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Protein

Uncharacterized protein C3orf18

Gene

C3orf18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C3orf18
Alternative name(s):
Protein G20
Gene namesi
Name:C3orf18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000088543.14
HGNCiHGNC:24837 C3orf18
neXtProtiNX_Q9UK00

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51161
OpenTargetsiENSG00000088543
PharmGKBiPA134941482

Polymorphism and mutation databases

BioMutaiC3orf18
DMDMi317373334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002288411 – 162Uncharacterized protein C3orf18Add BLAST162

Proteomic databases

PaxDbiQ9UK00
PeptideAtlasiQ9UK00
PRIDEiQ9UK00
ProteomicsDBi84698

PTM databases

iPTMnetiQ9UK00
PhosphoSitePlusiQ9UK00

Expressioni

Gene expression databases

BgeeiENSG00000088543 Expressed in 210 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_C3orf18
ExpressionAtlasiQ9UK00 baseline and differential
GenevisibleiQ9UK00 HS

Organism-specific databases

HPAiHPA012105

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349732

Structurei

3D structure databases

ProteinModelPortaliQ9UK00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1WR Eukaryota
ENOG410Y7Q7 LUCA
GeneTreeiENSGT00410000025882
HOGENOMiHOG000294070
HOVERGENiHBG081003
InParanoidiQ9UK00
OMAiNSTKIPD
OrthoDBiEOG091G1C3H
PhylomeDBiQ9UK00
TreeFamiTF332764

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9UK00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP
60 70 80 90 100
DAAGGTAGVG TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN
110 120 130 140 150
FDPTEEQDEL EQELLEHGRD AASVQAATSV QAMQGKTTLP SQGPLQRPSR
160
LVFTDVANAI HA
Length:162
Mass (Da):17,468
Last modified:January 11, 2011 - v2
Checksum:iD5B5DEFFE0E06D6E
GO
Isoform 2 (identifier: Q9UK00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-78: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):15,497
Checksum:iF058A1B7F0FEF0A8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYC4C9IYC4_HUMAN
Uncharacterized protein C3orf18
C3orf18
110Annotation score:
F8WCC4F8WCC4_HUMAN
Uncharacterized protein C3orf18
C3orf18
104Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0257208A → D. Corresponds to variant dbSNP:rs386598Ensembl.1
Natural variantiVAR_025721162A → V4 PublicationsCorresponds to variant dbSNP:rs1034405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04488059 – 78Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188706 mRNA Translation: AAF01050.1
AK308074 mRNA No translation available.
AL833938 mRNA Translation: CAD38793.1
AC096920 Genomic DNA No translation available.
BC034766 mRNA Translation: AAH34766.1
CCDSiCCDS2829.1 [Q9UK00-1]
CCDS54589.1 [Q9UK00-2]
RefSeqiNP_001165211.1, NM_001171740.2 [Q9UK00-1]
NP_001165212.1, NM_001171741.2 [Q9UK00-1]
NP_001165214.2, NM_001171743.2 [Q9UK00-2]
NP_057294.2, NM_016210.4 [Q9UK00-1]
XP_011532092.1, XM_011533790.1 [Q9UK00-2]
XP_016862036.1, XM_017006547.1 [Q9UK00-2]
UniGeneiHs.517860

Genome annotation databases

EnsembliENST00000357203; ENSP00000349732; ENSG00000088543 [Q9UK00-1]
ENST00000426034; ENSP00000387606; ENSG00000088543 [Q9UK00-1]
ENST00000441239; ENSP00000414124; ENSG00000088543 [Q9UK00-2]
ENST00000449241; ENSP00000404913; ENSG00000088543 [Q9UK00-1]
GeneIDi51161
KEGGihsa:51161
UCSCiuc003dar.4 human [Q9UK00-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188706 mRNA Translation: AAF01050.1
AK308074 mRNA No translation available.
AL833938 mRNA Translation: CAD38793.1
AC096920 Genomic DNA No translation available.
BC034766 mRNA Translation: AAH34766.1
CCDSiCCDS2829.1 [Q9UK00-1]
CCDS54589.1 [Q9UK00-2]
RefSeqiNP_001165211.1, NM_001171740.2 [Q9UK00-1]
NP_001165212.1, NM_001171741.2 [Q9UK00-1]
NP_001165214.2, NM_001171743.2 [Q9UK00-2]
NP_057294.2, NM_016210.4 [Q9UK00-1]
XP_011532092.1, XM_011533790.1 [Q9UK00-2]
XP_016862036.1, XM_017006547.1 [Q9UK00-2]
UniGeneiHs.517860

3D structure databases

ProteinModelPortaliQ9UK00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349732

PTM databases

iPTMnetiQ9UK00
PhosphoSitePlusiQ9UK00

Polymorphism and mutation databases

BioMutaiC3orf18
DMDMi317373334

Proteomic databases

PaxDbiQ9UK00
PeptideAtlasiQ9UK00
PRIDEiQ9UK00
ProteomicsDBi84698

Protocols and materials databases

DNASUi51161
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357203; ENSP00000349732; ENSG00000088543 [Q9UK00-1]
ENST00000426034; ENSP00000387606; ENSG00000088543 [Q9UK00-1]
ENST00000441239; ENSP00000414124; ENSG00000088543 [Q9UK00-2]
ENST00000449241; ENSP00000404913; ENSG00000088543 [Q9UK00-1]
GeneIDi51161
KEGGihsa:51161
UCSCiuc003dar.4 human [Q9UK00-1]

Organism-specific databases

CTDi51161
DisGeNETi51161
EuPathDBiHostDB:ENSG00000088543.14
GeneCardsiC3orf18
H-InvDBiHIX0003308
HGNCiHGNC:24837 C3orf18
HPAiHPA012105
neXtProtiNX_Q9UK00
OpenTargetsiENSG00000088543
PharmGKBiPA134941482
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1WR Eukaryota
ENOG410Y7Q7 LUCA
GeneTreeiENSGT00410000025882
HOGENOMiHOG000294070
HOVERGENiHBG081003
InParanoidiQ9UK00
OMAiNSTKIPD
OrthoDBiEOG091G1C3H
PhylomeDBiQ9UK00
TreeFamiTF332764

Miscellaneous databases

GenomeRNAii51161
PROiPR:Q9UK00

Gene expression databases

BgeeiENSG00000088543 Expressed in 210 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_C3orf18
ExpressionAtlasiQ9UK00 baseline and differential
GenevisibleiQ9UK00 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC018_HUMAN
AccessioniPrimary (citable) accession number: Q9UK00
Secondary accession number(s): C9JNP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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