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Protein

Zinc finger protein ZFP69B

Gene

ZFP69B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFP69B
Alternative name(s):
Zinc finger protein 643
Gene namesi
Name:ZFP69B
Synonyms:ZNF643
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187801.14
HGNCiHGNC:28053 ZFP69B
neXtProtiNX_Q9UJL9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi65243
OpenTargetsiENSG00000187801

Polymorphism and mutation databases

BioMutaiZFP69B
DMDMi342187319

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476971 – 534Zinc finger protein ZFP69BAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki235Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9UJL9
PeptideAtlasiQ9UJL9
PRIDEiQ9UJL9
ProteomicsDBi84630
84631 [Q9UJL9-2]

PTM databases

iPTMnetiQ9UJL9
PhosphoSitePlusiQ9UJL9

Expressioni

Gene expression databases

BgeeiENSG00000187801
CleanExiHS_ZNF643
ExpressionAtlasiQ9UJL9 baseline and differential
GenevisibleiQ9UJL9 HS

Organism-specific databases

HPAiHPA044289

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10322364,EBI-10171697

Protein-protein interaction databases

BioGridi122409, 2 interactors
IntActiQ9UJL9, 1 interactor
STRINGi9606.ENSP00000399664

Structurei

3D structure databases

ProteinModelPortaliQ9UJL9
SMRiQ9UJL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 145KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG062325
InParanoidiQ9UJL9
KOiK09228
OMAiIRHCKTH
OrthoDBiEOG091G02KC
PhylomeDBiQ9UJL9
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQQLLITLP TEASTWVKLR HPKAATERVA LWEDVTKMFK AEALLSQDAD
60 70 80 90 100
ETQGESLESR VTLGSLTAES QELLTFKDVS VDFTQEEWGQ LAPAHRNLYR
110 120 130 140 150
EVMLENYGNL VSVGCQLSKP GVISQLEKGE EPWLMERDIS GVPSSDLKSK
160 170 180 190 200
TKTKESALQN DISWEELHCG LMMERFTKGS SMYSTLGRIS KCNKLESQQE
210 220 230 240 250
NQRMGKGQIP LMCKKTFTQE RGQESNRFEK RINVKSEVMP GPIGLPRKRD
260 270 280 290 300
RKYDTPGKRS RYNIDLVNHS RSYTKMKTFE CNICEKIFKQ LIHLTEHMRI
310 320 330 340 350
HTGEKPFRCK ECGKAFSQSS SLIPHQRIHT GEKPYECKEC GKTFRHPSSL
360 370 380 390 400
TQHVRIHTGE KPYECRVCEK AFSQSIGLIQ HLRTHVREKP FTCKDCGKAF
410 420 430 440 450
FQIRHLRQHE IIHTGVKPYI CNVCSKTFSH STYLTQHQRT HTGERPYKCK
460 470 480 490 500
ECGKAFSQRI HLSIHQRVHT GVKPYECSHC GKAFRHDSSF AKHQRIHTGE
510 520 530
KPYDCNECGK AFSCSSSLIR HCKTHLRNTF SNVV
Length:534
Mass (Da):61,481
Last modified:July 27, 2011 - v2
Checksum:i7F63EF062570CEBE
GO
Isoform 2 (identifier: Q9UJL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:432
Mass (Da):49,925
Checksum:i489F7185464A0F1C
GO

Sequence cautioni

The sequence AAH17498 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI19856 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033584115C → Y. Corresponds to variant dbSNP:rs2272994Ensembl.1
Natural variantiVAR_052884359G → R. Corresponds to variant dbSNP:rs12407929Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416471 – 102Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137241 mRNA Translation: CAB70626.1
AL031985 Genomic DNA Translation: CAI19856.1 Sequence problems.
CN256362 mRNA No translation available.
BC017498 mRNA Translation: AAH17498.1 Different initiation.
CCDSiCCDS452.2 [Q9UJL9-1]
RefSeqiNP_075558.2, NM_023070.2 [Q9UJL9-1]
XP_005271194.1, XM_005271137.2 [Q9UJL9-1]
XP_005271196.1, XM_005271139.3 [Q9UJL9-2]
UniGeneiHs.133034
Hs.633186

Genome annotation databases

EnsembliENST00000361584; ENSP00000354547; ENSG00000187801 [Q9UJL9-1]
ENST00000411995; ENSP00000399664; ENSG00000187801 [Q9UJL9-1]
GeneIDi65243
KEGGihsa:65243
UCSCiuc001cfn.3 human [Q9UJL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZF69B_HUMAN
AccessioniPrimary (citable) accession number: Q9UJL9
Secondary accession number(s): Q5QPL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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