UniProtKB - Q9UJT2 (TSKS_HUMAN)

BLAST

>sp|Q9UJT2|TSKS_HUMAN Testis-specific serine kinase substrate OS=Homo sapiens OX=9606 GN=TSKS PE=1 SV=3
MASVVVKTIWQSKEIHEAGDTPTGVESCSQLVPEAPRRVTSRAKGIPKKKKAVSFHGVEP
QMSHQPMHWCLNLKRSSACTNVSLLNLAAMEPTDSTGTDSTVEDLSGQLTLAGPPASPTL
PWDPDDADITEILSGVNSGLVRAKDSITSLKEKTNRVNQHVQSLQSECSVLSENLERRRQ
EAEELEGYCIQLKENCWKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQE
AELQEPEEKQEPEEKQEPEEKQKPEAGLSWNSLGPAATSQGCPGPPGSPDKPSRPHGLVP
AGWGMGPRAGEGPYVSEQELQKLFTGIEELRREVSSLTARWHQEEGAVQEALRLLGGLGG
RVDGFLGQWERAQREQAQTARDLQELRGRADELCTMVERSAVSVASLRSELEGLGPLKPI
LEEFGRQFQNSRRGPDLSMNLDRSHQGNCARCASQGSQLSTESLQQLLDRALTSLVDEVK
QRGLTPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKP
EEKMATLDHLHLKMCSLHDHLSNLPLEGSTGTMGGGSSAGTPPKQGGSAPEQ

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History
Entry version 119 (07 Nov 2018)
Sequence version 3 (01 Mar 2001)
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Protein

Testis-specific serine kinase substrate

Gene

TSKS

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18533145

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19389623

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Testis-specific serine kinase substrate Short name: Testis-specific kinase substrate Alternative name(s): STK22 substrate 1
Gene namesⁱ	Name:TSKS Synonyms:STK22S1, TSKS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126467.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30719 TSKS
MIMⁱ	608253 gene
neXtProtⁱ	NX_Q9UJT2

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000126467
PharmGKBⁱ	PA164727339

Polymorphism and mutation databases

BioMutaⁱ	TSKS
DMDMⁱ	44888550

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000065665	1 – 592	Testis-specific serine kinase substrateAdd BLAST		592

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	217	PhosphoserineBy similarity	1
Modified residueⁱ	288	Phosphoserine; by TSSK1 and TSSK2By similarity	1
Modified residueⁱ	316	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UJT2
PaxDbⁱ	Q9UJT2
PeptideAtlas More...PeptideAtlasⁱ	Q9UJT2
PRIDEⁱ	Q9UJT2
ProteomicsDBⁱ	84647 84648 [Q9UJT2-2]

PTM databases

iPTMnetⁱ	Q9UJT2
PhosphoSitePlusⁱ	Q9UJT2

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000126467 Expressed in 88 organ(s), highest expression level in right testis
ExpressionAtlasⁱ	Q9UJT2 baseline and differential
Genevisibleⁱ	Q9UJT2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045729

HPAⁱ

HPA045729

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TSSK2	Q96PF2	7	EBI-852101,EBI-852089

With

Entry

#Exp.

IntAct

Notes

TSSK2

Q96PF2

EBI-852101,EBI-852089

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18533145

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121902, 27 interactors
IntActⁱ	Q9UJT2, 8 interactors
STRINGⁱ	9606.ENSP00000246801

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UJT2
SMRⁱ	Q9UJT2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IEF7 Eukaryota ENOG410YKYG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002611
HOGENOMⁱ	HOG000121770
HOVERGENⁱ	HBG050300
InParanoidⁱ	Q9UJT2
KEGG Orthology (KO) More...KOⁱ	K16492
OMAⁱ	PWAPDDP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G074P
PhylomeDBⁱ	Q9UJT2
TreeFamⁱ	TF337594

Family and domain databases

InterProⁱ	View protein in InterPro IPR028214 TSKS
PANTHERⁱ	PTHR14351 PTHR14351, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15358 TSKS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UJT2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVVVKTIW QSKEIHEAGD TPTGVESCSQ LVPEAPRRVT SRAKGIPKKK 
        60         70         80         90        100
KAVSFHGVEP QMSHQPMHWC LNLKRSSACT NVSLLNLAAM EPTDSTGTDS 
       110        120        130        140        150
TVEDLSGQLT LAGPPASPTL PWDPDDADIT EILSGVNSGL VRAKDSITSL 
       160        170        180        190        200
KEKTNRVNQH VQSLQSECSV LSENLERRRQ EAEELEGYCI QLKENCWKVT 
       210        220        230        240        250
RSVEDAEIKT NVLKQNSALL EEKLRYLQQQ LQDETPRRQE AELQEPEEKQ 
       260        270        280        290        300
EPEEKQEPEE KQKPEAGLSW NSLGPAATSQ GCPGPPGSPD KPSRPHGLVP 
       310        320        330        340        350
AGWGMGPRAG EGPYVSEQEL QKLFTGIEEL RREVSSLTAR WHQEEGAVQE 
       360        370        380        390        400
ALRLLGGLGG RVDGFLGQWE RAQREQAQTA RDLQELRGRA DELCTMVERS 
       410        420        430        440        450
AVSVASLRSE LEGLGPLKPI LEEFGRQFQN SRRGPDLSMN LDRSHQGNCA 
       460        470        480        490        500
RCASQGSQLS TESLQQLLDR ALTSLVDEVK QRGLTPACPS CQRLHKKILE 
       510        520        530        540        550
LERQALAKHV RAEALSSTLR LAQDEALRAK NLLLTDKMKP EEKMATLDHL 
       560        570        580        590 
HLKMCSLHDH LSNLPLEGST GTMGGGSSAG TPPKQGGSAP EQ

Length:592

Mass (Da):65,050

Last modified:March 1, 2001 - v3

Checksum:ⁱ87B262601EECE121

Isoform 2 (identifier: Q9UJT2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.
     201-221: RSVEDAEIKTNVLKQNSALLE → MGDSCPAVTFRSQKENRAGLQ
     254-259: Missing.

« Hide

        10         20         30         40         50
MGDSCPAVTF RSQKENRAGL QEKLRYLQQQ LQDETPRRQE AELQEPEEKQ 
        60         70         80         90        100
EPEEKQKPEA GLSWNSLGPA ATSQGCPGPP GSPDKPSRPH GLVPAGWGMG 
       110        120        130        140        150
PRAGEGPYVS EQELQKLFTG IEELRREVSS LTARWHQEEG AVQEALRLLG 
       160        170        180        190        200
GLGGRVDGFL GQWERAQREQ AQTARDLQEL RGRADELCTM VERSAVSVAS 
       210        220        230        240        250
LRSELEGLGP LKPILEEFGR QFQNSRRGPD LSMNLDRSHQ GNCARCASQG 
       260        270        280        290        300
SQLSTESLQQ LLDRALTSLV DEVKQRGLTP ACPSCQRLHK KILELERQAL 
       310        320        330        340        350
AKHVRAEALS STLRLAQDEA LRAKNLLLTD KMKPEEKMAT LDHLHLKMCS 
       360        370        380 
LHDHLSNLPL EGSTGTMGGG SSAGTPPKQG GSAPEQ

Show »

Length:386

Mass (Da):42,359

Checksum:ⁱ173256D6886BF931

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9K0I0	C9K0I0_HUMAN		Testis-specific serine kinase subst... Testis-specific serine kinase substrate	TSKS	392	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	272	S → G in AAL60464 (PubMed:15044604).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036272	19	G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs149529240Ensembl.	1
Natural variantⁱVAR_051459	167	E → K. Corresponds to variant dbSNP:rs34701020Ensembl.	1
Natural variantⁱVAR_051460	382	D → G1 PublicationCorresponds to variant dbSNP:rs2304202Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_009591	1 – 200	Missing in isoform 2. CuratedAdd BLAST	200
Alternative sequenceⁱVSP_009592	201 – 221	RSVED…SALLE → MGDSCPAVTFRSQKENRAGL Q in isoform 2. CuratedAdd BLAST	21
Alternative sequenceⁱVSP_009593	254 – 259	Missing in isoform 2. Curated	6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF200923 Genomic DNA Translation: AAF12819.3 AF411384 mRNA Translation: AAL60464.1 BC058862 mRNA Translation: AAH58862.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12780.1 [Q9UJT2-1]
PIRⁱ	JC7709
NCBI Reference Sequences More...RefSeqⁱ	NP_068379.1, NM_021733.1 [Q9UJT2-1]
UniGeneⁱ	Hs.515858

Genome annotation databases

Ensemblⁱ	ENST00000246801; ENSP00000246801; ENSG00000126467 [Q9UJT2-1]
GeneIDⁱ	60385
KEGGⁱ	hsa:60385
UCSC genome browser More...UCSCⁱ	uc002ppm.4 human [Q9UJT2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9UJT2	Uncharacterized protein		MACMU		592	UniRef90_Q9UJT2
TSKS isoform 2		PANTR		580
Testis specific serine kinase substrate		MACFA		580
Uncharacterized protein		COLAP		580
Uncharacterized protein		Cebus capucinus imitator		580
+24
Q9UJT2-2	Testis-specific serine kinase substrate		HUMAN		392	UniRef90_Q9UJT2-2
Testis specific serine kinase substrate		SAIBB		388
TSKS isoform 3		PANTR		380
Uncharacterized protein		MACMU		380
Uncharacterized protein		MACFA		380
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9UJT2	Testis-specific serine kinase substrate		RAT		585	UniRef50_Q9UJT2
Testis-specific serine kinase substrate		MOUSE		585
Uncharacterized protein		MACMU		592
Uncharacterized protein		RHIBE		580
TSKS isoform 2		PANTR		580
+320
Q9UJT2-2	Testis-specific serine kinase substrate		HUMAN		392	UniRef50_Q9UJT2-2
Testis specific serine kinase substrate		SAIBB		388
Uncharacterized protein		RHIBE		380
Uncharacterized protein		MACNE		380
Uncharacterized protein		COLAP		380
+18

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF200923 Genomic DNA Translation: AAF12819.3 AF411384 mRNA Translation: AAL60464.1 BC058862 mRNA Translation: AAH58862.1
CCDSⁱ	CCDS12780.1 [Q9UJT2-1]
PIRⁱ	JC7709
RefSeqⁱ	NP_068379.1, NM_021733.1 [Q9UJT2-1]
UniGeneⁱ	Hs.515858

3D structure databases

ProteinModelPortalⁱ	Q9UJT2
SMRⁱ	Q9UJT2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121902, 27 interactors
IntActⁱ	Q9UJT2, 8 interactors
STRINGⁱ	9606.ENSP00000246801

PTM databases

iPTMnetⁱ	Q9UJT2
PhosphoSitePlusⁱ	Q9UJT2

Polymorphism and mutation databases

BioMutaⁱ	TSKS
DMDMⁱ	44888550

Proteomic databases

EPDⁱ	Q9UJT2
PaxDbⁱ	Q9UJT2
PeptideAtlasⁱ	Q9UJT2
PRIDEⁱ	Q9UJT2
ProteomicsDBⁱ	84647 84648 [Q9UJT2-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000246801; ENSP00000246801; ENSG00000126467 [Q9UJT2-1]
GeneIDⁱ	60385
KEGGⁱ	hsa:60385
UCSCⁱ	uc002ppm.4 human [Q9UJT2-1]

Organism-specific databases

CTDⁱ	60385
EuPathDBⁱ	HostDB:ENSG00000126467.10
GeneCardsⁱ	TSKS
H-InvDBⁱ	HIX0040005 HIX0174448
HGNCⁱ	HGNC:30719 TSKS
HPAⁱ	HPA045729
MIMⁱ	608253 gene
neXtProtⁱ	NX_Q9UJT2
OpenTargetsⁱ	ENSG00000126467
PharmGKBⁱ	PA164727339
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEF7 Eukaryota ENOG410YKYG LUCA
GeneTreeⁱ	ENSGT00390000002611
HOGENOMⁱ	HOG000121770
HOVERGENⁱ	HBG050300
InParanoidⁱ	Q9UJT2
KOⁱ	K16492
OMAⁱ	PWAPDDP
OrthoDBⁱ	EOG091G074P
PhylomeDBⁱ	Q9UJT2
TreeFamⁱ	TF337594

Miscellaneous databases

GenomeRNAiⁱ	60385
Protein Ontology More...PROⁱ	PR:Q9UJT2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126467 Expressed in 88 organ(s), highest expression level in right testis
ExpressionAtlasⁱ	Q9UJT2 baseline and differential
Genevisibleⁱ	Q9UJT2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028214 TSKS
PANTHERⁱ	PTHR14351 PTHR14351, 1 hit
Pfamⁱ	View protein in Pfam PF15358 TSKS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TSKS_HUMAN
Accessionⁱ	Q9UJT2Primary (citable) accession number: Q9UJT2 Secondary accession number(s): Q8WXJ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q9UJT2 (TSKS_HUMAN)

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Testis-specific serine kinase substrate

TSKS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ