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UniProtKB - Q9UK33 (ZN580_HUMAN)
Protein
Zinc finger protein 580
Gene
ZNF580
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O2-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 92 – 114 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 120 – 142 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 150 – 172 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cellular response to hydrogen peroxide Source: UniProtKB
- chemotaxis Source: UniProtKB-KW
- inflammatory response Source: UniProtKB-KW
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of leukocyte chemotaxis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Chemotaxis, Inflammatory response, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UK33 |
SignaLinki | Q9UK33 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 580Alternative name(s): LDL-induced EC protein |
Gene namesi | Name:ZNF580 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29473, ZNF580 |
MIMi | 617888, gene |
neXtProti | NX_Q9UK33 |
VEuPathDBi | HostDB:ENSG00000213015 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Colocalized with SMAD2 in the nucleus.
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51157 |
OpenTargetsi | ENSG00000213015 |
PharmGKBi | PA134867016 |
Miscellaneous databases
Pharosi | Q9UK33, Tbio |
Genetic variation databases
BioMutai | ZNF580 |
DMDMi | 55976777 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047671 | 1 – 172 | Zinc finger protein 580Add BLAST | 172 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 31 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9UK33 |
jPOSTi | Q9UK33 |
MassIVEi | Q9UK33 |
MaxQBi | Q9UK33 |
PaxDbi | Q9UK33 |
PeptideAtlasi | Q9UK33 |
PRIDEi | Q9UK33 |
ProteomicsDBi | 84713 |
PTM databases
iPTMneti | Q9UK33 |
PhosphoSitePlusi | Q9UK33 |
Expressioni
Tissue specificityi
Expressed in endothelial cells.1 Publication
Inductioni
Up-regulated in presence of reactive oxygen species (ROS), like H2O2, through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).2 Publications
Gene expression databases
Bgeei | ENSG00000213015, Expressed in left uterine tube and 221 other tissues |
ExpressionAtlasi | Q9UK33, baseline and differential |
Genevisiblei | Q9UK33, HS |
Organism-specific databases
HPAi | ENSG00000213015, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SMAD2.
1 PublicationBinary interactionsi
Q9UK33
Protein-protein interaction databases
BioGRIDi | 119340, 29 interactors |
IntActi | Q9UK33, 25 interactors |
MINTi | Q9UK33 |
STRINGi | 9606.ENSP00000443957 |
Miscellaneous databases
RNActi | Q9UK33, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 93 | DisorderedSequence analysisAdd BLAST | 93 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 34 | Pro residuesSequence analysisAdd BLAST | 34 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 92 – 114 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 120 – 142 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 150 – 172 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163086 |
HOGENOMi | CLU_002678_42_5_1 |
InParanoidi | Q9UK33 |
OMAi | VPYMYTV |
PhylomeDBi | Q9UK33 |
TreeFami | TF338348 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9UK33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL
60 70 80 90 100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV
110 120 130 140 150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH
160 170
TCPLCPRRFQ DAAELAQHVR LH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ENY2 | K7ENY2_HUMAN | Zinc finger protein 580 | ZNF580 | 104 | Annotation score: | ||
K7ERU0 | K7ERU0_HUMAN | Zinc finger protein 580 | ZNF580 | 103 | Annotation score: | ||
K7EJ53 | K7EJ53_HUMAN | Zinc finger protein 580 | ZNF580 | 22 | Annotation score: |
Sequence cautioni
The sequence CAB94389 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF184939 mRNA Translation: AAD56549.1 AL359054 mRNA Translation: CAB94389.1 Different initiation. AK314888 mRNA Translation: BAG37402.1 BC017698 mRNA Translation: AAH17698.1 |
CCDSi | CCDS12931.1 |
RefSeqi | NP_001156895.1, NM_001163423.1 NP_057286.1, NM_016202.2 NP_996998.1, NM_207115.1 |
Genome annotation databases
Ensembli | ENST00000325333; ENSP00000320050; ENSG00000213015 ENST00000543039; ENSP00000443957; ENSG00000213015 ENST00000545125; ENSP00000446126; ENSG00000213015 |
GeneIDi | 51157 |
KEGGi | hsa:51157 |
MANE-Selecti | ENST00000325333.10; ENSP00000320050.4; NM_207115.2; NP_996998.1 |
UCSCi | uc002qlo.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF184939 mRNA Translation: AAD56549.1 AL359054 mRNA Translation: CAB94389.1 Different initiation. AK314888 mRNA Translation: BAG37402.1 BC017698 mRNA Translation: AAH17698.1 |
CCDSi | CCDS12931.1 |
RefSeqi | NP_001156895.1, NM_001163423.1 NP_057286.1, NM_016202.2 NP_996998.1, NM_207115.1 |
3D structure databases
SMRi | Q9UK33 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119340, 29 interactors |
IntActi | Q9UK33, 25 interactors |
MINTi | Q9UK33 |
STRINGi | 9606.ENSP00000443957 |
PTM databases
iPTMneti | Q9UK33 |
PhosphoSitePlusi | Q9UK33 |
Genetic variation databases
BioMutai | ZNF580 |
DMDMi | 55976777 |
Proteomic databases
EPDi | Q9UK33 |
jPOSTi | Q9UK33 |
MassIVEi | Q9UK33 |
MaxQBi | Q9UK33 |
PaxDbi | Q9UK33 |
PeptideAtlasi | Q9UK33 |
PRIDEi | Q9UK33 |
ProteomicsDBi | 84713 |
Protocols and materials databases
Antibodypediai | 19580, 87 antibodies from 15 providers |
DNASUi | 51157 |
Genome annotation databases
Ensembli | ENST00000325333; ENSP00000320050; ENSG00000213015 ENST00000543039; ENSP00000443957; ENSG00000213015 ENST00000545125; ENSP00000446126; ENSG00000213015 |
GeneIDi | 51157 |
KEGGi | hsa:51157 |
MANE-Selecti | ENST00000325333.10; ENSP00000320050.4; NM_207115.2; NP_996998.1 |
UCSCi | uc002qlo.4, human |
Organism-specific databases
CTDi | 51157 |
DisGeNETi | 51157 |
GeneCardsi | ZNF580 |
HGNCi | HGNC:29473, ZNF580 |
HPAi | ENSG00000213015, Low tissue specificity |
MIMi | 617888, gene |
neXtProti | NX_Q9UK33 |
OpenTargetsi | ENSG00000213015 |
PharmGKBi | PA134867016 |
VEuPathDBi | HostDB:ENSG00000213015 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163086 |
HOGENOMi | CLU_002678_42_5_1 |
InParanoidi | Q9UK33 |
OMAi | VPYMYTV |
PhylomeDBi | Q9UK33 |
TreeFami | TF338348 |
Enzyme and pathway databases
PathwayCommonsi | Q9UK33 |
SignaLinki | Q9UK33 |
Miscellaneous databases
BioGRID-ORCSi | 51157, 20 hits in 1068 CRISPR screens |
ChiTaRSi | ZNF580, human |
GenomeRNAii | 51157 |
Pharosi | Q9UK33, Tbio |
PROi | PR:Q9UK33 |
RNActi | Q9UK33, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213015, Expressed in left uterine tube and 221 other tissues |
ExpressionAtlasi | Q9UK33, baseline and differential |
Genevisiblei | Q9UK33, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN580_HUMAN | |
Accessioni | Q9UK33Primary (citable) accession number: Q9UK33 Secondary accession number(s): B2RC05, Q9NPP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot