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Protein

Zinc finger protein 225

Gene

ZNF225

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 225
Gene namesi
Name:ZNF225
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000256294.7
HGNCiHGNC:13018 ZNF225
neXtProtiNX_Q9UK10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256294
PharmGKBiPA37597

Polymorphism and mutation databases

BioMutaiZNF225
DMDMi110825755

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474661 – 706Zinc finger protein 225Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UK10
PaxDbiQ9UK10
PeptideAtlasiQ9UK10
PRIDEiQ9UK10
ProteomicsDBi84701

PTM databases

iPTMnetiQ9UK10
PhosphoSitePlusiQ9UK10

Expressioni

Gene expression databases

BgeeiENSG00000256294 Expressed in 150 organ(s), highest expression level in metanephros
CleanExiHS_ZNF225
ExpressionAtlasiQ9UK10 baseline and differential
GenevisibleiQ9UK10 HS

Organism-specific databases

HPAiHPA073778

Interactioni

Protein-protein interaction databases

BioGridi113551, 1 interactor
STRINGi9606.ENSP00000262894

Structurei

3D structure databases

ProteinModelPortaliQ9UK10
SMRiQ9UK10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150984
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UK10
KOiK09228
OMAiSHQNCEQ
OrthoDBiEOG091G02KC
PhylomeDBiQ9UK10
TreeFamiTF341885

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UK10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ
60 70 80 90 100
SLHRDTFHFL KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS
110 120 130 140 150
HQTWEQISSD LTRFQDSMVN SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG
160 170 180 190 200
RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE CGKSFCYSSA LRIHQRVHMG
210 220 230 240 250
EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG FSRRSGLYVH
260 270 280 290 300
RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR
310 320 330 340 350
ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG
360 370 380 390 400
KRFIYRQDLY KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF
410 420 430 440 450
KCEECGKGFY TNSQRYSHQR AHSGEKPYRC EECGKGYKRR LDLDFHQRVH
460 470 480 490 500
RGEKPYNCKE CGKSFGWASC LLNHQRIHSG EKPFKCEECG KRFTQNSQLY
510 520 530 540 550
THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY KCEECGKGFN
560 570 580 590 600
SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE
610 620 630 640 650
CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK
660 670 680 690 700
LLQCEDCGKS IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS

LFLNDT
Length:706
Mass (Da):82,471
Last modified:July 25, 2006 - v2
Checksum:i4C357A3AB1E32FB2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENA2K7ENA2_HUMAN
Zinc finger protein 225
ZNF225
122Annotation score:
K7ERU6K7ERU6_HUMAN
Zinc finger protein 225
ZNF225
51Annotation score:
K7ENC8K7ENC8_HUMAN
Zinc finger protein 225
ZNF225
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 147RQKP → KTET in AAF04107 (PubMed:12743021).Curated4
Sequence conflicti219L → Q in AAF04107 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03356050Q → R. Corresponds to variant dbSNP:rs34863330Ensembl.1
Natural variantiVAR_033561679T → S. Corresponds to variant dbSNP:rs16978738Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187991 mRNA Translation: AAF04107.1
AK223477 mRNA Translation: BAD97197.1
AK292437 mRNA Translation: BAF85126.1
AC021092 Genomic DNA Translation: AAF24967.1
AC074331 Genomic DNA Translation: AAF88105.1
CH471126 Genomic DNA Translation: EAW57255.1
BC108912 mRNA Translation: AAI08913.1
CCDSiCCDS46100.1
RefSeqiNP_001308614.1, NM_001321685.1
NP_037494.2, NM_013362.3
XP_011525587.1, XM_011527285.2
XP_011525588.1, XM_011527286.2
UniGeneiHs.279567
Hs.709835

Genome annotation databases

EnsembliENST00000262894; ENSP00000262894; ENSG00000256294
ENST00000590612; ENSP00000468686; ENSG00000256294
GeneIDi7768
KEGGihsa:7768
UCSCiuc002oyj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187991 mRNA Translation: AAF04107.1
AK223477 mRNA Translation: BAD97197.1
AK292437 mRNA Translation: BAF85126.1
AC021092 Genomic DNA Translation: AAF24967.1
AC074331 Genomic DNA Translation: AAF88105.1
CH471126 Genomic DNA Translation: EAW57255.1
BC108912 mRNA Translation: AAI08913.1
CCDSiCCDS46100.1
RefSeqiNP_001308614.1, NM_001321685.1
NP_037494.2, NM_013362.3
XP_011525587.1, XM_011527285.2
XP_011525588.1, XM_011527286.2
UniGeneiHs.279567
Hs.709835

3D structure databases

ProteinModelPortaliQ9UK10
SMRiQ9UK10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113551, 1 interactor
STRINGi9606.ENSP00000262894

PTM databases

iPTMnetiQ9UK10
PhosphoSitePlusiQ9UK10

Polymorphism and mutation databases

BioMutaiZNF225
DMDMi110825755

Proteomic databases

EPDiQ9UK10
PaxDbiQ9UK10
PeptideAtlasiQ9UK10
PRIDEiQ9UK10
ProteomicsDBi84701

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262894; ENSP00000262894; ENSG00000256294
ENST00000590612; ENSP00000468686; ENSG00000256294
GeneIDi7768
KEGGihsa:7768
UCSCiuc002oyj.2 human

Organism-specific databases

CTDi7768
EuPathDBiHostDB:ENSG00000256294.7
GeneCardsiZNF225
HGNCiHGNC:13018 ZNF225
HPAiHPA073778
neXtProtiNX_Q9UK10
OpenTargetsiENSG00000256294
PharmGKBiPA37597
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150984
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UK10
KOiK09228
OMAiSHQNCEQ
OrthoDBiEOG091G02KC
PhylomeDBiQ9UK10
TreeFamiTF341885

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GeneWikiiZNF225
GenomeRNAii7768
PROiPR:Q9UK10

Gene expression databases

BgeeiENSG00000256294 Expressed in 150 organ(s), highest expression level in metanephros
CleanExiHS_ZNF225
ExpressionAtlasiQ9UK10 baseline and differential
GenevisibleiQ9UK10 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN225_HUMAN
AccessioniPrimary (citable) accession number: Q9UK10
Secondary accession number(s): A8K8S2
, Q53F12, Q9NS46, Q9UID8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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