GGA1

Functionⁱ

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.1 Publication

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functionⁱ

ADP-ribosylation factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 12668765
- 12679809
protein heterodimerization activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 12668765

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
intracellular protein transport
Source: UniProtKB
Traceable author statementⁱ
- 20211637
positive regulation of protein catabolic process Source: Ensembl
toxin transport Source: Ensembl
vesicle-mediated transport Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs
R-HSA-977225 Amyloid fiber formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP-ribosylation factor-binding protein GGA1 Alternative name(s): Gamma-adaptin-related protein 1 Golgi-localized, gamma ear-containing, ARF-binding protein 1
Gene namesⁱ	Name:GGA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100083.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17842 GGA1
MIMⁱ	606004 gene
neXtProtⁱ	NX_Q9UJY5

Keywords - Cellular componentⁱ

Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	92	N → A: Abolishes interaction with IGF2R. 1 Publication	1
Mutagenesisⁱ	182	L → A: Abolishes interaction with ARF1, UBC and TSG101. 1 Publication	1
Mutagenesisⁱ	194	N → A: Abolishes interaction with ARF1 and RABEP1. 1 Publication	1
Mutagenesisⁱ	197	I → A: Abolishes interaction with ARF1, UBC and TSG101. 1 Publication	1
Mutagenesisⁱ	198	K → A: Abolishes interaction with ARF1. 1 Publication	1
Mutagenesisⁱ	200	M → A: Abolishes interaction with ARF1. 1 Publication	1
Mutagenesisⁱ	204	D → A: Abolishes interaction with ARF1. 1 Publication	1
Mutagenesisⁱ	259	M → K: Abolishes interaction with RABEP1.	1
Mutagenesisⁱ	260	R → A: No effect on interaction with RABEP1. 1 Publication	1
Mutagenesisⁱ	260	R → E: Abolishes interaction with RABEP1 and UBC. 1 Publication	1
Mutagenesisⁱ	264	F → A: Abolishes interaction with RABEP1. 1 Publication	1
Mutagenesisⁱ	267	A → D: Abolishes interaction with RABEP1 and UBC. 1 Publication	1
Mutagenesisⁱ	277	L → A: Abolishes interaction with RABEP1, UBC and TSG101. 1 Publication	1
Mutagenesisⁱ	281	L → A: Abolishes interaction with RABEP1. 1 Publication	1
Mutagenesisⁱ	284	N → A: Abolishes interaction with RABEP1. 1 Publication	1
Mutagenesisⁱ	284	N → S: Abolishes interaction with RABEP1. 1 Publication	1
Mutagenesisⁱ	355	S → A: Increased interaction with IGF2R. Reduced phosphorylation. 1 Publication	1
Mutagenesisⁱ	355	S → D: Abolishes interaction with IGF2R. 1 Publication	1
Mutagenesisⁱ	356 – 360	LLDDE → AADAA: Partial loss of clathrin-binding. 1 Publication	5
Mutagenesisⁱ	358	D → A: Increased interaction with IGF2R. 1 Publication	1
Mutagenesisⁱ	361 – 362	LM → AA: Increased interaction with IGF2R. 1 Publication	2
Mutagenesisⁱ	563	A → D: Abolishes interaction with CCDC91. 1 Publication	1
Mutagenesisⁱ	564	V → D: Abolishes interaction with CCDC91. 1 Publication	1
Mutagenesisⁱ	570	V → E: Abolishes interaction with CCDC91. 1 Publication	1
Mutagenesisⁱ	572	L → E: Abolishes interaction with CCDC91. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26088
Open Targets More...OpenTargetsⁱ	ENSG00000100083
PharmGKBⁱ	PA28657

Polymorphism and mutation databases

BioMutaⁱ	GGA1
DMDMⁱ	14548066

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000212680	1 – 639	ADP-ribosylation factor-binding protein GGA1Add BLAST		639

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	185	PhosphoserineCombined sources	1
Modified residueⁱ	355	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	418	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals.1 Publication

Ubiquitinated.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UJY5
PaxDbⁱ	Q9UJY5
PeptideAtlas More...PeptideAtlasⁱ	Q9UJY5
PRIDEⁱ	Q9UJY5
ProteomicsDBⁱ	84692 84693 [Q9UJY5-2] 84694 [Q9UJY5-3] 84695 [Q9UJY5-4] 84696 [Q9UJY5-5]

PTM databases

iPTMnetⁱ	Q9UJY5
PhosphoSitePlusⁱ	Q9UJY5

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.

Gene expression databases

Bgeeⁱ	ENSG00000100083 Expressed in 221 organ(s), highest expression level in right testis
CleanExⁱ	HS_GGA1
ExpressionAtlasⁱ	Q9UJY5 baseline and differential
Genevisibleⁱ	Q9UJY5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048280 HPA051016

HPAⁱ

HPA048280
HPA051016

Interactionⁱ

Subunit structureⁱ

Monomer. Interacts with NECAP1. Interacts with CNST (By similarity). Interacts with GGA2 and GGA3. Binds to clathrin and activated ARFs, including ARF1 and ARF6. Interacts with RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds CCDC91, P200, SYNRG, EPN4, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Interacts with RNF11.By similarity19 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Arf6	P62331	2	EBI-447141,EBI-988682	From Mus musculus.
C1orf216	Q8TAB5	3	EBI-447141,EBI-747505
DTNB	O60941	4	EBI-447141,EBI-740402
IGF2R	P11717	2	EBI-447141,EBI-1048580
MON2	Q7Z3U7	2	EBI-447141,EBI-358882
RABEP1	Q15276	8	EBI-447141,EBI-447043
RABGEF1	O18973	2	EBI-447141,EBI-447376	From Bos taurus.
RNF11	Q9Y3C5	3	EBI-447141,EBI-396669
SORT1	Q99523	2	EBI-447141,EBI-1057058
UBB	P0CG47	3	EBI-447141,EBI-413034

GO - Molecular functionⁱ

ADP-ribosylation factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 12668765
- 12679809
protein heterodimerization activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 12668765

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117540, 76 interactors
ELMⁱ	Q9UJY5
IntActⁱ	Q9UJY5, 38 interactors
Molecular INTeraction database More...MINTⁱ	Q9UJY5
STRINGⁱ	9606.ENSP00000341344

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 5	Combined sources	3
Helixⁱ	10 – 17	Combined sources	8
Helixⁱ	27 – 36	Combined sources	10
Helixⁱ	37 – 39	Combined sources	3
Beta strandⁱ	40 – 42	Combined sources	3
Helixⁱ	43 – 55	Combined sources	13
Helixⁱ	60 – 76	Combined sources	17
Helixⁱ	79 – 85	Combined sources	7
Helixⁱ	88 – 98	Combined sources	11
Turnⁱ	100 – 103	Combined sources	4
Helixⁱ	104 – 106	Combined sources	3
Helixⁱ	109 – 125	Combined sources	17
Helixⁱ	130 – 141	Combined sources	12
Helixⁱ	172 – 182	Combined sources	11
Helixⁱ	187 – 205	Combined sources	19
Helixⁱ	212 – 233	Combined sources	22
Turnⁱ	235 – 238	Combined sources	4
Helixⁱ	243 – 267	Combined sources	25
Helixⁱ	274 – 298	Combined sources	25
Helixⁱ	494 – 497	Combined sources	4
Helixⁱ	504 – 506	Combined sources	3
Beta strandⁱ	515 – 520	Combined sources	6
Beta strandⁱ	523 – 531	Combined sources	9
Beta strandⁱ	533 – 535	Combined sources	3
Beta strandⁱ	540 – 549	Combined sources	10
Beta strandⁱ	555 – 563	Combined sources	9
Beta strandⁱ	568 – 572	Combined sources	5
Beta strandⁱ	592 – 599	Combined sources	8
Beta strandⁱ	608 – 616	Combined sources	9
Beta strandⁱ	619 – 627	Combined sources	9
Turnⁱ	633 – 635	Combined sources	3
Helixⁱ	636 – 638	Combined sources	3

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00314
ProteinModelPortalⁱ	Q9UJY5
SMRⁱ	Q9UJY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UJY5

EvolutionaryTraceⁱ

Q9UJY5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	17 – 147	VHSPROSITE-ProRule annotationAdd BLAST	131
Domainⁱ	171 – 299	GATPROSITE-ProRule annotationAdd BLAST	129
Domainⁱ	510 – 631	GAEPROSITE-ProRule annotationAdd BLAST	122

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	114 – 274	Interaction with ARF3Add BLAST		161
Regionⁱ	300 – 509	Unstructured hingeAdd BLAST		210

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	358 – 362	Autoinhibitory		5

Domainⁱ

The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).

The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.

The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.

The GAE domain binds accessory proteins regulating GGAs function.

Sequence similaritiesⁱ

Belongs to the GGA protein family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150934
HOGENOMⁱ	HOG000231169
HOVERGENⁱ	HBG015945
InParanoidⁱ	Q9UJY5
KEGG Orthology (KO) More...KOⁱ	K12404
OMAⁱ	GFRVLFH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BQK
PhylomeDBⁱ	Q9UJY5
TreeFamⁱ	TF318574

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008152 Clathrin_a/b/g-adaptin_app_Ig IPR013041 Clathrin_app_Ig-like_sf IPR008942 ENTH_VHS IPR008153 GAE_dom IPR004152 GAT_dom IPR038425 GAT_sf IPR002014 VHS_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02883 Alpha_adaptinC2, 1 hit PF03127 GAT, 1 hit PF00790 VHS, 1 hit
SMARTⁱ	View protein in SMART SM00809 Alpha_adaptinC2, 1 hit SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit SSF49348 SSF49348, 1 hit
PROSITEⁱ	View protein in PROSITE PS50180 GAE, 1 hit PS50909 GAT, 1 hit PS50179 VHS, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UJY5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL 
        60         70         80         90        100
LAHKIQSPQE WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP 
       110        120        130        140        150
KYLGSRTSEK VKNKILELLY SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK 
       160        170        180        190        200
LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR LLKSSHPEDL RAANKLIKEM 
       210        220        230        240        250
VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA AAGSSEDLMK 
       260        270        280        290        300
ELYQRCERMR PTLFRLASDT EDNDEALAEI LQANDNLTQV INLYKQLVRG 
       310        320        330        340        350
EEVNGDATAG SIPGSTSALL DLSGLDLPPA GTTYPAMPTR PGEQASPEQP 
       360        370        380        390        400
SASVSLLDDE LMSLGLSDPT PPSGPSLDGT GWNSFQSSDA TEPPAPALAQ 
       410        420        430        440        450
APSMESRPPA QTSLPASSGL DDLDLLGKTL LQQSLPPESQ QVRWEKQQPT 
       460        470        480        490        500
PRLTLRDLQN KSSSCSSPSS SATSLLHTVS PEPPRPPQQP VPTELSLASI 
       510        520        530        540        550
TVPLESIKPS NILPVTVYDQ HGFRILFHFA RDPLPGRSDV LVVVVSMLST 
       560        570        580        590        600
APQPIRNIVF QSAVPKVMKV KLQPPSGTEL PAFNPIVHPS AITQVLLLAN 
       610        620        630 
PQKEKVRLRY KLTFTMGDQT YNEMGDVDQF PPPETWGSL

Length:639

Mass (Da):70,384

Last modified:May 1, 2000 - v1

Checksum:ⁱB0B6F089FA0F7DD5

GO

Isoform 2 (identifier: Q9UJY5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
69-101: Missing.

« Hide

        10         20         30         40         50
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL 
        60         70         80         90        100
LAHKIQSPQE WEAIQALTYL GSRTSEKVKN KILELLYSWT VGLPEEVKIA 
       110        120        130        140        150
EAYQMLKKQG IVKSDPKLPD DTTFPLPPPR PKNVIFEDEE KSKMLARLLK 
       160        170        180        190        200
SSHPEDLRAA NKLIKEMVQE DQKRMEKISK RVNAIEEVNN NVKLLTEMVM 
       210        220        230        240        250
SHSQGGAAAG SSEDLMKELY QRCERMRPTL FRLASDTEDN DEALAEILQA 
       260        270        280        290        300
NDNLTQVINL YKQLVRGEEV NGDATAGSIP GSTSALLDLS GLDLPPAGTT 
       310        320        330        340        350
YPAMPTRPGE QASPEQPSAS VSLLDDELMS LGLSDPTPPS GPSLDGTGWN 
       360        370        380        390        400
SFQSSDATEP PAPALAQAPS MESRPPAQTS LPASSGLDDL DLLGKTLLQQ 
       410        420        430        440        450
SLPPESQQVR WEKQQPTPRL TLRDLQNKSS SCSSPSSSAT SLLHTVSPEP 
       460        470        480        490        500
PRPPQQPVPT ELSLASITVP LESIKPSNIL PVTVYDQHGF RILFHFARDP 
       510        520        530        540        550
LPGRSDVLVV VVSMLSTAPQ PIRNIVFQSA VPKVMKVKLQ PPSGTELPAF 
       560        570        580        590        600
NPIVHPSAIT QVLLLANPQK EKVRLRYKLT FTMGDQTYNE MGDVDQFPPP 

ETWGSL

Note: No experimental confirmation available.

Show »

Length:606

Mass (Da):66,563

Checksum:ⁱ6231A20CC57997B1

GO

Isoform 3 (identifier: Q9UJY5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-73: Missing.

« Hide

        10         20         30         40         50
MKSCGKRFHD EVGKFRFLNE LIKVVSPKYL GSRTSEKVKN KILELLYSWT 
        60         70         80         90        100
VGLPEEVKIA EAYQMLKKQG IVKSDPKLPD DTTFPLPPPR PKNVIFEDEE 
       110        120        130        140        150
KSKMLARLLK SSHPEDLRAA NKLIKEMVQE DQKRMEKISK RVNAIEEVNN 
       160        170        180        190        200
NVKLLTEMVM SHSQGGAAAG SSEDLMKELY QRCERMRPTL FRLASDTEDN 
       210        220        230        240        250
DEALAEILQA NDNLTQVINL YKQLVRGEEV NGDATAGSIP GSTSALLDLS 
       260        270        280        290        300
GLDLPPAGTT YPAMPTRPGE QASPEQPSAS VSLLDDELMS LGLSDPTPPS 
       310        320        330        340        350
GPSLDGTGWN SFQSSDATEP PAPALAQAPS MESRPPAQTS LPASSGLDDL 
       360        370        380        390        400
DLLGKTLLQQ SLPPESQQVR WEKQQPTPRL TLRDLQNKSS SCSSPSSSAT 
       410        420        430        440        450
SLLHTVSPEP PRPPQQPVPT ELSLASITVP LESIKPSNIL PVTVYDQHGF 
       460        470        480        490        500
RILFHFARDP LPGRSDVLVV VVSMLSTAPQ PIRNIVFQSA VPKVMKVKLQ 
       510        520        530        540        550
PPSGTELPAF NPIVHPSAIT QVLLLANPQK EKVRLRYKLT FTMGDQTYNE 
       560 
MGDVDQFPPP ETWGSL

Show »

Length:566

Mass (Da):62,138

Checksum:ⁱF96825C24B633E03

GO

Isoform 4 (identifier: Q9UJY5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
277-363: Missing.

« Hide

        10         20         30         40         50
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL 
        60         70         80         90        100
LAHKIQSPQE WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP 
       110        120        130        140        150
KYLGSRTSEK VKNKILELLY SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK 
       160        170        180        190        200
LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR LLKSSHPEDL RAANKLIKEM 
       210        220        230        240        250
VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA AAGSSEDLMK 
       260        270        280        290        300
ELYQRCERMR PTLFRLASDT EDNDEALGLS DPTPPSGPSL DGTGWNSFQS 
       310        320        330        340        350
SDATEPPAPA LAQAPSMESR PPAQTSLPAS SGLDDLDLLG KTLLQQSLPP 
       360        370        380        390        400
ESQQVRWEKQ QPTPRLTLRD LQNKSSSCSS PSSSATSLLH TVSPEPPRPP 
       410        420        430        440        450
QQPVPTELSL ASITVPLESI KPSNILPVTV YDQHGFRILF HFARDPLPGR 
       460        470        480        490        500
SDVLVVVVSM LSTAPQPIRN IVFQSAVPKV MKVKLQPPSG TELPAFNPIV 
       510        520        530        540        550
HPSAITQVLL LANPQKEKVR LRYKLTFTMG DQTYNEMGDV DQFPPPETWG 

SL

Show »

Length:552

Mass (Da):61,379

Checksum:ⁱAC507C9F975A32C3

GO

Isoform 5 (identifier: Q9UJY5-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
70-89: LETCMKSCGKRFHDEVGKFR → RRGEATIRPPPCDDTKGGQD
90-639: Missing.

« Hide

        10         20         30         40         50
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL 
        60         70         80 
LAHKIQSPQE WEAIQALTVR RGEATIRPPP CDDTKGGQD

Show »

Length:89

Mass (Da):9,969

Checksum:ⁱF209D7D764D4CA7E

GO

Isoform 6 (identifier: Q9UJY5-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
68-68: T → TVRRGEATIRPPPCDDTK

« Hide

        10         20         30         40         50
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL 
        60         70         80         90        100
LAHKIQSPQE WEAIQALTVR RGEATIRPPP CDDTKVLETC MKSCGKRFHD 
       110        120        130        140        150
EVGKFRFLNE LIKVVSPKYL GSRTSEKVKN KILELLYSWT VGLPEEVKIA 
       160        170        180        190        200
EAYQMLKKQG IVKSDPKLPD DTTFPLPPPR PKNVIFEDEE KSKMLARLLK 
       210        220        230        240        250
SSHPEDLRAA NKLIKEMVQE DQKRMEKISK RVNAIEEVNN NVKLLTEMVM 
       260        270        280        290        300
SHSQGGAAAG SSEDLMKELY QRCERMRPTL FRLASDTEDN DEALAEILQA 
       310        320        330        340        350
NDNLTQVINL YKQLVRGEEV NGDATAGSIP GSTSALLDLS GLDLPPAGTT 
       360        370        380        390        400
YPAMPTRPGE QASPEQPSAS VSLLDDELMS LGLSDPTPPS GPSLDGTGWN 
       410        420        430        440        450
SFQSSDATEP PAPALAQAPS MESRPPAQTS LPASSGLDDL DLLGKTLLQQ 
       460        470        480        490        500
SLPPESQQVR WEKQQPTPRL TLRDLQNKSS SCSSPSSSAT SLLHTVSPEP 
       510        520        530        540        550
PRPPQQPVPT ELSLASITVP LESIKPSNIL PVTVYDQHGF RILFHFARDP 
       560        570        580        590        600
LPGRSDVLVV VVSMLSTAPQ PIRNIVFQSA VPKVMKVKLQ PPSGTELPAF 
       610        620        630        640        650
NPIVHPSAIT QVLLLANPQK EKVRLRYKLT FTMGDQTYNE MGDVDQFPPP 

ETWGSL

Note: No experimental confirmation available.

Show »

Length:656

Mass (Da):72,277

Checksum:ⁱ60EE957099B4847C

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B0QYR6	B0QYR6_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	246	Annotation score:
B0QYR5	B0QYR5_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	105	Annotation score:
B0QYS5	B0QYS5_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	108	Annotation score:
B0QYR9	B0QYR9_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	28	Annotation score:
B0QYS3	B0QYS3_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	70	Annotation score:
B0QYS0	B0QYS0_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	38	Annotation score:
B0QYS1	B0QYS1_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	40	Annotation score:
B0QYS2	B0QYS2_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	59	Annotation score:
B0QYR8	B0QYR8_HUMAN	ADP-ribosylation factor-binding pro... ADP-ribosylation factor-binding protein GGA1	GGA1	17	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036522	239	G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs765255006Ensembl.		1
Natural variantⁱVAR_036523	484	P → A in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042806	1 – 73	Missing in isoform 3. 1 PublicationAdd BLAST	73
Alternative sequenceⁱVSP_057352	68	T → TVRRGEATIRPPPCDDTK in isoform 6. 1 Publication	1
Alternative sequenceⁱVSP_001744	69 – 101	Missing in isoform 2. CuratedAdd BLAST	33
Alternative sequenceⁱVSP_042807	70 – 89	LETCM…VGKFR → RRGEATIRPPPCDDTKGGQD in isoform 5. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_042808	90 – 639	Missing in isoform 5. 1 PublicationAdd BLAST	550
Alternative sequenceⁱVSP_042809	277 – 363	Missing in isoform 4. 1 PublicationAdd BLAST	87

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF190862 mRNA Translation: AAF05707.1 AF218584 mRNA Translation: AAF42847.1 AF233521 mRNA Translation: AAF35393.1 CR456493 mRNA Translation: CAG30379.1 AK075256 mRNA Translation: BAC11501.1 AK122898 mRNA Translation: BAG53788.1 AK290548 mRNA Translation: BAF83237.1 AL035496 Genomic DNA No translation available. Z83844 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60169.1 BC000538 mRNA Translation: AAH00538.2 BC010917 mRNA Translation: AAH10917.1 BC029388 mRNA Translation: AAH29388.1 BC044629 mRNA Translation: AAH44629.1 AL110219 mRNA Translation: CAB53679.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13951.1 [Q9UJY5-1] CCDS33643.1 [Q9UJY5-4] CCDS54526.1 [Q9UJY5-3] CCDS87022.1 [Q9UJY5-6]
PIRⁱ	T14759
NCBI Reference Sequences More...RefSeqⁱ	NP_001001560.1, NM_001001560.2 [Q9UJY5-4] NP_001166158.1, NM_001172687.1 NP_001166159.1, NM_001172688.1 [Q9UJY5-3] NP_037497.1, NM_013365.4 [Q9UJY5-1] XP_005261574.1, XM_005261517.3 XP_005261577.1, XM_005261520.1 [Q9UJY5-3] XP_006724292.1, XM_006724229.1 [Q9UJY5-3] XP_011528424.1, XM_011530122.1 XP_016884249.1, XM_017028760.1 XP_016884250.1, XM_017028761.1 [Q9UJY5-3] XP_016884251.1, XM_017028762.1
UniGeneⁱ	Hs.499158

Genome annotation databases

Ensemblⁱ	ENST00000325180; ENSP00000321288; ENSG00000100083 [Q9UJY5-4] ENST00000343632; ENSP00000341344; ENSG00000100083 [Q9UJY5-1] ENST00000381756; ENSP00000371175; ENSG00000100083 [Q9UJY5-6] ENST00000406772; ENSP00000385287; ENSG00000100083 [Q9UJY5-3]
GeneIDⁱ	26088
KEGGⁱ	hsa:26088
UCSC genome browser More...UCSCⁱ	uc003atc.4 human [Q9UJY5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UJY5	Uncharacterized protein		RHIRO		735	UniRef90_Q9UJY5
GGA1 isoform 18 (Fragment)		PONAB		109
ADP-ribosylation factor-binding protein GGA1 (Fragment)		HUMAN		108
Uncharacterized protein		PAPAN		730
Golgi associated, gamma adaptin ear containing, ARF binding protein 1		CALJA		656
+90
Q9UJY5-4	ADP-ribosylation factor-binding protein GGA1 isoform X2		TARSY		554	UniRef90_Q9UJY5-4
GGA1 isoform 3		PANTR		552
Golgi associated, gamma adaptin ear containing, ARF binding protein 1		SAIBB		552
Uncharacterized protein		MACMU		552
Uncharacterized protein		MACFA		552
+22
Q9UJY5-5	Golgi-associated, gamma adaptin ear containing, ARF binding protein 1		PANTR		89	UniRef90_Q9UJY5-5

Protein	Similar proteins		Species	Score	Length	Source
Q9UJY5	Uncharacterized protein		RHIRO		735	UniRef50_Q9UJY5
GGA1 isoform 18 (Fragment)		PONAB		109
ADP-ribosylation factor-binding protein GGA1 (Fragment)		HUMAN		108
Uncharacterized protein		PAPAN		730
GGA1 isoform 5		PANTR		656
+234
Q9UJY5-2	ADP-ribosylation factor-binding protein GGA3 isoform X2		BALAS		599	UniRef50_Q9UJY5-2
Uncharacterized protein		FELCA		585
Uncharacterized protein		NOMLE		524
ADP-ribosylation factor-binding protein GGA3 isoform X2		ERIEU		525
UPI00077DEB7D		PERMB		609
+6
Q9UJY5-4	ADP-ribosylation factor-binding protein GGA1 isoform X2		TARSY		554	UniRef50_Q9UJY5-4
Uncharacterized protein		PAPAN		552
Uncharacterized protein		CERAT		552
Uncharacterized protein		RHIRO		552
Uncharacterized protein		MANLE		552
+51
Q9UJY5-5	Golgi-associated, gamma adaptin ear containing, ARF binding protein 1		PANTR		89	UniRef50_Q9UJY5-5
Uncharacterized protein		ANGAN		81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF190862 mRNA Translation: AAF05707.1 AF218584 mRNA Translation: AAF42847.1 AF233521 mRNA Translation: AAF35393.1 CR456493 mRNA Translation: CAG30379.1 AK075256 mRNA Translation: BAC11501.1 AK122898 mRNA Translation: BAG53788.1 AK290548 mRNA Translation: BAF83237.1 AL035496 Genomic DNA No translation available. Z83844 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60169.1 BC000538 mRNA Translation: AAH00538.2 BC010917 mRNA Translation: AAH10917.1 BC029388 mRNA Translation: AAH29388.1 BC044629 mRNA Translation: AAH44629.1 AL110219 mRNA Translation: CAB53679.1
CCDSⁱ	CCDS13951.1 [Q9UJY5-1] CCDS33643.1 [Q9UJY5-4] CCDS54526.1 [Q9UJY5-3] CCDS87022.1 [Q9UJY5-6]
PIRⁱ	T14759
RefSeqⁱ	NP_001001560.1, NM_001001560.2 [Q9UJY5-4] NP_001166158.1, NM_001172687.1 NP_001166159.1, NM_001172688.1 [Q9UJY5-3] NP_037497.1, NM_013365.4 [Q9UJY5-1] XP_005261574.1, XM_005261517.3 XP_005261577.1, XM_005261520.1 [Q9UJY5-3] XP_006724292.1, XM_006724229.1 [Q9UJY5-3] XP_011528424.1, XM_011530122.1 XP_016884249.1, XM_017028760.1 XP_016884250.1, XM_017028761.1 [Q9UJY5-3] XP_016884251.1, XM_017028762.1
UniGeneⁱ	Hs.499158

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1J2J	X-ray	1.60	B	166-210	[»]
	1JWF	X-ray	2.10	A	1-147	[»]
	1JWG	X-ray	2.00	A/B	1-147	[»]
	1NA8	X-ray	2.30	A/B	494-639	[»]
	1NAF	X-ray	2.80	A	165-314	[»]
	1NWM	X-ray	2.40	X	166-302	[»]
	1O3X	X-ray	2.10	A	166-305	[»]
	1OM9	X-ray	2.50	A/B	494-639	[»]
	1OXZ	X-ray	2.80	A	141-326	[»]
	1PY1	X-ray	2.60	A/B/C/D	2-157	[»]
	1UJJ	X-ray	2.60	A/B	1-147	[»]
	1UJK	X-ray	1.90	A/B	1-147	[»]
	1X79	X-ray	2.41	A	210-302	[»]
	2DWX	X-ray	2.55	A/B/C/D	507-639	[»]
				P/Q	376-388	[»]
	2DWY	X-ray	2.30	A/B/C/D	507-639	[»]
	3G2S	X-ray	1.70	A/B	1-147	[»]
	3G2T	X-ray	2.00	A/B	1-147	[»]
	3G2U	X-ray	2.30	A/B	1-147	[»]
	3G2V	X-ray	2.10	A/B	1-147	[»]
	3G2W	X-ray	2.40	A/B	1-147	[»]
				C/D	351-364	[»]
DisProtⁱ	DP00314
ProteinModelPortalⁱ	Q9UJY5
SMRⁱ	Q9UJY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117540, 76 interactors
ELMⁱ	Q9UJY5
IntActⁱ	Q9UJY5, 38 interactors
MINTⁱ	Q9UJY5
STRINGⁱ	9606.ENSP00000341344

PTM databases

iPTMnetⁱ	Q9UJY5
PhosphoSitePlusⁱ	Q9UJY5

Polymorphism and mutation databases

BioMutaⁱ	GGA1
DMDMⁱ	14548066

Proteomic databases

EPDⁱ	Q9UJY5
PaxDbⁱ	Q9UJY5
PeptideAtlasⁱ	Q9UJY5
PRIDEⁱ	Q9UJY5
ProteomicsDBⁱ	84692 84693 [Q9UJY5-2] 84694 [Q9UJY5-3] 84695 [Q9UJY5-4] 84696 [Q9UJY5-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26088
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325180; ENSP00000321288; ENSG00000100083 [Q9UJY5-4] ENST00000343632; ENSP00000341344; ENSG00000100083 [Q9UJY5-1] ENST00000381756; ENSP00000371175; ENSG00000100083 [Q9UJY5-6] ENST00000406772; ENSP00000385287; ENSG00000100083 [Q9UJY5-3]
GeneIDⁱ	26088
KEGGⁱ	hsa:26088
UCSCⁱ	uc003atc.4 human [Q9UJY5-1]

Organism-specific databases

CTDⁱ	26088
DisGeNETⁱ	26088
EuPathDBⁱ	HostDB:ENSG00000100083.18
GeneCardsⁱ	GGA1
HGNCⁱ	HGNC:17842 GGA1
HPAⁱ	HPA048280 HPA051016
MIMⁱ	606004 gene
neXtProtⁱ	NX_Q9UJY5
OpenTargetsⁱ	ENSG00000100083
PharmGKBⁱ	PA28657
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1087 Eukaryota ENOG410Y26G LUCA
GeneTreeⁱ	ENSGT00930000150934
HOGENOMⁱ	HOG000231169
HOVERGENⁱ	HBG015945
InParanoidⁱ	Q9UJY5
KOⁱ	K12404
OMAⁱ	GFRVLFH
OrthoDBⁱ	EOG091G0BQK
PhylomeDBⁱ	Q9UJY5
TreeFamⁱ	TF318574

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

ChiTaRSⁱ	GGA1 human
EvolutionaryTraceⁱ	Q9UJY5
GeneWikiⁱ	GGA1
GenomeRNAiⁱ	26088
Protein Ontology More...PROⁱ	PR:Q9UJY5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100083 Expressed in 221 organ(s), highest expression level in right testis
CleanExⁱ	HS_GGA1
ExpressionAtlasⁱ	Q9UJY5 baseline and differential
Genevisibleⁱ	Q9UJY5 HS

Family and domain databases

Gene3Dⁱ	1.20.58.160, 1 hit 1.25.40.90, 1 hit
InterProⁱ	View protein in InterPro IPR008152 Clathrin_a/b/g-adaptin_app_Ig IPR013041 Clathrin_app_Ig-like_sf IPR008942 ENTH_VHS IPR008153 GAE_dom IPR004152 GAT_dom IPR038425 GAT_sf IPR002014 VHS_dom
Pfamⁱ	View protein in Pfam PF02883 Alpha_adaptinC2, 1 hit PF03127 GAT, 1 hit PF00790 VHS, 1 hit
SMARTⁱ	View protein in SMART SM00809 Alpha_adaptinC2, 1 hit SM00288 VHS, 1 hit
SUPFAMⁱ	SSF48464 SSF48464, 1 hit SSF49348 SSF49348, 1 hit
PROSITEⁱ	View protein in PROSITE PS50180 GAE, 1 hit PS50909 GAT, 1 hit PS50179 VHS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GGA1_HUMAN
Accessionⁱ	Q9UJY5Primary (citable) accession number: Q9UJY5 Secondary accession number(s): A8K3D3 Q9UGW1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 198 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9UJY5 (GGA1_HUMAN)

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ADP-ribosylation factor-binding protein GGA1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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3D structure databases

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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PTM databases

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Protocols and materials databases

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Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ