Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (17 Jun 2020)
Sequence version 2 (21 Aug 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger protein 391

Gene

ZNF391

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri109 – 131C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 391
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF391
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124613.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18779 ZNF391

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UJN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
346157

Open Targets

More...
OpenTargetsi
ENSG00000124613

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868215

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UJN7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF391

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156630643

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002990341 – 358Zinc finger protein 391Add BLAST358

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UJN7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UJN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UJN7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UJN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UJN7

PeptideAtlas

More...
PeptideAtlasi
Q9UJN7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UJN7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84634

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UJN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UJN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124613 Expressed in right uterine tube and 100 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UJN7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UJN7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124613 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131374, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000244576

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UJN7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UJN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri109 – 131C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153104

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UJN7

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIIQHQR

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UJN7

TreeFam database of animal gene trees

More...
TreeFami
TF337055

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UJN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLRGNTAQ GPTNEEDYKN EGQLSRQTKC PAQKKSSFEN TVVRKVSVTL
60 70 80 90 100
KEIFTGEEGP ESSEFSLSPN LDAQQKIPKG HGSPISRKNS KDNSDLIKHQ
110 120 130 140 150
RLFSQRKPCK CNECEKAFSY QSDLLVHSRI HGGEKPFECN KCGKSFSRST
160 170 180 190 200
HLIEHQRTHT GEKPYECNEC GKAFSRSTHL SLHQRIHTGE KPYECSECGK
210 220 230 240 250
AFSRSTNLSQ HQRTHTQERP YKCNECGKAF GDRSTIIQHQ RIHTGENPYE
260 270 280 290 300
CSKCGKAFSW ISSLTEHQRT HTGENPYECS ECGKVFSRSS SLTEHQRIHS
310 320 330 340 350
GEKPHECRVC GKGFSRSSSL IIHQRTHTGE KPYKCNDCGK AFCQSSTLIR

HQHLHTKE
Length:358
Mass (Da):40,659
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCC67A6F7FE30187
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUF8C9JUF8_HUMAN
Zinc finger protein 391
ZNF391
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03477451K → R. Corresponds to variant dbSNP:rs10807020Ensembl.1
Natural variantiVAR_03477559G → C. Corresponds to variant dbSNP:rs10807021Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK294965 mRNA Translation: BAG58038.1
AL031118 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03096.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43429.1

NCBI Reference Sequences

More...
RefSeqi
NP_001070249.1, NM_001076781.2
NP_001309217.1, NM_001322288.1
NP_001309218.1, NM_001322289.1
NP_001309222.1, NM_001322293.1
XP_005249139.1, XM_005249082.3
XP_006715149.1, XM_006715086.2
XP_011512871.1, XM_011514569.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000244576; ENSP00000244576; ENSG00000124613

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
346157

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:346157

UCSC genome browser

More...
UCSCi
uc003njf.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294965 mRNA Translation: BAG58038.1
AL031118 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03096.1
CCDSiCCDS43429.1
RefSeqiNP_001070249.1, NM_001076781.2
NP_001309217.1, NM_001322288.1
NP_001309218.1, NM_001322289.1
NP_001309222.1, NM_001322293.1
XP_005249139.1, XM_005249082.3
XP_006715149.1, XM_006715086.2
XP_011512871.1, XM_011514569.1

3D structure databases

SMRiQ9UJN7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131374, 7 interactors
STRINGi9606.ENSP00000244576

PTM databases

iPTMnetiQ9UJN7
PhosphoSitePlusiQ9UJN7

Polymorphism and mutation databases

BioMutaiZNF391
DMDMi156630643

Proteomic databases

EPDiQ9UJN7
jPOSTiQ9UJN7
MassIVEiQ9UJN7
MaxQBiQ9UJN7
PaxDbiQ9UJN7
PeptideAtlasiQ9UJN7
PRIDEiQ9UJN7
ProteomicsDBi84634

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25789 66 antibodies

The DNASU plasmid repository

More...
DNASUi
346157

Genome annotation databases

EnsembliENST00000244576; ENSP00000244576; ENSG00000124613
GeneIDi346157
KEGGihsa:346157
UCSCiuc003njf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
346157
DisGeNETi346157
EuPathDBiHostDB:ENSG00000124613.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF391
HGNCiHGNC:18779 ZNF391
HPAiENSG00000124613 Low tissue specificity
neXtProtiNX_Q9UJN7
OpenTargetsiENSG00000124613
PharmGKBiPA134868215

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153104
HOGENOMiCLU_002678_2_1_1
InParanoidiQ9UJN7
OMAiTIIQHQR
OrthoDBi1318335at2759
PhylomeDBiQ9UJN7
TreeFamiTF337055

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
346157 0 hits in 808 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF391 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
346157
PharosiQ9UJN7 Tdark

Protein Ontology

More...
PROi
PR:Q9UJN7
RNActiQ9UJN7 protein

Gene expression databases

BgeeiENSG00000124613 Expressed in right uterine tube and 100 other tissues
ExpressionAtlasiQ9UJN7 baseline and differential
GenevisibleiQ9UJN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN391_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJN7
Secondary accession number(s): B4DH77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 17, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again