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Protein

Tubulointerstitial nephritis antigen

Gene

TINAG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.1 Publication

Miscellaneous

Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: ProtInc
  • nucleotide binding Source: ProtInc
  • polysaccharide binding Source: InterPro
  • scavenger receptor activity Source: InterPro

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • immune response Source: InterPro

Keywordsi

Biological processCell adhesion

Protein family/group databases

MEROPSiC01.973

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulointerstitial nephritis antigen
Short name:
TIN-Ag
Gene namesi
Name:TINAG
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137251.15
HGNCiHGNC:14599 TINAG
MIMi606749 gene
neXtProtiNX_Q9UJW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27283
OpenTargetsiENSG00000137251
PharmGKBiPA37905

Polymorphism and mutation databases

BioMutaiTINAG
DMDMi317373501

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506001 – 476Tubulointerstitial nephritis antigenAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 102AlternatePROSITE-ProRule annotation
Disulfide bondi81 ↔ 95AlternatePROSITE-ProRule annotation
Disulfide bondi81 ↔ 83AlternatePROSITE-ProRule annotation
Disulfide bondi87 ↔ 94PROSITE-ProRule annotation
Disulfide bondi95 ↔ 102AlternatePROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei49 – 50Cleavage; by furinSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UJW2
PaxDbiQ9UJW2
PeptideAtlasiQ9UJW2
PRIDEiQ9UJW2
ProteomicsDBi84670
84671 [Q9UJW2-2]

PTM databases

iPTMnetiQ9UJW2
PhosphoSitePlusiQ9UJW2

Expressioni

Tissue specificityi

Expressed in the kidney cortex, small intestine and cornea.3 Publications

Developmental stagei

Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.1 Publication

Gene expression databases

BgeeiENSG00000137251
CleanExiHS_TINAG
ExpressionAtlasiQ9UJW2 baseline and differential
GenevisibleiQ9UJW2 HS

Organism-specific databases

HPAiHPA035427

Interactioni

Protein-protein interaction databases

BioGridi118107, 27 interactors
IntActiQ9UJW2, 2 interactors
STRINGi9606.ENSP00000259782

Structurei

3D structure databases

ProteinModelPortaliQ9UJW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 107SMBPROSITE-ProRule annotationAdd BLAST49

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1544 Eukaryota
ENOG410YN9K LUCA
GeneTreeiENSGT00900000140859
HOGENOMiHOG000241342
HOVERGENiHBG053961
InParanoidiQ9UJW2
OMAiAWWYLRK
OrthoDBiEOG091G0A2N
PhylomeDBiQ9UJW2
TreeFamiTF313765

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR001212 Somatomedin_B_dom
IPR033164 TINAG
PANTHERiPTHR12411 PTHR12411, 1 hit
PTHR12411:SF274 PTHR12411:SF274, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF01033 Somatomedin_B, 1 hit
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SM00201 SO, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS00640 THIOL_PROTEASE_ASN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJW2-1) [UniParc]FASTAAdd to basket
Also known as: TIN11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWTGYKILIF SYLTTEIWME KQYLSQREVD LEAYFTRNHT VLQGTRFKRA
60 70 80 90 100
IFQGQYCRNF GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS
110 120 130 140 150
FCREEKEWPP HTQPWYPEGC FKDGQHYEEG SVIKENCNSC TCSGQQWKCS
160 170 180 190 200
QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW GMTLEDGFKF RLGTLPPSPM
210 220 230 240 250
LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC AASWAFSTAS
260 270 280 290 300
VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG
310 320 330 340 350
LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ
360 370 380 390 400
CSPPYRVSSN ETEIMKEIMQ NGPVQAIMQV REDFFHYKTG IYRHVTSTNK
410 420 430 440 450
ESEKYRKLQT HAVKLTGWGT LRGAQGQKEK FWIAANSWGK SWGENGYFRI
460 470
LRGVNESDIE KLIIAAWGQL TSSDEP
Note: Major isoform.
Length:476
Mass (Da):54,605
Last modified:January 11, 2011 - v3
Checksum:i6D90C734DAC3A5AE
GO
Isoform 2 (identifier: Q9UJW2-2) [UniParc]FASTAAdd to basket
Also known as: TIN21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     119-169: Missing.
     209-300: Missing.

Show »
Length:333
Mass (Da):38,724
Checksum:iE708C6B55D9DBF9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 8IL → FS in AAF08931 (PubMed:10752525).Curated2
Sequence conflicti7 – 8IL → FS in AAF08932 (PubMed:10752525).Curated2
Sequence conflicti175N → I in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti199P → L in BAA84949 (PubMed:10652240).Curated1
Sequence conflicti333H → D in AAF08931 (PubMed:10752525).Curated1
Sequence conflicti333H → D in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti381R → H in BAA84949 (PubMed:10652240).Curated1
Sequence conflicti421L → R in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti437S → F in AAF08931 (PubMed:10752525).Curated1
Sequence conflicti437S → F in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti463I → V in AAF08931 (PubMed:10752525).Curated1
Sequence conflicti463I → V in AAF08932 (PubMed:10752525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0470913T → A. Corresponds to variant dbSNP:rs16885197Ensembl.1
Natural variantiVAR_04709222Q → R. Corresponds to variant dbSNP:rs2297980Ensembl.1
Natural variantiVAR_047093158S → P2 PublicationsCorresponds to variant dbSNP:rs1058768Ensembl.1
Natural variantiVAR_047094413V → I. Corresponds to variant dbSNP:rs34011963Ensembl.1
Natural variantiVAR_047095433I → L. Corresponds to variant dbSNP:rs3736352Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050567119 – 169Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_050568209 – 300Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022277 mRNA Translation: BAA84949.1
AF195116 mRNA Translation: AAF08931.1
AF195117 mRNA Translation: AAF08932.1
AK312918 mRNA Translation: BAG35763.1
AL359380 Genomic DNA No translation available.
AL589946 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04437.1
CCDSiCCDS4955.1 [Q9UJW2-1]
PIRiJC7189
RefSeqiNP_055279.3, NM_014464.3 [Q9UJW2-1]
UniGeneiHs.127011

Genome annotation databases

EnsembliENST00000259782; ENSP00000259782; ENSG00000137251 [Q9UJW2-1]
GeneIDi27283
KEGGihsa:27283
UCSCiuc003pcj.3 human [Q9UJW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTINAG_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW2
Secondary accession number(s): Q5T467, Q9UJW1, Q9ULZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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