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UniProtKB - Q9UJW0 (DCTN4_HUMAN)

Protein

Dynactin subunit 4

Gene

DCTN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 4
Short name:
Dyn4
Alternative name(s):
Dynactin subunit p62
Gene namesi
Name:DCTN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000132912.12
HGNCiHGNC:15518 DCTN4
MIMi614758 gene
neXtProtiNX_Q9UJW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30C → S: Loss of ATP7B-binding; when associated with S-33; S-51; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi33C → S: Loss of ATP7B-binding; when associated with S-30; S-51; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi51C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi54C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi70C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi73C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi76C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi79C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi111C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi114C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-277 and S-280. 1 Publication1
Mutagenesisi277C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-114 and S-280. 1 Publication1
Mutagenesisi280C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-114 and S-277. 1 Publication1

Organism-specific databases

DisGeNETi51164
MalaCardsiDCTN4
OpenTargetsiENSG00000132912
Orphaneti586 Cystic fibrosis
PharmGKBiPA27183

Polymorphism and mutation databases

BioMutaiDCTN4
DMDMi62900106

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000798232 – 460Dynactin subunit 4Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei407PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UJW0
PaxDbiQ9UJW0
PeptideAtlasiQ9UJW0
PRIDEiQ9UJW0
ProteomicsDBi84667
84668 [Q9UJW0-2]
84669 [Q9UJW0-3]

PTM databases

iPTMnetiQ9UJW0
PhosphoSitePlusiQ9UJW0

Expressioni

Gene expression databases

BgeeiENSG00000132912 Expressed in 225 organ(s), highest expression level in cerebral cortex
CleanExiHS_DCTN4
ExpressionAtlasiQ9UJW0 baseline and differential
GenevisibleiQ9UJW0 HS

Organism-specific databases

HPAiCAB017532
HPA038026

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi119345, 55 interactors
CORUMiQ9UJW0
IntActiQ9UJW0, 20 interactors
MINTiQ9UJW0
STRINGi9606.ENSP00000414906

Structurei

3D structure databases

ProteinModelPortaliQ9UJW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 172Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dynactin subunit 4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3896 Eukaryota
ENOG410ZCK8 LUCA
GeneTreeiENSGT00390000006954
HOGENOMiHOG000007947
HOVERGENiHBG051324
InParanoidiQ9UJW0
KOiK10426
OMAiNCLENIP
OrthoDBiEOG091G0FIJ
PhylomeDBiQ9UJW0
TreeFamiTF105249

Family and domain databases

InterProiView protein in InterPro
IPR008603 DCTN4
PANTHERiPTHR13034 PTHR13034, 1 hit
PfamiView protein in Pfam
PF05502 Dynactin_p62, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLLQSDRV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY 
        60         70         80         90        100
CPSCLENMPS AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK 
       110        120        130        140        150
TTMKKAYYLA CGFCRWTSRD VGMADKSVAS GGWQEPENPH TQRMNKLIEY 
       160        170        180        190        200
YQQLAQKEKV ERDRKKLARR RNYMPLAFSD KYGLGTRLQR PRAGASISTL 
       210        220        230        240        250
AGLSLKEGED QKEIKIEPAQ AVDEVEPLPE DYYTRPVNLT EVTTLQQRLL 
       260        270        280        290        300
QPDFQPVCAS QLYPRHKHLL IKRSLRCRKC EHNLSKPEFN PTSIKFKIQL 
       310        320        330        340        350
VAVNYIPEVR IMSIPNLRYM KESQVLLTLT NPVENLTHVT LFECEEGDPD 
       360        370        380        390        400
DINSTAKVVV PPKELVLAGK DAAAEYDELA EPQDFQDDPD IIAFRKANKV 
       410        420        430        440        450
GIFIKVTPQR EEGEVTVCFK MKHDFKNLAA PIRPIEESDQ GTEVIWLTQH 
       460
VELSLGPLLP
Length:460
Mass (Da):52,337
Last modified:May 1, 2000 - v1
Checksum:i2105D6C0A713B11D
GO
Isoform 2 (identifier: Q9UJW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:403
Mass (Da):45,757
Checksum:i4919CE2359032038
GO
Isoform 3 (identifier: Q9UJW0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: S → SQHTIHVV

Show »
Length:467
Mass (Da):53,152
Checksum:i2D4A445A6B764656
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVE0H9KVE0_HUMAN
Dynactin subunit 4
DCTN4
134Annotation score:
E5RGG1E5RGG1_HUMAN
Dynactin subunit 4
DCTN4
114Annotation score:
E5RK21E5RK21_HUMAN
Dynactin subunit 4
DCTN4
91Annotation score:
E5RI97E5RI97_HUMAN
Dynactin subunit 4
DCTN4
86Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05403795P → T1 PublicationCorresponds to variant dbSNP:rs11550931Ensembl.1
Natural variantiVAR_033847263Y → C. Corresponds to variant dbSNP:rs35772018Ensembl.1
Natural variantiVAR_024336342F → L1 PublicationCorresponds to variant dbSNP:rs11954652Ensembl.1
Natural variantiVAR_024337438S → N. Corresponds to variant dbSNP:rs3733923Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413061 – 57Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_041307179S → SQHTIHVV in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195120 mRNA Translation: AAF03896.1
AK125973 mRNA Translation: BAG54272.1
AK000299 mRNA Translation: BAA91066.1
AC008450 Genomic DNA No translation available.
AC008453 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61706.1
CH471062 Genomic DNA Translation: EAW61707.1
CH471062 Genomic DNA Translation: EAW61709.1
BC026323 mRNA Translation: AAH26323.1
CCDSiCCDS4310.1 [Q9UJW0-1]
CCDS47310.1 [Q9UJW0-3]
CCDS47311.1 [Q9UJW0-2]
RefSeqiNP_001129115.1, NM_001135643.1 [Q9UJW0-3]
NP_001129116.1, NM_001135644.1 [Q9UJW0-2]
NP_057305.1, NM_016221.3 [Q9UJW0-1]
XP_011535946.1, XM_011537644.1 [Q9UJW0-2]
XP_011535947.1, XM_011537645.1 [Q9UJW0-2]
UniGeneiHs.675564

Genome annotation databases

EnsembliENST00000424236; ENSP00000411251; ENSG00000132912 [Q9UJW0-2]
ENST00000446090; ENSP00000414906; ENSG00000132912 [Q9UJW0-3]
ENST00000447998; ENSP00000416968; ENSG00000132912 [Q9UJW0-1]
GeneIDi51164
KEGGihsa:51164
UCSCiuc003lsu.4 human [Q9UJW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195120 mRNA Translation: AAF03896.1
AK125973 mRNA Translation: BAG54272.1
AK000299 mRNA Translation: BAA91066.1
AC008450 Genomic DNA No translation available.
AC008453 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61706.1
CH471062 Genomic DNA Translation: EAW61707.1
CH471062 Genomic DNA Translation: EAW61709.1
BC026323 mRNA Translation: AAH26323.1
CCDSiCCDS4310.1 [Q9UJW0-1]
CCDS47310.1 [Q9UJW0-3]
CCDS47311.1 [Q9UJW0-2]
RefSeqiNP_001129115.1, NM_001135643.1 [Q9UJW0-3]
NP_001129116.1, NM_001135644.1 [Q9UJW0-2]
NP_057305.1, NM_016221.3 [Q9UJW0-1]
XP_011535946.1, XM_011537644.1 [Q9UJW0-2]
XP_011535947.1, XM_011537645.1 [Q9UJW0-2]
UniGeneiHs.675564

3D structure databases

ProteinModelPortaliQ9UJW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119345, 55 interactors
CORUMiQ9UJW0
IntActiQ9UJW0, 20 interactors
MINTiQ9UJW0
STRINGi9606.ENSP00000414906

PTM databases

iPTMnetiQ9UJW0
PhosphoSitePlusiQ9UJW0

Polymorphism and mutation databases

BioMutaiDCTN4
DMDMi62900106

Proteomic databases

EPDiQ9UJW0
PaxDbiQ9UJW0
PeptideAtlasiQ9UJW0
PRIDEiQ9UJW0
ProteomicsDBi84667
84668 [Q9UJW0-2]
84669 [Q9UJW0-3]

Protocols and materials databases

DNASUi51164
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424236; ENSP00000411251; ENSG00000132912 [Q9UJW0-2]
ENST00000446090; ENSP00000414906; ENSG00000132912 [Q9UJW0-3]
ENST00000447998; ENSP00000416968; ENSG00000132912 [Q9UJW0-1]
GeneIDi51164
KEGGihsa:51164
UCSCiuc003lsu.4 human [Q9UJW0-1]

Organism-specific databases

CTDi51164
DisGeNETi51164
EuPathDBiHostDB:ENSG00000132912.12
GeneCardsiDCTN4
HGNCiHGNC:15518 DCTN4
HPAiCAB017532
HPA038026
MalaCardsiDCTN4
MIMi614758 gene
neXtProtiNX_Q9UJW0
OpenTargetsiENSG00000132912
Orphaneti586 Cystic fibrosis
PharmGKBiPA27183
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3896 Eukaryota
ENOG410ZCK8 LUCA
GeneTreeiENSGT00390000006954
HOGENOMiHOG000007947
HOVERGENiHBG051324
InParanoidiQ9UJW0
KOiK10426
OMAiNCLENIP
OrthoDBiEOG091G0FIJ
PhylomeDBiQ9UJW0
TreeFamiTF105249

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiDCTN4 human
GenomeRNAii51164
PROiPR:Q9UJW0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132912 Expressed in 225 organ(s), highest expression level in cerebral cortex
CleanExiHS_DCTN4
ExpressionAtlasiQ9UJW0 baseline and differential
GenevisibleiQ9UJW0 HS

Family and domain databases

InterProiView protein in InterPro
IPR008603 DCTN4
PANTHERiPTHR13034 PTHR13034, 1 hit
PfamiView protein in Pfam
PF05502 Dynactin_p62, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN4_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW0
Secondary accession number(s): B3KWW0
, D3DQH0, E5RGT5, Q8TAN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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