UniProtKB - Q9UJT2 (TSKS_HUMAN)
Protein
Testis-specific serine kinase substrate
Gene
TSKS
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
GO - Biological processi
- negative regulation of phosphatase activity Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9UJT2 |
Names & Taxonomyi
Protein namesi | Recommended name: Testis-specific serine kinase substrateShort name: Testis-specific kinase substrate Alternative name(s): STK22 substrate 1 |
Gene namesi | Name:TSKS Synonyms:STK22S1, TSKS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126467.10 |
HGNCi | HGNC:30719, TSKS |
MIMi | 608253, gene |
neXtProti | NX_Q9UJT2 |
Subcellular locationi
Cytoskeleton
- centriole 1 Publication
Note: Concentrates in spermatid centrioles during flagellogenesis.
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 60385 |
OpenTargetsi | ENSG00000126467 |
PharmGKBi | PA164727339 |
Miscellaneous databases
Pharosi | Q9UJT2, Tbio |
Polymorphism and mutation databases
BioMutai | TSKS |
DMDMi | 44888550 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065665 | 1 – 592 | Testis-specific serine kinase substrateAdd BLAST | 592 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 217 | PhosphoserineBy similarity | 1 | |
Modified residuei | 288 | Phosphoserine; by TSSK1 and TSSK2By similarity | 1 | |
Modified residuei | 316 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UJT2 |
MassIVEi | Q9UJT2 |
PaxDbi | Q9UJT2 |
PeptideAtlasi | Q9UJT2 |
PRIDEi | Q9UJT2 |
ProteomicsDBi | 84647 [Q9UJT2-1] 84648 [Q9UJT2-2] |
PTM databases
iPTMneti | Q9UJT2 |
PhosphoSitePlusi | Q9UJT2 |
Expressioni
Tissue specificityi
Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.2 Publications
Gene expression databases
Bgeei | ENSG00000126467, Expressed in quadriceps femoris and 111 other tissues |
ExpressionAtlasi | Q9UJT2, baseline and differential |
Genevisiblei | Q9UJT2, HS |
Organism-specific databases
HPAi | ENSG00000126467, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ9UJT2
With | #Exp. | IntAct |
---|---|---|
KRT27 [Q7Z3Y8] | 3 | EBI-852101,EBI-3044087 |
TPM3 [P06753] | 3 | EBI-852101,EBI-355607 |
TSSK1B [Q9BXA7] | 3 | EBI-852101,EBI-6423734 |
TSSK2 [Q96PF2] | 9 | EBI-852101,EBI-852089 |
Isoform 2 [Q9UJT2-2]
With | #Exp. | IntAct |
---|---|---|
TSSK2 [Q96PF2] | 2 | EBI-852113,EBI-852089 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121902, 30 interactors |
IntActi | Q9UJT2, 32 interactors |
STRINGi | 9606.ENSP00000246801 |
Miscellaneous databases
RNActi | Q9UJT2, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502RT0F, Eukaryota |
GeneTreei | ENSGT00390000002611 |
HOGENOMi | CLU_033722_0_0_1 |
InParanoidi | Q9UJT2 |
OMAi | PWAPDDP |
OrthoDBi | 732555at2759 |
PhylomeDBi | Q9UJT2 |
TreeFami | TF337594 |
Family and domain databases
InterProi | View protein in InterPro IPR028214, TSKS |
PANTHERi | PTHR14351, PTHR14351, 1 hit |
Pfami | View protein in Pfam PF15358, TSKS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UJT2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASVVVKTIW QSKEIHEAGD TPTGVESCSQ LVPEAPRRVT SRAKGIPKKK
60 70 80 90 100
KAVSFHGVEP QMSHQPMHWC LNLKRSSACT NVSLLNLAAM EPTDSTGTDS
110 120 130 140 150
TVEDLSGQLT LAGPPASPTL PWDPDDADIT EILSGVNSGL VRAKDSITSL
160 170 180 190 200
KEKTNRVNQH VQSLQSECSV LSENLERRRQ EAEELEGYCI QLKENCWKVT
210 220 230 240 250
RSVEDAEIKT NVLKQNSALL EEKLRYLQQQ LQDETPRRQE AELQEPEEKQ
260 270 280 290 300
EPEEKQEPEE KQKPEAGLSW NSLGPAATSQ GCPGPPGSPD KPSRPHGLVP
310 320 330 340 350
AGWGMGPRAG EGPYVSEQEL QKLFTGIEEL RREVSSLTAR WHQEEGAVQE
360 370 380 390 400
ALRLLGGLGG RVDGFLGQWE RAQREQAQTA RDLQELRGRA DELCTMVERS
410 420 430 440 450
AVSVASLRSE LEGLGPLKPI LEEFGRQFQN SRRGPDLSMN LDRSHQGNCA
460 470 480 490 500
RCASQGSQLS TESLQQLLDR ALTSLVDEVK QRGLTPACPS CQRLHKKILE
510 520 530 540 550
LERQALAKHV RAEALSSTLR LAQDEALRAK NLLLTDKMKP EEKMATLDHL
560 570 580 590
HLKMCSLHDH LSNLPLEGST GTMGGGSSAG TPPKQGGSAP EQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9K0I0 | C9K0I0_HUMAN | Testis-specific serine kinase subst... | TSKS | 392 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 272 | S → G in AAL60464 (PubMed:15044604).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036272 | 19 | G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs149529240Ensembl. | 1 | |
Natural variantiVAR_051459 | 167 | E → K. Corresponds to variant dbSNP:rs34701020Ensembl. | 1 | |
Natural variantiVAR_051460 | 382 | D → G1 PublicationCorresponds to variant dbSNP:rs2304202Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009591 | 1 – 200 | Missing in isoform 2. CuratedAdd BLAST | 200 | |
Alternative sequenceiVSP_009592 | 201 – 221 | RSVED…SALLE → MGDSCPAVTFRSQKENRAGL Q in isoform 2. CuratedAdd BLAST | 21 | |
Alternative sequenceiVSP_009593 | 254 – 259 | Missing in isoform 2. Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF200923 Genomic DNA Translation: AAF12819.3 AF411384 mRNA Translation: AAL60464.1 BC058862 mRNA Translation: AAH58862.1 |
CCDSi | CCDS12780.1 [Q9UJT2-1] |
PIRi | JC7709 |
RefSeqi | NP_068379.1, NM_021733.1 [Q9UJT2-1] |
Genome annotation databases
Ensembli | ENST00000246801; ENSP00000246801; ENSG00000126467 [Q9UJT2-1] |
GeneIDi | 60385 |
KEGGi | hsa:60385 |
UCSCi | uc002ppm.4, human [Q9UJT2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF200923 Genomic DNA Translation: AAF12819.3 AF411384 mRNA Translation: AAL60464.1 BC058862 mRNA Translation: AAH58862.1 |
CCDSi | CCDS12780.1 [Q9UJT2-1] |
PIRi | JC7709 |
RefSeqi | NP_068379.1, NM_021733.1 [Q9UJT2-1] |
3D structure databases
SMRi | Q9UJT2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121902, 30 interactors |
IntActi | Q9UJT2, 32 interactors |
STRINGi | 9606.ENSP00000246801 |
PTM databases
iPTMneti | Q9UJT2 |
PhosphoSitePlusi | Q9UJT2 |
Polymorphism and mutation databases
BioMutai | TSKS |
DMDMi | 44888550 |
Proteomic databases
EPDi | Q9UJT2 |
MassIVEi | Q9UJT2 |
PaxDbi | Q9UJT2 |
PeptideAtlasi | Q9UJT2 |
PRIDEi | Q9UJT2 |
ProteomicsDBi | 84647 [Q9UJT2-1] 84648 [Q9UJT2-2] |
Protocols and materials databases
Antibodypediai | 18691, 122 antibodies |
Genome annotation databases
Ensembli | ENST00000246801; ENSP00000246801; ENSG00000126467 [Q9UJT2-1] |
GeneIDi | 60385 |
KEGGi | hsa:60385 |
UCSCi | uc002ppm.4, human [Q9UJT2-1] |
Organism-specific databases
CTDi | 60385 |
DisGeNETi | 60385 |
EuPathDBi | HostDB:ENSG00000126467.10 |
GeneCardsi | TSKS |
HGNCi | HGNC:30719, TSKS |
HPAi | ENSG00000126467, Tissue enriched (testis) |
MIMi | 608253, gene |
neXtProti | NX_Q9UJT2 |
OpenTargetsi | ENSG00000126467 |
PharmGKBi | PA164727339 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RT0F, Eukaryota |
GeneTreei | ENSGT00390000002611 |
HOGENOMi | CLU_033722_0_0_1 |
InParanoidi | Q9UJT2 |
OMAi | PWAPDDP |
OrthoDBi | 732555at2759 |
PhylomeDBi | Q9UJT2 |
TreeFami | TF337594 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJT2 |
Miscellaneous databases
BioGRID-ORCSi | 60385, 6 hits in 850 CRISPR screens |
GenomeRNAii | 60385 |
Pharosi | Q9UJT2, Tbio |
PROi | PR:Q9UJT2 |
RNActi | Q9UJT2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126467, Expressed in quadriceps femoris and 111 other tissues |
ExpressionAtlasi | Q9UJT2, baseline and differential |
Genevisiblei | Q9UJT2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028214, TSKS |
PANTHERi | PTHR14351, PTHR14351, 1 hit |
Pfami | View protein in Pfam PF15358, TSKS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSKS_HUMAN | |
Accessioni | Q9UJT2Primary (citable) accession number: Q9UJT2 Secondary accession number(s): Q8WXJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations