ZNF580

Functionⁱ

Involved in the regulation of endothelial cell proliferation and migration. Mediates H₂O₂-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	92 – 114	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	120 – 142	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	150 – 172	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hydrogen peroxide
Source: UniProtKB
Inferred from direct assayⁱ
- 21830064
chemotaxis Source: UniProtKB-KW
inflammatory response Source: UniProtKB-KW
positive regulation of endothelial cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 20382120
positive regulation of endothelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 20382120
positive regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 20382120
- 21830064
positive regulation of interleukin-8 production
Source: UniProtKB
Inferred from direct assayⁱ
- 21830064
positive regulation of leukocyte chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 21830064

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Chemotaxis, Inflammatory response, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 580 Alternative name(s): LDL-induced EC protein
Gene namesⁱ	Name:ZNF580
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000213015.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29473 ZNF580
MIMⁱ	617888 gene
neXtProtⁱ	NX_Q9UK33

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000213015
PharmGKBⁱ	PA134867016

Polymorphism and mutation databases

BioMutaⁱ	ZNF580
DMDMⁱ	55976777

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047671	1 – 172	Zinc finger protein 580Add BLAST		172

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	31	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	118	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UK33
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UK33
PaxDbⁱ	Q9UK33
PeptideAtlas More...PeptideAtlasⁱ	Q9UK33
PRIDEⁱ	Q9UK33
ProteomicsDBⁱ	84713

PTM databases

iPTMnetⁱ	Q9UK33
PhosphoSitePlusⁱ	Q9UK33

Expressionⁱ

Tissue specificityⁱ

Expressed in endothelial cells.1 Publication

Inductionⁱ

Up-regulated in presence of reactive oxygen species (ROS), like H₂O₂, through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000213015 Expressed in 206 organ(s), highest expression level in left uterine tube
CleanExⁱ	HS_ZNF580
ExpressionAtlasⁱ	Q9UK33 baseline and differential
Genevisibleⁱ	Q9UK33 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054058

HPAⁱ

HPA054058

Interactionⁱ

Subunit structureⁱ

Interacts with SMAD2.1 Publication

Protein-protein interaction databases

BioGridⁱ	119340, 7 interactors
IntActⁱ	Q9UK33, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q9UK33
STRINGⁱ	9606.ENSP00000320050

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UK33
SMRⁱ	Q9UK33
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	5 – 88	Pro-richAdd BLAST		84

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	92 – 114	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	120 – 142	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	150 – 172	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149029
HOGENOMⁱ	HOG000059663
HOVERGENⁱ	HBG079385
InParanoidⁱ	Q9UK33
OMAⁱ	QSHRISH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0STS
PhylomeDBⁱ	Q9UK33
TreeFamⁱ	TF338348

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9UK33-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL 
        60         70         80         90        100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV 
       110        120        130        140        150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH 
       160        170 
TCPLCPRRFQ DAAELAQHVR LH

Length:172

Mass (Da):18,756

Last modified:May 1, 2000 - v1

Checksum:ⁱ55A89DD94E0440A8

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ENY2	K7ENY2_HUMAN	Zinc finger protein 580 Zinc finger protein 580	ZNF580	104	Annotation score:
K7ERU0	K7ERU0_HUMAN	Zinc finger protein 580 Zinc finger protein 580	ZNF580	103	Annotation score:
K7EJ53	K7EJ53_HUMAN	Zinc finger protein 580 Zinc finger protein 580	ZNF580	22	Annotation score:

Sequence cautionⁱ

The sequence CAB94389 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF184939 mRNA Translation: AAD56549.1 AL359054 mRNA Translation: CAB94389.1 Different initiation. AK314888 mRNA Translation: BAG37402.1 BC017698 mRNA Translation: AAH17698.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12931.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001156895.1, NM_001163423.1 NP_057286.1, NM_016202.2 NP_996998.1, NM_207115.1
UniGeneⁱ	Hs.631551

Genome annotation databases

Ensemblⁱ	ENST00000325333; ENSP00000320050; ENSG00000213015 ENST00000543039; ENSP00000443957; ENSG00000213015 ENST00000545125; ENSP00000446126; ENSG00000213015
GeneIDⁱ	51157
KEGGⁱ	hsa:51157
UCSC genome browser More...UCSCⁱ	uc002qlo.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK33	Zinc finger protein 580 (Fragment)		HUMAN		103	UniRef100_Q9UK33
ZNF580 isoform 1 (Fragment)		PONAB		103
ZNF580 isoform 5 (Fragment)		PANTR		103
Zinc finger protein 580		SAIBB		172
Uncharacterized protein		Cebus capucinus imitator		172
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9UK33	Zinc finger protein 580 (Fragment)		HUMAN		103	UniRef90_Q9UK33
ZNF580 isoform 1 (Fragment)		PONAB		103
ZNF580 isoform 5 (Fragment)		PANTR		103
Zinc finger protein 580		SAIBB		172
Uncharacterized protein		Cebus capucinus imitator		172
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9UK33	Zinc finger protein 580 (Fragment)		HUMAN		103	UniRef50_Q9UK33
ZNF580 isoform 1 (Fragment)		PONAB		103
ZNF580 isoform 5 (Fragment)		PANTR		103
Zinc finger protein 580		SAIBB		172
Uncharacterized protein		Cebus capucinus imitator		172
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF184939 mRNA Translation: AAD56549.1 AL359054 mRNA Translation: CAB94389.1 Different initiation. AK314888 mRNA Translation: BAG37402.1 BC017698 mRNA Translation: AAH17698.1
CCDSⁱ	CCDS12931.1
RefSeqⁱ	NP_001156895.1, NM_001163423.1 NP_057286.1, NM_016202.2 NP_996998.1, NM_207115.1
UniGeneⁱ	Hs.631551

3D structure databases

ProteinModelPortalⁱ	Q9UK33
SMRⁱ	Q9UK33
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119340, 7 interactors
IntActⁱ	Q9UK33, 22 interactors
MINTⁱ	Q9UK33
STRINGⁱ	9606.ENSP00000320050

PTM databases

iPTMnetⁱ	Q9UK33
PhosphoSitePlusⁱ	Q9UK33

Polymorphism and mutation databases

BioMutaⁱ	ZNF580
DMDMⁱ	55976777

Proteomic databases

EPDⁱ	Q9UK33
MaxQBⁱ	Q9UK33
PaxDbⁱ	Q9UK33
PeptideAtlasⁱ	Q9UK33
PRIDEⁱ	Q9UK33
ProteomicsDBⁱ	84713

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51157
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325333; ENSP00000320050; ENSG00000213015 ENST00000543039; ENSP00000443957; ENSG00000213015 ENST00000545125; ENSP00000446126; ENSG00000213015
GeneIDⁱ	51157
KEGGⁱ	hsa:51157
UCSCⁱ	uc002qlo.4 human

Organism-specific databases

CTDⁱ	51157
EuPathDBⁱ	HostDB:ENSG00000213015.8
GeneCardsⁱ	ZNF580
HGNCⁱ	HGNC:29473 ZNF580
HPAⁱ	HPA054058
MIMⁱ	617888 gene
neXtProtⁱ	NX_Q9UK33
OpenTargetsⁱ	ENSG00000213015
PharmGKBⁱ	PA134867016
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000149029
HOGENOMⁱ	HOG000059663
HOVERGENⁱ	HBG079385
InParanoidⁱ	Q9UK33
OMAⁱ	QSHRISH
OrthoDBⁱ	EOG091G0STS
PhylomeDBⁱ	Q9UK33
TreeFamⁱ	TF338348

Miscellaneous databases

GenomeRNAiⁱ	51157
Protein Ontology More...PROⁱ	PR:Q9UK33
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000213015 Expressed in 206 organ(s), highest expression level in left uterine tube
CleanExⁱ	HS_ZNF580
ExpressionAtlasⁱ	Q9UK33 baseline and differential
Genevisibleⁱ	Q9UK33 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN580_HUMAN
Accessionⁱ	Q9UK33Primary (citable) accession number: Q9UK33 Secondary accession number(s): B2RC05, Q9NPP7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q9UK33 (ZN580_HUMAN)

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Zinc finger protein 580

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ