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Protein

Testis-specific serine kinase substrate

Gene

TSKS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine kinase substrate
Short name:
Testis-specific kinase substrate
Alternative name(s):
STK22 substrate 1
Gene namesi
Name:TSKS
Synonyms:STK22S1, TSKS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126467.10
HGNCiHGNC:30719 TSKS
MIMi608253 gene
neXtProtiNX_Q9UJT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126467
PharmGKBiPA164727339

Polymorphism and mutation databases

BioMutaiTSKS
DMDMi44888550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656651 – 592Testis-specific serine kinase substrateAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineBy similarity1
Modified residuei288Phosphoserine; by TSSK1 and TSSK2By similarity1
Modified residuei316PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJT2
PaxDbiQ9UJT2
PeptideAtlasiQ9UJT2
PRIDEiQ9UJT2
ProteomicsDBi84647
84648 [Q9UJT2-2]

PTM databases

iPTMnetiQ9UJT2
PhosphoSitePlusiQ9UJT2

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.2 Publications

Gene expression databases

BgeeiENSG00000126467
ExpressionAtlasiQ9UJT2 baseline and differential
GenevisibleiQ9UJT2 HS

Organism-specific databases

HPAiHPA045729

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TSSK2Q96PF27EBI-852101,EBI-852089

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121902, 27 interactors
IntActiQ9UJT2, 8 interactors
STRINGi9606.ENSP00000246801

Structurei

3D structure databases

ProteinModelPortaliQ9UJT2
SMRiQ9UJT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEF7 Eukaryota
ENOG410YKYG LUCA
GeneTreeiENSGT00390000002611
HOGENOMiHOG000121770
HOVERGENiHBG050300
InParanoidiQ9UJT2
KOiK16492
OMAiRVNQHVQ
OrthoDBiEOG091G074P
PhylomeDBiQ9UJT2
TreeFamiTF337594

Family and domain databases

InterProiView protein in InterPro
IPR028214 TSKS
PANTHERiPTHR14351 PTHR14351, 1 hit
PfamiView protein in Pfam
PF15358 TSKS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVVVKTIW QSKEIHEAGD TPTGVESCSQ LVPEAPRRVT SRAKGIPKKK
60 70 80 90 100
KAVSFHGVEP QMSHQPMHWC LNLKRSSACT NVSLLNLAAM EPTDSTGTDS
110 120 130 140 150
TVEDLSGQLT LAGPPASPTL PWDPDDADIT EILSGVNSGL VRAKDSITSL
160 170 180 190 200
KEKTNRVNQH VQSLQSECSV LSENLERRRQ EAEELEGYCI QLKENCWKVT
210 220 230 240 250
RSVEDAEIKT NVLKQNSALL EEKLRYLQQQ LQDETPRRQE AELQEPEEKQ
260 270 280 290 300
EPEEKQEPEE KQKPEAGLSW NSLGPAATSQ GCPGPPGSPD KPSRPHGLVP
310 320 330 340 350
AGWGMGPRAG EGPYVSEQEL QKLFTGIEEL RREVSSLTAR WHQEEGAVQE
360 370 380 390 400
ALRLLGGLGG RVDGFLGQWE RAQREQAQTA RDLQELRGRA DELCTMVERS
410 420 430 440 450
AVSVASLRSE LEGLGPLKPI LEEFGRQFQN SRRGPDLSMN LDRSHQGNCA
460 470 480 490 500
RCASQGSQLS TESLQQLLDR ALTSLVDEVK QRGLTPACPS CQRLHKKILE
510 520 530 540 550
LERQALAKHV RAEALSSTLR LAQDEALRAK NLLLTDKMKP EEKMATLDHL
560 570 580 590
HLKMCSLHDH LSNLPLEGST GTMGGGSSAG TPPKQGGSAP EQ
Length:592
Mass (Da):65,050
Last modified:March 1, 2001 - v3
Checksum:i87B262601EECE121
GO
Isoform 2 (identifier: Q9UJT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.
     201-221: RSVEDAEIKTNVLKQNSALLE → MGDSCPAVTFRSQKENRAGLQ
     254-259: Missing.

Show »
Length:386
Mass (Da):42,359
Checksum:i173256D6886BF931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272S → G in AAL60464 (PubMed:15044604).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03627219G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs149529240Ensembl.1
Natural variantiVAR_051459167E → K. Corresponds to variant dbSNP:rs34701020Ensembl.1
Natural variantiVAR_051460382D → G1 PublicationCorresponds to variant dbSNP:rs2304202Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0095911 – 200Missing in isoform 2. CuratedAdd BLAST200
Alternative sequenceiVSP_009592201 – 221RSVED…SALLE → MGDSCPAVTFRSQKENRAGL Q in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_009593254 – 259Missing in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200923 Genomic DNA Translation: AAF12819.3
AF411384 mRNA Translation: AAL60464.1
BC058862 mRNA Translation: AAH58862.1
CCDSiCCDS12780.1 [Q9UJT2-1]
PIRiJC7709
RefSeqiNP_068379.1, NM_021733.1 [Q9UJT2-1]
UniGeneiHs.515858

Genome annotation databases

EnsembliENST00000246801; ENSP00000246801; ENSG00000126467 [Q9UJT2-1]
GeneIDi60385
KEGGihsa:60385
UCSCiuc002ppm.4 human [Q9UJT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSKS_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT2
Secondary accession number(s): Q8WXJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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