UniProtKB - Q9UJM3 (ERRFI_HUMAN)
ERBB receptor feedback inhibitor 1
ERRFI1
Functioni
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
By similarityGO - Molecular functioni
- GTPase activator activity Source: ProtInc
- protein kinase binding Source: UniProtKB
- SH3 domain binding Source: Ensembl
- small GTPase binding Source: Ensembl
GO - Biological processi
- cellular hyperosmotic response Source: Ensembl
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to epidermal growth factor stimulus Source: Ensembl
- cellular response to insulin stimulus Source: Ensembl
- cellular response to platelet-derived growth factor stimulus Source: Ensembl
- lung alveolus development Source: UniProtKB
- lung epithelium development Source: UniProtKB
- lung vasculature development Source: UniProtKB
- negative regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
- negative regulation of collagen biosynthetic process Source: Ensembl
- negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
- negative regulation of epidermal growth factor receptor signaling pathway Source: GO_Central
- negative regulation of ERK1 and ERK2 cascade Source: Ensembl
- negative regulation of interleukin-1 beta production Source: Ensembl
- negative regulation of protein autophosphorylation Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: Ensembl
- regulation of keratinocyte differentiation Source: UniProtKB
- regulation of type B pancreatic cell proliferation Source: Ensembl
- skin morphogenesis Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9UJM3 |
SignaLinki | Q9UJM3 |
SIGNORi | Q9UJM3 |
Names & Taxonomyi
Protein namesi | Recommended name: ERBB receptor feedback inhibitor 1Alternative name(s): Mitogen-inducible gene 6 protein Short name: MIG-6 |
Gene namesi | Name:ERRFI1 Synonyms:MIG6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18185, ERRFI1 |
MIMi | 608069, gene |
neXtProti | NX_Q9UJM3 |
VEuPathDBi | HostDB:ENSG00000116285 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 346 | M → A: Abolishes inhibition of EGFR activity. 1 Publication | 1 | |
Mutagenesisi | 352 | F → A: Abolishes inhibition of EGFR activity. 1 Publication | 1 | |
Mutagenesisi | 358 | Y → A: Abolishes inhibition of EGFR activity. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 54206 |
OpenTargetsi | ENSG00000116285 |
PharmGKBi | PA142671904 |
Miscellaneous databases
Pharosi | Q9UJM3, Tbio |
Genetic variation databases
BioMutai | ERRFI1 |
DMDMi | 27923810 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000096487 | 2 – 462 | ERBB receptor feedback inhibitor 1Add BLAST | 461 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 127 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 131 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 251 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Modified residuei | 302 | PhosphoserineBy similarity | 1 | |
Modified residuei | 461 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1566 |
EPDi | Q9UJM3 |
jPOSTi | Q9UJM3 |
MassIVEi | Q9UJM3 |
MaxQBi | Q9UJM3 |
PaxDbi | Q9UJM3 |
PeptideAtlasi | Q9UJM3 |
PRIDEi | Q9UJM3 |
ProteomicsDBi | 84632 |
PTM databases
iPTMneti | Q9UJM3 |
PhosphoSitePlusi | Q9UJM3 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000116285, Expressed in tibia and 218 other tissues |
ExpressionAtlasi | Q9UJM3, baseline and differential |
Genevisiblei | Q9UJM3, HS |
Organism-specific databases
HPAi | ENSG00000116285, Tissue enhanced (liver, pancreas) |
Interactioni
Subunit structurei
Interacts with ERBB2 (By similarity).
Interacts with EGFR.
By similarity1 PublicationBinary interactionsi
Q9UJM3
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- SH3 domain binding Source: Ensembl
- small GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 119923, 104 interactors |
DIPi | DIP-42379N |
IntActi | Q9UJM3, 33 interactors |
MINTi | Q9UJM3 |
STRINGi | 9606.ENSP00000366702 |
Miscellaneous databases
RNActi | Q9UJM3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UJM3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UJM3 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 225 – 374 | DisorderedSequence analysisAdd BLAST | 150 | |
Regioni | 334 – 363 | Interaction with EGFR and ERBB2 and regulation of EGFR activationAdd BLAST | 30 | |
Regioni | 415 – 448 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 329 – 347 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QPQW, Eukaryota |
GeneTreei | ENSGT00440000033870 |
HOGENOMi | CLU_604032_0_0_1 |
InParanoidi | Q9UJM3 |
OMAi | EETPPHM |
OrthoDBi | 644164at2759 |
PhylomeDBi | Q9UJM3 |
TreeFami | TF335720 |
Family and domain databases
IDEALi | IID00286 |
InterProi | View protein in InterPro IPR015116, Cdc42-bd-like IPR021619, Mig-6 |
Pfami | View protein in Pfam PF09027, GTPase_binding, 1 hit PF11555, Inhibitor_Mig-6, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI
60 70 80 90 100
TMAYSLNSSA QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS
110 120 130 140 150
ENLGPHEEDQ VVCGFKKLTV NGVCASTPPL TPIKNSPSLF PCAPLCERGS
160 170 180 190 200
RPLPPLPISE ALSLDDTDCE VEFLTSSDTD FLLEDSTLSD FKYDVPGRRS
210 220 230 240 250
FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP QTHRRLRRSH
260 270 280 290 300
SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR
310 320 330 340 350
WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ
360 370 380 390 400
SFAPDPKYVS SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER
410 420 430 440 450
PPYLDKYEKF FREAEETNGG AQIQPLPADC GISSATEKPD SKTKMDLGGH
460
VKRKHLSYVV SP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJB4 | K7EJB4_HUMAN | ERBB receptor feedback inhibitor 1 | ERRFI1 | 79 | Annotation score: | ||
K7ENI4 | K7ENI4_HUMAN | ERBB receptor feedback inhibitor 1 | ERRFI1 | 53 | Annotation score: | ||
K7ENN7 | K7ENN7_HUMAN | ERBB receptor feedback inhibitor 1 | ERRFI1 | 52 | Annotation score: | ||
K7EMD2 | K7EMD2_HUMAN | ERBB receptor feedback inhibitor 1 | ERRFI1 | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | A → T (PubMed:7641805).Curated | 1 | |
Sequence conflicti | 36 | S → C (PubMed:7641805).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063039 | 109 | D → N. Corresponds to variant dbSNP:rs34781518Ensembl. | 1 | |
Natural variantiVAR_050975 | 158 | I → L. Corresponds to variant dbSNP:rs34974993EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ276373 mRNA Translation: CAC20426.1 AL034417 Genomic DNA No translation available. AK315718 mRNA Translation: BAG38076.1 CH471130 Genomic DNA Translation: EAW71593.1 BC025337 mRNA Translation: AAH25337.1 AL137274 mRNA Translation: CAB70672.1 |
CCDSi | CCDS94.1 |
PIRi | T46346 |
RefSeqi | NP_061821.1, NM_018948.3 XP_006710760.1, XM_006710697.2 |
Genome annotation databases
Ensembli | ENST00000377482; ENSP00000366702; ENSG00000116285 |
GeneIDi | 54206 |
KEGGi | hsa:54206 |
MANE-Selecti | ENST00000377482.10; ENSP00000366702.5; NM_018948.4; NP_061821.1 |
UCSCi | uc001aoz.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ276373 mRNA Translation: CAC20426.1 AL034417 Genomic DNA No translation available. AK315718 mRNA Translation: BAG38076.1 CH471130 Genomic DNA Translation: EAW71593.1 BC025337 mRNA Translation: AAH25337.1 AL137274 mRNA Translation: CAB70672.1 |
CCDSi | CCDS94.1 |
PIRi | T46346 |
RefSeqi | NP_061821.1, NM_018948.3 XP_006710760.1, XM_006710697.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RF9 | X-ray | 3.50 | C/D | 315-374 | [»] | |
2RFD | X-ray | 3.60 | C/D | 340-364 | [»] | |
2RFE | X-ray | 2.90 | E/F | 325-364 | [»] | |
4I21 | X-ray | 3.37 | C/D | 315-374 | [»] | |
4R3P | X-ray | 2.90 | B | 392-398 | [»] | |
4R3R | X-ray | 3.25 | B | 392-398 | [»] | |
4ZJV | X-ray | 2.70 | C/D | 330-399 | [»] | |
SMRi | Q9UJM3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119923, 104 interactors |
DIPi | DIP-42379N |
IntActi | Q9UJM3, 33 interactors |
MINTi | Q9UJM3 |
STRINGi | 9606.ENSP00000366702 |
PTM databases
iPTMneti | Q9UJM3 |
PhosphoSitePlusi | Q9UJM3 |
Genetic variation databases
BioMutai | ERRFI1 |
DMDMi | 27923810 |
Proteomic databases
CPTACi | CPTAC-1566 |
EPDi | Q9UJM3 |
jPOSTi | Q9UJM3 |
MassIVEi | Q9UJM3 |
MaxQBi | Q9UJM3 |
PaxDbi | Q9UJM3 |
PeptideAtlasi | Q9UJM3 |
PRIDEi | Q9UJM3 |
ProteomicsDBi | 84632 |
Protocols and materials databases
Antibodypediai | 27548, 211 antibodies from 29 providers |
CPTCi | Q9UJM3, 2 antibodies |
DNASUi | 54206 |
Genome annotation databases
Ensembli | ENST00000377482; ENSP00000366702; ENSG00000116285 |
GeneIDi | 54206 |
KEGGi | hsa:54206 |
MANE-Selecti | ENST00000377482.10; ENSP00000366702.5; NM_018948.4; NP_061821.1 |
UCSCi | uc001aoz.4, human |
Organism-specific databases
CTDi | 54206 |
DisGeNETi | 54206 |
GeneCardsi | ERRFI1 |
HGNCi | HGNC:18185, ERRFI1 |
HPAi | ENSG00000116285, Tissue enhanced (liver, pancreas) |
MIMi | 608069, gene |
neXtProti | NX_Q9UJM3 |
OpenTargetsi | ENSG00000116285 |
PharmGKBi | PA142671904 |
VEuPathDBi | HostDB:ENSG00000116285 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPQW, Eukaryota |
GeneTreei | ENSGT00440000033870 |
HOGENOMi | CLU_604032_0_0_1 |
InParanoidi | Q9UJM3 |
OMAi | EETPPHM |
OrthoDBi | 644164at2759 |
PhylomeDBi | Q9UJM3 |
TreeFami | TF335720 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJM3 |
SignaLinki | Q9UJM3 |
SIGNORi | Q9UJM3 |
Miscellaneous databases
BioGRID-ORCSi | 54206, 9 hits in 1046 CRISPR screens |
ChiTaRSi | ERRFI1, human |
EvolutionaryTracei | Q9UJM3 |
GeneWikii | ERRFI1 |
GenomeRNAii | 54206 |
Pharosi | Q9UJM3, Tbio |
PROi | PR:Q9UJM3 |
RNActi | Q9UJM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116285, Expressed in tibia and 218 other tissues |
ExpressionAtlasi | Q9UJM3, baseline and differential |
Genevisiblei | Q9UJM3, HS |
Family and domain databases
IDEALi | IID00286 |
InterProi | View protein in InterPro IPR015116, Cdc42-bd-like IPR021619, Mig-6 |
Pfami | View protein in Pfam PF09027, GTPase_binding, 1 hit PF11555, Inhibitor_Mig-6, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ERRFI_HUMAN | |
Accessioni | Q9UJM3Primary (citable) accession number: Q9UJM3 Secondary accession number(s): B2RDX9, Q9NTG9, Q9UD05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 27, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families