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Protein

ERBB receptor feedback inhibitor 1

Gene

ERRFI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: ProtInc
  • protein kinase binding Source: UniProtKB
  • SH3 domain binding Source: Ensembl
  • small GTPase binding Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ9UJM3
SIGNORiQ9UJM3

Names & Taxonomyi

Protein namesi
Recommended name:
ERBB receptor feedback inhibitor 1
Alternative name(s):
Mitogen-inducible gene 6 protein
Short name:
MIG-6
Gene namesi
Name:ERRFI1
Synonyms:MIG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116285.12
HGNCiHGNC:18185 ERRFI1
MIMi608069 gene
neXtProtiNX_Q9UJM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi346M → A: Abolishes inhibition of EGFR activity. 1 Publication1
Mutagenesisi352F → A: Abolishes inhibition of EGFR activity. 1 Publication1
Mutagenesisi358Y → A: Abolishes inhibition of EGFR activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi54206
OpenTargetsiENSG00000116285
PharmGKBiPA142671904

Polymorphism and mutation databases

BioMutaiERRFI1
DMDMi27923810

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000964872 – 462ERBB receptor feedback inhibitor 1Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei127PhosphothreonineBy similarity1
Modified residuei131PhosphothreonineBy similarity1
Modified residuei251PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei302PhosphoserineBy similarity1
Modified residuei461PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UJM3
MaxQBiQ9UJM3
PaxDbiQ9UJM3
PeptideAtlasiQ9UJM3
PRIDEiQ9UJM3
ProteomicsDBi84632

PTM databases

iPTMnetiQ9UJM3
PhosphoSitePlusiQ9UJM3

Expressioni

Inductioni

Levels are very low in quiescent cells. Up-regulated by mitogens.

Gene expression databases

BgeeiENSG00000116285 Expressed in 202 organ(s), highest expression level in tibia
CleanExiHS_ERRFI1
ExpressionAtlasiQ9UJM3 baseline and differential
GenevisibleiQ9UJM3 HS

Organism-specific databases

HPAiHPA027206

Interactioni

Subunit structurei

Interacts with ERBB2 (By similarity). Interacts with EGFR.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119923, 95 interactors
DIPiDIP-42379N
IntActiQ9UJM3, 31 interactors
MINTiQ9UJM3
STRINGi9606.ENSP00000366702

Structurei

Secondary structure

1462
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UJM3
SMRiQ9UJM3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UJM3

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni334 – 363Interaction with EGFR and ERBB2 and regulation of EGFR activationAdd BLAST30

Domaini

The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer.1 Publication

Sequence similaritiesi

Belongs to the MIG6 family.Curated

Phylogenomic databases

eggNOGiENOG410IEVS Eukaryota
ENOG4111HB5 LUCA
GeneTreeiENSGT00440000033870
HOGENOMiHOG000234207
HOVERGENiHBG031710
InParanoidiQ9UJM3
OMAiYTHRASP
OrthoDBiEOG091G0BER
PhylomeDBiQ9UJM3
TreeFamiTF335720

Family and domain databases

InterProiView protein in InterPro
IPR021619 Mig-6
PfamiView protein in Pfam
PF11555 Inhibitor_Mig-6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UJM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI
60 70 80 90 100
TMAYSLNSSA QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS
110 120 130 140 150
ENLGPHEEDQ VVCGFKKLTV NGVCASTPPL TPIKNSPSLF PCAPLCERGS
160 170 180 190 200
RPLPPLPISE ALSLDDTDCE VEFLTSSDTD FLLEDSTLSD FKYDVPGRRS
210 220 230 240 250
FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP QTHRRLRRSH
260 270 280 290 300
SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR
310 320 330 340 350
WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ
360 370 380 390 400
SFAPDPKYVS SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER
410 420 430 440 450
PPYLDKYEKF FREAEETNGG AQIQPLPADC GISSATEKPD SKTKMDLGGH
460
VKRKHLSYVV SP
Length:462
Mass (Da):50,560
Last modified:May 1, 2000 - v1
Checksum:i7AFA9F6CEB602912
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENN7K7ENN7_HUMAN
ERBB receptor feedback inhibitor 1
ERRFI1
52Annotation score:
K7EMD2K7EMD2_HUMAN
ERBB receptor feedback inhibitor 1
ERRFI1
74Annotation score:
K7ENI4K7ENI4_HUMAN
ERBB receptor feedback inhibitor 1
ERRFI1
53Annotation score:
K7EJB4K7EJB4_HUMAN
ERBB receptor feedback inhibitor 1
ERRFI1
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → T (PubMed:7641805).Curated1
Sequence conflicti36S → C (PubMed:7641805).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063039109D → N. Corresponds to variant dbSNP:rs34781518Ensembl.1
Natural variantiVAR_050975158I → L. Corresponds to variant dbSNP:rs34974993Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276373 mRNA Translation: CAC20426.1
AL034417 Genomic DNA No translation available.
AK315718 mRNA Translation: BAG38076.1
CH471130 Genomic DNA Translation: EAW71593.1
BC025337 mRNA Translation: AAH25337.1
AL137274 mRNA Translation: CAB70672.1
CCDSiCCDS94.1
PIRiT46346
RefSeqiNP_061821.1, NM_018948.3
XP_006710760.1, XM_006710697.2
UniGeneiHs.605445

Genome annotation databases

EnsembliENST00000377482; ENSP00000366702; ENSG00000116285
GeneIDi54206
KEGGihsa:54206
UCSCiuc001aoz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276373 mRNA Translation: CAC20426.1
AL034417 Genomic DNA No translation available.
AK315718 mRNA Translation: BAG38076.1
CH471130 Genomic DNA Translation: EAW71593.1
BC025337 mRNA Translation: AAH25337.1
AL137274 mRNA Translation: CAB70672.1
CCDSiCCDS94.1
PIRiT46346
RefSeqiNP_061821.1, NM_018948.3
XP_006710760.1, XM_006710697.2
UniGeneiHs.605445

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RF9X-ray3.50C/D315-374[»]
2RFDX-ray3.60C/D340-364[»]
2RFEX-ray2.90E/F325-364[»]
4I21X-ray3.37C/D315-374[»]
4R3PX-ray2.90B392-398[»]
4R3RX-ray3.25B392-398[»]
4ZJVX-ray2.70C/D330-399[»]
ProteinModelPortaliQ9UJM3
SMRiQ9UJM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119923, 95 interactors
DIPiDIP-42379N
IntActiQ9UJM3, 31 interactors
MINTiQ9UJM3
STRINGi9606.ENSP00000366702

PTM databases

iPTMnetiQ9UJM3
PhosphoSitePlusiQ9UJM3

Polymorphism and mutation databases

BioMutaiERRFI1
DMDMi27923810

Proteomic databases

EPDiQ9UJM3
MaxQBiQ9UJM3
PaxDbiQ9UJM3
PeptideAtlasiQ9UJM3
PRIDEiQ9UJM3
ProteomicsDBi84632

Protocols and materials databases

DNASUi54206
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377482; ENSP00000366702; ENSG00000116285
GeneIDi54206
KEGGihsa:54206
UCSCiuc001aoz.4 human

Organism-specific databases

CTDi54206
DisGeNETi54206
EuPathDBiHostDB:ENSG00000116285.12
GeneCardsiERRFI1
HGNCiHGNC:18185 ERRFI1
HPAiHPA027206
MIMi608069 gene
neXtProtiNX_Q9UJM3
OpenTargetsiENSG00000116285
PharmGKBiPA142671904
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVS Eukaryota
ENOG4111HB5 LUCA
GeneTreeiENSGT00440000033870
HOGENOMiHOG000234207
HOVERGENiHBG031710
InParanoidiQ9UJM3
OMAiYTHRASP
OrthoDBiEOG091G0BER
PhylomeDBiQ9UJM3
TreeFamiTF335720

Enzyme and pathway databases

SignaLinkiQ9UJM3
SIGNORiQ9UJM3

Miscellaneous databases

ChiTaRSiERRFI1 human
EvolutionaryTraceiQ9UJM3
GeneWikiiERRFI1
GenomeRNAii54206
PROiPR:Q9UJM3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116285 Expressed in 202 organ(s), highest expression level in tibia
CleanExiHS_ERRFI1
ExpressionAtlasiQ9UJM3 baseline and differential
GenevisibleiQ9UJM3 HS

Family and domain databases

InterProiView protein in InterPro
IPR021619 Mig-6
PfamiView protein in Pfam
PF11555 Inhibitor_Mig-6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERRFI_HUMAN
AccessioniPrimary (citable) accession number: Q9UJM3
Secondary accession number(s): B2RDX9, Q9NTG9, Q9UD05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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