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Entry version 172 (11 Dec 2019)
Sequence version 2 (02 Nov 2010)
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Protein

Zinc finger protein 112

Gene

ZNF112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 112
Short name:
Zfp-112
Alternative name(s):
Zinc finger protein 228
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF112
Synonyms:ZFP112, ZNF228
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000062370.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12892 ZNF112

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UJU3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7771

Open Targets

More...
OpenTargetsi
ENSG00000062370

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UJU3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF112

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033503

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474691 – 913Zinc finger protein 112Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki890Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UJU3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UJU3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UJU3

PeptideAtlas

More...
PeptideAtlasi
Q9UJU3

PRoteomics IDEntifications database

More...
PRIDEi
Q9UJU3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84656 [Q9UJU3-1]
84657 [Q9UJU3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UJU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UJU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000062370 Expressed in 190 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UJU3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UJU3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023856

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113554, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UJU3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337081

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UJU3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UJU3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UJU3

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCQVWAG

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UJU3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ
60 70 80 90 100
PFKPDLISQL EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP
110 120 130 140 150
KELSSRQTWQ QSAGGLIRCQ DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ
160 170 180 190 200
ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH HSWRKMYLKE SHNYQCRCQQ
210 220 230 240 250
ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI MKVSLLNQES
260 270 280 290 300
IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL
310 320 330 340 350
LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE
360 370 380 390 400
LIHTGEMSYR HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS
410 420 430 440 450
CLQVHQKIHT EEKLYTDIEY GKSFICSSNL DIQHRVHMEE NSYNSEECGN
460 470 480 490 500
GFSLASHFQD LQIVHTKEQP YKRYVCSNSF SHNLYLQGHP KIHIGEKPRK
510 520 530 540 550
EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL NVHQRVHTGE
560 570 580 590 600
KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ
610 620 630 640 650
RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF
660 670 680 690 700
NLQIHQRVHT GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK
710 720 730 740 750
SFSQRSYLQS HQSVHSGERP YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK
760 770 780 790 800
CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE VCTKGFSESS RLQAHQRVHV
810 820 830 840 850
EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK GFSQRSNLQA
860 870 880 890 900
HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS
910
SENLHRNEDS VLF
Length:913
Mass (Da):105,842
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45F1E5A0EFBDFFC0
GO
Isoform 2 (identifier: Q9UJU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:907
Mass (Da):105,077
Checksum:i7F61E43A71DD354F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN57K7EN57_HUMAN
Zinc finger protein 112
ZNF112
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIR6K7EIR6_HUMAN
Zinc finger protein 112
ZNF112
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENS0K7ENS0_HUMAN
Zinc finger protein 112
ZNF112
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQV5K7EQV5_HUMAN
Zinc finger protein 112
ZNF112
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3 – 5KFQ → VSK in AAF12816 (PubMed:12743021).Curated3
Sequence conflicti113A → T in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti143V → A in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti222K → E in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti261T → S in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti392N → S in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti813G → A in AAF12816 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06041454P → S. Corresponds to variant dbSNP:rs11673395Ensembl.1
Natural variantiVAR_057377159F → L2 PublicationsCorresponds to variant dbSNP:rs4280359Ensembl.1
Natural variantiVAR_057378163G → E. Corresponds to variant dbSNP:rs16978965Ensembl.1
Natural variantiVAR_057379287T → K. Corresponds to variant dbSNP:rs10419604Ensembl.1
Natural variantiVAR_060415446E → Q3 PublicationsCorresponds to variant dbSNP:rs2722723Ensembl.1
Natural variantiVAR_060416485Y → H3 PublicationsCorresponds to variant dbSNP:rs2722722Ensembl.1
Natural variantiVAR_057380780E → A. Corresponds to variant dbSNP:rs2609881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0399291 – 6Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF198358 mRNA Translation: AAF12816.1
AC084239 Genomic DNA Translation: AAG23968.1
AC138473 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57269.1
BC101753 mRNA Translation: AAI01754.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12637.1 [Q9UJU3-2]
CCDS54276.1 [Q9UJU3-1]

NCBI Reference Sequences

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RefSeqi
NP_001076804.1, NM_001083335.1 [Q9UJU3-1]
NP_001335211.1, NM_001348282.1 [Q9UJU3-2]
NP_001335212.1, NM_001348283.1 [Q9UJU3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000337401; ENSP00000337081; ENSG00000062370 [Q9UJU3-1]
ENST00000354340; ENSP00000346305; ENSG00000062370 [Q9UJU3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7771

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7771

UCSC genome browser

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UCSCi
uc002ozc.5 human [Q9UJU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198358 mRNA Translation: AAF12816.1
AC084239 Genomic DNA Translation: AAG23968.1
AC138473 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57269.1
BC101753 mRNA Translation: AAI01754.1
CCDSiCCDS12637.1 [Q9UJU3-2]
CCDS54276.1 [Q9UJU3-1]
RefSeqiNP_001076804.1, NM_001083335.1 [Q9UJU3-1]
NP_001335211.1, NM_001348282.1 [Q9UJU3-2]
NP_001335212.1, NM_001348283.1 [Q9UJU3-2]

3D structure databases

SMRiQ9UJU3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113554, 6 interactors
IntActiQ9UJU3, 2 interactors
STRINGi9606.ENSP00000337081

PTM databases

iPTMnetiQ9UJU3
PhosphoSitePlusiQ9UJU3

Polymorphism and mutation databases

BioMutaiZNF112
DMDMi311033503

Proteomic databases

jPOSTiQ9UJU3
MassIVEiQ9UJU3
PaxDbiQ9UJU3
PeptideAtlasiQ9UJU3
PRIDEiQ9UJU3
ProteomicsDBi84656 [Q9UJU3-1]
84657 [Q9UJU3-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7771

Genome annotation databases

EnsembliENST00000337401; ENSP00000337081; ENSG00000062370 [Q9UJU3-1]
ENST00000354340; ENSP00000346305; ENSG00000062370 [Q9UJU3-2]
GeneIDi7771
KEGGihsa:7771
UCSCiuc002ozc.5 human [Q9UJU3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7771
DisGeNETi7771
EuPathDBiHostDB:ENSG00000062370.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF112
HGNCiHGNC:12892 ZNF112
HPAiHPA023856
neXtProtiNX_Q9UJU3
OpenTargetsiENSG00000062370

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162215
HOGENOMiHOG000234617
InParanoidiQ9UJU3
KOiK09228
OMAiLCQVWAG
OrthoDBi1318335at2759
PhylomeDBiQ9UJU3

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF112 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7771
PharosiQ9UJU3 Tdark

Protein Ontology

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PROi
PR:Q9UJU3
RNActiQ9UJU3 protein

Gene expression databases

BgeeiENSG00000062370 Expressed in 190 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ9UJU3 baseline and differential
GenevisibleiQ9UJU3 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN112_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJU3
Secondary accession number(s): A4FU53, Q9HCA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: December 11, 2019
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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