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UniProtKB - Q9UJU6 (DBNL_HUMAN)

Entry version 192 (25 May 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Drebrin-like protein

Gene

DBNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity).

May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processAdaptive immunity, Endocytosis, Immunity, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UJU6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6794361, Neurexins and neuroligins
R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UJU6

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UJU6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Drebrin-like protein
Alternative name(s):
Cervical SH3P7
Cervical mucin-associated protein
Drebrin-F
HPK1-interacting protein of 55 kDa
Short name:
HIP-55
SH3 domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DBNL
Synonyms:CMAP, SH3P7
ORF Names:PP5423
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2696, DBNL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610106, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UJU6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136279

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi361D → A: Abolishes cleavage by caspase-3. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		28988

MalaCards human disease database

More...MalaCardsi		DBNL

Open Targets

More...OpenTargetsi		ENSG00000136279

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27164

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UJU6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DBNL

Domain mapping of disease mutations (DMDM)

More...DMDMi		51316115

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797931 – 430Drebrin-like proteinAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphothreonineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei176N6-acetyllysineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei288N6-acetyllysineCombined sources1
Modified residuei291PhosphothreonineCombined sources1
Modified residuei334PhosphotyrosineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Isoform 4 (identifier: Q9UJU6-4)
Modified residuei137PhosphoserineCombined sources1
Isoform 6 (identifier: Q9UJU6-6)
Modified residuei183PhosphoserineCombined sources1
Isoform 2 (identifier: Q9UJU6-2)
Modified residuei232PhosphoserineCombined sources1
Isoform 3 (identifier: Q9UJU6-3)
Modified residuei232PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded by caspases during apoptosis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei361 – 362Cleavage; by caspase-32

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UJU6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UJU6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UJU6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UJU6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UJU6

PeptideAtlas

More...PeptideAtlasi		Q9UJU6

PRoteomics IDEntifications database

More...PRIDEi		Q9UJU6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3878
3970
84659 [Q9UJU6-1]
84660 [Q9UJU6-2]
84661 [Q9UJU6-3]
8938

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9UJU6-2 [Q9UJU6-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		Q9UJU6

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UJU6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UJU6

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UJU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UJU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136279, Expressed in lower esophagus mucosa and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UJU6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UJU6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136279, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHANK2, SHANK3 and SYN1.

Interacts with FGD1 and DNM1.

Interacts with ANKRD54.

Interacts with COBL.

Interacts with WASL and WIPF1 (By similarity).

Interacts with MAP4K1 and PRAM1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118809, 124 interactors

Protein interaction database and analysis system

More...IntActi		Q9UJU6, 34 interactors

Molecular INTeraction database

More...MINTi		Q9UJU6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417653

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UJU6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UJU6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UJU6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UJU6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 133ADF-HPROSITE-ProRule annotationAdd BLAST130
Domaini371 – 430SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 283DisorderedSequence analysisAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili176 – 231Sequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 248Polar residuesSequence analysisAdd BLAST22
Compositional biasi249 – 265Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi266 – 283Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABP1 family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3655, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013085_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UJU6

Identification of Orthologs from Complete Genome Data

More...OMAi		TNIDMVD

Database of Orthologous Groups

More...OrthoDBi		885776at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UJU6

TreeFam database of animal gene trees

More...TreeFami		TF318935

Family and domain databases

Conserved Domains Database

More...CDDi		cd11960, SH3_Abp1_eu, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002108, ADF-H
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR029923, Dbnl
IPR035717, Drebrin-like_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR10829:SF12, PTHR10829:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00241, Cofilin_ADF, 1 hit
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00102, ADF, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51263, ADF_H, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL 
        60         70         80         90        100
EEMVEELNSG KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH 
       110        120        130        140        150
VSTMASFLKG AHVTINARAE EDVEPECIME KVAKASGANY SFHKESGRFQ 
       160        170        180        190        200
DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW AKAEKEEENR RLEEKRRAEE 
       210        220        230        240        250
AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ QEVVSRNRNE 
       260        270        280        290        300
QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE 
       310        320        330        340        350
PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV 
       360        370        380        390        400
QQQGAGSEHI DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG 
       410        420        430
IEVIDEGWWR GYGPDGHFGM FPANYVELIE
Length:430
Mass (Da):48,207
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E8C42ED047257AE
GO
Isoform 2 (identifier: Q9UJU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS

Show »
Length:431
Mass (Da):48,294
Checksum:iD18F9D316FFD0B4E
GO
Isoform 3 (identifier: Q9UJU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS
     251-251: Q → QGSTCASLQ

Show »
Length:439
Mass (Da):49,042
Checksum:i8C044FBD0E82C6D5
GO
Isoform 4 (identifier: Q9UJU6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: MAANLSRNGP...HVSTMASFLK → MKATAMTSAWLAQG
     234-234: Q → QS

Show »
Length:336
Mass (Da):37,959
Checksum:iCDDA7B4BDFAADB32
GO
Isoform 5 (identifier: Q9UJU6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:327
Mass (Da):37,101
Checksum:iBE4C189EDD962834
GO
Isoform 6 (identifier: Q9UJU6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-158: Missing.
     234-234: Q → QS

Show »
Length:382
Mass (Da):43,041
Checksum:i9B904F935E7107E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5J4H0Y5J4_HUMAN
Drebrin-like protein
DBNL
359Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DDD6B4DDD6_HUMAN
Drebrin-like protein
DBNL
406Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C111H7C111_HUMAN
Drebrin-like protein
DBNL
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBG8F8WBG8_HUMAN
Drebrin-like protein
DBNL
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFE1F8WFE1_HUMAN
Drebrin-like protein
DBNL
87Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBB2F8WBB2_HUMAN
Drebrin-like protein
DBNL
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC20F8WC20_HUMAN
Drebrin-like protein
DBNL
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2V3F2Z2V3_HUMAN
Drebrin-like protein
DBNL
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB73F8WB73_HUMAN
Drebrin-like protein
DBNL
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCK3F8WCK3_HUMAN
Drebrin-like protein
DBNL
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8N → K in AAG17262 (PubMed:15498874).Curated1
Sequence conflicti98A → S in AAF81273 (Ref. 3) Curated1
Sequence conflicti98A → S in AAG13120 (Ref. 3) Curated1
Sequence conflicti235R → S in AAF81273 (Ref. 3) Curated1
Sequence conflicti235R → S in AAG13120 (Ref. 3) Curated1
Sequence conflicti430E → D in CAG33448 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547791 – 109MAANL…ASFLK → MKATAMTSAWLAQG in isoform 4. CuratedAdd BLAST109
Alternative sequenceiVSP_0547801 – 103Missing in isoform 5. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_057346110 – 158Missing in isoform 6. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_011398234Q → QS in isoform 2, isoform 3, isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_011399251Q → QGSTCASLQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF197060 mRNA Translation: AAF13701.1
AF077353 mRNA Translation: AAF80228.1
AF250287 mRNA Translation: AAF81273.1
AF151364 mRNA Translation: AAG13120.1
AF218020 mRNA Translation: AAG17262.2
AK027367 mRNA Translation: BAB55065.1
AK293279 mRNA Translation: BAG56807.1
AK293698 mRNA Translation: BAG57133.1
CR457167 mRNA Translation: CAG33448.1
AC017116 Genomic DNA No translation available.
CH236960 Genomic DNA Translation: EAL23770.1
CH471128 Genomic DNA Translation: EAW61132.1
BC011677 mRNA Translation: AAH11677.1
BC031687 mRNA Translation: AAH31687.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34622.1 [Q9UJU6-2]
CCDS34623.1 [Q9UJU6-1]
CCDS47579.1 [Q9UJU6-3]
CCDS64633.1 [Q9UJU6-4]
CCDS64634.1 [Q9UJU6-5]

NCBI Reference Sequences

More...RefSeqi		NP_001014436.1, NM_001014436.2 [Q9UJU6-1]
NP_001116428.1, NM_001122956.1 [Q9UJU6-3]
NP_001271242.1, NM_001284313.1 [Q9UJU6-5]
NP_001271244.1, NM_001284315.1 [Q9UJU6-4]
NP_054782.2, NM_014063.6 [Q9UJU6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000440166.5; ENSP00000415173.1; ENSG00000136279.21 [Q9UJU6-5]
ENST00000448521.6; ENSP00000411701.1; ENSG00000136279.21
ENST00000456905.5; ENSP00000416421.1; ENSG00000136279.21 [Q9UJU6-6]
ENST00000468694.5; ENSP00000417653.1; ENSG00000136279.21 [Q9UJU6-3]
ENST00000490734.6; ENSP00000417749.2; ENSG00000136279.21 [Q9UJU6-4]
ENST00000494774.5; ENSP00000419992.1; ENSG00000136279.21 [Q9UJU6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		28988

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:28988

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000448521.6; ENSP00000411701.1; NM_001014436.3; NP_001014436.1

UCSC genome browser

More...UCSCi		uc003tjo.5, human [Q9UJU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197060 mRNA Translation: AAF13701.1
AF077353 mRNA Translation: AAF80228.1
AF250287 mRNA Translation: AAF81273.1
AF151364 mRNA Translation: AAG13120.1
AF218020 mRNA Translation: AAG17262.2
AK027367 mRNA Translation: BAB55065.1
AK293279 mRNA Translation: BAG56807.1
AK293698 mRNA Translation: BAG57133.1
CR457167 mRNA Translation: CAG33448.1
AC017116 Genomic DNA No translation available.
CH236960 Genomic DNA Translation: EAL23770.1
CH471128 Genomic DNA Translation: EAW61132.1
BC011677 mRNA Translation: AAH11677.1
BC031687 mRNA Translation: AAH31687.1
CCDSiCCDS34622.1 [Q9UJU6-2]
CCDS34623.1 [Q9UJU6-1]
CCDS47579.1 [Q9UJU6-3]
CCDS64633.1 [Q9UJU6-4]
CCDS64634.1 [Q9UJU6-5]
RefSeqiNP_001014436.1, NM_001014436.2 [Q9UJU6-1]
NP_001116428.1, NM_001122956.1 [Q9UJU6-3]
NP_001271242.1, NM_001284313.1 [Q9UJU6-5]
NP_001271244.1, NM_001284315.1 [Q9UJU6-4]
NP_054782.2, NM_014063.6 [Q9UJU6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X67NMR-A1-133[»]
AlphaFoldDBiQ9UJU6
SMRiQ9UJU6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118809, 124 interactors
IntActiQ9UJU6, 34 interactors
MINTiQ9UJU6
STRINGi9606.ENSP00000417653

PTM databases

GlyGeniQ9UJU6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9UJU6
MetOSiteiQ9UJU6
PhosphoSitePlusiQ9UJU6

Genetic variation databases

BioMutaiDBNL
DMDMi51316115

2D gel databases

OGPiQ9UJU6

Proteomic databases

EPDiQ9UJU6
jPOSTiQ9UJU6
MassIVEiQ9UJU6
MaxQBiQ9UJU6
PaxDbiQ9UJU6
PeptideAtlasiQ9UJU6
PRIDEiQ9UJU6
ProteomicsDBi3878
3970
84659 [Q9UJU6-1]
84660 [Q9UJU6-2]
84661 [Q9UJU6-3]
8938
TopDownProteomicsiQ9UJU6-2 [Q9UJU6-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9UJU6, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13203, 266 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		28988

Genome annotation databases

EnsembliENST00000440166.5; ENSP00000415173.1; ENSG00000136279.21 [Q9UJU6-5]
ENST00000448521.6; ENSP00000411701.1; ENSG00000136279.21
ENST00000456905.5; ENSP00000416421.1; ENSG00000136279.21 [Q9UJU6-6]
ENST00000468694.5; ENSP00000417653.1; ENSG00000136279.21 [Q9UJU6-3]
ENST00000490734.6; ENSP00000417749.2; ENSG00000136279.21 [Q9UJU6-4]
ENST00000494774.5; ENSP00000419992.1; ENSG00000136279.21 [Q9UJU6-2]
GeneIDi28988
KEGGihsa:28988
MANE-SelectiENST00000448521.6; ENSP00000411701.1; NM_001014436.3; NP_001014436.1
UCSCiuc003tjo.5, human [Q9UJU6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		28988
DisGeNETi28988

GeneCards: human genes, protein and diseases

More...GeneCardsi		DBNL
HGNCiHGNC:2696, DBNL
HPAiENSG00000136279, Low tissue specificity
MalaCardsiDBNL
MIMi610106, gene
neXtProtiNX_Q9UJU6
OpenTargetsiENSG00000136279
PharmGKBiPA27164
VEuPathDBiHostDB:ENSG00000136279

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3655, Eukaryota
GeneTreeiENSGT00940000156732
HOGENOMiCLU_013085_0_1_1
InParanoidiQ9UJU6
OMAiTNIDMVD
OrthoDBi885776at2759
PhylomeDBiQ9UJU6
TreeFamiTF318935

Enzyme and pathway databases

PathwayCommonsiQ9UJU6
ReactomeiR-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6794361, Neurexins and neuroligins
R-HSA-6798695, Neutrophil degranulation
SignaLinkiQ9UJU6
SIGNORiQ9UJU6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		28988, 15 hits in 1074 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DBNL, human
EvolutionaryTraceiQ9UJU6

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Drebrin-like

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		28988
PharosiQ9UJU6, Tbio

Protein Ontology

More...PROi		PR:Q9UJU6
RNActiQ9UJU6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136279, Expressed in lower esophagus mucosa and 199 other tissues
ExpressionAtlasiQ9UJU6, baseline and differential
GenevisibleiQ9UJU6, HS

Family and domain databases

CDDicd11960, SH3_Abp1_eu, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108, ADF-H
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR029923, Dbnl
IPR035717, Drebrin-like_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR10829:SF12, PTHR10829:SF12, 1 hit
PfamiView protein in Pfam
PF00241, Cofilin_ADF, 1 hit
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00102, ADF, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51263, ADF_H, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDBNL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJU6
Secondary accession number(s): A4D2I9
, B4DDP6, B4DEM2, C9J7P1, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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