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Protein

F-box only protein 2

Gene

FBXO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei173Important for carbohydrate bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 2
Gene namesi
Name:FBXO2
Synonyms:FBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116661.9
HGNCiHGNC:13581 FBXO2
MIMi607112 gene
neXtProtiNX_Q9UK22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi26232
OpenTargetsiENSG00000116661
PharmGKBiPA31895

Polymorphism and mutation databases

BioMutaiFBXO2
DMDMi51338836

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198751 – 296F-box only protein 2Add BLAST296

Proteomic databases

EPDiQ9UK22
MaxQBiQ9UK22
PaxDbiQ9UK22
PeptideAtlasiQ9UK22
PRIDEiQ9UK22
ProteomicsDBi84707

PTM databases

iPTMnetiQ9UK22
PhosphoSitePlusiQ9UK22

Expressioni

Gene expression databases

BgeeiENSG00000116661 Expressed in 187 organ(s), highest expression level in amygdala
CleanExiHS_FBXO2
ExpressionAtlasiQ9UK22 baseline and differential
GenevisibleiQ9UK22 HS

Organism-specific databases

HPAiHPA005472

Interactioni

Subunit structurei

Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632088EBI-4287196,EBI-307486

Protein-protein interaction databases

BioGridi117623, 52 interactors
IntActiQ9UK22, 7 interactors
STRINGi9606.ENSP00000346240

Structurei

3D structure databases

ProteinModelPortaliQ9UK22
SMRiQ9UK22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 91F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini113 – 296FBAPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 212Carbohydrate bindingBy similarity3
Regioni278 – 279Carbohydrate bindingBy similarity2

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ9UK22
KOiK10099
OMAiIHDESVK
OrthoDBiEOG091G0G3L
PhylomeDBiQ9UK22
TreeFamiTF320527

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12125 PTHR12125, 1 hit
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UK22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL
60 70 80 90 100
PEPLLLRVLA ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE
110 120 130 140 150
GGVEEERDHW QQFYFLSKRR RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE
160 170 180 190 200
LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ VIDLQAEGYW EELLDTTQPA
210 220 230 240 250
IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA VPQDSDGGGW
260 270 280 290
MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP
Length:296
Mass (Da):33,328
Last modified:August 16, 2004 - v2
Checksum:i5226F19E27D884AF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNH2R4GNH2_HUMAN
F-box only protein 2
FBXO2
120Annotation score:
A0A286YF37A0A286YF37_HUMAN
F-box only protein 2
FBXO2
268Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45Missing in AAF01822 (PubMed:10531037).Curated1
Sequence conflicti125R → C in CAG46907 (Ref. 2) Curated1
Sequence conflicti163E → D in CAG46907 (Ref. 2) Curated1
Sequence conflicti275D → G in AAF04515 (PubMed:10531035).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049036118K → T1 PublicationCorresponds to variant dbSNP:rs9614Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187318 mRNA Translation: AAF01822.1
CR542110 mRNA Translation: CAG46907.1
AK313019 mRNA Translation: BAG35854.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71689.1
BC025233 mRNA Translation: AAH25233.1
BC096747 mRNA Translation: AAH96747.1
AF174594 mRNA Translation: AAF04515.1
CCDSiCCDS130.1
RefSeqiNP_036300.2, NM_012168.5
UniGeneiHs.132753
Hs.556006

Genome annotation databases

EnsembliENST00000354287; ENSP00000346240; ENSG00000116661
GeneIDi26232
KEGGihsa:26232
UCSCiuc001asj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187318 mRNA Translation: AAF01822.1
CR542110 mRNA Translation: CAG46907.1
AK313019 mRNA Translation: BAG35854.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71689.1
BC025233 mRNA Translation: AAH25233.1
BC096747 mRNA Translation: AAH96747.1
AF174594 mRNA Translation: AAF04515.1
CCDSiCCDS130.1
RefSeqiNP_036300.2, NM_012168.5
UniGeneiHs.132753
Hs.556006

3D structure databases

ProteinModelPortaliQ9UK22
SMRiQ9UK22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117623, 52 interactors
IntActiQ9UK22, 7 interactors
STRINGi9606.ENSP00000346240

PTM databases

iPTMnetiQ9UK22
PhosphoSitePlusiQ9UK22

Polymorphism and mutation databases

BioMutaiFBXO2
DMDMi51338836

Proteomic databases

EPDiQ9UK22
MaxQBiQ9UK22
PaxDbiQ9UK22
PeptideAtlasiQ9UK22
PRIDEiQ9UK22
ProteomicsDBi84707

Protocols and materials databases

DNASUi26232
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354287; ENSP00000346240; ENSG00000116661
GeneIDi26232
KEGGihsa:26232
UCSCiuc001asj.4 human

Organism-specific databases

CTDi26232
DisGeNETi26232
EuPathDBiHostDB:ENSG00000116661.9
GeneCardsiFBXO2
HGNCiHGNC:13581 FBXO2
HPAiHPA005472
MIMi607112 gene
neXtProtiNX_Q9UK22
OpenTargetsiENSG00000116661
PharmGKBiPA31895
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOGENOMiHOG000231084
HOVERGENiHBG003593
InParanoidiQ9UK22
KOiK10099
OMAiIHDESVK
OrthoDBiEOG091G0G3L
PhylomeDBiQ9UK22
TreeFamiTF320527

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXO2 human
GeneWikiiFBXO2
GenomeRNAii26232
PROiPR:Q9UK22
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116661 Expressed in 187 organ(s), highest expression level in amygdala
CleanExiHS_FBXO2
ExpressionAtlasiQ9UK22 baseline and differential
GenevisibleiQ9UK22 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR039752 F-box_only
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12125 PTHR12125, 1 hit
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UK22
Secondary accession number(s): B2R7K7
, Q5TGY0, Q6FGJ7, Q8TB29, Q9UKC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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