UniProtKB - Q9UK17 (KCND3_HUMAN)
Protein
Potassium voltage-gated channel subfamily D member 3
Gene
KCND3
Organism
Homo sapiens (Human)
Status
Functioni
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 104 | Zinc | 1 | |
Metal bindingi | 131 | Zinc | 1 | |
Metal bindingi | 132 | Zinc | 1 |
GO - Molecular functioni
- A-type (transient outward) potassium channel activity Source: ProtInc
- ion channel binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- cardiac conduction Source: Reactome
- membrane repolarization Source: BHF-UCL
- membrane repolarization during cardiac muscle cell action potential Source: BHF-UCL
- membrane repolarization during ventricular cardiac muscle cell action potential Source: GOC
- potassium ion export across plasma membrane Source: BHF-UCL
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: ProtInc
- protein homooligomerization Source: InterPro
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of ion transmembrane transport Source: UniProtKB-KW
- ventricular cardiac muscle cell membrane repolarization Source: BHF-UCL
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Metal-binding, Potassium, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UK17 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
Protein family/group databases
TCDBi | 1.A.1.2.19, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily D member 3Alternative name(s): Voltage-gated potassium channel subunit Kv4.3 |
Gene namesi | Name:KCND3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171385.9 |
HGNCi | HGNC:6239, KCND3 |
MIMi | 605411, gene |
neXtProti | NX_Q9UK17 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
- sarcolemma By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- dendrite By similarity
Note: Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.By similarity
Plasma Membrane
- integral component of postsynaptic specialization membrane Source: Ensembl
- plasma membrane Source: Reactome
- postsynaptic membrane Source: GO_Central
- sarcolemma Source: UniProtKB-SubCell
- voltage-gated potassium channel complex Source: BHF-UCL
Other locations
- dendrite Source: GO_Central
- dendritic spine Source: GO_Central
- GABA-ergic synapse Source: Ensembl
- integral component of membrane Source: GO_Central
- neuronal cell body Source: GO_Central
- postsynaptic density Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 181 | CytoplasmicSequence analysisAdd BLAST | 181 | |
Transmembranei | 182 – 202 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 243 – 256 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 257 – 277 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 307 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 320 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 321 – 341 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Intramembranei | 360 – 380 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 382 – 402 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 403 – 655 | CytoplasmicSequence analysisAdd BLAST | 253 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Involvement in diseasei
Spinocerebellar ataxia 19 (SCA19)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA19 is a relatively mild, cerebellar ataxic syndrome with cognitive impairment, pyramidal tract involvement, tremor and peripheral neuropathy, and mild atrophy of the cerebellar hemispheres and vermis.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070785 | 227 | Missing in SCA19; results in reduced channel activity consistent with impaired cell surface expression of the mutant protein. 1 Publication | 1 | |
Natural variantiVAR_070786 | 338 | V → E in SCA19. 1 Publication | 1 | |
Natural variantiVAR_070787 | 345 | G → V in SCA19. 1 PublicationCorresponds to variant dbSNP:rs797045634EnsemblClinVar. | 1 | |
Natural variantiVAR_070788 | 352 | T → P in SCA19; loss of channel activity. 1 PublicationCorresponds to variant dbSNP:rs397515476EnsemblClinVar. | 1 | |
Natural variantiVAR_070789 | 373 | M → I in SCA19; unknown pathological significance; causes reduced channel activity. 1 PublicationCorresponds to variant dbSNP:rs397515477EnsemblClinVar. | 1 | |
Natural variantiVAR_070790 | 377 | T → M in SCA19. 1 Publication | 1 | |
Natural variantiVAR_079709 | 384 | G → S in SCA19. 1 Publication | 1 | |
Natural variantiVAR_070791 | 390 | S → N in SCA19; unknown pathological significance; results in impaired cell surface expression. 1 PublicationCorresponds to variant dbSNP:rs397515478EnsemblClinVar. | 1 |
Brugada syndrome 9 (BRGDA9)2 Publications
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067694 | 392 | V → I in BRGDA9; unknown pathological significance; gain of function mutation. 1 PublicationCorresponds to variant dbSNP:rs786205867EnsemblClinVar. | 1 | |
Natural variantiVAR_073831 | 450 | L → F in BRGDA9; unknown pathological significance; gain of function mutation. 1 PublicationCorresponds to variant dbSNP:rs150401343EnsemblClinVar. | 1 | |
Natural variantiVAR_067695 | 530 | S → R in BRGDA9; unknown pathological significance; does not affect the electrophysiological properties of the channel. 1 Publication | 1 | |
Natural variantiVAR_067696 | 600 | G → R in BRGDA9; unknown pathological significance; gain of function mutation. 2 PublicationsCorresponds to variant dbSNP:rs149344567EnsemblClinVar. | 1 |
Keywords - Diseasei
Brugada syndrome, Disease mutation, Neurodegeneration, Spinocerebellar ataxiaOrganism-specific databases
DisGeNETi | 3752 |
GeneReviewsi | KCND3 |
MalaCardsi | KCND3 |
MIMi | 607346, phenotype 616399, phenotype |
OpenTargetsi | ENSG00000171385 |
Orphaneti | 130, Brugada syndrome 98772, Spinocerebellar ataxia type 19/22 |
PharmGKBi | PA210 |
Miscellaneous databases
Pharosi | Q9UK17, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1964 |
DrugBanki | DB06637, Dalfampridine DB00280, Disopyramide DB04855, Dronedarone DB00228, Enflurane DB00458, Imipramine DB11633, Isavuconazole DB01110, Miconazole DB01115, Nifedipine DB01069, Promethazine DB06217, Vernakalant |
DrugCentrali | Q9UK17 |
Polymorphism and mutation databases
BioMutai | KCND3 |
DMDMi | 92090984 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054068 | 1 – 655 | Potassium voltage-gated channel subfamily D member 3Add BLAST | 655 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 153 | PhosphoserineBy similarity | 1 | |
Modified residuei | 459 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 569 | Phosphoserine; by CaMK2DBy similarity | 1 | |
Modified residuei | 585 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Regulated through phosphorylation at Ser-569 by CaMK2D.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q9UK17 |
PaxDbi | Q9UK17 |
PeptideAtlasi | Q9UK17 |
PRIDEi | Q9UK17 |
ProteomicsDBi | 84705 [Q9UK17-1] 84706 [Q9UK17-2] |
PTM databases
iPTMneti | Q9UK17 |
PhosphoSitePlusi | Q9UK17 |
Expressioni
Tissue specificityi
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.3 Publications
Gene expression databases
Bgeei | ENSG00000171385, Expressed in cerebellum and 223 other tissues |
ExpressionAtlasi | Q9UK17, baseline and differential |
Genevisiblei | Q9UK17, HS |
Organism-specific databases
HPAi | ENSG00000171385, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Homotetramer or heterotetramer with KCND1 and/or KCND2. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity).
Interacts with KCNE1, KCNE2, SCN1B and KCNAB1 and DLG1.
By similarity4 PublicationsBinary interactionsi
Q9UK17
With | #Exp. | IntAct |
---|---|---|
KCNIP1 [Q9NZI2] | 3 | EBI-9825212,EBI-2120635 |
GO - Molecular functioni
- ion channel binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109954, 41 interactors |
ComplexPortali | CPX-3256, Kv4.3-KChIP1 channel complex |
CORUMi | Q9UK17 |
IntActi | Q9UK17, 2 interactors |
STRINGi | 9606.ENSP00000319591 |
Chemistry databases
BindingDBi | Q9UK17 |
Miscellaneous databases
RNActi | Q9UK17, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UK17 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UK17 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 20 | Interaction with KCNIP2By similarityAdd BLAST | 19 | |
Regioni | 472 – 487 | Mediates dendritic targetingBy similarityAdd BLAST | 16 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 367 – 372 | Selectivity filterBy similarity | 6 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4390, Eukaryota |
GeneTreei | ENSGT00940000155343 |
HOGENOMi | CLU_011722_9_1_1 |
InParanoidi | Q9UK17 |
OMAi | RPNCKAA |
OrthoDBi | 469107at2759 |
PhylomeDBi | Q9UK17 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004056, K_chnl_volt-dep_Kv4.3 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01518, KV43CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UK17-1) [UniParc]FASTAAdd to basket
Also known as: KCND3L, Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR
60 70 80 90 100
FQTWRTTLER YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT
110 120 130 140 150
GKLHYPRYEC ISAYDDELAF YGILPEIIGD CCYEEYKDRK RENAERLMDD
160 170 180 190 200
NDSENNQESM PSLSFRQTMW RAFENPHTST LALVFYYVTG FFIAVSVITN
210 220 230 240 250
VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE YLLRLFAAPS
260 270 280 290 300
RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF
310 320 330 340 350
SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK
360 370 380 390 400
FTSIPASFWY TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP
410 420 430 440 450
VIVSNFSRIY HQNQRADKRR AQKKARLARI RVAKTGSSNA YLHSKRNGLL
460 470 480 490 500
NEALELTGTP EEEHMGKTTS LIESQHHHLL HCLEKTTGLS YLVDDPLLSV
510 520 530 540 550
RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHP GLTTTCCSRR
560 570 580 590 600
SKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG
610 620 630 640 650
LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSIASNVV
KVSAL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 239 | V → G in AAC05121 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 239 | V → G in AAC05122 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 239 | V → G in AAD38898 (PubMed:10729221).Curated | 1 | |
Sequence conflicti | 375 | P → L in AAC05121 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 375 | P → L in AAC05122 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 375 | P → L in AAD38898 (PubMed:10729221).Curated | 1 | |
Sequence conflicti | 408 | R → G in AAF01044 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 408 | R → G in AAF01045 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 452 | E → G in AAF01044 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 452 | E → G in AAF01045 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 531 | T → Q in AAF01044 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 531 | T → Q in AAF01045 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 564 | A → D in AAF01044 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 564 | A → D in AAF01045 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 646 | A → T in AAC05121 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 646 | A → T in AAC05122 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 646 | A → T in AAF01045 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 646 | A → T in AAD38898 (PubMed:10729221).Curated | 1 | |
Sequence conflicti | 654 | A → V in AAC05121 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 654 | A → V in AAC05122 (PubMed:9843794).Curated | 1 | |
Sequence conflicti | 654 | A → V in AAF01044 (PubMed:10200233).Curated | 1 | |
Sequence conflicti | 654 | A → V in AAD38898 (PubMed:10729221).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035775 | 94 | V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1349469134Ensembl. | 1 | |
Natural variantiVAR_070785 | 227 | Missing in SCA19; results in reduced channel activity consistent with impaired cell surface expression of the mutant protein. 1 Publication | 1 | |
Natural variantiVAR_070786 | 338 | V → E in SCA19. 1 Publication | 1 | |
Natural variantiVAR_070787 | 345 | G → V in SCA19. 1 PublicationCorresponds to variant dbSNP:rs797045634EnsemblClinVar. | 1 | |
Natural variantiVAR_070788 | 352 | T → P in SCA19; loss of channel activity. 1 PublicationCorresponds to variant dbSNP:rs397515476EnsemblClinVar. | 1 | |
Natural variantiVAR_070789 | 373 | M → I in SCA19; unknown pathological significance; causes reduced channel activity. 1 PublicationCorresponds to variant dbSNP:rs397515477EnsemblClinVar. | 1 | |
Natural variantiVAR_070790 | 377 | T → M in SCA19. 1 Publication | 1 | |
Natural variantiVAR_079709 | 384 | G → S in SCA19. 1 Publication | 1 | |
Natural variantiVAR_070791 | 390 | S → N in SCA19; unknown pathological significance; results in impaired cell surface expression. 1 PublicationCorresponds to variant dbSNP:rs397515478EnsemblClinVar. | 1 | |
Natural variantiVAR_067694 | 392 | V → I in BRGDA9; unknown pathological significance; gain of function mutation. 1 PublicationCorresponds to variant dbSNP:rs786205867EnsemblClinVar. | 1 | |
Natural variantiVAR_073831 | 450 | L → F in BRGDA9; unknown pathological significance; gain of function mutation. 1 PublicationCorresponds to variant dbSNP:rs150401343EnsemblClinVar. | 1 | |
Natural variantiVAR_067695 | 530 | S → R in BRGDA9; unknown pathological significance; does not affect the electrophysiological properties of the channel. 1 Publication | 1 | |
Natural variantiVAR_067696 | 600 | G → R in BRGDA9; unknown pathological significance; gain of function mutation. 2 PublicationsCorresponds to variant dbSNP:rs149344567EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008826 | 488 – 506 | Missing in isoform 2. 4 PublicationsAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF048712 mRNA Translation: AAC05121.1 AF048713 mRNA Translation: AAC05122.1 AF187963 mRNA Translation: AAF01044.1 AF187964 mRNA Translation: AAF01045.1 AF205856 mRNA Translation: AAF20924.1 AF205857 mRNA Translation: AAF20925.1 AF120491 mRNA Translation: AAD38898.1 AF166011, AF166009, AF166010 Genomic DNA Translation: AAF68177.1 AF166011, AF166009, AF166010 Genomic DNA Translation: AAF68178.1 AL512665 Genomic DNA No translation available. AL450997 Genomic DNA No translation available. AL049557 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56511.1 BC113475 mRNA Translation: AAI13476.1 BC113477 mRNA Translation: AAI13478.1 |
CCDSi | CCDS843.1 [Q9UK17-1] CCDS844.1 [Q9UK17-2] |
RefSeqi | NP_004971.2, NM_004980.4 [Q9UK17-1] NP_751948.1, NM_172198.2 [Q9UK17-2] XP_005270908.1, XM_005270851.4 XP_006710692.1, XM_006710629.3 [Q9UK17-1] XP_006710693.1, XM_006710630.3 XP_016856733.1, XM_017001244.1 [Q9UK17-1] |
Genome annotation databases
Ensembli | ENST00000302127; ENSP00000306923; ENSG00000171385 [Q9UK17-2] ENST00000315987; ENSP00000319591; ENSG00000171385 [Q9UK17-1] ENST00000369697; ENSP00000358711; ENSG00000171385 [Q9UK17-2] |
GeneIDi | 3752 |
KEGGi | hsa:3752 |
UCSCi | uc001ebu.2, human [Q9UK17-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Potassium voltage-gated channel, Shal-related subfamily, member 3 (KCND3) Leiden Open Variation Database (LOVD) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF048712 mRNA Translation: AAC05121.1 AF048713 mRNA Translation: AAC05122.1 AF187963 mRNA Translation: AAF01044.1 AF187964 mRNA Translation: AAF01045.1 AF205856 mRNA Translation: AAF20924.1 AF205857 mRNA Translation: AAF20925.1 AF120491 mRNA Translation: AAD38898.1 AF166011, AF166009, AF166010 Genomic DNA Translation: AAF68177.1 AF166011, AF166009, AF166010 Genomic DNA Translation: AAF68178.1 AL512665 Genomic DNA No translation available. AL450997 Genomic DNA No translation available. AL049557 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56511.1 BC113475 mRNA Translation: AAI13476.1 BC113477 mRNA Translation: AAI13478.1 |
CCDSi | CCDS843.1 [Q9UK17-1] CCDS844.1 [Q9UK17-2] |
RefSeqi | NP_004971.2, NM_004980.4 [Q9UK17-1] NP_751948.1, NM_172198.2 [Q9UK17-2] XP_005270908.1, XM_005270851.4 XP_006710692.1, XM_006710629.3 [Q9UK17-1] XP_006710693.1, XM_006710630.3 XP_016856733.1, XM_017001244.1 [Q9UK17-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S1G | X-ray | 2.60 | A/B | 29-143 | [»] | |
2NZ0 | X-ray | 3.20 | B/D | 6-145 | [»] | |
SMRi | Q9UK17 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109954, 41 interactors |
ComplexPortali | CPX-3256, Kv4.3-KChIP1 channel complex |
CORUMi | Q9UK17 |
IntActi | Q9UK17, 2 interactors |
STRINGi | 9606.ENSP00000319591 |
Chemistry databases
BindingDBi | Q9UK17 |
ChEMBLi | CHEMBL1964 |
DrugBanki | DB06637, Dalfampridine DB00280, Disopyramide DB04855, Dronedarone DB00228, Enflurane DB00458, Imipramine DB11633, Isavuconazole DB01110, Miconazole DB01115, Nifedipine DB01069, Promethazine DB06217, Vernakalant |
DrugCentrali | Q9UK17 |
Protein family/group databases
TCDBi | 1.A.1.2.19, the voltage-gated ion channel (vic) superfamily |
PTM databases
iPTMneti | Q9UK17 |
PhosphoSitePlusi | Q9UK17 |
Polymorphism and mutation databases
BioMutai | KCND3 |
DMDMi | 92090984 |
Proteomic databases
MassIVEi | Q9UK17 |
PaxDbi | Q9UK17 |
PeptideAtlasi | Q9UK17 |
PRIDEi | Q9UK17 |
ProteomicsDBi | 84705 [Q9UK17-1] 84706 [Q9UK17-2] |
Protocols and materials databases
ABCDi | Q9UK17, 2 sequenced antibodies |
Antibodypediai | 20128, 211 antibodies |
DNASUi | 3752 |
Genome annotation databases
Ensembli | ENST00000302127; ENSP00000306923; ENSG00000171385 [Q9UK17-2] ENST00000315987; ENSP00000319591; ENSG00000171385 [Q9UK17-1] ENST00000369697; ENSP00000358711; ENSG00000171385 [Q9UK17-2] |
GeneIDi | 3752 |
KEGGi | hsa:3752 |
UCSCi | uc001ebu.2, human [Q9UK17-1] |
Organism-specific databases
CTDi | 3752 |
DisGeNETi | 3752 |
EuPathDBi | HostDB:ENSG00000171385.9 |
GeneCardsi | KCND3 |
GeneReviewsi | KCND3 |
HGNCi | HGNC:6239, KCND3 |
HPAi | ENSG00000171385, Tissue enhanced (brain) |
MalaCardsi | KCND3 |
MIMi | 605411, gene 607346, phenotype 616399, phenotype |
neXtProti | NX_Q9UK17 |
OpenTargetsi | ENSG00000171385 |
Orphaneti | 130, Brugada syndrome 98772, Spinocerebellar ataxia type 19/22 |
PharmGKBi | PA210 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4390, Eukaryota |
GeneTreei | ENSGT00940000155343 |
HOGENOMi | CLU_011722_9_1_1 |
InParanoidi | Q9UK17 |
OMAi | RPNCKAA |
OrthoDBi | 469107at2759 |
PhylomeDBi | Q9UK17 |
TreeFami | TF313103 |
Enzyme and pathway databases
PathwayCommonsi | Q9UK17 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
Miscellaneous databases
BioGRID-ORCSi | 3752, 17 hits in 844 CRISPR screens |
ChiTaRSi | KCND3, human |
EvolutionaryTracei | Q9UK17 |
GeneWikii | KCND3 |
GenomeRNAii | 3752 |
Pharosi | Q9UK17, Tclin |
PROi | PR:Q9UK17 |
RNActi | Q9UK17, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171385, Expressed in cerebellum and 223 other tissues |
ExpressionAtlasi | Q9UK17, baseline and differential |
Genevisiblei | Q9UK17, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004056, K_chnl_volt-dep_Kv4.3 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01518, KV43CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCND3_HUMAN | |
Accessioni | Q9UK17Primary (citable) accession number: Q9UK17 Secondary accession number(s): O60576 Q9UK16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations