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UniProtKB - Q9UJM8 (HAOX1_HUMAN)

Entry version 177 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Hydroxyacid oxidase 1

Gene

HAO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMNPROSITE-ProRule annotation1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=141 µM for glycolate1 Publication
  2. KM=40 µM for 2-hydroxy octanoate1 Publication
  3. KM=2200 µM for glyoxylate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolate degradation

    This protein is involved in step 1 of the subpathway that synthesizes 3-phospho-D-glycerate from glycolate.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. Hydroxyacid oxidase 1 (HAO1)
    2. no protein annotated in this organism
    3. no protein annotated in this organism
    4. no protein annotated in this organism
    This subpathway is part of the pathway glycolate degradation, which is itself part of Organic acid metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-phospho-D-glycerate from glycolate, the pathway glycolate degradation and in Organic acid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei26Substrate1
    Binding sitei108FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei130FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei132FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei132Substrate1
    Binding sitei158FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei167Substrate1
    Binding sitei236FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei258FMNPROSITE-ProRule annotation3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei260Proton acceptor1
    Binding sitei263Substrate1
    Binding sitei315FMNPROSITE-ProRule annotation3 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi291 – 315FMNPROSITE-ProRule annotationAdd BLAST25
    Nucleotide bindingi291 – 295FMN bindingPROSITE-ProRule annotation3 Publications5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFlavoprotein, FMN

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.1.3.15, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q9UJM8

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-389661, Glyoxylate metabolism and glycine degradation
    R-HSA-9033241, Peroxisomal protein import

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q9UJM8

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00864;UER00830

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hydroxyacid oxidase 1 (EC:1.1.3.15)
    Short name:
    HAOX1
    Alternative name(s):
    Glycolate oxidase
    Short name:
    GOX
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HAO1
    Synonyms:GOX1, HAOX1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:4809, HAO1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		605023, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9UJM8

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000101323.4

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Peroxisome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		54363

    Open Targets

    More...    OpenTargetsi    		ENSG00000101323

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA29185

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9UJM8, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4229

    Drug and drug target database

    More...    DrugBanki    		DB07907, (2S)-2-HYDROXYOCTANOIC ACID
    DB07060, 3-(INDOL-3-YL) LACTATE
    DB03064, 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline
    DB04374, 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole
    DB06979, 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid
    DB02279, Benzoylformic Acid
    DB03247, Flavin mononucleotide
    DB02164, N-sulfo-flavin mononucleotide
    DB03884, Phenylpyruvic acid

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		HAO1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		13124294

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002063181 – 370Hydroxyacid oxidase 1Add BLAST370

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184N6-succinyllysineBy similarity1
    Modified residuei194PhosphoserineBy similarity1
    Modified residuei230PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9UJM8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9UJM8

    PeptideAtlas

    More...    PeptideAtlasi    		Q9UJM8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9UJM8

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		84633

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9UJM8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9UJM8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Liver.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000101323, Expressed in right lobe of liver and 27 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9UJM8, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9UJM8, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000101323, Tissue enriched (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		119941, 4 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9UJM8, 3 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000368066

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9UJM8

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9UJM8, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1370
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9UJM8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q9UJM8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 365FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST365

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi368 – 370Microbody targeting signalSequence analysis3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0538, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000018717

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_020639_6_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9UJM8

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		RIWFRPQ

    Database of Orthologous Groups

    More...    OrthoDBi    		879633at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9UJM8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313363

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd02809, alpha_hydroxyacid_oxid_FMN, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR013785, Aldolase_TIM
    IPR012133, Alpha-hydoxy_acid_DH_FMN
    IPR000262, FMN-dep_DH
    IPR037396, FMN_HAD
    IPR008259, FMN_hydac_DH_AS

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01070, FMN_dh, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF000138, Al-hdrx_acd_dh, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit
    PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9UJM8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLPRLICIND YEQHAKSVLP KSIYDYYRSG ANDEETLADN IAAFSRWKLY 
            60         70         80         90        100
    PRMLRNVAET DLSTSVLGQR VSMPICVGAT AMQRMAHVDG ELATVRACQS 
           110        120        130        140        150
    LGTGMMLSSW ATSSIEEVAE AGPEALRWLQ LYIYKDREVT KKLVRQAEKM 
           160        170        180        190        200
    GYKAIFVTVD TPYLGNRLDD VRNRFKLPPQ LRMKNFETST LSFSPEENFG 
           210        220        230        240        250
    DDSGLAAYVA KAIDPSISWE DIKWLRRLTS LPIVAKGILR GDDAREAVKH 
           260        270        280        290        300
    GLNGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV 
           310        320        330        340        350
    LKALALGAKA VFVGRPIVWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ 
           360        370
    NVKVIDKTLV RKNPLAVSKI
    Length:370
    Mass (Da):40,924
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC683C6F7CB5FD323
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF244134 mRNA Translation: AAF63219.1
    AF231916 mRNA Translation: AAF40199.1
    AL121739 mRNA Translation: CAB57329.1
    AB024079 mRNA Translation: BAA82872.1
    AL021879 Genomic DNA No translation available.
    BC113665 mRNA Translation: AAI13666.1
    BC113667 mRNA Translation: AAI13668.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS13100.1

    NCBI Reference Sequences

    More...    RefSeqi    		NP_060015.1, NM_017545.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000378789; ENSP00000368066; ENSG00000101323

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		54363

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:54363

    UCSC genome browser

    More...    UCSCi    		uc002wmw.2, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF244134 mRNA Translation: AAF63219.1
    AF231916 mRNA Translation: AAF40199.1
    AL121739 mRNA Translation: CAB57329.1
    AB024079 mRNA Translation: BAA82872.1
    AL021879 Genomic DNA No translation available.
    BC113665 mRNA Translation: AAI13666.1
    BC113667 mRNA Translation: AAI13668.1
    CCDSiCCDS13100.1
    RefSeqiNP_060015.1, NM_017545.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2NZLX-ray1.35A1-370[»]
    2RDTX-ray1.95A1-370[»]
    2RDUX-ray1.65A1-370[»]
    2RDWX-ray1.95A1-370[»]
    2W0UX-ray2.84A/B/C/D1-370[»]
    5QIBX-ray1.48A1-368[»]
    5QICX-ray1.34A1-368[»]
    5QIDX-ray1.45A1-368[»]
    5QIEX-ray1.34A1-368[»]
    5QIFX-ray1.20A1-368[»]
    5QIGX-ray1.42A1-368[»]
    5QIHX-ray1.33A1-368[»]
    6GMBX-ray1.35A1-362[»]
    6GMCX-ray1.20A1-362[»]
    SMRiQ9UJM8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi119941, 4 interactors
    IntActiQ9UJM8, 3 interactors
    STRINGi9606.ENSP00000368066

    Chemistry databases

    BindingDBiQ9UJM8
    ChEMBLiCHEMBL4229
    DrugBankiDB07907, (2S)-2-HYDROXYOCTANOIC ACID
    DB07060, 3-(INDOL-3-YL) LACTATE
    DB03064, 3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline
    DB04374, 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole
    DB06979, 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid
    DB02279, Benzoylformic Acid
    DB03247, Flavin mononucleotide
    DB02164, N-sulfo-flavin mononucleotide
    DB03884, Phenylpyruvic acid

    PTM databases

    iPTMnetiQ9UJM8
    PhosphoSitePlusiQ9UJM8

    Genetic variation databases

    BioMutaiHAO1
    DMDMi13124294

    Proteomic databases

    MassIVEiQ9UJM8
    PaxDbiQ9UJM8
    PeptideAtlasiQ9UJM8
    PRIDEiQ9UJM8
    ProteomicsDBi84633

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		8448, 380 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		54363

    Genome annotation databases

    EnsembliENST00000378789; ENSP00000368066; ENSG00000101323
    GeneIDi54363
    KEGGihsa:54363
    UCSCiuc002wmw.2, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		54363
    DisGeNETi54363

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		HAO1
    HGNCiHGNC:4809, HAO1
    HPAiENSG00000101323, Tissue enriched (liver)
    MIMi605023, gene
    neXtProtiNX_Q9UJM8
    OpenTargetsiENSG00000101323
    PharmGKBiPA29185
    VEuPathDBiHostDB:ENSG00000101323.4

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0538, Eukaryota
    GeneTreeiENSGT00390000018717
    HOGENOMiCLU_020639_6_1_1
    InParanoidiQ9UJM8
    OMAiRIWFRPQ
    OrthoDBi879633at2759
    PhylomeDBiQ9UJM8
    TreeFamiTF313363

    Enzyme and pathway databases

    UniPathwayiUPA00864;UER00830
    BRENDAi1.1.3.15, 2681
    PathwayCommonsiQ9UJM8
    ReactomeiR-HSA-389661, Glyoxylate metabolism and glycine degradation
    R-HSA-9033241, Peroxisomal protein import
    SABIO-RKiQ9UJM8

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		54363, 1 hit in 870 CRISPR screens
    EvolutionaryTraceiQ9UJM8

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		54363
    PharosiQ9UJM8, Tchem

    Protein Ontology

    More...    PROi    		PR:Q9UJM8
    RNActiQ9UJM8, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000101323, Expressed in right lobe of liver and 27 other tissues
    ExpressionAtlasiQ9UJM8, baseline and differential
    GenevisibleiQ9UJM8, HS

    Family and domain databases

    CDDicd02809, alpha_hydroxyacid_oxid_FMN, 1 hit
    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR013785, Aldolase_TIM
    IPR012133, Alpha-hydoxy_acid_DH_FMN
    IPR000262, FMN-dep_DH
    IPR037396, FMN_HAD
    IPR008259, FMN_hydac_DH_AS
    PfamiView protein in Pfam
    PF01070, FMN_dh, 1 hit
    PIRSFiPIRSF000138, Al-hdrx_acd_dh, 1 hit
    PROSITEiView protein in PROSITE
    PS00557, FMN_HYDROXY_ACID_DH_1, 1 hit
    PS51349, FMN_HYDROXY_ACID_DH_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAOX1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJM8
    Secondary accession number(s): Q14CQ0, Q9UPZ0, Q9Y3I7
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: February 10, 2021
    This is version 177 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
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