UniProtKB - Q9UJU2 (LEF1_HUMAN)
Lymphoid enhancer-binding factor 1
LEF1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 299 – 367 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- armadillo repeat domain binding Source: BHF-UCL
- beta-catenin binding Source: BHF-UCL
- C2H2 zinc finger domain binding Source: UniProtKB
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB
- DNA binding, bending Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- estrogen receptor activity Source: UniProtKB
- estrogen receptor binding Source: UniProtKB
- gamma-catenin binding Source: BHF-UCL
- histone binding Source: UniProtKB
- histone deacetylase binding Source: ParkinsonsUK-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
- sequence-specific DNA binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anatomical structure regression Source: Ensembl
- apoptotic process involved in blood vessel morphogenesis Source: Ensembl
- B cell proliferation Source: Ensembl
- beta-catenin-TCF complex assembly Source: Reactome
- BMP signaling pathway Source: Ensembl
- branching involved in blood vessel morphogenesis Source: Ensembl
- canonical Wnt signaling pathway Source: BHF-UCL
- cell chemotaxis Source: UniProtKB
- cellular response to cytokine stimulus Source: BHF-UCL
- cellular response to interleukin-4 Source: UniProtKB
- chorio-allantoic fusion Source: Ensembl
- dentate gyrus development Source: Ensembl
- embryonic limb morphogenesis Source: Ensembl
- epithelial to mesenchymal transition Source: BHF-UCL
- face morphogenesis Source: Ensembl
- forebrain neuroblast division Source: Ensembl
- forebrain radial glial cell differentiation Source: Ensembl
- formation of radial glial scaffolds Source: Ensembl
- granulocyte differentiation Source: Reactome
- histone H3 acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- mammary gland development Source: Ensembl
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of apoptotic process in bone marrow cell Source: UniProtKB
- negative regulation of cell-cell adhesion Source: UniProtKB
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of estrogen receptor binding Source: UniProtKB
- negative regulation of interleukin-13 production Source: UniProtKB
- negative regulation of interleukin-4 production Source: UniProtKB
- negative regulation of interleukin-5 production Source: UniProtKB
- negative regulation of striated muscle tissue development Source: Ensembl
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neutrophil differentiation Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: Ensembl
- osteoblast differentiation Source: UniProtKB
- paraxial mesoderm formation Source: Ensembl
- positive regulation by host of viral transcription Source: UniProtKB
- positive regulation of cell-cell adhesion Source: UniProtKB
- positive regulation of cell cycle process Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cell proliferation in bone marrow Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of gamma-delta T cell differentiation Source: UniProtKB
- positive regulation of gene expression Source: AgBase
- positive regulation of granulocyte differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
- regulation of Wnt signaling pathway Source: Ensembl
- secondary palate development Source: BHF-UCL
- sensory perception of taste Source: Ensembl
- somitogenesis Source: Ensembl
- sprouting angiogenesis Source: Ensembl
- T cell receptor V(D)J recombination Source: Ensembl
- T-helper 1 cell differentiation Source: UniProtKB
- tongue development Source: Ensembl
- trachea gland development Source: Ensembl
- Wnt signaling pathway, calcium modulating pathway Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9UJU2 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-4086398, Ca2+ pathway R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265, Repression of WNT target genes R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8951430, RUNX3 regulates WNT signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | Q9UJU2 |
SIGNORi | Q9UJU2 |
Names & Taxonomyi
Protein namesi | Recommended name: Lymphoid enhancer-binding factor 1Short name: LEF-1 Alternative name(s): T cell-specific transcription factor 1-alpha Short name: TCF1-alpha |
Gene namesi | Name:LEF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6551, LEF1 |
MIMi | 153245, gene |
neXtProti | NX_Q9UJU2 |
VEuPathDBi | HostDB:ENSG00000138795.9 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Note: Found in nuclear bodies upon PIASG binding.By similarity
Nucleus
- beta-catenin-TCF complex Source: ParkinsonsUK-UCL
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-DNA complex Source: BHF-UCL
- transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 155 | T → A: Reduced phosphorylation by NLK; when associated with A-166. 1 Publication | 1 | |
Mutagenesisi | 166 | S → A: Reduced phosphorylation by NLK; when associated with A-155. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51176 |
OpenTargetsi | ENSG00000138795 |
PharmGKBi | PA30331 |
Miscellaneous databases
Pharosi | Q9UJU2, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3217392 |
DrugBanki | DB00903, Etacrynic acid |
Genetic variation databases
BioMutai | LEF1 |
DMDMi | 8928194 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048595 | 1 – 399 | Lymphoid enhancer-binding factor 1Add BLAST | 399 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity | ||
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 155 | Phosphothreonine; by NLK1 Publication | 1 | |
Modified residuei | 166 | Phosphoserine; by NLK1 Publication | 1 | |
Cross-linki | 269 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9UJU2 |
MassIVEi | Q9UJU2 |
PaxDbi | Q9UJU2 |
PeptideAtlasi | Q9UJU2 |
PRIDEi | Q9UJU2 |
ProteomicsDBi | 19686 84650 [Q9UJU2-1] 84651 [Q9UJU2-2] 84652 [Q9UJU2-3] 84653 [Q9UJU2-4] 84654 [Q9UJU2-5] 84655 [Q9UJU2-6] |
TopDownProteomicsi | Q9UJU2-2 [Q9UJU2-2] |
PTM databases
GlyConnecti | 2055, 1 N-Linked glycan (1 site) |
GlyGeni | Q9UJU2, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | Q9UJU2 |
PhosphoSitePlusi | Q9UJU2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000138795, Expressed in female gonad and 220 other tissues |
ExpressionAtlasi | Q9UJU2, baseline and differential |
Genevisiblei | Q9UJU2, HS |
Organism-specific databases
HPAi | ENSG00000138795, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Binds the armadillo repeat of CTNNB1 and forms a stable complex.
Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC.
Interacts with NLK.
By similarity5 PublicationsBinary interactionsi
Hide detailsQ9UJU2
With | #Exp. | IntAct |
---|---|---|
CTNNB1 [P35222] | 10 | EBI-926131,EBI-491549 |
FHIT [P49789] | 2 | EBI-926131,EBI-741760 |
IGF1R [P08069] | 5 | EBI-926131,EBI-475981 |
NFE2L2 [Q16236] | 3 | EBI-926131,EBI-2007911 |
GO - Molecular functioni
- armadillo repeat domain binding Source: BHF-UCL
- beta-catenin binding Source: BHF-UCL
- C2H2 zinc finger domain binding Source: UniProtKB
- estrogen receptor binding Source: UniProtKB
- gamma-catenin binding Source: BHF-UCL
- histone binding Source: UniProtKB
- histone deacetylase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 119354, 52 interactors |
ComplexPortali | CPX-316, beta1-catenin - LEF1 complex |
CORUMi | Q9UJU2 |
DIPi | DIP-29946N |
IntActi | Q9UJU2, 25 interactors |
MINTi | Q9UJU2 |
STRINGi | 9606.ENSP00000265165 |
Miscellaneous databases
RNActi | Q9UJU2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | CTNNB1-bindingBy similarityAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 6 – 13 | Poly-Gly | 8 | |
Compositional biasi | 14 – 52 | Asp/Glu-rich (acidic)Add BLAST | 39 | |
Compositional biasi | 77 – 273 | Pro-richAdd BLAST | 197 | |
Compositional biasi | 374 – 379 | Poly-Lys | 6 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3248, Eukaryota |
GeneTreei | ENSGT00940000159660 |
HOGENOMi | CLU_013229_5_0_1 |
InParanoidi | Q9UJU2 |
OMAi | SQDSYHD |
OrthoDBi | 807716at2759 |
PhylomeDBi | Q9UJU2 |
TreeFami | TF318448 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR028769, LEF1 IPR024940, TCF/LEF |
PANTHERi | PTHR10373, PTHR10373, 1 hit PTHR10373:SF11, PTHR10373:SF11, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPQLSGGGGG GGGDPELCAT DEMIPFKDEG DPQKEKIFAE ISHPEEEGDL
60 70 80 90 100
ADIKSSLVNE SEIIPASNGH EVARQAQTSQ EPYHDKAREH PDDGKHPDGG
110 120 130 140 150
LYNKGPSYSS YSGYIMMPNM NNDPYMSNGS LSPPIPRTSN KVPVVQPSHA
160 170 180 190 200
VHPLTPLITY SDEHFSPGSH PSHIPSDVNS KQGMSRHPPA PDIPTFYPLS
210 220 230 240 250
PGGVGQITPP LGWQGQPVYP ITGGFRQPYP SSLSVDTSMS RFSHHMIPGP
260 270 280 290 300
PGPHTTGIPH PAIVTPQVKQ EHPHTDSDLM HVKPQHEQRK EQEPKRPHIK
310 320 330 340 350
KPLNAFMLYM KEMRANVVAE CTLKESAAIN QILGRRWHAL SREEQAKYYE
360 370 380 390
LARKERQLHM QLYPGWSARD NYGKKKKRKR EKLQESASGT GPRMTAAYI
The sequence of this isoform differs from the canonical sequence as follows:
283-399: KPQHEQRKEQ...TGPRMTAAYI → CSAFLLPHPF...SQKDLTLRSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RAB1 | D6RAB1_HUMAN | Lymphoid enhancer-binding factor 1 | LEF1 | 173 | Annotation score: | ||
D6RID7 | D6RID7_HUMAN | Lymphoid enhancer-binding factor 1 | LEF1 | 133 | Annotation score: | ||
D6RIV1 | D6RIV1_HUMAN | Lymphoid enhancer-binding factor 1 | LEF1 | 145 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | Q → R in BAH13928 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035935 | 113 | G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs369649181Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007022 | 1 – 115 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 115 | |
Alternative sequenceiVSP_044877 | 1 – 70 | MPQLS…ASNGH → MA in isoform 7. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_040068 | 214 – 241 | Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_002188 | 283 – 399 | KPQHE…TAAYI → CSAFLLPHPFLIPSTPSPNH HHHHLLGSLSMNRERSRSQK DLTLRSL in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_040069 | 390 – 399 | TGPRMTAAYI → GKRSSFPTCKAKAATPGPLL EMEAC in isoform 6. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF288571 mRNA Translation: AAG01022.1 AF198532 mRNA Translation: AAF13268.1 AF294627 mRNA Translation: AAG26886.1 AK294395 mRNA Translation: BAG57649.1 AK303272 mRNA Translation: BAH13928.1 AC092539 Genomic DNA No translation available. AC097067 Genomic DNA No translation available. AC118062 Genomic DNA No translation available. AC123576 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06223.1 CH471057 Genomic DNA Translation: EAX06225.1 BC040559 mRNA Translation: AAH40559.1 BC050632 mRNA Translation: AAH50632.1 |
CCDSi | CCDS3679.1 [Q9UJU2-1] CCDS47122.1 [Q9UJU2-6] CCDS47123.1 [Q9UJU2-5] CCDS54791.1 [Q9UJU2-7] |
PIRi | A39625 |
RefSeqi | NP_001124185.1, NM_001130713.2 [Q9UJU2-5] NP_001124186.1, NM_001130714.2 [Q9UJU2-6] NP_001159591.1, NM_001166119.1 [Q9UJU2-7] NP_057353.1, NM_016269.4 [Q9UJU2-1] |
Genome annotation databases
Ensembli | ENST00000265165; ENSP00000265165; ENSG00000138795 [Q9UJU2-1] ENST00000379951; ENSP00000369284; ENSG00000138795 [Q9UJU2-6] ENST00000438313; ENSP00000406176; ENSG00000138795 [Q9UJU2-5] ENST00000506680; ENSP00000422334; ENSG00000138795 [Q9UJU2-2] ENST00000510624; ENSP00000422840; ENSG00000138795 [Q9UJU2-7] |
GeneIDi | 51176 |
KEGGi | hsa:51176 |
UCSCi | uc003hyt.3, human [Q9UJU2-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF288571 mRNA Translation: AAG01022.1 AF198532 mRNA Translation: AAF13268.1 AF294627 mRNA Translation: AAG26886.1 AK294395 mRNA Translation: BAG57649.1 AK303272 mRNA Translation: BAH13928.1 AC092539 Genomic DNA No translation available. AC097067 Genomic DNA No translation available. AC118062 Genomic DNA No translation available. AC123576 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06223.1 CH471057 Genomic DNA Translation: EAX06225.1 BC040559 mRNA Translation: AAH40559.1 BC050632 mRNA Translation: AAH50632.1 |
CCDSi | CCDS3679.1 [Q9UJU2-1] CCDS47122.1 [Q9UJU2-6] CCDS47123.1 [Q9UJU2-5] CCDS54791.1 [Q9UJU2-7] |
PIRi | A39625 |
RefSeqi | NP_001124185.1, NM_001130713.2 [Q9UJU2-5] NP_001124186.1, NM_001130714.2 [Q9UJU2-6] NP_001159591.1, NM_001166119.1 [Q9UJU2-7] NP_057353.1, NM_016269.4 [Q9UJU2-1] |
3D structure databases
BMRBi | Q9UJU2 |
SMRi | Q9UJU2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119354, 52 interactors |
ComplexPortali | CPX-316, beta1-catenin - LEF1 complex |
CORUMi | Q9UJU2 |
DIPi | DIP-29946N |
IntActi | Q9UJU2, 25 interactors |
MINTi | Q9UJU2 |
STRINGi | 9606.ENSP00000265165 |
Chemistry databases
ChEMBLi | CHEMBL3217392 |
DrugBanki | DB00903, Etacrynic acid |
PTM databases
GlyConnecti | 2055, 1 N-Linked glycan (1 site) |
GlyGeni | Q9UJU2, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | Q9UJU2 |
PhosphoSitePlusi | Q9UJU2 |
Genetic variation databases
BioMutai | LEF1 |
DMDMi | 8928194 |
Proteomic databases
jPOSTi | Q9UJU2 |
MassIVEi | Q9UJU2 |
PaxDbi | Q9UJU2 |
PeptideAtlasi | Q9UJU2 |
PRIDEi | Q9UJU2 |
ProteomicsDBi | 19686 84650 [Q9UJU2-1] 84651 [Q9UJU2-2] 84652 [Q9UJU2-3] 84653 [Q9UJU2-4] 84654 [Q9UJU2-5] 84655 [Q9UJU2-6] |
TopDownProteomicsi | Q9UJU2-2 [Q9UJU2-2] |
Protocols and materials databases
Antibodypediai | 912, 770 antibodies |
DNASUi | 51176 |
Genome annotation databases
Ensembli | ENST00000265165; ENSP00000265165; ENSG00000138795 [Q9UJU2-1] ENST00000379951; ENSP00000369284; ENSG00000138795 [Q9UJU2-6] ENST00000438313; ENSP00000406176; ENSG00000138795 [Q9UJU2-5] ENST00000506680; ENSP00000422334; ENSG00000138795 [Q9UJU2-2] ENST00000510624; ENSP00000422840; ENSG00000138795 [Q9UJU2-7] |
GeneIDi | 51176 |
KEGGi | hsa:51176 |
UCSCi | uc003hyt.3, human [Q9UJU2-1] |
Organism-specific databases
CTDi | 51176 |
DisGeNETi | 51176 |
GeneCardsi | LEF1 |
HGNCi | HGNC:6551, LEF1 |
HPAi | ENSG00000138795, Tissue enriched (lymphoid) |
MIMi | 153245, gene |
neXtProti | NX_Q9UJU2 |
OpenTargetsi | ENSG00000138795 |
PharmGKBi | PA30331 |
VEuPathDBi | HostDB:ENSG00000138795.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3248, Eukaryota |
GeneTreei | ENSGT00940000159660 |
HOGENOMi | CLU_013229_5_0_1 |
InParanoidi | Q9UJU2 |
OMAi | SQDSYHD |
OrthoDBi | 807716at2759 |
PhylomeDBi | Q9UJU2 |
TreeFami | TF318448 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJU2 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-4086398, Ca2+ pathway R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265, Repression of WNT target genes R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8951430, RUNX3 regulates WNT signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | Q9UJU2 |
SIGNORi | Q9UJU2 |
Miscellaneous databases
BioGRID-ORCSi | 51176, 5 hits in 1017 CRISPR screens |
ChiTaRSi | LEF1, human |
GeneWikii | Lymphoid_enhancer-binding_factor_1 |
GenomeRNAii | 51176 |
Pharosi | Q9UJU2, Tchem |
PROi | PR:Q9UJU2 |
RNActi | Q9UJU2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138795, Expressed in female gonad and 220 other tissues |
ExpressionAtlasi | Q9UJU2, baseline and differential |
Genevisiblei | Q9UJU2, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR028769, LEF1 IPR024940, TCF/LEF |
PANTHERi | PTHR10373, PTHR10373, 1 hit PTHR10373:SF11, PTHR10373:SF11, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LEF1_HUMAN | |
Accessioni | Q9UJU2Primary (citable) accession number: Q9UJU2 Secondary accession number(s): B4DG38 Q9HAZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families