RPS6KA6

Functionⁱ

Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺By similarity

Activity regulationⁱ

Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	105	ATPPROSITE-ProRule annotation	1
Active siteⁱ	198	Proton acceptorBy similarity	1
Binding siteⁱ	455	ATPPROSITE-ProRule annotation	1
Active siteⁱ	543	Proton acceptorBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	79 – 87	ATPPROSITE-ProRule annotation		9
Nucleotide bindingⁱ	432 – 440	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
kinase activity Source: Reactome
magnesium ion binding Source: InterPro
protein kinase activity
Source: ProtInc
Traceable author statementⁱ
- 10644430
protein serine/threonine kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 10644430
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15042092
negative regulation of embryonic development Source: UniProtKB
negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
negative regulation of mesoderm development Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10644430

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 2681
Reactomeⁱ	R-HSA-437239 Recycling pathway of L1 R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-444257 RSK activation
SignaLinkⁱ	Q9UK32

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribosomal protein S6 kinase alpha-6 (EC:2.7.11.1) Short name: S6K-alpha-6 Alternative name(s): 90 kDa ribosomal protein S6 kinase 6 Short name: p90-RSK 6 Short name: p90RSK6 Ribosomal S6 kinase 4 Short name: RSK-4 pp90RSK4
Gene namesⁱ	Name:RPS6KA6 Synonyms:RSK4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072133.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10435 RPS6KA6
MIMⁱ	300303 gene
neXtProtⁱ	NX_Q9UK32

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	372	S → A: No effect on activity. 1 Publication	1
Mutagenesisⁱ	389	S → A: Strongly decreases activity. 1 Publication	1
Mutagenesisⁱ	581	T → A: No effect on activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27330
Open Targets More...OpenTargetsⁱ	ENSG00000072133
PharmGKBⁱ	PA34850

Chemistry databases

ChEMBLⁱ	CHEMBL4924
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1530

Polymorphism and mutation databases

BioMutaⁱ	RPS6KA6
DMDMⁱ	11133131

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086209	1 – 745	Ribosomal protein S6 kinase alpha-6Add BLAST		745

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	232	Phosphoserine1 Publication	1
Modified residueⁱ	372	Phosphoserine1 Publication	1
Modified residueⁱ	389	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	581	Phosphothreonine1 Publication	1

Post-translational modificationⁱ

Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UK32
PaxDbⁱ	Q9UK32
PeptideAtlas More...PeptideAtlasⁱ	Q9UK32
PRIDEⁱ	Q9UK32
ProteomicsDBⁱ	84712

PTM databases

iPTMnetⁱ	Q9UK32
PhosphoSitePlusⁱ	Q9UK32

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000072133 Expressed in 161 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_RPS6KA6
Genevisibleⁱ	Q9UK32 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002852 HPA003904

HPAⁱ

HPA002852
HPA003904

Interactionⁱ

Subunit structureⁱ

Forms a complex with MAPK3/ERK1 but not with MAPK9 or MAPK14 in serum-starved cells.

Protein-protein interaction databases

BioGridⁱ	118144, 36 interactors
IntActⁱ	Q9UK32, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q9UK32
STRINGⁱ	9606.ENSP00000262752

Chemistry databases

BindingDBⁱ

Q9UK32

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UK32
SMRⁱ	Q9UK32
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	73 – 330	Protein kinase 1PROSITE-ProRule annotationAdd BLAST	258
Domainⁱ	331 – 400	AGC-kinase C-terminalAdd BLAST	70
Domainⁱ	426 – 683	Protein kinase 2PROSITE-ProRule annotationAdd BLAST	258

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0598 Eukaryota ENOG410XNPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148962
HOGENOMⁱ	HOG000233033
HOVERGENⁱ	HBG108317
InParanoidⁱ	Q9UK32
KEGG Orthology (KO) More...KOⁱ	K04373
OMAⁱ	WIACRDQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05Z7
PhylomeDBⁱ	Q9UK32
TreeFamⁱ	TF313438

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR011009 Kinase-like_dom_sf IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR016239 Ribosomal_S6_kinase_II IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 2 hits PF00433 Pkinase_C, 1 hit
PIRSFⁱ	PIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTⁱ	View protein in SMART SM00133 S_TK_X, 1 hit SM00220 S_TKc, 2 hits
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 2 hits PS50011 PROTEIN_KINASE_DOM, 2 hits PS00108 PROTEIN_KINASE_ST, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9UK32-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPFAPQDEP WDREMEVFSG GGASSGEVNG LKMVDEPMEE GEADSCHDEG 
        60         70         80         90        100
VVKEIPITHH VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ 
       110        120        130        140        150
LYAMKVLKKA SLKVRDRVRT KMERDILVEV NHPFIVKLHY AFQTEGKLYL 
       160        170        180        190        200
ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA ELALALDHLH QLGIVYRDLK 
       210        220        230        240        250
PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM APEVVNRRGH 
       260        270        280        290        300
SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA 
       310        320        330        340        350
QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA 
       360        370        380        390        400
SGKPDDTFCF DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK 
       410        420        430        440        450
ITPITSANVL PIVQINGNAA QFGEVYELKE DIGVGSYSVC KRCIHATTNM 
       460        470        480        490        500
EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI ITLKDVFDDG RYVYLVTDLM 
       510        520        530        540        550
KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV HRDLKPSNIL 
       560        570        580        590        600
YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD 
       610        620        630        640        650
AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD 
       660        670        680        690        700
NISDGAKDLL SHMLHMDPHQ RYTAEQILKH SWITHRDQLP NDQPKRNDVS 
       710        720        730        740 
HVVKGAMVAT YSALTHKTFQ PVLEPVAASS LAQRRSMKKR TSTGL

Length:745

Mass (Da):83,872

Last modified:May 1, 2000 - v1

Checksum:ⁱ5EC5AB2FA1C19DE8

GO

Isoform 2 (identifier: Q9UK32-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-27: MLPFAPQDEPWDREMEVFSGGGASSGE → MGLSTSAIWKNTRVEIVNPYEVKRKVK

« Hide

        10         20         30         40         50
MGLSTSAIWK NTRVEIVNPY EVKRKVKVNG LKMVDEPMEE GEADSCHDEG 
        60         70         80         90        100
VVKEIPITHH VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ 
       110        120        130        140        150
LYAMKVLKKA SLKVRDRVRT KMERDILVEV NHPFIVKLHY AFQTEGKLYL 
       160        170        180        190        200
ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA ELALALDHLH QLGIVYRDLK 
       210        220        230        240        250
PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM APEVVNRRGH 
       260        270        280        290        300
SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA 
       310        320        330        340        350
QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA 
       360        370        380        390        400
SGKPDDTFCF DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK 
       410        420        430        440        450
ITPITSANVL PIVQINGNAA QFGEVYELKE DIGVGSYSVC KRCIHATTNM 
       460        470        480        490        500
EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI ITLKDVFDDG RYVYLVTDLM 
       510        520        530        540        550
KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV HRDLKPSNIL 
       560        570        580        590        600
YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD 
       610        620        630        640        650
AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD 
       660        670        680        690        700
NISDGAKDLL SHMLHMDPHQ RYTAEQILKH SWITHRDQLP NDQPKRNDVS 
       710        720        730        740 
HVVKGAMVAT YSALTHKTFQ PVLEPVAASS LAQRRSMKKR TSTGL

Note: No experimental confirmation available.

Show »

Length:745

Mass (Da):84,093

Checksum:ⁱD8EB15DB8C280DDD

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	116	D → G in CAG38803 (Ref. 2) Curated	1
Sequence conflictⁱ	295	F → L in CAG38803 (Ref. 2) Curated	1
Sequence conflictⁱ	341	R → G in CAG38803 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040637	140	Y → C in a lung large cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040638	258	S → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_030670	692	D → N1 PublicationCorresponds to variant dbSNP:rs6616890Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056181	1 – 27	MLPFA…ASSGE → MGLSTSAIWKNTRVEIVNPY EVKRKVK in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF184965 mRNA Translation: AAF13190.1 CR536566 mRNA Translation: CAG38803.1 AK313240 mRNA Translation: BAG36051.1 AL389887 Genomic DNA No translation available. AL354653 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98575.1 BC143648 mRNA Translation: AAI43649.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14451.1 [Q9UK32-1] CCDS83480.1 [Q9UK32-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317441.1, NM_001330512.1 [Q9UK32-2] NP_055311.1, NM_014496.4 [Q9UK32-1] XP_011529219.1, XM_011530917.2 [Q9UK32-2]
UniGeneⁱ	Hs.234478

Genome annotation databases

Ensemblⁱ	ENST00000262752; ENSP00000262752; ENSG00000072133 [Q9UK32-1] ENST00000620340; ENSP00000483896; ENSG00000072133 [Q9UK32-2]
GeneIDⁱ	27330
KEGGⁱ	hsa:27330
UCSC genome browser More...UCSCⁱ	uc004eej.3 human [Q9UK32-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UK32	Ribosomal protein S6 kinase		PANTR		745	UniRef100_Q9UK32
Ribosomal protein S6 kinase		PANPA		745
UPI0007DBD5F6		PANTR		618
Q9UK32-2	Ribosomal protein S6 kinase		PANTR		745	UniRef100_A0A2I3S8A4
Ribosomal protein S6 kinase		PANPA		745
UPI0007DC5DCA		HUMAN		762
UPI0004F07FE0		PANPA		713
UPI000387C454		HUMAN		624
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9UK32	Ribosomal protein S6 kinase		PANTR		745	UniRef90_Q9UK32
Ribosomal protein S6 kinase		PANPA		745
Ribosomal protein S6 kinase		AOTNA		783
Ribosomal protein S6 kinase		Enhydra lutris kenyoni		752
Ribosomal protein S6 kinase		MYOLU		748
+171

Protein	Similar proteins		Species	Score	Length	Source
Q9UK32	Ribosomal protein S6 kinase alpha-3	)	HUMAN		740	UniRef50_P51812
Ribosomal protein S6 kinase alpha-3	)	MOUSE		740
Ribosomal protein S6 kinase 2 alpha		CHICK		752
Ribosomal protein S6 kinase alpha-1		RAT		735
Ribosomal protein S6 kinase		CALJA		740
+1222

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF184965 mRNA Translation: AAF13190.1 CR536566 mRNA Translation: CAG38803.1 AK313240 mRNA Translation: BAG36051.1 AL389887 Genomic DNA No translation available. AL354653 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98575.1 BC143648 mRNA Translation: AAI43649.1
CCDSⁱ	CCDS14451.1 [Q9UK32-1] CCDS83480.1 [Q9UK32-2]
RefSeqⁱ	NP_001317441.1, NM_001330512.1 [Q9UK32-2] NP_055311.1, NM_014496.4 [Q9UK32-1] XP_011529219.1, XM_011530917.2 [Q9UK32-2]
UniGeneⁱ	Hs.234478

3D structure databases

ProteinModelPortalⁱ	Q9UK32
SMRⁱ	Q9UK32
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118144, 36 interactors
IntActⁱ	Q9UK32, 29 interactors
MINTⁱ	Q9UK32
STRINGⁱ	9606.ENSP00000262752

Chemistry databases

BindingDBⁱ	Q9UK32
ChEMBLⁱ	CHEMBL4924
GuidetoPHARMACOLOGYⁱ	1530

PTM databases

iPTMnetⁱ	Q9UK32
PhosphoSitePlusⁱ	Q9UK32

Polymorphism and mutation databases

BioMutaⁱ	RPS6KA6
DMDMⁱ	11133131

Proteomic databases

EPDⁱ	Q9UK32
PaxDbⁱ	Q9UK32
PeptideAtlasⁱ	Q9UK32
PRIDEⁱ	Q9UK32
ProteomicsDBⁱ	84712

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27330
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262752; ENSP00000262752; ENSG00000072133 [Q9UK32-1] ENST00000620340; ENSP00000483896; ENSG00000072133 [Q9UK32-2]
GeneIDⁱ	27330
KEGGⁱ	hsa:27330
UCSCⁱ	uc004eej.3 human [Q9UK32-1]

Organism-specific databases

CTDⁱ	27330
DisGeNETⁱ	27330
EuPathDBⁱ	HostDB:ENSG00000072133.10
GeneCardsⁱ	RPS6KA6
HGNCⁱ	HGNC:10435 RPS6KA6
HPAⁱ	HPA002852 HPA003904
MIMⁱ	300303 gene
neXtProtⁱ	NX_Q9UK32
OpenTargetsⁱ	ENSG00000072133
PharmGKBⁱ	PA34850
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0598 Eukaryota ENOG410XNPH LUCA
GeneTreeⁱ	ENSGT00920000148962
HOGENOMⁱ	HOG000233033
HOVERGENⁱ	HBG108317
InParanoidⁱ	Q9UK32
KOⁱ	K04373
OMAⁱ	WIACRDQ
OrthoDBⁱ	EOG091G05Z7
PhylomeDBⁱ	Q9UK32
TreeFamⁱ	TF313438

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 2681
Reactomeⁱ	R-HSA-437239 Recycling pathway of L1 R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-444257 RSK activation
SignaLinkⁱ	Q9UK32

Miscellaneous databases

ChiTaRSⁱ	RPS6KA6 human
GenomeRNAiⁱ	27330
Protein Ontology More...PROⁱ	PR:Q9UK32
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000072133 Expressed in 161 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_RPS6KA6
Genevisibleⁱ	Q9UK32 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR011009 Kinase-like_dom_sf IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR016239 Ribosomal_S6_kinase_II IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 2 hits PF00433 Pkinase_C, 1 hit
PIRSFⁱ	PIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTⁱ	View protein in SMART SM00133 S_TK_X, 1 hit SM00220 S_TKc, 2 hits
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 2 hits PS50011 PROTEIN_KINASE_DOM, 2 hits PS00108 PROTEIN_KINASE_ST, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KS6A6_HUMAN
Accessionⁱ	Q9UK32Primary (citable) accession number: Q9UK32 Secondary accession number(s): B2R854 , B7ZL90, Q6FHX2, Q8WX28, Q9H4S6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	September 12, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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UniProtKB - Q9UK32 (KS6A6_HUMAN)

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Ribosomal protein S6 kinase alpha-6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Cytosol

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ