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Protein

F-box/LRR-repeat protein 7

Gene

FBXL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
F-box protein FBL6/FBL7
Gene namesi
Name:FBXL7
Synonyms:FBL6, FBL7, KIAA0840
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000183580.9
HGNCiHGNC:13604 FBXL7
MIMi605656 gene
neXtProtiNX_Q9UJT9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi23194
OpenTargetsiENSG00000183580
PharmGKBiPA28027

Polymorphism and mutation databases

DMDMi37537858

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198491 – 491F-box/LRR-repeat protein 7Add BLAST491

Proteomic databases

PaxDbiQ9UJT9
PeptideAtlasiQ9UJT9
PRIDEiQ9UJT9
ProteomicsDBi84649

PTM databases

iPTMnetiQ9UJT9
PhosphoSitePlusiQ9UJT9

Expressioni

Gene expression databases

BgeeiENSG00000183580
CleanExiHS_FBXL7
ExpressionAtlasiQ9UJT9 baseline and differential
GenevisibleiQ9UJT9 HS

Organism-specific databases

HPAiHPA055464

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).By similarity

Protein-protein interaction databases

BioGridi116803, 8 interactors
IntActiQ9UJT9, 7 interactors
STRINGi9606.ENSP00000423630

Structurei

3D structure databases

ProteinModelPortaliQ9UJT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 157F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati170 – 195LRR 1Add BLAST26
Repeati196 – 221LRR 2Add BLAST26
Repeati222 – 247LRR 3Add BLAST26
Repeati253 – 281LRR 4Add BLAST29
Repeati282 – 307LRR 5Add BLAST26
Repeati308 – 333LRR 6Add BLAST26
Repeati334 – 359LRR 7Add BLAST26
Repeati360 – 385LRR 8Add BLAST26
Repeati386 – 411LRR 9Add BLAST26
Repeati412 – 437LRR 10Add BLAST26
Repeati438 – 463LRR 11Add BLAST26

Sequence similaritiesi

Belongs to the FBXL7 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT22 Eukaryota
ENOG410YA1Y LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000116328
HOVERGENiHBG051591
InParanoidiQ9UJT9
KOiK10273
OMAiLMLETVI
OrthoDBiEOG091G06QE
PhylomeDBiQ9UJT9
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 5 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 11 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT
60 70 80 90 100
LSTPSPALIC PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL
110 120 130 140 150
IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD
160 170 180 190 200
PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VTVSGCRRLT
210 220 230 240 250
DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK
260 270 280 290 300
VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
310 320 330 340 350
THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES
360 370 380 390 400
RLRYLSIAHC GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN
410 420 430 440 450
CTKLKSLDIG KCPLVSDTGL ECLALNCFNL KRLSLKSCES ITGQGLQIVA
460 470 480 490
ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
Length:491
Mass (Da):54,575
Last modified:May 1, 2000 - v1
Checksum:iA70C092A4E748C69
GO
Isoform 2 (identifier: Q9UJT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,844
Checksum:iE815536979F050AB
GO

Sequence cautioni

The sequence BAA74863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547511 – 47Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199356 mRNA Translation: AAF09248.1
AB020647 mRNA Translation: BAA74863.2 Different initiation.
AC091970 Genomic DNA No translation available.
AC091872 Genomic DNA No translation available.
AC027332 Genomic DNA No translation available.
AC010638 Genomic DNA No translation available.
AC010477 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08029.1
BC075061 mRNA Translation: AAH75061.1
BC136424 mRNA Translation: AAI36425.1
AF174593 mRNA Translation: AAF04514.1
CCDSiCCDS54833.1 [Q9UJT9-1]
CCDS64129.1 [Q9UJT9-2]
RefSeqiNP_001265246.1, NM_001278317.1 [Q9UJT9-2]
NP_036436.1, NM_012304.4 [Q9UJT9-1]
XP_011512300.1, XM_011513998.1 [Q9UJT9-2]
UniGeneiHs.433057

Genome annotation databases

EnsembliENST00000504595; ENSP00000423630; ENSG00000183580 [Q9UJT9-1]
ENST00000510662; ENSP00000425184; ENSG00000183580 [Q9UJT9-2]
GeneIDi23194
KEGGihsa:23194
UCSCiuc003jfn.3 human [Q9UJT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFBXL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT9
Secondary accession number(s): B9EGF1, D6RDY7, O94926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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