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Protein

SERTA domain-containing protein 3

Gene

SERTAD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Strong transcriptional coactivator.1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 3
Alternative name(s):
Replication protein-binding trans-activator
Short name:
RPA-binding trans-activator
Gene namesi
Name:SERTAD3
Synonyms:RBT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167565.12
HGNCiHGNC:17931 SERTAD3
MIMi612125 gene
neXtProtiNX_Q9UJW9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29946
OpenTargetsiENSG00000167565
PharmGKBiPA134941720

Polymorphism and mutation databases

BioMutaiSERTAD3
DMDMi60415943

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916151 – 196SERTA domain-containing protein 3Add BLAST196

Proteomic databases

EPDiQ9UJW9
PaxDbiQ9UJW9
PeptideAtlasiQ9UJW9
PRIDEiQ9UJW9
ProteomicsDBi84676

PTM databases

iPTMnetiQ9UJW9
PhosphoSitePlusiQ9UJW9

Expressioni

Gene expression databases

BgeeiENSG00000167565
CleanExiHS_SERTAD3
ExpressionAtlasiQ9UJW9 baseline and differential
GenevisibleiQ9UJW9 HS

Organism-specific databases

HPAiHPA068262

Interactioni

Subunit structurei

Interacts with RPA2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118983, 10 interactors
IntActiQ9UJW9, 62 interactors
STRINGi9606.ENSP00000325414

Structurei

3D structure databases

ProteinModelPortaliQ9UJW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 73SERTAPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410JAJA Eukaryota
ENOG41119NJ LUCA
GeneTreeiENSGT00730000111546
HOGENOMiHOG000133073
HOVERGENiHBG055009
InParanoidiQ9UJW9
OMAiEDEKWDW
OrthoDBiEOG091G0U23
PhylomeDBiQ9UJW9
TreeFamiTF101069

Family and domain databases

InterProiView protein in InterPro
IPR009263 SERTA_dom
PfamiView protein in Pfam
PF06031 SERTA, 1 hit
PROSITEiView protein in PROSITE
PS51053 SERTA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UJW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP
60 70 80 90 100
SLRRHVLIHN TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR
110 120 130 140 150
ELDTSMDGTE PPQNPVTPLG LQNEVPPQPD PVFLEALSSR YLGDSGLDDF
160 170 180 190
FLDIDTSAVE KEPARAPPEP PHNLFCAPGS WEWNELDHIM EIILGS
Length:196
Mass (Da):21,769
Last modified:February 1, 2005 - v2
Checksum:i9C54AFA126F17AF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → E in AAF05761 (PubMed:10982866).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA Translation: AAF05761.1
AK074604 mRNA Translation: BAG51975.1
CH471126 Genomic DNA Translation: EAW56966.1
BC014061 mRNA Translation: AAH14061.1
BC050643 mRNA Translation: AAH50643.1
CCDSiCCDS12558.1
RefSeqiNP_037500.2, NM_013368.3
NP_976219.1, NM_203344.2
XP_005258889.1, XM_005258832.3
XP_006723242.1, XM_006723179.3
UniGeneiHs.515412

Genome annotation databases

EnsembliENST00000322354; ENSP00000325414; ENSG00000167565
ENST00000392028; ENSP00000375882; ENSG00000167565
GeneIDi29946
KEGGihsa:29946
UCSCiuc002onu.5 human

Similar proteinsi

Entry informationi

Entry nameiSRTD3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW9
Secondary accession number(s): B3KQB3, Q96CQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 18, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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