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Protein

Zinc finger protein 223

Gene

ZNF223

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 223
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF223
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000178386.12

Human Gene Nomenclature Database

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HGNCi
HGNC:13016 ZNF223

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UK11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7766

Open Targets

More...
OpenTargetsi
ENSG00000178386

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37595

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF223

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474641 – 482Zinc finger protein 223Add BLAST482

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UK11

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UK11

PeptideAtlas

More...
PeptideAtlasi
Q9UK11

PRoteomics IDEntifications database

More...
PRIDEi
Q9UK11

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84702

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UK11

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UK11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178386 Expressed in 127 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UK11 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UK11 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067823

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113549, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UK11, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000467018

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UK11

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UK11

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UK11

KEGG Orthology (KO)

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KOi
K09228

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UK11

TreeFam database of animal gene trees

More...
TreeFami
TF341885

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UK11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMSKEAVTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
PFHRDTFHFL REEKFWMMDI ATQREGNSGG KIQPEMKTFP EAGPHEGWSC
110 120 130 140 150
QQIWEEIASD LTRPQDSTIK SSQFFEQGDA HSQVEEGLSI MHTGQKPSNC
160 170 180 190 200
GKCKQSFSDM SIFDLPQQIR SAEKSHSCDE CGKSFCYISA LHIHQRVHLG
210 220 230 240 250
EKLFKCDVCG KEFSQSLHLQ THQRVHTGEK PFKCEQCGRG FRCRSALTVH
260 270 280 290 300
CKLHMGEKHY NCEACGRAFI HDFQLQKHQR IHTGEKPFKC EICSVSFRLR
310 320 330 340 350
SSLNRHCVVH TGKKPNSTGE YGKGFIRRLD LCKHQTIHTG EKPYNCKECG
360 370 380 390 400
KSFRRSSYLL IHQRVHTGEK PYKCDKCGKS YITKSGLDLH HRAHTGERPY
410 420 430 440 450
NCDDCGKSFR QASSILNHKR LHCRKKPFKC EDCGKKLVYR SYRKDQQKNH
460 470 480
SGENPSKCED CGKRYKRRLN LDIILSLFLN DT
Length:482
Mass (Da):55,763
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2543E98D86F55E51
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPW2K7EPW2_HUMAN
Zinc finger protein 223
ZNF223
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER65K7ER65_HUMAN
Zinc finger protein 223
ZNF223
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ32K7EQ32_HUMAN
Zinc finger protein 223
ZNF223
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB03531 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25L → M in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti153C → S in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti294 – 295SV → GK in AAF04105 (PubMed:12743021).Curated2
Sequence conflicti298R → C in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti308V → M in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti312 – 323GKKPN…GEYGK → AEKLYKSEKYGR in AAF04105 (PubMed:12743021).CuratedAdd BLAST12
Sequence conflicti327R → D in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti332C → H in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti336T → M in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti339 – 341TGE → MGQ in AAF04105 (PubMed:12743021).Curated3
Sequence conflicti354 – 355RR → KW in AAF04105 (PubMed:12743021).Curated2
Sequence conflicti361I → V in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti375 – 376DK → EE in AAF04105 (PubMed:12743021).Curated2
Sequence conflicti380S → G in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti383T → S in AAF04105 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06042460L → I. Corresponds to variant dbSNP:rs4130101Ensembl.1
Natural variantiVAR_060425138L → I3 PublicationsCorresponds to variant dbSNP:rs6509138Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF187989 mRNA Translation: AAF04105.1
AK292327 mRNA Translation: BAF85016.1
AC092072 Genomic DNA No translation available.
BC022466 mRNA Translation: AAH22466.1
U46189 Genomic DNA Translation: AAB03531.1 Sequence problems.
AC084219 Genomic DNA Translation: AAG23844.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12635.1

NCBI Reference Sequences

More...
RefSeqi
NP_037493.3, NM_013361.5
XP_016882747.1, XM_017027258.1
XP_016882748.1, XM_017027259.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.720813

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000434772; ENSP00000401947; ENSG00000178386

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7766

UCSC genome browser

More...
UCSCi
uc002oyf.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187989 mRNA Translation: AAF04105.1
AK292327 mRNA Translation: BAF85016.1
AC092072 Genomic DNA No translation available.
BC022466 mRNA Translation: AAH22466.1
U46189 Genomic DNA Translation: AAB03531.1 Sequence problems.
AC084219 Genomic DNA Translation: AAG23844.1
CCDSiCCDS12635.1
RefSeqiNP_037493.3, NM_013361.5
XP_016882747.1, XM_017027258.1
XP_016882748.1, XM_017027259.1
UniGeneiHs.720813

3D structure databases

ProteinModelPortaliQ9UK11
SMRiQ9UK11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113549, 25 interactors
IntActiQ9UK11, 6 interactors
STRINGi9606.ENSP00000467018

PTM databases

iPTMnetiQ9UK11
PhosphoSitePlusiQ9UK11

Polymorphism and mutation databases

BioMutaiZNF223
DMDMi311033504

Proteomic databases

EPDiQ9UK11
PaxDbiQ9UK11
PeptideAtlasiQ9UK11
PRIDEiQ9UK11
ProteomicsDBi84702

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434772; ENSP00000401947; ENSG00000178386
GeneIDi7766
KEGGihsa:7766
UCSCiuc002oyf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7766
DisGeNETi7766
EuPathDBiHostDB:ENSG00000178386.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF223
HGNCiHGNC:13016 ZNF223
HPAiHPA067823
neXtProtiNX_Q9UK11
OpenTargetsiENSG00000178386
PharmGKBiPA37595

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164111
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UK11
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ9UK11
TreeFamiTF341885

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF223 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7766

Protein Ontology

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PROi
PR:Q9UK11

Gene expression databases

BgeeiENSG00000178386 Expressed in 127 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9UK11 baseline and differential
GenevisibleiQ9UK11 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN223_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK11
Secondary accession number(s): Q15736, Q8TBJ3, Q9HCA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: December 5, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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