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Protein

F-box only protein 2

Gene

FBXO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei173Important for carbohydrate bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO2
Synonyms:FBX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116661.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13581 FBXO2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607112 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UK22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26232

Open Targets

More...
OpenTargetsi
ENSG00000116661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31895

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51338836

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198751 – 296F-box only protein 2Add BLAST296

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UK22

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UK22

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UK22

PeptideAtlas

More...
PeptideAtlasi
Q9UK22

PRoteomics IDEntifications database

More...
PRIDEi
Q9UK22

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84707

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UK22

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UK22

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116661 Expressed in 187 organ(s), highest expression level in amygdala

CleanEx database of gene expression profiles

More...
CleanExi
HS_FBXO2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UK22 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UK22 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005472

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632088EBI-4287196,EBI-307486

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117623, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UK22, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UK22

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UK22

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 91F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini113 – 296FBAPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni210 – 212Carbohydrate bindingBy similarity3
Regioni278 – 279Carbohydrate bindingBy similarity2

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK6V Eukaryota
ENOG4111MF5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160929

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231084

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003593

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UK22

KEGG Orthology (KO)

More...
KOi
K10099

Identification of Orthologs from Complete Genome Data

More...
OMAi
IHDESVK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G3L

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UK22

TreeFam database of animal gene trees

More...
TreeFami
TF320527

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12125 PTHR12125, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646 F-box, 1 hit
PF04300 FBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01198 FBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UK22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL
60 70 80 90 100
PEPLLLRVLA ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE
110 120 130 140 150
GGVEEERDHW QQFYFLSKRR RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE
160 170 180 190 200
LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ VIDLQAEGYW EELLDTTQPA
210 220 230 240 250
IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA VPQDSDGGGW
260 270 280 290
MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP
Length:296
Mass (Da):33,328
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5226F19E27D884AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNH2R4GNH2_HUMAN
F-box only protein 2
FBXO2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YF37A0A286YF37_HUMAN
F-box only protein 2
FBXO2
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45Missing in AAF01822 (PubMed:10531037).Curated1
Sequence conflicti125R → C in CAG46907 (Ref. 2) Curated1
Sequence conflicti163E → D in CAG46907 (Ref. 2) Curated1
Sequence conflicti275D → G in AAF04515 (PubMed:10531035).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049036118K → T1 PublicationCorresponds to variant dbSNP:rs9614Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF187318 mRNA Translation: AAF01822.1
CR542110 mRNA Translation: CAG46907.1
AK313019 mRNA Translation: BAG35854.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71689.1
BC025233 mRNA Translation: AAH25233.1
BC096747 mRNA Translation: AAH96747.1
AF174594 mRNA Translation: AAF04515.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS130.1

NCBI Reference Sequences

More...
RefSeqi
NP_036300.2, NM_012168.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.132753
Hs.556006

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354287; ENSP00000346240; ENSG00000116661

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26232

UCSC genome browser

More...
UCSCi
uc001asj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187318 mRNA Translation: AAF01822.1
CR542110 mRNA Translation: CAG46907.1
AK313019 mRNA Translation: BAG35854.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71689.1
BC025233 mRNA Translation: AAH25233.1
BC096747 mRNA Translation: AAH96747.1
AF174594 mRNA Translation: AAF04515.1
CCDSiCCDS130.1
RefSeqiNP_036300.2, NM_012168.5
UniGeneiHs.132753
Hs.556006

3D structure databases

ProteinModelPortaliQ9UK22
SMRiQ9UK22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117623, 52 interactors
IntActiQ9UK22, 7 interactors
STRINGi9606.ENSP00000346240

PTM databases

iPTMnetiQ9UK22
PhosphoSitePlusiQ9UK22

Polymorphism and mutation databases

BioMutaiFBXO2
DMDMi51338836

Proteomic databases

EPDiQ9UK22
MaxQBiQ9UK22
PaxDbiQ9UK22
PeptideAtlasiQ9UK22
PRIDEiQ9UK22
ProteomicsDBi84707

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26232
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354287; ENSP00000346240; ENSG00000116661
GeneIDi26232
KEGGihsa:26232
UCSCiuc001asj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26232
DisGeNETi26232
EuPathDBiHostDB:ENSG00000116661.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXO2
HGNCiHGNC:13581 FBXO2
HPAiHPA005472
MIMi607112 gene
neXtProtiNX_Q9UK22
OpenTargetsiENSG00000116661
PharmGKBiPA31895

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00940000160929
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ9UK22
KOiK10099
OMAiIHDESVK
OrthoDBiEOG091G0G3L
PhylomeDBiQ9UK22
TreeFamiTF320527

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBXO2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FBXO2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26232

Protein Ontology

More...
PROi
PR:Q9UK22

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116661 Expressed in 187 organ(s), highest expression level in amygdala
CleanExiHS_FBXO2
ExpressionAtlasiQ9UK22 baseline and differential
GenevisibleiQ9UK22 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12125 PTHR12125, 1 hit
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK22
Secondary accession number(s): B2R7K7
, Q5TGY0, Q6FGJ7, Q8TB29, Q9UKC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 16, 2004
Last modified: December 5, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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