Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

GNG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene namesi
Name:GNG8
Synonyms:GNG9, GNGT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167414.4
HGNCiHGNC:19664 GNG8
neXtProtiNX_Q9UK08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi94235
OpenTargetsiENSG00000167414
PharmGKBiPA134921496

Polymorphism and mutation databases

BioMutaiGNG8
DMDMi12232629

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126491 – 67Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8Add BLAST67
PropeptideiPRO_000001265068 – 70Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Cysteine methyl esterBy similarity1
Lipidationi67S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9UK08
PeptideAtlasiQ9UK08
PRIDEiQ9UK08
ProteomicsDBi84700
TopDownProteomicsiQ9UK08

Expressioni

Gene expression databases

BgeeiENSG00000167414 Expressed in 96 organ(s), highest expression level in hypothalamus
CleanExiHS_GNG8
GenevisibleiQ9UK08 HS

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCR5P323023EBI-9074207,EBI-2835269

Protein-protein interaction databases

BioGridi125148, 5 interactors
IntActiQ9UK08, 1 interactor
STRINGi9606.ENSP00000300873

Structurei

3D structure databases

ProteinModelPortaliQ9UK08
SMRiQ9UK08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiQ9UK08
KOiK04544
OMAiNIERMMV
OrthoDBiEOG091G17J0
PhylomeDBiQ9UK08
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UK08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV
60 70
TPVPAAENPF RDKRLFCVLL
Length:70
Mass (Da):7,841
Last modified:May 1, 2000 - v1
Checksum:i153205CC7F38EE40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188179 Genomic DNA Translation: AAF04569.1
AF493875 mRNA Translation: AAM12589.1
BC095514 mRNA Translation: AAH95514.1
CCDSiCCDS12687.1
RefSeqiNP_150283.1, NM_033258.1
XP_016882992.1, XM_017027503.1
XP_016882993.1, XM_017027504.1
XP_016882994.1, XM_017027505.1
UniGeneiHs.283961
Hs.296529

Genome annotation databases

EnsembliENST00000300873; ENSP00000300873; ENSG00000167414
GeneIDi94235
KEGGihsa:94235
UCSCiuc010xyd.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188179 Genomic DNA Translation: AAF04569.1
AF493875 mRNA Translation: AAM12589.1
BC095514 mRNA Translation: AAH95514.1
CCDSiCCDS12687.1
RefSeqiNP_150283.1, NM_033258.1
XP_016882992.1, XM_017027503.1
XP_016882993.1, XM_017027504.1
XP_016882994.1, XM_017027505.1
UniGeneiHs.283961
Hs.296529

3D structure databases

ProteinModelPortaliQ9UK08
SMRiQ9UK08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125148, 5 interactors
IntActiQ9UK08, 1 interactor
STRINGi9606.ENSP00000300873

Polymorphism and mutation databases

BioMutaiGNG8
DMDMi12232629

Proteomic databases

PaxDbiQ9UK08
PeptideAtlasiQ9UK08
PRIDEiQ9UK08
ProteomicsDBi84700
TopDownProteomicsiQ9UK08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300873; ENSP00000300873; ENSG00000167414
GeneIDi94235
KEGGihsa:94235
UCSCiuc010xyd.3 human

Organism-specific databases

CTDi94235
DisGeNETi94235
EuPathDBiHostDB:ENSG00000167414.4
GeneCardsiGNG8
HGNCiHGNC:19664 GNG8
neXtProtiNX_Q9UK08
OpenTargetsiENSG00000167414
PharmGKBiPA134921496
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiQ9UK08
KOiK04544
OMAiNIERMMV
OrthoDBiEOG091G17J0
PhylomeDBiQ9UK08
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

GenomeRNAii94235
PROiPR:Q9UK08

Gene expression databases

BgeeiENSG00000167414 Expressed in 96 organ(s), highest expression level in hypothalamus
CleanExiHS_GNG8
GenevisibleiQ9UK08 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG8_HUMAN
AccessioniPrimary (citable) accession number: Q9UK08
Secondary accession number(s): Q4VBM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again