UniProtKB - Q9UJN7 (ZN391_HUMAN)
Protein
Zinc finger protein 391
Gene
ZNF391
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 109 – 131 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 215 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 221 – 243 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 249 – 271 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UJN7 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 391 |
Gene namesi | Name:ZNF391 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18779, ZNF391 |
neXtProti | NX_Q9UJN7 |
VEuPathDBi | HostDB:ENSG00000124613.8 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 346157 |
OpenTargetsi | ENSG00000124613 |
PharmGKBi | PA134868215 |
Miscellaneous databases
Pharosi | Q9UJN7, Tdark |
Genetic variation databases
BioMutai | ZNF391 |
DMDMi | 156630643 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299034 | 1 – 358 | Zinc finger protein 391Add BLAST | 358 |
Proteomic databases
EPDi | Q9UJN7 |
jPOSTi | Q9UJN7 |
MassIVEi | Q9UJN7 |
MaxQBi | Q9UJN7 |
PaxDbi | Q9UJN7 |
PeptideAtlasi | Q9UJN7 |
PRIDEi | Q9UJN7 |
ProteomicsDBi | 84634 |
PTM databases
iPTMneti | Q9UJN7 |
PhosphoSitePlusi | Q9UJN7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124613, Expressed in right uterine tube and 122 other tissues |
ExpressionAtlasi | Q9UJN7, baseline and differential |
Genevisiblei | Q9UJN7, HS |
Organism-specific databases
HPAi | ENSG00000124613, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131374, 7 interactors |
STRINGi | 9606.ENSP00000244576 |
Miscellaneous databases
RNActi | Q9UJN7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 109 – 131 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 137 – 159 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 165 – 187 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 193 – 215 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 221 – 243 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 249 – 271 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153104 |
HOGENOMi | CLU_002678_2_1_1 |
InParanoidi | Q9UJN7 |
OMAi | TIIQHQR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9UJN7 |
TreeFami | TF337055 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UJN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESLRGNTAQ GPTNEEDYKN EGQLSRQTKC PAQKKSSFEN TVVRKVSVTL
60 70 80 90 100
KEIFTGEEGP ESSEFSLSPN LDAQQKIPKG HGSPISRKNS KDNSDLIKHQ
110 120 130 140 150
RLFSQRKPCK CNECEKAFSY QSDLLVHSRI HGGEKPFECN KCGKSFSRST
160 170 180 190 200
HLIEHQRTHT GEKPYECNEC GKAFSRSTHL SLHQRIHTGE KPYECSECGK
210 220 230 240 250
AFSRSTNLSQ HQRTHTQERP YKCNECGKAF GDRSTIIQHQ RIHTGENPYE
260 270 280 290 300
CSKCGKAFSW ISSLTEHQRT HTGENPYECS ECGKVFSRSS SLTEHQRIHS
310 320 330 340 350
GEKPHECRVC GKGFSRSSSL IIHQRTHTGE KPYKCNDCGK AFCQSSTLIR
HQHLHTKE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JUF8 | C9JUF8_HUMAN | Zinc finger protein 391 | ZNF391 | 133 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034774 | 51 | K → R. Corresponds to variant dbSNP:rs10807020Ensembl. | 1 | |
Natural variantiVAR_034775 | 59 | G → C. Corresponds to variant dbSNP:rs10807021Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294965 mRNA Translation: BAG58038.1 AL031118 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03096.1 |
CCDSi | CCDS43429.1 |
RefSeqi | NP_001070249.1, NM_001076781.2 NP_001309217.1, NM_001322288.1 NP_001309218.1, NM_001322289.1 NP_001309222.1, NM_001322293.1 XP_005249139.1, XM_005249082.3 XP_006715149.1, XM_006715086.2 XP_011512871.1, XM_011514569.1 |
Genome annotation databases
Ensembli | ENST00000244576; ENSP00000244576; ENSG00000124613 |
GeneIDi | 346157 |
KEGGi | hsa:346157 |
UCSCi | uc003njf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294965 mRNA Translation: BAG58038.1 AL031118 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03096.1 |
CCDSi | CCDS43429.1 |
RefSeqi | NP_001070249.1, NM_001076781.2 NP_001309217.1, NM_001322288.1 NP_001309218.1, NM_001322289.1 NP_001309222.1, NM_001322293.1 XP_005249139.1, XM_005249082.3 XP_006715149.1, XM_006715086.2 XP_011512871.1, XM_011514569.1 |
3D structure databases
SMRi | Q9UJN7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131374, 7 interactors |
STRINGi | 9606.ENSP00000244576 |
PTM databases
iPTMneti | Q9UJN7 |
PhosphoSitePlusi | Q9UJN7 |
Genetic variation databases
BioMutai | ZNF391 |
DMDMi | 156630643 |
Proteomic databases
EPDi | Q9UJN7 |
jPOSTi | Q9UJN7 |
MassIVEi | Q9UJN7 |
MaxQBi | Q9UJN7 |
PaxDbi | Q9UJN7 |
PeptideAtlasi | Q9UJN7 |
PRIDEi | Q9UJN7 |
ProteomicsDBi | 84634 |
Protocols and materials databases
Antibodypediai | 25789, 69 antibodies |
DNASUi | 346157 |
Genome annotation databases
Ensembli | ENST00000244576; ENSP00000244576; ENSG00000124613 |
GeneIDi | 346157 |
KEGGi | hsa:346157 |
UCSCi | uc003njf.2, human |
Organism-specific databases
CTDi | 346157 |
DisGeNETi | 346157 |
GeneCardsi | ZNF391 |
HGNCi | HGNC:18779, ZNF391 |
HPAi | ENSG00000124613, Low tissue specificity |
neXtProti | NX_Q9UJN7 |
OpenTargetsi | ENSG00000124613 |
PharmGKBi | PA134868215 |
VEuPathDBi | HostDB:ENSG00000124613.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153104 |
HOGENOMi | CLU_002678_2_1_1 |
InParanoidi | Q9UJN7 |
OMAi | TIIQHQR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9UJN7 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJN7 |
Miscellaneous databases
BioGRID-ORCSi | 346157, 1 hit in 1014 CRISPR screens |
ChiTaRSi | ZNF391, human |
GenomeRNAii | 346157 |
Pharosi | Q9UJN7, Tdark |
PROi | PR:Q9UJN7 |
RNActi | Q9UJN7, protein |
Gene expression databases
Bgeei | ENSG00000124613, Expressed in right uterine tube and 122 other tissues |
ExpressionAtlasi | Q9UJN7, baseline and differential |
Genevisiblei | Q9UJN7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN391_HUMAN | |
Accessioni | Q9UJN7Primary (citable) accession number: Q9UJN7 Secondary accession number(s): B4DH77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families