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Protein

Drebrin-like protein

Gene

DBNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processAdaptive immunity, Endocytosis, Immunity, Transport

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6798695 Neutrophil degranulation
SignaLinkiQ9UJU6
SIGNORiQ9UJU6

Names & Taxonomyi

Protein namesi
Recommended name:
Drebrin-like protein
Alternative name(s):
Cervical SH3P7
Cervical mucin-associated protein
Drebrin-F
HPK1-interacting protein of 55 kDa
Short name:
HIP-55
SH3 domain-containing protein 7
Gene namesi
Name:DBNL
Synonyms:CMAP, SH3P7
ORF Names:PP5423
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136279.18
HGNCiHGNC:2696 DBNL
MIMi610106 gene
neXtProtiNX_Q9UJU6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi361D → A: Abolishes cleavage by caspase-3. 1 Publication1

Organism-specific databases

DisGeNETi28988
OpenTargetsiENSG00000136279
PharmGKBiPA27164

Polymorphism and mutation databases

BioMutaiDBNL
DMDMi51316115

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797931 – 430Drebrin-like proteinAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphothreonineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei176N6-acetyllysineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei288N6-acetyllysineCombined sources1
Modified residuei291PhosphothreonineCombined sources1
Modified residuei334PhosphotyrosineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Isoform 4 (identifier: Q9UJU6-4)
Modified residuei137PhosphoserineCombined sources1
Isoform 6 (identifier: Q9UJU6-6)
Modified residuei183PhosphoserineCombined sources1
Isoform 2 (identifier: Q9UJU6-2)
Modified residuei232PhosphoserineCombined sources1
Isoform 3 (identifier: Q9UJU6-3)
Modified residuei232PhosphoserineCombined sources1

Post-translational modificationi

Degraded by caspases during apoptosis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei361 – 362Cleavage; by caspase-32

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UJU6
PaxDbiQ9UJU6
PeptideAtlasiQ9UJU6
PRIDEiQ9UJU6
ProteomicsDBi84659
84660 [Q9UJU6-2]
84661 [Q9UJU6-3]
TopDownProteomicsiQ9UJU6-2 [Q9UJU6-2]

2D gel databases

OGPiQ9UJU6

PTM databases

iPTMnetiQ9UJU6
PhosphoSitePlusiQ9UJU6

Miscellaneous databases

PMAP-CutDBiQ9UJU6

Expressioni

Gene expression databases

BgeeiENSG00000136279 Expressed in 182 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_DBNL
ExpressionAtlasiQ9UJU6 baseline and differential
GenevisibleiQ9UJU6 HS

Organism-specific databases

HPAiHPA020265
HPA027735

Interactioni

Subunit structurei

Interacts with SHANK2, SHANK3 and SYN1. Interacts with FGD1 and DNM1. Interacts with ANKRD54. Interacts with COBL. Interacts with WASL and WIPF1 (By similarity). Interacts with MAP4K1 and PRAM1.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118809, 62 interactors
IntActiQ9UJU6, 11 interactors
MINTiQ9UJU6
STRINGi9606.ENSP00000417653

Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UJU6
SMRiQ9UJU6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UJU6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 133ADF-HPROSITE-ProRule annotationAdd BLAST130
Domaini371 – 430SH3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili176 – 231Sequence analysisAdd BLAST56

Domaini

The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.

Sequence similaritiesi

Belongs to the ABP1 family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3655 Eukaryota
ENOG410XRVX LUCA
GeneTreeiENSGT00530000062953
HOGENOMiHOG000008567
HOVERGENiHBG051316
InParanoidiQ9UJU6
KOiK20520
OMAiGYEGQTN
OrthoDBiEOG091G05KP
PhylomeDBiQ9UJU6
TreeFamiTF318935

Family and domain databases

CDDicd11960 SH3_Abp1_eu, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029923 Dbnl
IPR035717 Drebrin-like_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10829:SF12 PTHR10829:SF12, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
PS50002 SH3, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL
60 70 80 90 100
EEMVEELNSG KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH
110 120 130 140 150
VSTMASFLKG AHVTINARAE EDVEPECIME KVAKASGANY SFHKESGRFQ
160 170 180 190 200
DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW AKAEKEEENR RLEEKRRAEE
210 220 230 240 250
AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ QEVVSRNRNE
260 270 280 290 300
QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE
310 320 330 340 350
PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV
360 370 380 390 400
QQQGAGSEHI DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG
410 420 430
IEVIDEGWWR GYGPDGHFGM FPANYVELIE
Length:430
Mass (Da):48,207
Last modified:May 1, 2000 - v1
Checksum:i7E8C42ED047257AE
GO
Isoform 2 (identifier: Q9UJU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS

Note: No experimental confirmation available.Combined sources
Show »
Length:431
Mass (Da):48,294
Checksum:iD18F9D316FFD0B4E
GO
Isoform 3 (identifier: Q9UJU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS
     251-251: Q → QGSTCASLQ

Note: No experimental confirmation available.Combined sources
Show »
Length:439
Mass (Da):49,042
Checksum:i8C044FBD0E82C6D5
GO
Isoform 4 (identifier: Q9UJU6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: MAANLSRNGP...HVSTMASFLK → MKATAMTSAWLAQG
     234-234: Q → QS

Show »
Length:336
Mass (Da):37,959
Checksum:iCDDA7B4BDFAADB32
GO
Isoform 5 (identifier: Q9UJU6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:327
Mass (Da):37,101
Checksum:iBE4C189EDD962834
GO
Isoform 6 (identifier: Q9UJU6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-158: Missing.
     234-234: Q → QS

Note: No experimental confirmation available.Combined sources
Show »
Length:382
Mass (Da):43,041
Checksum:i9B904F935E7107E7
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DDD6B4DDD6_HUMAN
cDNA FLJ59450, highly similar to Dr...
DBNL
406Annotation score:
H0Y5J4H0Y5J4_HUMAN
Drebrin-like protein
DBNL
359Annotation score:
F8WBG8F8WBG8_HUMAN
Drebrin-like protein
DBNL
128Annotation score:
H7C111H7C111_HUMAN
Drebrin-like protein
DBNL
138Annotation score:
F8WBB2F8WBB2_HUMAN
Drebrin-like protein
DBNL
62Annotation score:
F8WFE1F8WFE1_HUMAN
Drebrin-like protein
DBNL
87Annotation score:
F8WC20F8WC20_HUMAN
Drebrin-like protein
DBNL
50Annotation score:
F2Z2V3F2Z2V3_HUMAN
Drebrin-like protein
DBNL
27Annotation score:
F8WCK3F8WCK3_HUMAN
Drebrin-like protein
DBNL
40Annotation score:
F8WB73F8WB73_HUMAN
Drebrin-like protein
DBNL
31Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8N → K in AAG17262 (PubMed:15498874).Curated1
Sequence conflicti98A → S in AAF81273 (Ref. 3) Curated1
Sequence conflicti98A → S in AAG13120 (Ref. 3) Curated1
Sequence conflicti235R → S in AAF81273 (Ref. 3) Curated1
Sequence conflicti235R → S in AAG13120 (Ref. 3) Curated1
Sequence conflicti430E → D in CAG33448 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547791 – 109MAANL…ASFLK → MKATAMTSAWLAQG in isoform 4. CuratedAdd BLAST109
Alternative sequenceiVSP_0547801 – 103Missing in isoform 5. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_057346110 – 158Missing in isoform 6. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_011398234Q → QS in isoform 2, isoform 3, isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_011399251Q → QGSTCASLQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197060 mRNA Translation: AAF13701.1
AF077353 mRNA Translation: AAF80228.1
AF250287 mRNA Translation: AAF81273.1
AF151364 mRNA Translation: AAG13120.1
AF218020 mRNA Translation: AAG17262.2
AK027367 mRNA Translation: BAB55065.1
AK293279 mRNA Translation: BAG56807.1
AK293698 mRNA Translation: BAG57133.1
CR457167 mRNA Translation: CAG33448.1
AC017116 Genomic DNA No translation available.
CH236960 Genomic DNA Translation: EAL23770.1
CH471128 Genomic DNA Translation: EAW61132.1
BC011677 mRNA Translation: AAH11677.1
BC031687 mRNA Translation: AAH31687.1
CCDSiCCDS34622.1 [Q9UJU6-2]
CCDS34623.1 [Q9UJU6-1]
CCDS47579.1 [Q9UJU6-3]
CCDS64633.1 [Q9UJU6-4]
CCDS64634.1 [Q9UJU6-5]
RefSeqiNP_001014436.1, NM_001014436.2 [Q9UJU6-1]
NP_001116428.1, NM_001122956.1 [Q9UJU6-3]
NP_001271242.1, NM_001284313.1 [Q9UJU6-5]
NP_001271244.1, NM_001284315.1 [Q9UJU6-4]
NP_054782.2, NM_014063.6 [Q9UJU6-2]
UniGeneiHs.436500

Genome annotation databases

EnsembliENST00000440166; ENSP00000415173; ENSG00000136279 [Q9UJU6-5]
ENST00000448521; ENSP00000411701; ENSG00000136279 [Q9UJU6-1]
ENST00000456905; ENSP00000416421; ENSG00000136279 [Q9UJU6-6]
ENST00000468694; ENSP00000417653; ENSG00000136279 [Q9UJU6-3]
ENST00000490734; ENSP00000417749; ENSG00000136279 [Q9UJU6-4]
ENST00000494774; ENSP00000419992; ENSG00000136279 [Q9UJU6-2]
GeneIDi28988
KEGGihsa:28988
UCSCiuc003tjo.5 human [Q9UJU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197060 mRNA Translation: AAF13701.1
AF077353 mRNA Translation: AAF80228.1
AF250287 mRNA Translation: AAF81273.1
AF151364 mRNA Translation: AAG13120.1
AF218020 mRNA Translation: AAG17262.2
AK027367 mRNA Translation: BAB55065.1
AK293279 mRNA Translation: BAG56807.1
AK293698 mRNA Translation: BAG57133.1
CR457167 mRNA Translation: CAG33448.1
AC017116 Genomic DNA No translation available.
CH236960 Genomic DNA Translation: EAL23770.1
CH471128 Genomic DNA Translation: EAW61132.1
BC011677 mRNA Translation: AAH11677.1
BC031687 mRNA Translation: AAH31687.1
CCDSiCCDS34622.1 [Q9UJU6-2]
CCDS34623.1 [Q9UJU6-1]
CCDS47579.1 [Q9UJU6-3]
CCDS64633.1 [Q9UJU6-4]
CCDS64634.1 [Q9UJU6-5]
RefSeqiNP_001014436.1, NM_001014436.2 [Q9UJU6-1]
NP_001116428.1, NM_001122956.1 [Q9UJU6-3]
NP_001271242.1, NM_001284313.1 [Q9UJU6-5]
NP_001271244.1, NM_001284315.1 [Q9UJU6-4]
NP_054782.2, NM_014063.6 [Q9UJU6-2]
UniGeneiHs.436500

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X67NMR-A1-133[»]
ProteinModelPortaliQ9UJU6
SMRiQ9UJU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118809, 62 interactors
IntActiQ9UJU6, 11 interactors
MINTiQ9UJU6
STRINGi9606.ENSP00000417653

PTM databases

iPTMnetiQ9UJU6
PhosphoSitePlusiQ9UJU6

Polymorphism and mutation databases

BioMutaiDBNL
DMDMi51316115

2D gel databases

OGPiQ9UJU6

Proteomic databases

EPDiQ9UJU6
PaxDbiQ9UJU6
PeptideAtlasiQ9UJU6
PRIDEiQ9UJU6
ProteomicsDBi84659
84660 [Q9UJU6-2]
84661 [Q9UJU6-3]
TopDownProteomicsiQ9UJU6-2 [Q9UJU6-2]

Protocols and materials databases

DNASUi28988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000440166; ENSP00000415173; ENSG00000136279 [Q9UJU6-5]
ENST00000448521; ENSP00000411701; ENSG00000136279 [Q9UJU6-1]
ENST00000456905; ENSP00000416421; ENSG00000136279 [Q9UJU6-6]
ENST00000468694; ENSP00000417653; ENSG00000136279 [Q9UJU6-3]
ENST00000490734; ENSP00000417749; ENSG00000136279 [Q9UJU6-4]
ENST00000494774; ENSP00000419992; ENSG00000136279 [Q9UJU6-2]
GeneIDi28988
KEGGihsa:28988
UCSCiuc003tjo.5 human [Q9UJU6-1]

Organism-specific databases

CTDi28988
DisGeNETi28988
EuPathDBiHostDB:ENSG00000136279.18
GeneCardsiDBNL
HGNCiHGNC:2696 DBNL
HPAiHPA020265
HPA027735
MIMi610106 gene
neXtProtiNX_Q9UJU6
OpenTargetsiENSG00000136279
PharmGKBiPA27164
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3655 Eukaryota
ENOG410XRVX LUCA
GeneTreeiENSGT00530000062953
HOGENOMiHOG000008567
HOVERGENiHBG051316
InParanoidiQ9UJU6
KOiK20520
OMAiGYEGQTN
OrthoDBiEOG091G05KP
PhylomeDBiQ9UJU6
TreeFamiTF318935

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6798695 Neutrophil degranulation
SignaLinkiQ9UJU6
SIGNORiQ9UJU6

Miscellaneous databases

ChiTaRSiDBNL human
EvolutionaryTraceiQ9UJU6
GeneWikiiDrebrin-like
GenomeRNAii28988
PMAP-CutDBiQ9UJU6
PROiPR:Q9UJU6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136279 Expressed in 182 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_DBNL
ExpressionAtlasiQ9UJU6 baseline and differential
GenevisibleiQ9UJU6 HS

Family and domain databases

CDDicd11960 SH3_Abp1_eu, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029923 Dbnl
IPR035717 Drebrin-like_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10829:SF12 PTHR10829:SF12, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDBNL_HUMAN
AccessioniPrimary (citable) accession number: Q9UJU6
Secondary accession number(s): A4D2I9
, B4DDP6, B4DEM2, C9J7P1, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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