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Entry version 174 (02 Dec 2020)
Sequence version 2 (25 Jul 2006)
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Protein

Zinc finger protein 225

Gene

ZNF225

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UK10

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 225
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF225
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000256294.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13018, ZNF225

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UK10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000256294

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37597

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UK10, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF225

Domain mapping of disease mutations (DMDM)

More...
DMDMi
110825755

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474661 – 706Zinc finger protein 225Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UK10

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UK10

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UK10

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UK10

PeptideAtlas

More...
PeptideAtlasi
Q9UK10

PRoteomics IDEntifications database

More...
PRIDEi
Q9UK10

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84701

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UK10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UK10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000256294, Expressed in calcaneal tendon and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UK10, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UK10, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000256294, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113551, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UK10, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262894

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UK10, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UK10

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160225

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UK10

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRKCKKF

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UK10

TreeFam database of animal gene trees

More...
TreeFami
TF341885

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 17 hits
PS50157, ZINC_FINGER_C2H2_2, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UK10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ
60 70 80 90 100
SLHRDTFHFL KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS
110 120 130 140 150
HQTWEQISSD LTRFQDSMVN SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG
160 170 180 190 200
RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE CGKSFCYSSA LRIHQRVHMG
210 220 230 240 250
EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG FSRRSGLYVH
260 270 280 290 300
RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR
310 320 330 340 350
ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG
360 370 380 390 400
KRFIYRQDLY KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF
410 420 430 440 450
KCEECGKGFY TNSQRYSHQR AHSGEKPYRC EECGKGYKRR LDLDFHQRVH
460 470 480 490 500
RGEKPYNCKE CGKSFGWASC LLNHQRIHSG EKPFKCEECG KRFTQNSQLY
510 520 530 540 550
THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY KCEECGKGFN
560 570 580 590 600
SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE
610 620 630 640 650
CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK
660 670 680 690 700
LLQCEDCGKS IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS

LFLNDT
Length:706
Mass (Da):82,471
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C357A3AB1E32FB2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENC8K7ENC8_HUMAN
Zinc finger protein 225
ZNF225
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENA2K7ENA2_HUMAN
Zinc finger protein 225
ZNF225
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERU6K7ERU6_HUMAN
Zinc finger protein 225
ZNF225
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144 – 147RQKP → KTET in AAF04107 (PubMed:12743021).Curated4
Sequence conflicti219L → Q in AAF04107 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03356050Q → R. Corresponds to variant dbSNP:rs34863330Ensembl.1
Natural variantiVAR_033561679T → S. Corresponds to variant dbSNP:rs16978738Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF187991 mRNA Translation: AAF04107.1
AK223477 mRNA Translation: BAD97197.1
AK292437 mRNA Translation: BAF85126.1
AC021092 Genomic DNA Translation: AAF24967.1
AC074331 Genomic DNA Translation: AAF88105.1
CH471126 Genomic DNA Translation: EAW57255.1
BC108912 mRNA Translation: AAI08913.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46100.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308614.1, NM_001321685.1
NP_037494.2, NM_013362.3
XP_011525587.1, XM_011527285.2
XP_011525588.1, XM_011527286.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262894; ENSP00000262894; ENSG00000256294
ENST00000590612; ENSP00000468686; ENSG00000256294

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7768

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7768

UCSC genome browser

More...
UCSCi
uc002oyj.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187991 mRNA Translation: AAF04107.1
AK223477 mRNA Translation: BAD97197.1
AK292437 mRNA Translation: BAF85126.1
AC021092 Genomic DNA Translation: AAF24967.1
AC074331 Genomic DNA Translation: AAF88105.1
CH471126 Genomic DNA Translation: EAW57255.1
BC108912 mRNA Translation: AAI08913.1
CCDSiCCDS46100.1
RefSeqiNP_001308614.1, NM_001321685.1
NP_037494.2, NM_013362.3
XP_011525587.1, XM_011527285.2
XP_011525588.1, XM_011527286.2

3D structure databases

SMRiQ9UK10
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113551, 3 interactors
IntActiQ9UK10, 1 interactor
STRINGi9606.ENSP00000262894

PTM databases

iPTMnetiQ9UK10
PhosphoSitePlusiQ9UK10

Polymorphism and mutation databases

BioMutaiZNF225
DMDMi110825755

Proteomic databases

EPDiQ9UK10
jPOSTiQ9UK10
MassIVEiQ9UK10
PaxDbiQ9UK10
PeptideAtlasiQ9UK10
PRIDEiQ9UK10
ProteomicsDBi84701

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49032, 131 antibodies

Genome annotation databases

EnsembliENST00000262894; ENSP00000262894; ENSG00000256294
ENST00000590612; ENSP00000468686; ENSG00000256294
GeneIDi7768
KEGGihsa:7768
UCSCiuc002oyj.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7768
EuPathDBiHostDB:ENSG00000256294.7

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF225
HGNCiHGNC:13018, ZNF225
HPAiENSG00000256294, Low tissue specificity
neXtProtiNX_Q9UK10
OpenTargetsiENSG00000256294
PharmGKBiPA37597

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000160225
HOGENOMiCLU_002678_44_5_1
InParanoidiQ9UK10
OMAiGRKCKKF
OrthoDBi1318335at2759
PhylomeDBiQ9UK10
TreeFamiTF341885

Enzyme and pathway databases

PathwayCommonsiQ9UK10
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7768, 7 hits in 864 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF225

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7768
PharosiQ9UK10, Tdark

Protein Ontology

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PROi
PR:Q9UK10
RNActiQ9UK10, protein

Gene expression databases

BgeeiENSG00000256294, Expressed in calcaneal tendon and 168 other tissues
ExpressionAtlasiQ9UK10, baseline and differential
GenevisibleiQ9UK10, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 17 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 17 hits
PS50157, ZINC_FINGER_C2H2_2, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN225_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UK10
Secondary accession number(s): A8K8S2
, Q53F12, Q9NS46, Q9UID8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 25, 2006
Last modified: December 2, 2020
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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