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Protein

Zinc finger protein 229

Gene

ZNF229

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri291 – 315C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri349 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 566C2H2-type 9PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri572 – 594C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri684 – 706C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri712 – 734C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 229
Gene namesi
Name:ZNF229
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000278318.4
HGNCiHGNC:13022 ZNF229
neXtProtiNX_Q9UJW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37601

Polymorphism and mutation databases

BioMutaiZNF229
DMDMi296453070

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474701 – 825Zinc finger protein 229Add BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9UJW7
PeptideAtlasiQ9UJW7
PRIDEiQ9UJW7
ProteomicsDBi84674

2D gel databases

REPRODUCTION-2DPAGEiQ9UJW7

PTM databases

iPTMnetiQ9UJW7
PhosphoSitePlusiQ9UJW7

Expressioni

Gene expression databases

BgeeiENSG00000278318 Expressed in 122 organ(s), highest expression level in adrenal tissue
CleanExiHS_ZNF229
ExpressionAtlasiQ9UJW7 baseline and differential
GenevisibleiQ9UJW7 HS

Organism-specific databases

HPAiHPA001494

Interactioni

Protein-protein interaction databases

IntActiQ9UJW7, 2 interactors
STRINGi9606.ENSP00000466519

Structurei

3D structure databases

ProteinModelPortaliQ9UJW7
SMRiQ9UJW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 108KRABPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri291 – 315C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri349 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 539C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri545 – 566C2H2-type 9PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri572 – 594C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri684 – 706C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri712 – 734C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UJW7
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ9UJW7

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL
60 70 80 90 100
LDSTQRQLYQ DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH
110 120 130 140 150
KELSSCKIWE EVAGELPGSQ DCRVNLQGKD FQFSEDAAPH QGWEGASTPC
160 170 180 190 200
FPIENSLDSL QGDGLIGLEN QQFPAWRAIR PIPIQGSWAK AFVNQLGDVQ
210 220 230 240 250
ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC GCNKCRKDCI
260 270 280 290 300
KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE
310 320 330 340 350
GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR
360 370 380 390 400
CDVCGKGFRY KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT
410 420 430 440 450
GEKPYKCSEC GKGFSYSSVL QVHQRLHTGE KPYTCSECGK GFCAKSALHK
460 470 480 490 500
HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ KTHTGERPYQ CDKCGKGFSH
510 520 530 540 550
NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT GEKPYKCECG
560 570 580 590 600
KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY
610 620 630 640 650
VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH
660 670 680 690 700
TGEKPYRCQE CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR
710 720 730 740 750
THQRLHTGEK PYTCCECGKG FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS
760 770 780 790 800
QSSHLQGHQR VHTGEKPYKC EECGKGFGRN SCLHVHQRVH TGEKPYTCGV
810 820
CGKGFSYTSG LRNHQRVHLG ENPYK
Length:825
Mass (Da):93,707
Last modified:May 18, 2010 - v3
Checksum:i301AE62BDAA872F6
GO
Isoform 2 (identifier: Q9UJW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-80: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:819
Mass (Da):93,041
Checksum:i0070ACBE4332D807
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVZ7A0A087WVZ7_HUMAN
Zinc finger protein 229
ZNF229
819Annotation score:
A0A087X068A0A087X068_HUMAN
Zinc finger protein 229
ZNF229
83Annotation score:
K7EIU9K7EIU9_HUMAN
Zinc finger protein 229
ZNF229
12Annotation score:

Sequence cautioni

The sequence AAG23970 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057408156S → F1 PublicationCorresponds to variant dbSNP:rs2571174Ensembl.1
Natural variantiVAR_057409337R → C. Corresponds to variant dbSNP:rs12151338Ensembl.1
Natural variantiVAR_061942417S → N. Corresponds to variant dbSNP:rs57014690Ensembl.1
Natural variantiVAR_060426662G → R1 PublicationCorresponds to variant dbSNP:rs1434579Ensembl.1
Natural variantiVAR_060427804G → R. Corresponds to variant dbSNP:rs10409807Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05477875 – 80Missing in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084239 Genomic DNA Translation: AAG23970.1 Sequence problems.
BC150612 mRNA Translation: AAI50613.1
AF192979 mRNA Translation: AAF07964.1
AY166791 mRNA Translation: AAO45840.1
AB209357 mRNA Translation: BAD92594.1
CCDSiCCDS42574.1 [Q9UJW7-1]
CCDS62706.1 [Q9UJW7-2]
RefSeqiNP_055333.3, NM_014518.3
UniGeneiHs.709348

Genome annotation databases

EnsembliENST00000614049; ENSP00000479884; ENSG00000278318
GeneIDi7772
KEGGihsa:7772
UCSCiuc032hzj.2 human [Q9UJW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084239 Genomic DNA Translation: AAG23970.1 Sequence problems.
BC150612 mRNA Translation: AAI50613.1
AF192979 mRNA Translation: AAF07964.1
AY166791 mRNA Translation: AAO45840.1
AB209357 mRNA Translation: BAD92594.1
CCDSiCCDS42574.1 [Q9UJW7-1]
CCDS62706.1 [Q9UJW7-2]
RefSeqiNP_055333.3, NM_014518.3
UniGeneiHs.709348

3D structure databases

ProteinModelPortaliQ9UJW7
SMRiQ9UJW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UJW7, 2 interactors
STRINGi9606.ENSP00000466519

PTM databases

iPTMnetiQ9UJW7
PhosphoSitePlusiQ9UJW7

Polymorphism and mutation databases

BioMutaiZNF229
DMDMi296453070

2D gel databases

REPRODUCTION-2DPAGEiQ9UJW7

Proteomic databases

PaxDbiQ9UJW7
PeptideAtlasiQ9UJW7
PRIDEiQ9UJW7
ProteomicsDBi84674

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614049; ENSP00000479884; ENSG00000278318
GeneIDi7772
KEGGihsa:7772
UCSCiuc032hzj.2 human [Q9UJW7-1]

Organism-specific databases

CTDi7772
EuPathDBiHostDB:ENSG00000278318.4
GeneCardsiZNF229
HGNCiHGNC:13022 ZNF229
HPAiHPA001494
neXtProtiNX_Q9UJW7
PharmGKBiPA37601
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UJW7
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ9UJW7

Miscellaneous databases

ChiTaRSiZNF229 human
GenomeRNAii7772
PROiPR:Q9UJW7

Gene expression databases

BgeeiENSG00000278318 Expressed in 122 organ(s), highest expression level in adrenal tissue
CleanExiHS_ZNF229
ExpressionAtlasiQ9UJW7 baseline and differential
GenevisibleiQ9UJW7 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN229_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW7
Secondary accession number(s): B2RWN3, Q59FV2, Q86WL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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