Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9UJV3 (TRIM1_HUMAN)

Protein

Probable E3 ubiquitin-protein ligase MID2

Gene

MID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in microtubule stabilization.1 Publication

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 80RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri137 – 184B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri190 – 232B box-type 2PROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • microtubule binding Source: UniProtKB
  • phosphoprotein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transferase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Protein family/group databases

MoonDBiQ9UJV3 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase MID2 (EC:2.3.2.27)
Alternative name(s):
Midin-2
Midline defect 2
Midline-2
RING finger protein 60
RING-type E3 ubiquitin transferase MID2Curated
Tripartite motif-containing protein 1
Gene namesi
Name:MID2
Synonyms:FXY2, RNF60, TRIM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000080561.13
HGNCiHGNC:7096 MID2
MIMi300204 gene
neXtProtiNX_Q9UJV3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 101 (MRX101)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX101 clinical features include global developmental delay, hyperactivity often with aggressive outbursts, and seizures in some patients. Several affected individuals have long face, prominent ears, and squint or strabismus.
See also OMIM:300928
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071836347R → Q in MRX101; the mutant is abnormally localized in aggregates or enclosed in cytoplasmic vesicles rather than being bound to microtubules. 1 PublicationCorresponds to variant dbSNP:rs587777605EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi11043
MalaCardsiMID2
MIMi300928 phenotype
OpenTargetsiENSG00000080561
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA30817

Polymorphism and mutation databases

BioMutaiMID2
DMDMi294862489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000561931 – 735Probable E3 ubiquitin-protein ligase MID2Add BLAST735

Post-translational modificationi

Phosphorylated on serine and threonine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJV3
PaxDbiQ9UJV3
PeptideAtlasiQ9UJV3
PRIDEiQ9UJV3
ProteomicsDBi84662
84663 [Q9UJV3-2]

PTM databases

iPTMnetiQ9UJV3
PhosphoSitePlusiQ9UJV3

Expressioni

Tissue specificityi

Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.

Gene expression databases

BgeeiENSG00000080561 Expressed in 176 organ(s), highest expression level in muscle tissue
CleanExiHS_MID2
ExpressionAtlasiQ9UJV3 baseline and differential
GenevisibleiQ9UJV3 HS

Interactioni

Subunit structurei

Homodimer or heterodimer with MID1. Interacts with IGBP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
B3KPU63EBI-10172526,EBI-10175879
ADAMTSL4Q6UY14-35EBI-10172526,EBI-10173507
AENQ8WTP83EBI-10172526,EBI-8637627
AQP1P299723EBI-10172526,EBI-745213
ATRIPQ8WXE13EBI-10172526,EBI-747353
AXIN1A0A0S2Z4M13EBI-10172526,EBI-16429430
AXIN1O151693EBI-10172526,EBI-710484
BCL6BA8KA135EBI-10172526,EBI-10174813
BRMS1LQ5PSV43EBI-10172526,EBI-5666615
BYSLQ138957EBI-10172526,EBI-358049
CALCOCO2Q131373EBI-10172526,EBI-739580
CARD9Q9H257-24EBI-10172526,EBI-11530605
CBX8Q9HC525EBI-10172526,EBI-712912
CCDC120Q96HB5-43EBI-10172526,EBI-10185348
CCDC42Q96M953EBI-10172526,EBI-747041
CCHCR1Q8TD31-37EBI-10172526,EBI-10175300
CEP57L1Q8IYX83EBI-10172526,EBI-1104570
CEP57L1Q8IYX8-23EBI-10172526,EBI-10181988
CHD2O146473EBI-10172526,EBI-1210503
CTSZQ9UBR25EBI-10172526,EBI-8636823
DCXO436023EBI-10172526,EBI-8646694
DGCR6LQ9BY275EBI-10172526,EBI-742953
DIEXFQ68CQ43EBI-10172526,EBI-747711
DMRT3Q9NQL95EBI-10172526,EBI-9679045
ELOAQ142413EBI-10172526,EBI-742350
FAM107AO95990-33EBI-10172526,EBI-10192902
FAM161AQ3B8205EBI-10172526,EBI-719941
FAM208BQ5VWN64EBI-10172526,EBI-745958
FAM214AQ32MH53EBI-10172526,EBI-2866142
FAM90A1Q86YD75EBI-10172526,EBI-6658203
FARS2O953635EBI-10172526,EBI-2513774
FBF1Q8TES7-63EBI-10172526,EBI-10244131
FBXL18Q96D163EBI-10172526,EBI-744419
FLJ13057Q53SE73EBI-10172526,EBI-10172181
FRMD6Q96NE93EBI-10172526,EBI-741729
GMCL1Q96IK54EBI-10172526,EBI-2548508
GMCL2Q8NEA94EBI-10172526,EBI-745707
GOLGA2Q083793EBI-10172526,EBI-618309
GORASP2Q9H8Y85EBI-10172526,EBI-739467
HOXB9P174825EBI-10172526,EBI-745290
IL16Q14005-24EBI-10172526,EBI-17178971
IQCNQ9H0B33EBI-10172526,EBI-745878
ISCUQ9H1K13EBI-10172526,EBI-1047335
JOSD1Q150403EBI-10172526,EBI-2510602
KIFC3Q9BVG83EBI-10172526,EBI-2125614
KIFC3Q9BVG8-54EBI-10172526,EBI-14069005
LENG1Q96BZ85EBI-10172526,EBI-726510
LGALS14Q8TCE95EBI-10172526,EBI-10274069
LGALS8O002143EBI-10172526,EBI-740058
LNX1Q8TBB14EBI-10172526,EBI-739832
MAGOHBQ96A723EBI-10172526,EBI-746778
METTL17Q9H7H06EBI-10172526,EBI-749353
MFAP1P550815EBI-10172526,EBI-1048159
MID1O1534410EBI-10172526,EBI-2340316
MID1IP1Q9NPA33EBI-10172526,EBI-750096
MOSP005403EBI-10172526,EBI-1757866
NR1D2Q6NSM03EBI-10172526,EBI-10250949
NXF1Q9UBU93EBI-10172526,EBI-398874
OTUB2Q96DC93EBI-10172526,EBI-746259
PPP1R18Q6NYC85EBI-10172526,EBI-2557469
PRPF3O433953EBI-10172526,EBI-744322
PRPF31Q8WWY38EBI-10172526,EBI-1567797
PSMA1P257865EBI-10172526,EBI-359352
RCOR3Q9P2K33EBI-10172526,EBI-743428
RNF6A0A0S2Z4G93EBI-10172526,EBI-16428950
RPH3ALQ9UNE23EBI-10172526,EBI-2855824
RPP25LQ8N5L83EBI-10172526,EBI-10189722
RUNX1T1Q06455-43EBI-10172526,EBI-10224192
RXRBP28702-33EBI-10172526,EBI-16429492
RYDENQ9NUL53EBI-10172526,EBI-10313866
SCNM1Q9BWG63EBI-10172526,EBI-748391
SDCBPO005603EBI-10172526,EBI-727004
SLC25A48Q6ZT893EBI-10172526,EBI-10255185
SLC25A6P122363EBI-10172526,EBI-356254
SNAI1O958633EBI-10172526,EBI-1045459
SNAP47Q5SQN13EBI-10172526,EBI-10244848
SPATA24Q86W543EBI-10172526,EBI-3916986
SPG21Q9NZD85EBI-10172526,EBI-742688
SPRY2O435973EBI-10172526,EBI-742487
STX11O755583EBI-10172526,EBI-714135
SYT17Q9BSW77EBI-10172526,EBI-745392
TCEA2Q155603EBI-10172526,EBI-710310
THAP7Q9BT495EBI-10172526,EBI-741350
TOP3BO959855EBI-10172526,EBI-373403
TRIM27P143733EBI-10172526,EBI-719493
TRIM42Q8IWZ53EBI-10172526,EBI-5235829
TRIM54Q9BYV25EBI-10172526,EBI-2130429
TRIM69Q86WT6-24EBI-10172526,EBI-11525489
TSGA10Q9BZW73EBI-10172526,EBI-744794
UBE2D1P516685EBI-10172526,EBI-743540
UBE2D4Q9Y2X85EBI-10172526,EBI-745527
UBE2E2Q96LR55EBI-10172526,EBI-2129763
UBTD1Q9HAC83EBI-10172526,EBI-745871
UNC45AQ9H3U13EBI-10172526,EBI-1048763
UTP23Q9BRU93EBI-10172526,EBI-5457544
WT1-ASQ062505EBI-10172526,EBI-10223946
ZBTB24O431675EBI-10172526,EBI-744471
ZC2HC1CQ53FD03EBI-10172526,EBI-740767
ZFABQ9Y2603EBI-10172526,EBI-750052
ZFYVE21Q9BQ243EBI-10172526,EBI-2849569
ZGPATA0A0S2Z6H03EBI-10172526,EBI-16428984
ZGPATQ8N5A53EBI-10172526,EBI-3439227
ZGPATQ8N5A5-28EBI-10172526,EBI-10183064
ZNF165Q53Z403EBI-10172526,EBI-10186058
ZNF24P170283EBI-10172526,EBI-707773
ZNF250P15622-33EBI-10172526,EBI-10177272
ZNF417Q8TAU35EBI-10172526,EBI-740727
ZNF438Q7Z4V04EBI-10172526,EBI-11962468
ZNF440Q8IYI85EBI-10172526,EBI-726439
ZNF564Q8TBZ85EBI-10172526,EBI-10273713
ZNF587Q96SQ55EBI-10172526,EBI-6427977
ZNF688A0A0S2Z5X43EBI-10172526,EBI-16429014
ZNF785A8K8V03EBI-10172526,EBI-3925400
ZNF792Q3KQV35EBI-10172526,EBI-10240849
ZSCAN12O433095EBI-10172526,EBI-1210440

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116231, 151 interactors
IntActiQ9UJV3, 238 interactors
MINTiQ9UJV3
STRINGi9606.ENSP00000262843

Structurei

Secondary structure

1735
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UJV3
SMRiQ9UJV3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UJV3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 399COSPROSITE-ProRule annotationAdd BLAST60
Domaini398 – 531Fibronectin type-IIIAdd BLAST134
Domaini516 – 709B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili233 – 301Sequence analysisAdd BLAST69

Domaini

The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates dimerization.By similarity
Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 80RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri137 – 184B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri190 – 232B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF1 Eukaryota
ENOG410YTG8 LUCA
GeneTreeiENSGT00760000118878
HOGENOMiHOG000049193
HOVERGENiHBG056432
InParanoidiQ9UJV3
KOiK10647
OMAiTWYAIGV
OrthoDBiEOG091G02K9
PhylomeDBiQ9UJV3
TreeFamiTF333654

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd13739 SPRY_PRY_TRIM1, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003649 Bbox_C
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR033491 MID2
IPR035752 SPRY/PRY_TRIM1
IPR003877 SPRY_dom
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR44073:SF2 PTHR44073:SF2, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGESPASVVL NASGGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC 
        60         70         80         90        100
FSCAHRILVS SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ 
       110        120        130        140        150
NIIDRFQKAS VSGPNSPSES RRERTYRPTT AMSSERIACQ FCEQDPPRDA 
       160        170        180        190        200
VKTCITCEVS YCDRCLRATH PNKKPFTSHR LVEPVPDTHL RGITCLDHEN 
       210        220        230        240        250
EKVNMYCVSD DQLICALCKL VGRHRDHQVA SLNDRFEKLK QTLEMNLTNL 
       260        270        280        290        300
VKRNSELENQ MAKLIQICQQ VEVNTAMHEA KLMEECDELV EIIQQRKQMI 
       310        320        330        340        350
AVKIKETKVM KLRKLAQQVA NCRQCLERST VLINQAEHIL KENDQARFLQ 
       360        370        380        390        400
SAKNIAERVA MATASSQVLI PDINFNDAFE NFALDFSREK KLLEGLDYLT 
       410        420        430        440        450
APNPPSIREE LCTASHDTIT VHWISDDEFS ISSYELQYTI FTGQANFISK 
       460        470        480        490        500
SWCSWGLWPE IRKCKEAVSC SRLAGAPRGL YNSVDSWMIV PNIKQNHYTV 
       510        520        530        540        550
HGLQSGTRYI FIVKAINQAG SRNSEPTRLK TNSQPFKLDP KMTHKKLKIS 
       560        570        580        590        600
NDGLQMEKDE SSLKKSHTPE RFSGTGCYGA AGNIFIDSGC HYWEVVMGSS 
       610        620        630        640        650
TWYAIGIAYK SAPKNEWIGK NASSWVFSRC NSNFVVRHNN KEMLVDVPPH 
       660        670        680        690        700
LKRLGVLLDY DNNMLSFYDP ANSLHLHTFD VTFILPVCPT FTIWNKSLMI 
       710        720        730 
LSGLPAPDFI DYPERQECNC RPQESPYVSG MKTCH
Length:735
Mass (Da):83,210
Last modified:April 20, 2010 - v3
Checksum:i22A0EC26B050EA21
GO
Isoform 2 (identifier: Q9UJV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-479: Missing.

Show »
Length:705
Mass (Da):79,865
Checksum:i130A24684FB5AEC7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVI4A6PVI4_HUMAN
Probable E3 ubiquitin-protein ligas...
MID2
218Annotation score:

Sequence cautioni

The sequence AAF07341 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH17707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB56154 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071835343N → S Polymorphism; the protein is normally bound to microtubules. 1 PublicationCorresponds to variant dbSNP:rs551253128Ensembl.1
Natural variantiVAR_071836347R → Q in MRX101; the mutant is abnormally localized in aggregates or enclosed in cytoplasmic vesicles rather than being bound to microtubules. 1 PublicationCorresponds to variant dbSNP:rs587777605EnsemblClinVar.1
Natural variantiVAR_052123378A → D. Corresponds to variant dbSNP:rs12849510Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009009450 – 479Missing in isoform 2. 3 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196481 mRNA Translation: AAF07341.1 Different initiation.
Y18880 mRNA Translation: CAB56154.1 Different initiation.
AL034399 Genomic DNA No translation available.
AL109946 Genomic DNA No translation available.
BC017707 mRNA Translation: AAH17707.1 Different initiation.
BT006663 mRNA Translation: AAP35309.1
CCDSiCCDS14532.2 [Q9UJV3-1]
CCDS14533.2 [Q9UJV3-2]
RefSeqiNP_036348.2, NM_012216.3 [Q9UJV3-1]
NP_438112.2, NM_052817.2 [Q9UJV3-2]
XP_005262119.1, XM_005262062.4
XP_016884728.1, XM_017029239.1
UniGeneiHs.12256

Genome annotation databases

EnsembliENST00000262843; ENSP00000262843; ENSG00000080561 [Q9UJV3-1]
ENST00000443968; ENSP00000413976; ENSG00000080561 [Q9UJV3-2]
GeneIDi11043
KEGGihsa:11043
UCSCiuc004enk.4 human [Q9UJV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196481 mRNA Translation: AAF07341.1 Different initiation.
Y18880 mRNA Translation: CAB56154.1 Different initiation.
AL034399 Genomic DNA No translation available.
AL109946 Genomic DNA No translation available.
BC017707 mRNA Translation: AAH17707.1 Different initiation.
BT006663 mRNA Translation: AAP35309.1
CCDSiCCDS14532.2 [Q9UJV3-1]
CCDS14533.2 [Q9UJV3-2]
RefSeqiNP_036348.2, NM_012216.3 [Q9UJV3-1]
NP_438112.2, NM_052817.2 [Q9UJV3-2]
XP_005262119.1, XM_005262062.4
XP_016884728.1, XM_017029239.1
UniGeneiHs.12256

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJANMR-A182-252[»]
2DMKNMR-A394-537[»]
ProteinModelPortaliQ9UJV3
SMRiQ9UJV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116231, 151 interactors
IntActiQ9UJV3, 238 interactors
MINTiQ9UJV3
STRINGi9606.ENSP00000262843

Protein family/group databases

MoonDBiQ9UJV3 Predicted

PTM databases

iPTMnetiQ9UJV3
PhosphoSitePlusiQ9UJV3

Polymorphism and mutation databases

BioMutaiMID2
DMDMi294862489

Proteomic databases

EPDiQ9UJV3
PaxDbiQ9UJV3
PeptideAtlasiQ9UJV3
PRIDEiQ9UJV3
ProteomicsDBi84662
84663 [Q9UJV3-2]

Protocols and materials databases

DNASUi11043
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262843; ENSP00000262843; ENSG00000080561 [Q9UJV3-1]
ENST00000443968; ENSP00000413976; ENSG00000080561 [Q9UJV3-2]
GeneIDi11043
KEGGihsa:11043
UCSCiuc004enk.4 human [Q9UJV3-1]

Organism-specific databases

CTDi11043
DisGeNETi11043
EuPathDBiHostDB:ENSG00000080561.13
GeneCardsiMID2
HGNCiHGNC:7096 MID2
MalaCardsiMID2
MIMi300204 gene
300928 phenotype
neXtProtiNX_Q9UJV3
OpenTargetsiENSG00000080561
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA30817
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITF1 Eukaryota
ENOG410YTG8 LUCA
GeneTreeiENSGT00760000118878
HOGENOMiHOG000049193
HOVERGENiHBG056432
InParanoidiQ9UJV3
KOiK10647
OMAiTWYAIGV
OrthoDBiEOG091G02K9
PhylomeDBiQ9UJV3
TreeFamiTF333654

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

EvolutionaryTraceiQ9UJV3
GeneWikiiMID2
GenomeRNAii11043
PROiPR:Q9UJV3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080561 Expressed in 176 organ(s), highest expression level in muscle tissue
CleanExiHS_MID2
ExpressionAtlasiQ9UJV3 baseline and differential
GenevisibleiQ9UJV3 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd13739 SPRY_PRY_TRIM1, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003649 Bbox_C
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR033491 MID2
IPR035752 SPRY/PRY_TRIM1
IPR003877 SPRY_dom
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR44073:SF2 PTHR44073:SF2, 1 hit
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRIM1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJV3
Secondary accession number(s): A6NEL8
, A6PVI5, Q5JYF5, Q8WWK1, Q9UJR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again