UniProtKB - Q9UJM3 (ERRFI_HUMAN)

BLAST

>sp|Q9UJM3|ERRFI_HUMAN ERBB receptor feedback inhibitor 1 OS=Homo sapiens OX=9606 GN=ERRFI1 PE=1 SV=1
MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSA
QERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTV
NGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTD
FLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPP
QTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRR
WSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVS
SKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGG
AQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP

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History
Entry version 140 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

ERBB receptor feedback inhibitor 1

Gene

ERRFI1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).By similarity

GO - Molecular functionⁱ

GTPase activator activity
Source: ProtInc
Traceable author statementⁱ
- 10749885
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18046415
SH3 domain binding Source: Ensembl
small GTPase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular hyperosmotic response Source: Ensembl
cellular response to dexamethasone stimulus Source: Ensembl
cellular response to epidermal growth factor stimulus Source: Ensembl
cellular response to insulin stimulus Source: Ensembl
cellular response to platelet-derived growth factor stimulus Source: Ensembl
lung alveolus development Source: UniProtKB
lung epithelium development Source: UniProtKB
lung vasculature development Source: UniProtKB
negative regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
negative regulation of collagen biosynthetic process Source: Ensembl
negative regulation of epidermal growth factor-activated receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18046415
negative regulation of epidermal growth factor receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of ERK1 and ERK2 cascade Source: Ensembl
negative regulation of interleukin-1 beta production Source: Ensembl
negative regulation of protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18046415
negative regulation of tumor necrosis factor biosynthetic process Source: Ensembl
regulation of keratinocyte differentiation Source: UniProtKB
regulation of type B pancreatic cell proliferation Source: Ensembl
skin morphogenesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	Q9UJM3
SIGNORⁱ	Q9UJM3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ERBB receptor feedback inhibitor 1 Alternative name(s): Mitogen-inducible gene 6 protein Short name: MIG-6
Gene namesⁱ	Name:ERRFI1 Synonyms:MIG6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116285.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18185 ERRFI1
MIMⁱ	608069 gene
neXtProtⁱ	NX_Q9UJM3

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	346	M → A: Abolishes inhibition of EGFR activity. 1 Publication	1
Mutagenesisⁱ	352	F → A: Abolishes inhibition of EGFR activity. 1 Publication	1
Mutagenesisⁱ	358	Y → A: Abolishes inhibition of EGFR activity. 1 Publication	1

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54206
Open Targets More...OpenTargetsⁱ	ENSG00000116285
PharmGKBⁱ	PA142671904

Polymorphism and mutation databases

BioMutaⁱ	ERRFI1
DMDMⁱ	27923810

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000096487	2 – 462	ERBB receptor feedback inhibitor 1Add BLAST		461

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	127	PhosphothreonineBy similarity	1
Modified residueⁱ	131	PhosphothreonineBy similarity	1
Modified residueⁱ	251	PhosphoserineCombined sources	1
Modified residueⁱ	273	PhosphoserineCombined sources	1
Modified residueⁱ	302	PhosphoserineBy similarity	1
Modified residueⁱ	461	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UJM3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UJM3
PaxDbⁱ	Q9UJM3
PeptideAtlas More...PeptideAtlasⁱ	Q9UJM3
PRIDEⁱ	Q9UJM3
ProteomicsDBⁱ	84632

PTM databases

iPTMnetⁱ	Q9UJM3
PhosphoSitePlusⁱ	Q9UJM3

Expressionⁱ

Inductionⁱ

Levels are very low in quiescent cells. Up-regulated by mitogens.

Gene expression databases

Bgeeⁱ	ENSG00000116285 Expressed in 202 organ(s), highest expression level in tibia
CleanExⁱ	HS_ERRFI1
ExpressionAtlasⁱ	Q9UJM3 baseline and differential
Genevisibleⁱ	Q9UJM3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027206

HPAⁱ

HPA027206

Interactionⁱ

Subunit structureⁱ

Interacts with ERBB2 (By similarity). Interacts with EGFR.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CHEK1	O14757	2	EBI-2941912,EBI-974488
EGFR	P00533	13	EBI-2941912,EBI-297353
ERBB2	P04626	3	EBI-2941912,EBI-641062
GRB2	P62993	12	EBI-2941912,EBI-401755
SFN	P31947	3	EBI-2941912,EBI-476295

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18046415
SH3 domain binding Source: Ensembl
small GTPase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119923, 95 interactors
Database of interacting proteins More...DIPⁱ	DIP-42379N
IntActⁱ	Q9UJM3, 31 interactors
Molecular INTeraction database More...MINTⁱ	Q9UJM3
STRINGⁱ	9606.ENSP00000366702

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	342 – 344	Combined sources	3
Turnⁱ	356 – 358	Combined sources	3
Beta strandⁱ	378 – 382	Combined sources	5
Beta strandⁱ	390 – 397	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UJM3
SMRⁱ	Q9UJM3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UJM3

EvolutionaryTraceⁱ

Q9UJM3

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	334 – 363	Interaction with EGFR and ERBB2 and regulation of EGFR activationAdd BLAST		30

Domainⁱ

The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer.1 Publication

Sequence similaritiesⁱ

Belongs to the MIG6 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEVS Eukaryota ENOG4111HB5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033870
HOGENOMⁱ	HOG000234207
HOVERGENⁱ	HBG031710
InParanoidⁱ	Q9UJM3
OMAⁱ	YTHRASP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BER
PhylomeDBⁱ	Q9UJM3
TreeFamⁱ	TF335720

Family and domain databases

InterProⁱ	View protein in InterPro IPR021619 Mig-6
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11555 Inhibitor_Mig-6, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9UJM3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI 
        60         70         80         90        100
TMAYSLNSSA QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS 
       110        120        130        140        150
ENLGPHEEDQ VVCGFKKLTV NGVCASTPPL TPIKNSPSLF PCAPLCERGS 
       160        170        180        190        200
RPLPPLPISE ALSLDDTDCE VEFLTSSDTD FLLEDSTLSD FKYDVPGRRS 
       210        220        230        240        250
FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP QTHRRLRRSH 
       260        270        280        290        300
SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR 
       310        320        330        340        350
WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ 
       360        370        380        390        400
SFAPDPKYVS SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER 
       410        420        430        440        450
PPYLDKYEKF FREAEETNGG AQIQPLPADC GISSATEKPD SKTKMDLGGH 
       460 
VKRKHLSYVV SP

Length:462

Mass (Da):50,560

Last modified:May 1, 2000 - v1

Checksum:ⁱ7AFA9F6CEB602912

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ENN7	K7ENN7_HUMAN	ERBB receptor feedback inhibitor 1 ERBB receptor feedback inhibitor 1	ERRFI1	52	Annotation score:
K7EMD2	K7EMD2_HUMAN	ERBB receptor feedback inhibitor 1 ERBB receptor feedback inhibitor 1	ERRFI1	74	Annotation score:
K7ENI4	K7ENI4_HUMAN	ERBB receptor feedback inhibitor 1 ERBB receptor feedback inhibitor 1	ERRFI1	53	Annotation score:
K7EJB4	K7EJB4_HUMAN	ERBB receptor feedback inhibitor 1 ERBB receptor feedback inhibitor 1	ERRFI1	79	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	7	A → T (PubMed:7641805).Curated		1
Sequence conflictⁱ	36	S → C (PubMed:7641805).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063039	109	D → N. Corresponds to variant dbSNP:rs34781518Ensembl.		1
Natural variantⁱVAR_050975	158	I → L. Corresponds to variant dbSNP:rs34974993Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ276373 mRNA Translation: CAC20426.1 AL034417 Genomic DNA No translation available. AK315718 mRNA Translation: BAG38076.1 CH471130 Genomic DNA Translation: EAW71593.1 BC025337 mRNA Translation: AAH25337.1 AL137274 mRNA Translation: CAB70672.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS94.1
PIRⁱ	T46346
NCBI Reference Sequences More...RefSeqⁱ	NP_061821.1, NM_018948.3 XP_006710760.1, XM_006710697.2
UniGeneⁱ	Hs.605445

Genome annotation databases

Ensemblⁱ	ENST00000377482; ENSP00000366702; ENSG00000116285
GeneIDⁱ	54206
KEGGⁱ	hsa:54206
UCSC genome browser More...UCSCⁱ	uc001aoz.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UJM3	ERBB receptor feedback inhibitor 1		HUMAN		462	UniRef100_Q9UJM3
UPI000040EA29		HUMAN		387
UPI0000205482		HUMAN		411

Protein	Similar proteins		Species	Score	Length	Source
Q9UJM3	ERBB receptor feedback inhibitor 1		HUMAN		462	UniRef90_Q9UJM3
ERBB receptor feedback inhibitor 1		PANTR		462
Uncharacterized protein		PANPA		462
ERBB receptor feedback inhibitor 1		MACMU		462
ERBB receptor feedback inhibitor 1		MACFA		462
+31

Protein	Similar proteins		Species	Score	Length	Source
Q9UJM3	ERBB receptor feedback inhibitor 1		RAT		459	UniRef50_P05432
ERBB receptor feedback inhibitor 1		MOUSE		461
Uncharacterized protein		PELSI		464
ERBB receptor feedback inhibitor 1		PHYCD		460
ERBB receptor feedback inhibitor 1 isoform X1		BALAS		466
+185

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ276373 mRNA Translation: CAC20426.1 AL034417 Genomic DNA No translation available. AK315718 mRNA Translation: BAG38076.1 CH471130 Genomic DNA Translation: EAW71593.1 BC025337 mRNA Translation: AAH25337.1 AL137274 mRNA Translation: CAB70672.1
CCDSⁱ	CCDS94.1
PIRⁱ	T46346
RefSeqⁱ	NP_061821.1, NM_018948.3 XP_006710760.1, XM_006710697.2
UniGeneⁱ	Hs.605445

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2RF9	X-ray	3.50	C/D	315-374	[»]
	2RFD	X-ray	3.60	C/D	340-364	[»]
	2RFE	X-ray	2.90	E/F	325-364	[»]
	4I21	X-ray	3.37	C/D	315-374	[»]
	4R3P	X-ray	2.90	B	392-398	[»]
	4R3R	X-ray	3.25	B	392-398	[»]
	4ZJV	X-ray	2.70	C/D	330-399	[»]
ProteinModelPortalⁱ	Q9UJM3
SMRⁱ	Q9UJM3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119923, 95 interactors
DIPⁱ	DIP-42379N
IntActⁱ	Q9UJM3, 31 interactors
MINTⁱ	Q9UJM3
STRINGⁱ	9606.ENSP00000366702

PTM databases

iPTMnetⁱ	Q9UJM3
PhosphoSitePlusⁱ	Q9UJM3

Polymorphism and mutation databases

BioMutaⁱ	ERRFI1
DMDMⁱ	27923810

Proteomic databases

EPDⁱ	Q9UJM3
MaxQBⁱ	Q9UJM3
PaxDbⁱ	Q9UJM3
PeptideAtlasⁱ	Q9UJM3
PRIDEⁱ	Q9UJM3
ProteomicsDBⁱ	84632

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54206
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377482; ENSP00000366702; ENSG00000116285
GeneIDⁱ	54206
KEGGⁱ	hsa:54206
UCSCⁱ	uc001aoz.4 human

Organism-specific databases

CTDⁱ	54206
DisGeNETⁱ	54206
EuPathDBⁱ	HostDB:ENSG00000116285.12
GeneCardsⁱ	ERRFI1
HGNCⁱ	HGNC:18185 ERRFI1
HPAⁱ	HPA027206
MIMⁱ	608069 gene
neXtProtⁱ	NX_Q9UJM3
OpenTargetsⁱ	ENSG00000116285
PharmGKBⁱ	PA142671904
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEVS Eukaryota ENOG4111HB5 LUCA
GeneTreeⁱ	ENSGT00440000033870
HOGENOMⁱ	HOG000234207
HOVERGENⁱ	HBG031710
InParanoidⁱ	Q9UJM3
OMAⁱ	YTHRASP
OrthoDBⁱ	EOG091G0BER
PhylomeDBⁱ	Q9UJM3
TreeFamⁱ	TF335720

Enzyme and pathway databases

SignaLinkⁱ	Q9UJM3
SIGNORⁱ	Q9UJM3

Miscellaneous databases

ChiTaRSⁱ	ERRFI1 human
EvolutionaryTraceⁱ	Q9UJM3
GeneWikiⁱ	ERRFI1
GenomeRNAiⁱ	54206
Protein Ontology More...PROⁱ	PR:Q9UJM3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116285 Expressed in 202 organ(s), highest expression level in tibia
CleanExⁱ	HS_ERRFI1
ExpressionAtlasⁱ	Q9UJM3 baseline and differential
Genevisibleⁱ	Q9UJM3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR021619 Mig-6
Pfamⁱ	View protein in Pfam PF11555 Inhibitor_Mig-6, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ERRFI_HUMAN
Accessionⁱ	Q9UJM3Primary (citable) accession number: Q9UJM3 Secondary accession number(s): B2RDX9, Q9NTG9, Q9UD05
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UJM3 (ERRFI_HUMAN)

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ERBB receptor feedback inhibitor 1

ERRFI1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ