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UniProtKB - Q9UJV3 (TRIM1_HUMAN)

Entry version 202 (23 Feb 2022)
Sequence version 3 (20 Apr 2010)
Previous versions | rss
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Protein

Probable E3 ubiquitin-protein ligase MID2

Gene

MID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in microtubule stabilization.

1 Publication

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi195ZincPROSITE-ProRule annotation1
Metal bindingi198ZincPROSITE-ProRule annotation1
Metal bindingi218ZincPROSITE-ProRule annotation1
Metal bindingi224ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri30 – 80RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri137 – 184B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri190 – 232B box-type 2PROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UJV3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UJV3

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q9UJV3, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase MID2 (EC:2.3.2.27)
Alternative name(s):
Midin-2
Midline defect 2
Midline-2
RING finger protein 60
RING-type E3 ubiquitin transferase MID2Curated
Tripartite motif-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MID2
Synonyms:FXY2, RNF60, TRIM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7096, MID2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300204, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UJV3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000080561

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder, X-linked 101 (XLID101)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. XLID101 clinical features include global developmental delay, hyperactivity often with aggressive outbursts, and seizures in some patients. Several affected individuals have long face, prominent ears, and squint or strabismus.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071836347R → Q in XLID101; the mutant is abnormally localized in aggregates or enclosed in cytoplasmic vesicles rather than being bound to microtubules. 1 PublicationCorresponds to variant dbSNP:rs587777605EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		11043

MalaCards human disease database

More...MalaCardsi		MID2
MIMi300928, phenotype

Open Targets

More...OpenTargetsi		ENSG00000080561

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		777, X-linked non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30817

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UJV3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MID2

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862489

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561931 – 735Probable E3 ubiquitin-protein ligase MID2Add BLAST735

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UJV3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UJV3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UJV3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UJV3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UJV3

PeptideAtlas

More...PeptideAtlasi		Q9UJV3

PRoteomics IDEntifications database

More...PRIDEi		Q9UJV3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84662 [Q9UJV3-1]
84663 [Q9UJV3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UJV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UJV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000080561, Expressed in stomach and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UJV3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UJV3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000080561, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer with MID1.

Interacts with IGBP1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

MID2 - isoform 2 [Q9UJV3-2]
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]6EBI-10172526,EBI-10173507
AEN [Q8WTP8]3EBI-10172526,EBI-8637627
ALDH3B1 [P43353]3EBI-10172526,EBI-2558314
ANKS1A [Q49AR9]3EBI-10172526,EBI-11954519
AP1M1 [Q9BXS5]3EBI-10172526,EBI-541426
AQP1 [P29972]3EBI-10172526,EBI-745213
ARHGEF5 [Q12774]3EBI-10172526,EBI-602199
ATRIP [Q8WXE1]3EBI-10172526,EBI-747353
AXIN1 [A0A0S2Z4M1]3EBI-10172526,EBI-16429430
AXIN1 [O15169]3EBI-10172526,EBI-710484
BAHD1 [Q8TBE0]3EBI-10172526,EBI-742750
BCL6B [A8KA13]6EBI-10172526,EBI-10174813
BLK [P51451]3EBI-10172526,EBI-2105445
BLZF1 [Q9H2G9]5EBI-10172526,EBI-2548012
BRMS1L [Q5PSV4]3EBI-10172526,EBI-5666615
BYSL [Q13895]8EBI-10172526,EBI-358049
CALCOCO2 [Q13137]3EBI-10172526,EBI-739580
CARD9 - isoform 2 [Q9H257-2]3EBI-10172526,EBI-11530605
CARHSP1 [Q9Y2V2]3EBI-10172526,EBI-718719
CBX8 [Q9HC52]6EBI-10172526,EBI-712912
CCDC120 [Q96HB5]3EBI-10172526,EBI-744556
CCDC120 - isoform 4 [Q96HB5-4]3EBI-10172526,EBI-10185348
CCDC185 [Q8N715]3EBI-10172526,EBI-740814
CCDC42 [Q96M95]3EBI-10172526,EBI-747041
CCDC42 - isoform 2 [Q96M95-2]3EBI-10172526,EBI-11750401
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-10172526,EBI-10175300
CDK18 [Q07002]3EBI-10172526,EBI-746238
CEP57L1 [Q8IYX8]3EBI-10172526,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-10172526,EBI-10181988
CFP [P27918]3EBI-10172526,EBI-9038570
CHD2 [O14647]3EBI-10172526,EBI-1210503
CNNM3 [Q8NE01]3EBI-10172526,EBI-741032
COX5B [P10606]3EBI-10172526,EBI-1053725
CPSF4 - isoform 2 [O95639-2]3EBI-10172526,EBI-13063650
CRACR2A [Q9BSW2]3EBI-10172526,EBI-739773
CREBRF [Q8IUR6]3EBI-10172526,EBI-1042699
CTSZ [Q9UBR2]6EBI-10172526,EBI-8636823
DCX [O43602]3EBI-10172526,EBI-8646694
DCX - isoform 2 [O43602-2]3EBI-10172526,EBI-14148644
DGCR6L [Q9BY27]6EBI-10172526,EBI-742953
DMRT3 [Q9NQL9]6EBI-10172526,EBI-9679045
DYDC1 [Q8WWB3]3EBI-10172526,EBI-740680
EFHC2 [Q5JST6]3EBI-10172526,EBI-2349927
EGFL7 [Q9UHF1]3EBI-10172526,EBI-949532
EIF1AD [Q8N9N8]3EBI-10172526,EBI-750700
ELOA [Q14241]3EBI-10172526,EBI-742350
ENKD1 [Q9H0I2]3EBI-10172526,EBI-744099
EPN2 - isoform 2 [O95208-2]3EBI-10172526,EBI-12135243
ETNK2 [Q9NVF9]3EBI-10172526,EBI-751864
FAM107A - isoform 3 [O95990-3]3EBI-10172526,EBI-10192902
FAM161A [Q3B820]6EBI-10172526,EBI-719941
FAM161B [Q96MY7]3EBI-10172526,EBI-7225287
FAM214A [Q32MH5]3EBI-10172526,EBI-2866142
FAM214B [Q7L5A3]3EBI-10172526,EBI-745689
FAM50B [Q9Y247]3EBI-10172526,EBI-742802
FAM90A1 [Q86YD7]6EBI-10172526,EBI-6658203
FARS2 [O95363]6EBI-10172526,EBI-2513774
FASTKD5 [Q7L8L6]3EBI-10172526,EBI-747570
FBF1 - isoform 6 [Q8TES7-6]3EBI-10172526,EBI-10244131
FBXL18 [Q96D16]3EBI-10172526,EBI-744419
FBXW5 [Q969U6]3EBI-10172526,EBI-741068
FLJ13057 [Q53SE7]3EBI-10172526,EBI-10172181
FOXD4L3 [Q6VB84]3EBI-10172526,EBI-11961494
FRMD6 [Q96NE9]3EBI-10172526,EBI-741729
FSD2 [A1L4K1]3EBI-10172526,EBI-5661036
GAS2L2 [Q8NHY3]3EBI-10172526,EBI-7960826
GAS8 [O95995]3EBI-10172526,EBI-1052570
GCC1 [Q96CN9]3EBI-10172526,EBI-746252
GEM [P55040]4EBI-10172526,EBI-744104
GMCL1 [Q96IK5]5EBI-10172526,EBI-2548508
GOLGA2 [Q08379]3EBI-10172526,EBI-618309
GOLGA7 [Q7Z5G4]3EBI-10172526,EBI-4403685
GORASP2 [Q9H8Y8]6EBI-10172526,EBI-739467
GPANK1 [O95872]3EBI-10172526,EBI-751540
GPKOW [Q92917]3EBI-10172526,EBI-746309
GSC2 [O15499]3EBI-10172526,EBI-19954058
HAPLN2 [Q9GZV7]3EBI-10172526,EBI-11956675
HCK - isoform 2 [P08631-2]3EBI-10172526,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-10172526,EBI-11953488
HDX [Q7Z353]3EBI-10172526,EBI-1052734
HOXB2 [P14652]3EBI-10172526,EBI-5329558
HOXB5 [P09067]3EBI-10172526,EBI-3893317
HOXB9 [P17482]6EBI-10172526,EBI-745290
IGFN1 - isoform 5 [Q86VF2-5]3EBI-10172526,EBI-11955401
IHO1 [Q8IYA8]3EBI-10172526,EBI-8638439
IKZF3 [Q9UKT9]5EBI-10172526,EBI-747204
IL16 - isoform 2 [Q14005-2]6EBI-10172526,EBI-17178971
INO80B [Q9C086]3EBI-10172526,EBI-715611
IQCN [Q9H0B3]3EBI-10172526,EBI-745878
ISCU [Q9H1K1]3EBI-10172526,EBI-1047335
ITGB4 - isoform Beta-4A [P16144-2]3EBI-10172526,EBI-11051601
JOSD1 [Q15040]3EBI-10172526,EBI-2510602
KANK2 [Q63ZY3]3EBI-10172526,EBI-2556193
KIF9 [Q9HAQ2]3EBI-10172526,EBI-8472129
KIFC3 [Q9BVG8]3EBI-10172526,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-10172526,EBI-14069005
KRT27 [Q7Z3Y8]3EBI-10172526,EBI-3044087
KRT31 [Q15323]3EBI-10172526,EBI-948001
KRT40 [Q6A162]3EBI-10172526,EBI-10171697
KRT75 [O95678]3EBI-10172526,EBI-2949715
KRT76 [Q01546]3EBI-10172526,EBI-2952745
LAGE3 [Q14657]3EBI-10172526,EBI-1052105
LENG1 [Q96BZ8]6EBI-10172526,EBI-726510
LGALS14 [Q8TCE9]6EBI-10172526,EBI-10274069
LGALS8 [O00214]3EBI-10172526,EBI-740058
LGALS8 - isoform 2 [O00214-2]3EBI-10172526,EBI-12069522
LMNB2 [Q03252]3EBI-10172526,EBI-2830427
LMNTD2 [Q8IXW0]3EBI-10172526,EBI-12028858
LMO3 - isoform 4 [Q8TAP4-4]3EBI-10172526,EBI-11742507
LMO4 [P61968]3EBI-10172526,EBI-2798728
LNX1 [Q8TBB1]6EBI-10172526,EBI-739832
LONRF1 [Q17RB8]3EBI-10172526,EBI-2341787
LRRC45 [Q96CN5]3EBI-10172526,EBI-2805176
LZTS1 [Q9Y250]3EBI-10172526,EBI-1216080
LZTS2 [Q9BRK4]3EBI-10172526,EBI-741037
MAGEA6 [P43360]3EBI-10172526,EBI-1045155
MAGOHB [Q96A72]3EBI-10172526,EBI-746778
MEOX1 [P50221]3EBI-10172526,EBI-2864512
MEOX2 [Q6FHY5]3EBI-10172526,EBI-16439278
METTL17 [Q9H7H0]6EBI-10172526,EBI-749353
METTL17 - isoform 2 [Q9H7H0-2]3EBI-10172526,EBI-11098807
MFAP1 [P55081]6EBI-10172526,EBI-1048159
MGC50722 [Q8IVT4]3EBI-10172526,EBI-14086479
MID1 [O15344]9EBI-10172526,EBI-2340316
MID1IP1 [Q9NPA3]3EBI-10172526,EBI-750096
itself4EBI-10172526,EBI-10172526
MMTAG2 [Q9BU76]3EBI-10172526,EBI-742459
MOS [P00540]3EBI-10172526,EBI-1757866
NCOA4 - isoform 3 [Q13772-3]3EBI-10172526,EBI-12054609
NR1D2 [Q6NSM0]3EBI-10172526,EBI-10250949
NSMF - isoform 2 [Q6X4W1-2]3EBI-10172526,EBI-12028784
NXF1 [Q9UBU9]3EBI-10172526,EBI-398874
OTUB2 [Q96DC9]3EBI-10172526,EBI-746259
PICK1 [Q9NRD5]3EBI-10172526,EBI-79165
PKN1 [Q16512]3EBI-10172526,EBI-602382
POLDIP3 [Q8WUT1]3EBI-10172526,EBI-10276663
PPP1R18 [Q6NYC8]6EBI-10172526,EBI-2557469
PRPF3 [O43395]3EBI-10172526,EBI-744322
PRPF31 [Q8WWY3]11EBI-10172526,EBI-1567797
PSMA1 [P25786]6EBI-10172526,EBI-359352
PTCD2 [Q8WV60]3EBI-10172526,EBI-12154567
PTPDC1 [A2A3K4]3EBI-10172526,EBI-11603375
QARS1 [P47897]3EBI-10172526,EBI-347462
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-10172526,EBI-14093916
RANBP3L [Q86VV4]3EBI-10172526,EBI-12028066
RCOR3 [Q9P2K3]3EBI-10172526,EBI-743428
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-10172526,EBI-1504830
REL - isoform 2 [Q04864-2]3EBI-10172526,EBI-10829018
RLN1 [P04808]3EBI-10172526,EBI-12071382
RNF6 [A0A0S2Z4G9]3EBI-10172526,EBI-16428950
RORB - isoform 1 [Q92753-1]3EBI-10172526,EBI-18560266
RPH3AL [Q9UNE2]3EBI-10172526,EBI-2855824
RPP25L [Q8N5L8]3EBI-10172526,EBI-10189722
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-10172526,EBI-11984663
RUNX1T1 - isoform 4 [Q06455-4]3EBI-10172526,EBI-10224192
RXRB - isoform 2 [P28702-3]3EBI-10172526,EBI-16429492
SCNM1 [Q9BWG6]3EBI-10172526,EBI-748391
SDCBP [O00560]3EBI-10172526,EBI-727004
SEPTIN1 [Q8WYJ6]3EBI-10172526,EBI-693002
SHFL [Q9NUL5]3EBI-10172526,EBI-10313866
SLC25A48 [Q6ZT89]3EBI-10172526,EBI-10255185
SLC25A48 - isoform 3 [Q6ZT89-3]3EBI-10172526,EBI-12065614
SLC25A6 [P12236]3EBI-10172526,EBI-356254
SNAI1 [O95863]3EBI-10172526,EBI-1045459
SNAP47 [Q5SQN1]3EBI-10172526,EBI-10244848
SPATA24 [Q86W54]3EBI-10172526,EBI-3916986
SPG21 [Q9NZD8]6EBI-10172526,EBI-742688
SPRY2 [O43597]3EBI-10172526,EBI-742487
STX11 [O75558]3EBI-10172526,EBI-714135
SYNGAP1 [Q96PV0]3EBI-10172526,EBI-2682386
SYT17 [Q9BSW7]10EBI-10172526,EBI-745392
TASOR2 [Q5VWN6]3EBI-10172526,EBI-745958
TBC1D22B [Q9NU19]3EBI-10172526,EBI-8787464
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-10172526,EBI-11974855
TCEA2 [Q15560]3EBI-10172526,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-10172526,EBI-11955057
TEKT1 [Q969V4]3EBI-10172526,EBI-10180409
THAP7 [Q9BT49]6EBI-10172526,EBI-741350
TOP3B [O95985]6EBI-10172526,EBI-373403
TRIM27 [P14373]3EBI-10172526,EBI-719493
TRIM41 [Q8WV44]3EBI-10172526,EBI-725997
TRIM42 [Q8IWZ5]3EBI-10172526,EBI-5235829
TRIM54 [Q9BYV2]6EBI-10172526,EBI-2130429
TRIM69 - isoform 2 [Q86WT6-2]3EBI-10172526,EBI-11525489
TRPV6 [Q9Y260]3EBI-10172526,EBI-750052
TSGA10 [Q9BZW7]3EBI-10172526,EBI-744794
TTC23 - isoform 3 [Q5W5X9-3]3EBI-10172526,EBI-9090990
UBE2D1 [P51668]6EBI-10172526,EBI-743540
UBE2D2 [P62837]3EBI-10172526,EBI-347677
UBE2D3 [P61077]3EBI-10172526,EBI-348268
UBE2D4 [Q9Y2X8]6EBI-10172526,EBI-745527
UBE2E2 [Q96LR5]6EBI-10172526,EBI-2129763
UBE2E3 [Q969T4]3EBI-10172526,EBI-348496
UBE2K [P61086]3EBI-10172526,EBI-473850
UBTD1 [Q9HAC8]3EBI-10172526,EBI-745871
UNC45A [Q9H3U1]3EBI-10172526,EBI-1048763
USP2 [O75604]3EBI-10172526,EBI-743272
USP25 [Q9UHP3]3EBI-10172526,EBI-2513462
USP54 - isoform 6 [Q70EL1-9]3EBI-10172526,EBI-11975223
UTP23 [Q9BRU9]3EBI-10172526,EBI-5457544
UTP25 [Q68CQ4]3EBI-10172526,EBI-747711
WT1-AS [Q06250]3EBI-10172526,EBI-10223946
ZBTB16 [Q05516]3EBI-10172526,EBI-711925
ZBTB24 [O43167]6EBI-10172526,EBI-744471
ZBTB42 [B2RXF5]3EBI-10172526,EBI-12287587
ZC2HC1C [Q53FD0]3EBI-10172526,EBI-740767
ZFYVE21 [Q9BQ24]3EBI-10172526,EBI-2849569
ZGPAT [A0A0S2Z6H0]3EBI-10172526,EBI-16428984
ZGPAT [Q8N5A5]3EBI-10172526,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]9EBI-10172526,EBI-10183064
ZIM2 [Q9NZV7]3EBI-10172526,EBI-11962760
ZNF124 [Q15973]3EBI-10172526,EBI-2555767
ZNF165 [P49910]3EBI-10172526,EBI-741694
ZNF165 [Q53Z40]3EBI-10172526,EBI-10186058
ZNF177 - isoform 2 [Q13360-2]3EBI-10172526,EBI-12272076
ZNF24 [P17028]3EBI-10172526,EBI-707773
ZNF250 - isoform 3 [P15622-3]3EBI-10172526,EBI-10177272
ZNF266 [Q14584]3EBI-10172526,EBI-7115319
ZNF408 [Q9H9D4]3EBI-10172526,EBI-347633
ZNF410 - isoform 3 [Q86VK4-3]3EBI-10172526,EBI-11741890
ZNF417 [Q8TAU3]6EBI-10172526,EBI-740727
ZNF438 [Q7Z4V0]6EBI-10172526,EBI-11962468
ZNF440 [Q8IYI8]6EBI-10172526,EBI-726439
ZNF497 [Q6ZNH5]3EBI-10172526,EBI-10486136
ZNF552 [Q9H707]3EBI-10172526,EBI-2555731
ZNF564 [Q8TBZ8]6EBI-10172526,EBI-10273713
ZNF587 [Q96SQ5]6EBI-10172526,EBI-6427977
ZNF648 [Q5T619]3EBI-10172526,EBI-11985915
ZNF669 [Q96BR6]3EBI-10172526,EBI-12006574
ZNF688 [A0A0S2Z5X4]3EBI-10172526,EBI-16429014
ZNF696 [Q9H7X3]3EBI-10172526,EBI-11090299
ZNF764 [Q96H86]3EBI-10172526,EBI-745775
ZNF774 [Q6NX45]3EBI-10172526,EBI-10251462
ZNF784 [Q8NCA9]3EBI-10172526,EBI-7138303
ZNF785 [A8K8V0]3EBI-10172526,EBI-3925400
ZNF792 [Q3KQV3]6EBI-10172526,EBI-10240849
ZRANB1 [Q9UGI0]3EBI-10172526,EBI-527853
ZSCAN12 [O43309]6EBI-10172526,EBI-1210440
B3KPU63EBI-10172526,EBI-10175879

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116231, 279 interactors

Protein interaction database and analysis system

More...IntActi		Q9UJV3, 252 interactors

Molecular INTeraction database

More...MINTi		Q9UJV3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262843

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UJV3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1735
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9UJV3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UJV3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UJV3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini340 – 399COSPROSITE-ProRule annotationAdd BLAST60
Domaini398 – 531Fibronectin type-IIIAdd BLAST134
Domaini516 – 709B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili233 – 301Sequence analysisAdd BLAST69

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates dimerization.By similarity
Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 80RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri137 – 184B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri190 – 232B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159460

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013137_19_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UJV3

Identification of Orthologs from Complete Genome Data

More...OMAi		GERIACQ

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UJV3

TreeFam database of animal gene trees

More...TreeFami		TF333654

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit
cd13739, SPRY_PRY_TRIM1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit
2.60.40.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003649, Bbox_C
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR017903, COS_domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR033491, MID2
IPR040859, Midline-1_COS
IPR035752, SPRY/PRY_TRIM1
IPR003877, SPRY_dom
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...PANTHERi		PTHR24099:SF12, PTHR24099:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18568, COS, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 2 hits
SM00060, FN3, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS51262, COS, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGESPASVVL NASGGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC 
        60         70         80         90        100
FSCAHRILVS SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ 
       110        120        130        140        150
NIIDRFQKAS VSGPNSPSES RRERTYRPTT AMSSERIACQ FCEQDPPRDA 
       160        170        180        190        200
VKTCITCEVS YCDRCLRATH PNKKPFTSHR LVEPVPDTHL RGITCLDHEN 
       210        220        230        240        250
EKVNMYCVSD DQLICALCKL VGRHRDHQVA SLNDRFEKLK QTLEMNLTNL 
       260        270        280        290        300
VKRNSELENQ MAKLIQICQQ VEVNTAMHEA KLMEECDELV EIIQQRKQMI 
       310        320        330        340        350
AVKIKETKVM KLRKLAQQVA NCRQCLERST VLINQAEHIL KENDQARFLQ 
       360        370        380        390        400
SAKNIAERVA MATASSQVLI PDINFNDAFE NFALDFSREK KLLEGLDYLT 
       410        420        430        440        450
APNPPSIREE LCTASHDTIT VHWISDDEFS ISSYELQYTI FTGQANFISK 
       460        470        480        490        500
SWCSWGLWPE IRKCKEAVSC SRLAGAPRGL YNSVDSWMIV PNIKQNHYTV 
       510        520        530        540        550
HGLQSGTRYI FIVKAINQAG SRNSEPTRLK TNSQPFKLDP KMTHKKLKIS 
       560        570        580        590        600
NDGLQMEKDE SSLKKSHTPE RFSGTGCYGA AGNIFIDSGC HYWEVVMGSS 
       610        620        630        640        650
TWYAIGIAYK SAPKNEWIGK NASSWVFSRC NSNFVVRHNN KEMLVDVPPH 
       660        670        680        690        700
LKRLGVLLDY DNNMLSFYDP ANSLHLHTFD VTFILPVCPT FTIWNKSLMI 
       710        720        730 
LSGLPAPDFI DYPERQECNC RPQESPYVSG MKTCH
Length:735
Mass (Da):83,210
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22A0EC26B050EA21
GO
Isoform 2 (identifier: Q9UJV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-479: Missing.

Show »
Length:705
Mass (Da):79,865
Checksum:i130A24684FB5AEC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVI4A6PVI4_HUMAN
Probable E3 ubiquitin-protein ligas...
MID2
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF07341 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH17707 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB56154 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071835343N → S The protein is normally bound to microtubules. 1 PublicationCorresponds to variant dbSNP:rs551253128EnsemblClinVar.1
Natural variantiVAR_071836347R → Q in XLID101; the mutant is abnormally localized in aggregates or enclosed in cytoplasmic vesicles rather than being bound to microtubules. 1 PublicationCorresponds to variant dbSNP:rs587777605EnsemblClinVar.1
Natural variantiVAR_052123378A → D. Corresponds to variant dbSNP:rs12849510Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009009450 – 479Missing in isoform 2. 3 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF196481 mRNA Translation: AAF07341.1 Different initiation.
Y18880 mRNA Translation: CAB56154.1 Different initiation.
AL034399 Genomic DNA No translation available.
AL109946 Genomic DNA No translation available.
BC017707 mRNA Translation: AAH17707.1 Different initiation.
BT006663 mRNA Translation: AAP35309.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14532.2 [Q9UJV3-1]
CCDS14533.2 [Q9UJV3-2]

NCBI Reference Sequences

More...RefSeqi		NP_036348.2, NM_012216.3 [Q9UJV3-1]
NP_438112.2, NM_052817.2 [Q9UJV3-2]
XP_005262119.1, XM_005262062.4
XP_016884728.1, XM_017029239.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262843; ENSP00000262843; ENSG00000080561
ENST00000443968; ENSP00000413976; ENSG00000080561 [Q9UJV3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11043

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000262843.11; ENSP00000262843.6; NM_012216.4; NP_036348.2

UCSC genome browser

More...UCSCi		uc004enk.4, human [Q9UJV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196481 mRNA Translation: AAF07341.1 Different initiation.
Y18880 mRNA Translation: CAB56154.1 Different initiation.
AL034399 Genomic DNA No translation available.
AL109946 Genomic DNA No translation available.
BC017707 mRNA Translation: AAH17707.1 Different initiation.
BT006663 mRNA Translation: AAP35309.1
CCDSiCCDS14532.2 [Q9UJV3-1]
CCDS14533.2 [Q9UJV3-2]
RefSeqiNP_036348.2, NM_012216.3 [Q9UJV3-1]
NP_438112.2, NM_052817.2 [Q9UJV3-2]
XP_005262119.1, XM_005262062.4
XP_016884728.1, XM_017029239.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJANMR-A182-252[»]
2DMKNMR-A394-537[»]
BMRBiQ9UJV3
SMRiQ9UJV3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116231, 279 interactors
IntActiQ9UJV3, 252 interactors
MINTiQ9UJV3
STRINGi9606.ENSP00000262843

Protein family/group databases

MoonDBiQ9UJV3, Predicted

PTM databases

iPTMnetiQ9UJV3
PhosphoSitePlusiQ9UJV3

Genetic variation databases

BioMutaiMID2
DMDMi294862489

Proteomic databases

EPDiQ9UJV3
jPOSTiQ9UJV3
MassIVEiQ9UJV3
MaxQBiQ9UJV3
PaxDbiQ9UJV3
PeptideAtlasiQ9UJV3
PRIDEiQ9UJV3
ProteomicsDBi84662 [Q9UJV3-1]
84663 [Q9UJV3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29334, 185 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		11043

Genome annotation databases

EnsembliENST00000262843; ENSP00000262843; ENSG00000080561
ENST00000443968; ENSP00000413976; ENSG00000080561 [Q9UJV3-2]
GeneIDi11043
KEGGihsa:11043
MANE-SelectiENST00000262843.11; ENSP00000262843.6; NM_012216.4; NP_036348.2
UCSCiuc004enk.4, human [Q9UJV3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11043
DisGeNETi11043

GeneCards: human genes, protein and diseases

More...GeneCardsi		MID2
HGNCiHGNC:7096, MID2
HPAiENSG00000080561, Low tissue specificity
MalaCardsiMID2
MIMi300204, gene
300928, phenotype
neXtProtiNX_Q9UJV3
OpenTargetsiENSG00000080561
Orphaneti777, X-linked non-syndromic intellectual disability
PharmGKBiPA30817
VEuPathDBiHostDB:ENSG00000080561

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000159460
HOGENOMiCLU_013137_19_4_1
InParanoidiQ9UJV3
OMAiGERIACQ
OrthoDBi172471at2759
PhylomeDBiQ9UJV3
TreeFamiTF333654

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9UJV3
SignaLinkiQ9UJV3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11043, 3 hits in 704 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MID2, human
EvolutionaryTraceiQ9UJV3

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MID2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11043
PharosiQ9UJV3, Tbio

Protein Ontology

More...PROi		PR:Q9UJV3
RNActiQ9UJV3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000080561, Expressed in stomach and 192 other tissues
ExpressionAtlasiQ9UJV3, baseline and differential
GenevisibleiQ9UJV3, HS

Family and domain databases

CDDicd00063, FN3, 1 hit
cd13739, SPRY_PRY_TRIM1, 1 hit
Gene3Di2.60.120.920, 1 hit
2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003649, Bbox_C
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR017903, COS_domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR033491, MID2
IPR040859, Midline-1_COS
IPR035752, SPRY/PRY_TRIM1
IPR003877, SPRY_dom
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR24099:SF12, PTHR24099:SF12, 1 hit
PfamiView protein in Pfam
PF18568, COS, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PF13445, zf-RING_UBOX, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 2 hits
SM00060, FN3, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS51262, COS, 1 hit
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJV3
Secondary accession number(s): A6NEL8
, A6PVI5, Q5JYF5, Q8WWK1, Q9UJR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: April 20, 2010
Last modified: February 23, 2022
This is version 202 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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