined sources	4
Beta strandⁱ	417 – 423	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UK39
SMRⁱ	Q9UK39
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	343 – 353	Interaction with PPARGBy similarityAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0620 Eukaryota COG5239 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074364
HOGENOMⁱ	HOG000237357
HOVERGENⁱ	HBG006512
InParanoidⁱ	Q9UK39
KEGG Orthology (KO) More...KOⁱ	K18764
OMAⁱ	RTDCPSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BF8
PhylomeDBⁱ	Q9UK39
TreeFamⁱ	TF323175

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09096 Deadenylase_nocturnin, 1 hit
Gene3Dⁱ	3.60.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR034965 Deadenylase_nocturnin IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit
SUPFAMⁱ	SSF56219 SSF56219, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9UK39-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MFHSPRRLCS ALLQRDAPGL RRLPAPGLRR PLSPPAAVPR PASPRLLAAA 
        60         70         80         90        100
SAASGAARSC SRTVCSMGTG TSRLYSALAK TLNSSAASQH PEYLVSPDPE 
       110        120        130        140        150
HLEPIDPKEL LEECRAVLHT RPPRFQRDFV DLRTDCPSTH PPIRVMQWNI 
       160        170        180        190        200
LAQALGEGKD NFVQCPVEAL KWEERKCLIL EEILAYQPDI LCLQEVDHYF 
       210        220        230        240        250
DTFQPLLSRL GYQGTFFPKP WSPCLDVEHN NGPDGCALFF LQNRFKLVNS 
       260        270        280        290        300
ANIRLTAMTL KTNQVAIAQT LECKESGRQF CIAVTHLKAR TGWERFRSAQ 
       310        320        330        340        350
GCDLLQNLQN ITQGAKIPLI VCGDFNAEPT EEVYKHFASS SLNLNSAYKL 
       360        370        380        390        400
LSADGQSEPP YTTWKIRTSG ECRHTLDYIW YSKHALNVRS ALDLLTEEQI 
       410        420        430 
GPNRLPSFNY PSDHLSLVCD FSFTEESDGL S

Length:431

Mass (Da):48,196

Last modified:November 4, 2008 - v2

Checksum:ⁱ5BDEFC43173B2D0C

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q8WTX0	Q8WTX0_HUMAN		CCR4 carbon catabolite repression 4... CCR4 carbon catabolite repression 4-like (S. cerevisiae), isoform CRA_b (CCRN4L protein) (Nocturnin)	NOCT CCRN4L, hCG_1735627	167	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	16	D → G in AAD56548 (PubMed:10521507).Curated	1
Sequence conflictⁱ	69	T → N in AAG01387 (Ref. 4) Curated	1
Sequence conflictⁱ	77	A → G in AAD56548 (PubMed:10521507).Curated	1
Sequence conflictⁱ	266	A → T in AAG01389 (Ref. 4) Curated	1
Sequence conflictⁱ	341	S → N in AAD56548 (PubMed:10521507).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_047096	140	H → Y. Corresponds to variant dbSNP:rs2271777Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF183961 mRNA Translation: AAD56548.1 CH471056 Genomic DNA Translation: EAX05129.1 CH471056 Genomic DNA Translation: EAX05131.1 BC113494 mRNA Translation: AAI13495.1 BC113500 mRNA Translation: AAI13501.1 AF199492 Genomic DNA Translation: AAG01387.1 AF199493 mRNA Translation: AAG01388.1 AF199494 Transcribed RNA Translation: AAG01389.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3743.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036250.2, NM_012118.3
UniGeneⁱ	Hs.639842 Hs.656047

Genome annotation databases

Ensemblⁱ	ENST00000280614; ENSP00000280614; ENSG00000151014
GeneIDⁱ	25819
KEGGⁱ	hsa:25819
UCSC genome browser More...UCSCⁱ	uc003ihl.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK39	nocturnin		DELLE		538	UniRef90_Q9UK39
nocturnin		TURTR		533
Uncharacterized protein		PROCO		437
Uncharacterized protein		CAVPO		432
Uncharacterized protein		Cebus capucinus imitator		431
+30

Protein	Similar proteins		Species	Score	Length	Source
Q9UK39	nocturnin		DELLE		538	UniRef50_Q9UK39
nocturnin		TURTR		533
Uncharacterized protein		PROCO		437
Uncharacterized protein		CAVPO		432
Uncharacterized protein		Cebus capucinus imitator		431
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF183961 mRNA Translation: AAD56548.1 CH471056 Genomic DNA Translation: EAX05129.1 CH471056 Genomic DNA Translation: EAX05131.1 BC113494 mRNA Translation: AAI13495.1 BC113500 mRNA Translation: AAI13501.1 AF199492 Genomic DNA Translation: AAG01387.1 AF199493 mRNA Translation: AAG01388.1 AF199494 Transcribed RNA Translation: AAG01389.1
CCDSⁱ	CCDS3743.1
RefSeqⁱ	NP_036250.2, NM_012118.3
UniGeneⁱ	Hs.639842 Hs.656047

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6BT1	X-ray	1.48	A	120-431	[»]
	6BT2	X-ray	2.41	A/B	120-431	[»]
	6DIP	X-ray	2.60	A	122-426	[»]
ProteinModelPortalⁱ	Q9UK39
SMRⁱ	Q9UK39
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117347, 34 interactors
IntActⁱ	Q9UK39, 2 interactors
STRINGⁱ	9606.ENSP00000280614

PTM databases

iPTMnetⁱ	Q9UK39
PhosphoSitePlusⁱ	Q9UK39

Polymorphism and mutation databases

DMDMⁱ	212276446

DMDMⁱ

212276446

Proteomic databases

EPDⁱ	Q9UK39
MaxQBⁱ	Q9UK39
PaxDbⁱ	Q9UK39
PeptideAtlasⁱ	Q9UK39
PRIDEⁱ	Q9UK39
ProteomicsDBⁱ	84714

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000280614; ENSP00000280614; ENSG00000151014
GeneIDⁱ	25819
KEGGⁱ	hsa:25819
UCSCⁱ	uc003ihl.5 human

Organism-specific databases

CTDⁱ	25819
DisGeNETⁱ	25819
EuPathDBⁱ	HostDB:ENSG00000151014.5
GeneCardsⁱ	NOCT
H-InvDBⁱ	HIX0004503
HGNCⁱ	HGNC:14254 NOCT
HPAⁱ	HPA012287 HPA053714
MIMⁱ	608468 gene
neXtProtⁱ	NX_Q9UK39
OpenTargetsⁱ	ENSG00000151014
PharmGKBⁱ	PA26176
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0620 Eukaryota COG5239 LUCA
GeneTreeⁱ	ENSGT00550000074364
HOGENOMⁱ	HOG000237357
HOVERGENⁱ	HBG006512
InParanoidⁱ	Q9UK39
KOⁱ	K18764
OMAⁱ	RTDCPSS
OrthoDBⁱ	EOG091G0BF8
PhylomeDBⁱ	Q9UK39
TreeFamⁱ	TF323175

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

Reactomeⁱ

R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression

Miscellaneous databases

ChiTaRSⁱ	NOCT human
GenomeRNAiⁱ	25819
Protein Ontology More...PROⁱ	PR:Q9UK39
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151014 Expressed in 127 organ(s), highest expression level in vagina
CleanExⁱ	HS_CCR4 HS_CCRN4L
ExpressionAtlasⁱ	Q9UK39 baseline and differential
Genevisibleⁱ	Q9UK39 HS

Family and domain databases

CDDⁱ	cd09096 Deadenylase_nocturnin, 1 hit
Gene3Dⁱ	3.60.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR034965 Deadenylase_nocturnin IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase
Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit
SUPFAMⁱ	SSF56219 SSF56219, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOCT_HUMAN
Accessionⁱ	Q9UK39Primary (citable) accession number: Q9UK39 Secondary accession number(s): D3DNY5 , Q14D51, Q9HD93, Q9HD94, Q9HD95
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 4, 2008
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Help

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UniProtKB - Q9UK39 (NOCT_HUMAN)

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Nocturnin

NOCT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ