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Entry version 162 (17 Jun 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Tubulointerstitial nephritis antigen

Gene

TINAG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.1 Publication

Miscellaneous

Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C01.973

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulointerstitial nephritis antigen
Short name:
TIN-Ag
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TINAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137251.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14599 TINAG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606749 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UJW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27283

Open Targets

More...
OpenTargetsi
ENSG00000137251

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37905

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UJW2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TINAG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373501

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000506001 – 476Tubulointerstitial nephritis antigenAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 102AlternatePROSITE-ProRule annotation
Disulfide bondi81 ↔ 95AlternatePROSITE-ProRule annotation
Disulfide bondi81 ↔ 83AlternatePROSITE-ProRule annotation
Disulfide bondi87 ↔ 94PROSITE-ProRule annotation
Disulfide bondi95 ↔ 102AlternatePROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei49 – 50Cleavage; by furinSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UJW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UJW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UJW2

PeptideAtlas

More...
PeptideAtlasi
Q9UJW2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UJW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84670 [Q9UJW2-1]
84671 [Q9UJW2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UJW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UJW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the kidney cortex, small intestine and cornea.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137251 Expressed in kidney epithelium and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UJW2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UJW2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137251 Group enriched (intestine, kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118107, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UJW2, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259782

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UJW2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 107SMBPROSITE-ProRule annotationAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1544 Eukaryota
ENOG410YN9K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012184_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UJW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLDQRNC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UJW2

TreeFam database of animal gene trees

More...
TreeFami
TF313765

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000668 Peptidase_C1A_C
IPR001212 Somatomedin_B_dom
IPR033164 TINAG

The PANTHER Classification System

More...
PANTHERi
PTHR12411:SF274 PTHR12411:SF274, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF01033 Somatomedin_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00645 Pept_C1, 1 hit
SM00201 SO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS00640 THIOL_PROTEASE_ASN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJW2-1) [UniParc]FASTAAdd to basket
Also known as: TIN11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWTGYKILIF SYLTTEIWME KQYLSQREVD LEAYFTRNHT VLQGTRFKRA
60 70 80 90 100
IFQGQYCRNF GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS
110 120 130 140 150
FCREEKEWPP HTQPWYPEGC FKDGQHYEEG SVIKENCNSC TCSGQQWKCS
160 170 180 190 200
QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW GMTLEDGFKF RLGTLPPSPM
210 220 230 240 250
LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC AASWAFSTAS
260 270 280 290 300
VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG
310 320 330 340 350
LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ
360 370 380 390 400
CSPPYRVSSN ETEIMKEIMQ NGPVQAIMQV REDFFHYKTG IYRHVTSTNK
410 420 430 440 450
ESEKYRKLQT HAVKLTGWGT LRGAQGQKEK FWIAANSWGK SWGENGYFRI
460 470
LRGVNESDIE KLIIAAWGQL TSSDEP
Note: Major isoform.
Length:476
Mass (Da):54,605
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D90C734DAC3A5AE
GO
Isoform 2 (identifier: Q9UJW2-2) [UniParc]FASTAAdd to basket
Also known as: TIN21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     119-169: Missing.
     209-300: Missing.

Show »
Length:333
Mass (Da):38,724
Checksum:iE708C6B55D9DBF9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T466Q5T466_HUMAN
Tubulointerstitial nephritis antige...
TINAG
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T471Q5T471_HUMAN
Tubulointerstitial nephritis antige...
TINAG
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7 – 8IL → FS in AAF08931 (PubMed:10752525).Curated2
Sequence conflicti7 – 8IL → FS in AAF08932 (PubMed:10752525).Curated2
Sequence conflicti175N → I in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti199P → L in BAA84949 (PubMed:10652240).Curated1
Sequence conflicti333H → D in AAF08931 (PubMed:10752525).Curated1
Sequence conflicti333H → D in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti381R → H in BAA84949 (PubMed:10652240).Curated1
Sequence conflicti421L → R in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti437S → F in AAF08931 (PubMed:10752525).Curated1
Sequence conflicti437S → F in AAF08932 (PubMed:10752525).Curated1
Sequence conflicti463I → V in AAF08931 (PubMed:10752525).Curated1
Sequence conflicti463I → V in AAF08932 (PubMed:10752525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0470913T → A. Corresponds to variant dbSNP:rs16885197Ensembl.1
Natural variantiVAR_04709222Q → R. Corresponds to variant dbSNP:rs2297980Ensembl.1
Natural variantiVAR_047093158S → P2 PublicationsCorresponds to variant dbSNP:rs1058768Ensembl.1
Natural variantiVAR_047094413V → I. Corresponds to variant dbSNP:rs34011963Ensembl.1
Natural variantiVAR_047095433I → L. Corresponds to variant dbSNP:rs3736352Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050567119 – 169Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_050568209 – 300Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB022277 mRNA Translation: BAA84949.1
AF195116 mRNA Translation: AAF08931.1
AF195117 mRNA Translation: AAF08932.1
AK312918 mRNA Translation: BAG35763.1
AL359380 Genomic DNA No translation available.
AL589946 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04437.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4955.1 [Q9UJW2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7189

NCBI Reference Sequences

More...
RefSeqi
NP_055279.3, NM_014464.3 [Q9UJW2-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27283

UCSC genome browser

More...
UCSCi
uc003pcj.3 human [Q9UJW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022277 mRNA Translation: BAA84949.1
AF195116 mRNA Translation: AAF08931.1
AF195117 mRNA Translation: AAF08932.1
AK312918 mRNA Translation: BAG35763.1
AL359380 Genomic DNA No translation available.
AL589946 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04437.1
CCDSiCCDS4955.1 [Q9UJW2-1]
PIRiJC7189
RefSeqiNP_055279.3, NM_014464.3 [Q9UJW2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118107, 27 interactors
IntActiQ9UJW2, 24 interactors
STRINGi9606.ENSP00000259782

Protein family/group databases

MEROPSiC01.973

PTM databases

iPTMnetiQ9UJW2
PhosphoSitePlusiQ9UJW2

Polymorphism and mutation databases

BioMutaiTINAG
DMDMi317373501

Proteomic databases

EPDiQ9UJW2
MassIVEiQ9UJW2
PaxDbiQ9UJW2
PeptideAtlasiQ9UJW2
PRIDEiQ9UJW2
ProteomicsDBi84670 [Q9UJW2-1]
84671 [Q9UJW2-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9UJW2 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
31018 72 antibodies

The DNASU plasmid repository

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DNASUi
27283

Genome annotation databases

GeneIDi27283
KEGGihsa:27283
UCSCiuc003pcj.3 human [Q9UJW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27283
DisGeNETi27283
EuPathDBiHostDB:ENSG00000137251.15

GeneCards: human genes, protein and diseases

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GeneCardsi
TINAG
HGNCiHGNC:14599 TINAG
HPAiENSG00000137251 Group enriched (intestine, kidney)
MIMi606749 gene
neXtProtiNX_Q9UJW2
OpenTargetsiENSG00000137251
PharmGKBiPA37905

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1544 Eukaryota
ENOG410YN9K LUCA
GeneTreeiENSGT00940000161065
HOGENOMiCLU_012184_3_2_1
InParanoidiQ9UJW2
OMAiPLDQRNC
PhylomeDBiQ9UJW2
TreeFamiTF313765

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
27283 6 hits in 787 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TINAG

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27283
PharosiQ9UJW2 Tbio

Protein Ontology

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PROi
PR:Q9UJW2
RNActiQ9UJW2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000137251 Expressed in kidney epithelium and 37 other tissues
ExpressionAtlasiQ9UJW2 baseline and differential
GenevisibleiQ9UJW2 HS

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000668 Peptidase_C1A_C
IPR001212 Somatomedin_B_dom
IPR033164 TINAG
PANTHERiPTHR12411:SF274 PTHR12411:SF274, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF01033 Somatomedin_B, 1 hit
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SM00201 SO, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS00640 THIOL_PROTEASE_ASN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTINAG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJW2
Secondary accession number(s): Q5T467, Q9UJW1, Q9ULZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 11, 2011
Last modified: June 17, 2020
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Peptidase families
    Classification of peptidase families and list of entries
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