LEF1

Functionⁱ

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.By similarity3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	299 – 367	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

armadillo repeat domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12408825
beta-catenin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 9488439
C2H2 zinc finger domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18445004
chromatin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20360943
DNA binding Source: UniProtKB
DNA binding, bending Source: UniProtKB
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23001182
DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11751639
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
enhancer binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7657162
estrogen receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18794125
estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18794125
gamma-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14661054
histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20363964
histone deacetylase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 18936100
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: ParkinsonsUK-UCL
RNA polymerase II regulatory region sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 23001182
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9308964
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alpha-beta T cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
anatomical structure regression Source: Ensembl
apoptotic process involved in blood vessel morphogenesis Source: Ensembl
apoptotic process involved in morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
B cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
beta-catenin-TCF complex assembly Source: Reactome
BMP signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
branching involved in blood vessel morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10644691
- 20123964
cell chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 19576624
cellular response to cytokine stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23001182
cellular response to interleukin-4
Source: UniProtKB
Inferred from direct assayⁱ
- 18579517
chorio-allantoic fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dentate gyrus development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
embryonic limb morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
epithelial to mesenchymal transition Source: BHF-UCL
eye pigmentation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
face morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
forebrain neuroblast division
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
forebrain radial glial cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
formation of radial glial scaffolds
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histone H3 acetylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20363964
histone H4 acetylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20363964
mammary gland development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20360943
negative regulation of apoptotic process in bone marrow
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17063141
negative regulation of cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 19653274
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20360943
negative regulation of DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18445004
negative regulation of estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18794125
negative regulation of interleukin-13 production
Source: UniProtKB
Inferred from direct assayⁱ
- 18445004
negative regulation of interleukin-4 production
Source: UniProtKB
Inferred from direct assayⁱ
- 18445004
negative regulation of interleukin-5 production
Source: UniProtKB
Inferred from direct assayⁱ
- 18445004
negative regulation of striated muscle tissue development Source: Ensembl
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18794125
- 19653274
negative regulation of transcription by RNA polymerase II Source: Ensembl
neutrophil differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17063141
odontoblast differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
odontogenesis of dentin-containing tooth Source: Ensembl
osteoblast differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 20128911
paraxial mesoderm formation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation by host of viral transcription
Source: UniProtKB
Inferred from direct assayⁱ
- 7657162
positive regulation of cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 19653274
positive regulation of cell cycle process
Source: UniProtKB
Inferred from direct assayⁱ
- 19653274
positive regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20360943
positive regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 19653274
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 19351848
- 19653274
positive regulation of cell proliferation in bone marrow
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17063141
positive regulation of epithelial to mesenchymal transition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20018240
positive regulation of gene expression
Source: AgBase
Inferred from direct assayⁱ
- 16344550
positive regulation of granulocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 19620402
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 11751639
regulation of cell-cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of Wnt signaling pathway Source: Ensembl
secondary palate development Source: BHF-UCL
sensory perception of taste Source: Ensembl
somitogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sprouting angiogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
T cell receptor V(D)J recombination Source: Ensembl
T-helper 1 cell differentiation Source: UniProtKB
tongue development Source: Ensembl
trachea gland development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 23001182
Wnt signaling pathway, calcium modulating pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402 Deactivation of the beta-catenin transactivating complex R-HSA-4086398 Ca2+ pathway R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265 Repression of WNT target genes R-HSA-8951430 RUNX3 regulates WNT signaling
SignaLinkⁱ	Q9UJU2
SIGNORⁱ	Q9UJU2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lymphoid enhancer-binding factor 1 Short name: LEF-1 Alternative name(s): T cell-specific transcription factor 1-alpha Short name: TCF1-alpha
Gene namesⁱ	Name:LEF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138795.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6551 LEF1
MIMⁱ	153245 gene
neXtProtⁱ	NX_Q9UJU2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	155	T → A: Reduced phosphorylation by NLK; when associated with A-166. 1 Publication		1
Mutagenesisⁱ	166	S → A: Reduced phosphorylation by NLK; when associated with A-155. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51176
Open Targets More...OpenTargetsⁱ	ENSG00000138795
PharmGKBⁱ	PA30331

Chemistry databases

ChEMBLⁱ	CHEMBL3217392

ChEMBLⁱ

CHEMBL3217392

Polymorphism and mutation databases

BioMutaⁱ	LEF1
DMDMⁱ	8928194

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048595	1 – 399	Lymphoid enhancer-binding factor 1Add BLAST		399

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	132	PhosphoserineCombined sources	1
Modified residueⁱ	155	Phosphothreonine; by NLK1 Publication	1
Modified residueⁱ	166	Phosphoserine; by NLK1 Publication	1
Cross-linkⁱ	269	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationⁱ

Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9UJU2
PeptideAtlas More...PeptideAtlasⁱ	Q9UJU2
PRIDEⁱ	Q9UJU2
ProteomicsDBⁱ	84650 84651 [Q9UJU2-2] 84652 [Q9UJU2-3] 84653 [Q9UJU2-4] 84654 [Q9UJU2-5] 84655 [Q9UJU2-6]
TopDownProteomicsⁱ	Q9UJU2-2 [Q9UJU2-2]

PTM databases

iPTMnetⁱ	Q9UJU2
PhosphoSitePlusⁱ	Q9UJU2

Expressionⁱ

Tissue specificityⁱ

Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000138795 Expressed in 202 organ(s), highest expression level in female gonad
CleanExⁱ	HS_LEF1
ExpressionAtlasⁱ	Q9UJU2 baseline and differential
Genevisibleⁱ	Q9UJU2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB019405 HPA002087

HPAⁱ

CAB019405
HPA002087

Interactionⁱ

Subunit structureⁱ

Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CTNNB1	P35222	9	EBI-926131,EBI-491549
FHIT	P49789	2	EBI-926131,EBI-741760
IGF1R	P08069	5	EBI-926131,EBI-475981

GO - Molecular functionⁱ

armadillo repeat domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12408825
beta-catenin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 9488439
C2H2 zinc finger domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18445004
estrogen receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18794125
gamma-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14661054
histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20363964
histone deacetylase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 18936100

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119354, 40 interactors
ComplexPortalⁱ	CPX-316 beta1-catenin - LEF1 complex
Database of interacting proteins More...DIPⁱ	DIP-29946N
IntActⁱ	Q9UJU2, 23 interactors
Molecular INTeraction database More...MINTⁱ	Q9UJU2
STRINGⁱ	9606.ENSP00000265165

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UJU2
SMRⁱ	Q9UJU2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 62	CTNNB1-bindingBy similarityAdd BLAST		62

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	6 – 13	Poly-Gly	8
Compositional biasⁱ	14 – 52	Asp/Glu-rich (acidic)Add BLAST	39
Compositional biasⁱ	77 – 273	Pro-richAdd BLAST	197
Compositional biasⁱ	374 – 379	Poly-Lys	6

Domainⁱ

Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors.

Sequence similaritiesⁱ

Belongs to the TCF/LEF family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3248 Eukaryota ENOG41109RU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009964
HOGENOMⁱ	HOG000116032
HOVERGENⁱ	HBG000419
InParanoidⁱ	Q9UJU2
KEGG Orthology (KO) More...KOⁱ	K04492
OMAⁱ	GYSGYIM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0705
PhylomeDBⁱ	Q9UJU2
TreeFamⁱ	TF318448

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit 4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR027397 Catenin_binding_dom_sf IPR013558 CTNNB1-bd_N IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR028769 LEF1 IPR024940 TCF/LEF
PANTHERⁱ	PTHR10373 PTHR10373, 1 hit PTHR10373:SF11 PTHR10373:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08347 CTNNB1_binding, 1 hit PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UJU2-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQLSGGGGG GGGDPELCAT DEMIPFKDEG DPQKEKIFAE ISHPEEEGDL 
        60         70         80         90        100
ADIKSSLVNE SEIIPASNGH EVARQAQTSQ EPYHDKAREH PDDGKHPDGG 
       110        120        130        140        150
LYNKGPSYSS YSGYIMMPNM NNDPYMSNGS LSPPIPRTSN KVPVVQPSHA 
       160        170        180        190        200
VHPLTPLITY SDEHFSPGSH PSHIPSDVNS KQGMSRHPPA PDIPTFYPLS 
       210        220        230        240        250
PGGVGQITPP LGWQGQPVYP ITGGFRQPYP SSLSVDTSMS RFSHHMIPGP 
       260        270        280        290        300
PGPHTTGIPH PAIVTPQVKQ EHPHTDSDLM HVKPQHEQRK EQEPKRPHIK 
       310        320        330        340        350
KPLNAFMLYM KEMRANVVAE CTLKESAAIN QILGRRWHAL SREEQAKYYE 
       360        370        380        390 
LARKERQLHM QLYPGWSARD NYGKKKKRKR EKLQESASGT GPRMTAAYI

Note: Produced by alternative promoter usage.

Length:399

Mass (Da):44,201

Last modified:May 1, 2000 - v1

Checksum:ⁱD480D440698EEFE3

GO

Isoform 2 (identifier: Q9UJU2-2) [UniParc]FASTA Add to basket

Also known as: B, 8A

The sequence of this isoform differs from the canonical sequence as follows:
283-399: KPQHEQRKEQ...TGPRMTAAYI → CSAFLLPHPF...SQKDLTLRSL

« Hide

        10         20         30         40         50
MPQLSGGGGG GGGDPELCAT DEMIPFKDEG DPQKEKIFAE ISHPEEEGDL 
        60         70         80         90        100
ADIKSSLVNE SEIIPASNGH EVARQAQTSQ EPYHDKAREH PDDGKHPDGG 
       110        120        130        140        150
LYNKGPSYSS YSGYIMMPNM NNDPYMSNGS LSPPIPRTSN KVPVVQPSHA 
       160        170        180        190        200
VHPLTPLITY SDEHFSPGSH PSHIPSDVNS KQGMSRHPPA PDIPTFYPLS 
       210        220        230        240        250
PGGVGQITPP LGWQGQPVYP ITGGFRQPYP SSLSVDTSMS RFSHHMIPGP 
       260        270        280        290        300
PGPHTTGIPH PAIVTPQVKQ EHPHTDSDLM HVCSAFLLPH PFLIPSTPSP 
       310        320 
NHHHHHLLGS LSMNRERSRS QKDLTLRSL

Note: Produced by alternative splicing of isoform 1. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:329

Mass (Da):35,672

Checksum:ⁱ3632325D440CA5DD

GO

Isoform 3 (identifier: Q9UJU2-3) [UniParc]FASTA Add to basket

Also known as: LEF-1-DN

The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.

« Hide

        10         20         30         40         50
MMPNMNNDPY MSNGSLSPPI PRTSNKVPVV QPSHAVHPLT PLITYSDEHF 
        60         70         80         90        100
SPGSHPSHIP SDVNSKQGMS RHPPAPDIPT FYPLSPGGVG QITPPLGWQG 
       110        120        130        140        150
QPVYPITGGF RQPYPSSLSV DTSMSRFSHH MIPGPPGPHT TGIPHPAIVT 
       160        170        180        190        200
PQVKQEHPHT DSDLMHVKPQ HEQRKEQEPK RPHIKKPLNA FMLYMKEMRA 
       210        220        230        240        250
NVVAECTLKE SAAINQILGR RWHALSREEQ AKYYELARKE RQLHMQLYPG 
       260        270        280 
WSARDNYGKK KKRKREKLQE SASGTGPRMT AAYI

Note: Produced by alternative promoter usage. Acts as dominant negative mutant.

Show »

Length:284

Mass (Da):31,919

Checksum:ⁱ22320A1A195401ED

GO

Isoform 4 (identifier: Q9UJU2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
283-399: KPQHEQRKEQ...TGPRMTAAYI → CSAFLLPHPF...SQKDLTLRSL

« Hide

        10         20         30         40         50
MMPNMNNDPY MSNGSLSPPI PRTSNKVPVV QPSHAVHPLT PLITYSDEHF 
        60         70         80         90        100
SPGSHPSHIP SDVNSKQGMS RHPPAPDIPT FYPLSPGGVG QITPPLGWQG 
       110        120        130        140        150
QPVYPITGGF RQPYPSSLSV DTSMSRFSHH MIPGPPGPHT TGIPHPAIVT 
       160        170        180        190        200
PQVKQEHPHT DSDLMHVCSA FLLPHPFLIP STPSPNHHHH HLLGSLSMNR 
       210 
ERSRSQKDLT LRSL

Note: Produced by alternative splicing of isoform 3.

Show »

Length:214

Mass (Da):23,390

Checksum:ⁱDDBF9358A5E8944C

GO

Isoform 5 (identifier: Q9UJU2-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
214-241: Missing.

« Hide

        10         20         30         40         50
MPQLSGGGGG GGGDPELCAT DEMIPFKDEG DPQKEKIFAE ISHPEEEGDL 
        60         70         80         90        100
ADIKSSLVNE SEIIPASNGH EVARQAQTSQ EPYHDKAREH PDDGKHPDGG 
       110        120        130        140        150
LYNKGPSYSS YSGYIMMPNM NNDPYMSNGS LSPPIPRTSN KVPVVQPSHA 
       160        170        180        190        200
VHPLTPLITY SDEHFSPGSH PSHIPSDVNS KQGMSRHPPA PDIPTFYPLS 
       210        220        230        240        250
PGGVGQITPP LGWFSHHMIP GPPGPHTTGI PHPAIVTPQV KQEHPHTDSD 
       260        270        280        290        300
LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML YMKEMRANVV AECTLKESAA 
       310        320        330        340        350
INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA RDNYGKKKKR 
       360        370 
KREKLQESAS GTGPRMTAAY I

Note: Produced by alternative splicing of isoform 1.

Show »

Length:371

Mass (Da):41,162

Checksum:ⁱF929C8679F4EC1A3

GO

Isoform 6 (identifier: Q9UJU2-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
214-241: Missing.
390-399: TGPRMTAAYI → GKRSSFPTCKAKAATPGPLLEMEAC

« Hide

        10         20         30         40         50
MPQLSGGGGG GGGDPELCAT DEMIPFKDEG DPQKEKIFAE ISHPEEEGDL 
        60         70         80         90        100
ADIKSSLVNE SEIIPASNGH EVARQAQTSQ EPYHDKAREH PDDGKHPDGG 
       110        120        130        140        150
LYNKGPSYSS YSGYIMMPNM NNDPYMSNGS LSPPIPRTSN KVPVVQPSHA 
       160        170        180        190        200
VHPLTPLITY SDEHFSPGSH PSHIPSDVNS KQGMSRHPPA PDIPTFYPLS 
       210        220        230        240        250
PGGVGQITPP LGWFSHHMIP GPPGPHTTGI PHPAIVTPQV KQEHPHTDSD 
       260        270        280        290        300
LMHVKPQHEQ RKEQEPKRPH IKKPLNAFML YMKEMRANVV AECTLKESAA 
       310        320        330        340        350
INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA RDNYGKKKKR 
       360        370        380 
KREKLQESAS GGKRSSFPTC KAKAATPGPL LEMEAC

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

Show »

Length:386

Mass (Da):42,676

Checksum:ⁱ918B4201D718A485

GO

Isoform 7 (identifier: Q9UJU2-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-70: MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGH → MA
214-241: Missing.

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        10         20         30         40         50
MAEVARQAQT SQEPYHDKAR EHPDDGKHPD GGLYNKGPSY SSYSGYIMMP 
        60         70         80         90        100
NMNNDPYMSN GSLSPPIPRT SNKVPVVQPS HAVHPLTPLI TYSDEHFSPG 
       110        120        130        140        150
SHPSHIPSDV NSKQGMSRHP PAPDIPTFYP LSPGGVGQIT PPLGWFSHHM 
       160        170        180        190        200
IPGPPGPHTT GIPHPAIVTP QVKQEHPHTD SDLMHVKPQH EQRKEQEPKR 
       210        220        230        240        250
PHIKKPLNAF MLYMKEMRAN VVAECTLKES AAINQILGRR WHALSREEQA 
       260        270        280        290        300
KYYELARKER QLHMQLYPGW SARDNYGKKK KRKREKLQES ASGTGPRMTA 

AYI

Note: No experimental confirmation available.

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Length:303

Mass (Da):34,103

Checksum:ⁱ38F7331074A62A79

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RIV1	D6RIV1_HUMAN	Lymphoid enhancer-binding factor 1 Lymphoid enhancer-binding factor 1	LEF1	145	Annotation score:
D6RAB1	D6RAB1_HUMAN	Lymphoid enhancer-binding factor 1 Lymphoid enhancer-binding factor 1	LEF1	173	Annotation score:
D6RID7	D6RID7_HUMAN	Lymphoid enhancer-binding factor 1 Lymphoid enhancer-binding factor 1	LEF1	133	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	146	Q → R in BAH13928 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035935	113	G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs369649181Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_007022	1 – 115	Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST	115
Alternative sequenceⁱVSP_044877	1 – 70	MPQLS…ASNGH → MA in isoform 7. 1 PublicationAdd BLAST	70
Alternative sequenceⁱVSP_040068	214 – 241	Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST	28
Alternative sequenceⁱVSP_002188	283 – 399	KPQHE…TAAYI → CSAFLLPHPFLIPSTPSPNH HHHHLLGSLSMNRERSRSQK DLTLRSL in isoform 2 and isoform 4. 1 PublicationAdd BLAST	117
Alternative sequenceⁱVSP_040069	390 – 399	TGPRMTAAYI → GKRSSFPTCKAKAATPGPLL EMEAC in isoform 6. 1 Publication	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF288571 mRNA Translation: AAG01022.1 AF198532 mRNA Translation: AAF13268.1 AF294627 mRNA Translation: AAG26886.1 AK294395 mRNA Translation: BAG57649.1 AK303272 mRNA Translation: BAH13928.1 AC092539 Genomic DNA No translation available. AC097067 Genomic DNA No translation available. AC118062 Genomic DNA No translation available. AC123576 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06223.1 CH471057 Genomic DNA Translation: EAX06225.1 BC040559 mRNA Translation: AAH40559.1 BC050632 mRNA Translation: AAH50632.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3679.1 [Q9UJU2-1] CCDS47122.1 [Q9UJU2-6] CCDS47123.1 [Q9UJU2-5] CCDS54791.1 [Q9UJU2-7]
PIRⁱ	A39625
NCBI Reference Sequences More...RefSeqⁱ	NP_001124185.1, NM_001130713.2 [Q9UJU2-5] NP_001124186.1, NM_001130714.2 [Q9UJU2-6] NP_001159591.1, NM_001166119.1 [Q9UJU2-7] NP_057353.1, NM_016269.4 [Q9UJU2-1]
UniGeneⁱ	Hs.743478

Genome annotation databases

Ensemblⁱ	ENST00000265165; ENSP00000265165; ENSG00000138795 [Q9UJU2-1] ENST00000379951; ENSP00000369284; ENSG00000138795 [Q9UJU2-6] ENST00000438313; ENSP00000406176; ENSG00000138795 [Q9UJU2-5] ENST00000506680; ENSP00000422334; ENSG00000138795 [Q9UJU2-2] ENST00000510624; ENSP00000422840; ENSG00000138795 [Q9UJU2-7]
GeneIDⁱ	51176
KEGGⁱ	hsa:51176
UCSC genome browser More...UCSCⁱ	uc003hyt.3 human [Q9UJU2-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UJU2	Lymphoid enhancer-binding factor 1, isoform CRA_b		HUMAN		399	UniRef100_Q9UJU2
Uncharacterized protein DKFZp586H0919 (Fragment)		HUMAN		69
Isoform 3 of Lymphoid enhancer-binding factor 1		HUMAN		284

Protein	Similar proteins		Species	Score	Length	Source
Q9UJU2	Lymphoid enhancer-binding factor 1	)	MOUSE		397	UniRef90_P27782
Lymphoid enhancer-binding factor 1		RAT		397
Uncharacterized protein		PROCO		432
Uncharacterized protein		FELCA		423
lymphoid enhancer-binding factor 1 isoform X2		Enhydra lutris kenyoni		400
+188
Q9UJU2-2	Isoform 4 of Lymphoid enhancer-binding factor 1		HUMAN		214	UniRef90_Q9UJU2-2
LEF1 isoform 4		PANTR		329
LEF1 isoform 4		PONAB		328
Q9UJU2-4	Isoform 2 of Lymphoid enhancer-binding factor 1		HUMAN		329	UniRef90_Q9UJU2-2
LEF1 isoform 4		PANTR		329
LEF1 isoform 4		PONAB		328
Q9UJU2-5	Isoform 6 of Lymphoid enhancer-binding factor 1		HUMAN		386	UniRef90_Q9UJU2-6
Uncharacterized protein		CALJA		386
Uncharacterized protein		MACMU		386
Uncharacterized protein		COLAP		386
LEF1 isoform 1		PONAB		386
+101
Q9UJU2-6	Uncharacterized protein		CALJA		386	UniRef90_Q9UJU2-6
Uncharacterized protein		MACMU		386
Uncharacterized protein		COLAP		386
LEF1 isoform 1		PONAB		386
LEF1 isoform 1		PANTR		386
+101
Q9UJU2-7	lymphoid enhancer-binding factor 1 isoform X7		DELLE		303	UniRef90_Q9UJU2-7
Uncharacterized protein		FELCA		303
LEF1 isoform 8		PANTR		303
Uncharacterized protein		MACMU		303
Uncharacterized protein		CALJA		303
+37

Protein	Similar proteins		Species	Score	Length	Source
Q9UJU2	Lymphoid enhancer-binding factor 1	)	MOUSE		397	UniRef50_P27782
Lymphoid enhancer-binding factor 1		RAT		397
Uncharacterized protein		PROCO		432
Uncharacterized protein		FELCA		423
lymphoid enhancer-binding factor 1 isoform X2		Enhydra lutris kenyoni		400
+302
Q9UJU2-2	Isoform 4 of Lymphoid enhancer-binding factor 1		HUMAN		214	UniRef50_Q9UJU2-2
LEF1 isoform 4		PANTR		329
LEF1 isoform 4		PONAB		328
lymphoid enhancer-binding factor 1		ERIEU		359
Uncharacterized protein		POEFO		370
+11
Q9UJU2-4	Isoform 2 of Lymphoid enhancer-binding factor 1		HUMAN		329	UniRef50_Q9UJU2-2
LEF1 isoform 4		PANTR		329
LEF1 isoform 4		PONAB		328
lymphoid enhancer-binding factor 1		ERIEU		359
Uncharacterized protein		POEFO		370
+11
Q9UJU2-7	lymphoid enhancer-binding factor 1 isoform X7		DELLE		303	UniRef50_Q9UJU2-7
LEF1 isoform 8		PANTR		303
Uncharacterized protein		MACMU		303
Uncharacterized protein		CALJA		303
Uncharacterized protein		COLAP		303
+125

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF288571 mRNA Translation: AAG01022.1 AF198532 mRNA Translation: AAF13268.1 AF294627 mRNA Translation: AAG26886.1 AK294395 mRNA Translation: BAG57649.1 AK303272 mRNA Translation: BAH13928.1 AC092539 Genomic DNA No translation available. AC097067 Genomic DNA No translation available. AC118062 Genomic DNA No translation available. AC123576 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06223.1 CH471057 Genomic DNA Translation: EAX06225.1 BC040559 mRNA Translation: AAH40559.1 BC050632 mRNA Translation: AAH50632.1
CCDSⁱ	CCDS3679.1 [Q9UJU2-1] CCDS47122.1 [Q9UJU2-6] CCDS47123.1 [Q9UJU2-5] CCDS54791.1 [Q9UJU2-7]
PIRⁱ	A39625
RefSeqⁱ	NP_001124185.1, NM_001130713.2 [Q9UJU2-5] NP_001124186.1, NM_001130714.2 [Q9UJU2-6] NP_001159591.1, NM_001166119.1 [Q9UJU2-7] NP_057353.1, NM_016269.4 [Q9UJU2-1]
UniGeneⁱ	Hs.743478

3D structure databases

ProteinModelPortalⁱ	Q9UJU2
SMRⁱ	Q9UJU2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119354, 40 interactors
ComplexPortalⁱ	CPX-316 beta1-catenin - LEF1 complex
DIPⁱ	DIP-29946N
IntActⁱ	Q9UJU2, 23 interactors
MINTⁱ	Q9UJU2
STRINGⁱ	9606.ENSP00000265165

Chemistry databases

ChEMBLⁱ	CHEMBL3217392

ChEMBLⁱ

CHEMBL3217392

PTM databases

iPTMnetⁱ	Q9UJU2
PhosphoSitePlusⁱ	Q9UJU2

Polymorphism and mutation databases

BioMutaⁱ	LEF1
DMDMⁱ	8928194

Proteomic databases

PaxDbⁱ	Q9UJU2
PeptideAtlasⁱ	Q9UJU2
PRIDEⁱ	Q9UJU2
ProteomicsDBⁱ	84650 84651 [Q9UJU2-2] 84652 [Q9UJU2-3] 84653 [Q9UJU2-4] 84654 [Q9UJU2-5] 84655 [Q9UJU2-6]
TopDownProteomicsⁱ	Q9UJU2-2 [Q9UJU2-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51176
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265165; ENSP00000265165; ENSG00000138795 [Q9UJU2-1] ENST00000379951; ENSP00000369284; ENSG00000138795 [Q9UJU2-6] ENST00000438313; ENSP00000406176; ENSG00000138795 [Q9UJU2-5] ENST00000506680; ENSP00000422334; ENSG00000138795 [Q9UJU2-2] ENST00000510624; ENSP00000422840; ENSG00000138795 [Q9UJU2-7]
GeneIDⁱ	51176
KEGGⁱ	hsa:51176
UCSCⁱ	uc003hyt.3 human [Q9UJU2-1]

Organism-specific databases

CTDⁱ	51176
DisGeNETⁱ	51176
EuPathDBⁱ	HostDB:ENSG00000138795.9
GeneCardsⁱ	LEF1
HGNCⁱ	HGNC:6551 LEF1
HPAⁱ	CAB019405 HPA002087
MIMⁱ	153245 gene
neXtProtⁱ	NX_Q9UJU2
OpenTargetsⁱ	ENSG00000138795
PharmGKBⁱ	PA30331
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3248 Eukaryota ENOG41109RU LUCA
GeneTreeⁱ	ENSGT00390000009964
HOGENOMⁱ	HOG000116032
HOVERGENⁱ	HBG000419
InParanoidⁱ	Q9UJU2
KOⁱ	K04492
OMAⁱ	GYSGYIM
OrthoDBⁱ	EOG091G0705
PhylomeDBⁱ	Q9UJU2
TreeFamⁱ	TF318448

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402 Deactivation of the beta-catenin transactivating complex R-HSA-4086398 Ca2+ pathway R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265 Repression of WNT target genes R-HSA-8951430 RUNX3 regulates WNT signaling
SignaLinkⁱ	Q9UJU2
SIGNORⁱ	Q9UJU2

Miscellaneous databases

ChiTaRSⁱ	LEF1 human
GeneWikiⁱ	Lymphoid_enhancer-binding_factor_1
GenomeRNAiⁱ	51176
Protein Ontology More...PROⁱ	PR:Q9UJU2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000138795 Expressed in 202 organ(s), highest expression level in female gonad
CleanExⁱ	HS_LEF1
ExpressionAtlasⁱ	Q9UJU2 baseline and differential
Genevisibleⁱ	Q9UJU2 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit 4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR027397 Catenin_binding_dom_sf IPR013558 CTNNB1-bd_N IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR028769 LEF1 IPR024940 TCF/LEF
PANTHERⁱ	PTHR10373 PTHR10373, 1 hit PTHR10373:SF11 PTHR10373:SF11, 1 hit
Pfamⁱ	View protein in Pfam PF08347 CTNNB1_binding, 1 hit PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LEF1_HUMAN
Accessionⁱ	Q9UJU2Primary (citable) accession number: Q9UJU2 Secondary accession number(s): B4DG38 , B7Z8E2, E9PDK3, Q3ZCU4, Q9HAZ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9UJU2 (LEF1_HUMAN)

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Lymphoid enhancer-binding factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ