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Protein

Meteorin

Gene

METRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meteorin
Gene namesi
Name:METRN
Synonyms:C16orf23
ORF Names:RJD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103260.8
HGNCiHGNC:14151 METRN
MIMi610998 gene
neXtProtiNX_Q9UJH8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79006
OpenTargetsiENSG00000103260
PharmGKBiPA25537

Polymorphism and mutation databases

BioMutaiMETRN
DMDMi50401202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000002168024 – 293MeteorinAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 51PROSITE-ProRule annotation
Disulfide bondi82 ↔ 118PROSITE-ProRule annotation
Disulfide bondi171 ↔ 242PROSITE-ProRule annotation
Disulfide bondi174 ↔ 266PROSITE-ProRule annotation
Disulfide bondi184 ↔ 288PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UJH8
PeptideAtlasiQ9UJH8
PRIDEiQ9UJH8
ProteomicsDBi84625

PTM databases

iPTMnetiQ9UJH8
PhosphoSitePlusiQ9UJH8

Expressioni

Gene expression databases

BgeeiENSG00000103260 Expressed in 205 organ(s), highest expression level in substantia nigra
CleanExiHS_METRN
ExpressionAtlasiQ9UJH8 baseline and differential
GenevisibleiQ9UJH8 HS

Organism-specific databases

HPAiHPA051164

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi122477, 4 interactors
STRINGi9606.ENSP00000455068

Structurei

3D structure databases

ProteinModelPortaliQ9UJH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the meteorin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKV7 Eukaryota
ENOG4111FCI LUCA
GeneTreeiENSGT00390000001390
HOGENOMiHOG000236301
HOVERGENiHBG052461
InParanoidiQ9UJH8
OMAiGAIEWLY
OrthoDBiEOG091G0FAE
PhylomeDBiQ9UJH8
TreeFamiTF330918

Family and domain databases

InterProiView protein in InterPro
IPR039229 Meteorin
PANTHERiPTHR28593:SF2 PTHR28593:SF2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UJH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFPAAALLC ALCCGLLAPA ARAGYSEERC SWRGSGLTQE PGSVGQLALA
60 70 80 90 100
CAEGAVEWLY PAGALRLTLG GPDPRARPGI ACLRPVRPFA GAQVFAERAG
110 120 130 140 150
GALELLLAEG PGPAGGRCVR WGPRERRALF LQATPHQDIS RRVAAFRFEL
160 170 180 190 200
REDGRPELPP QAHGLGVDGA CRPCSDAELL LAACTSDFVI HGIIHGVTHD
210 220 230 240 250
VELQESVITV VAARVLRQTP PLFQAGRSGD QGLTSIRTPL RCGVHPGPGT
260 270 280 290
FLFMGWSRFG EARLGCAPRF QEFRRAYEAA RAAHLHPCEV ALH
Length:293
Mass (Da):31,207
Last modified:July 19, 2004 - v2
Checksum:i45B9136BF9153F28
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KMW6J3KMW6_HUMAN
Meteorin
METRN
187Annotation score:
I3L2T3I3L2T3_HUMAN
Meteorin
METRN
175Annotation score:
H3BUM1H3BUM1_HUMAN
Meteorin
METRN
160Annotation score:
H3BSC8H3BSC8_HUMAN
Meteorin
METRN
69Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA Translation: AAK61247.1
Z97653 Genomic DNA No translation available.
BC000662 mRNA Translation: AAH00662.1
CCDSiCCDS10422.1
RefSeqiNP_076947.1, NM_024042.3
UniGeneiHs.533772
Hs.732288

Genome annotation databases

EnsembliENST00000568223; ENSP00000455068; ENSG00000103260
GeneIDi79006
KEGGihsa:79006
UCSCiuc010bra.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006464 Genomic DNA Translation: AAK61247.1
Z97653 Genomic DNA No translation available.
BC000662 mRNA Translation: AAH00662.1
CCDSiCCDS10422.1
RefSeqiNP_076947.1, NM_024042.3
UniGeneiHs.533772
Hs.732288

3D structure databases

ProteinModelPortaliQ9UJH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122477, 4 interactors
STRINGi9606.ENSP00000455068

PTM databases

iPTMnetiQ9UJH8
PhosphoSitePlusiQ9UJH8

Polymorphism and mutation databases

BioMutaiMETRN
DMDMi50401202

Proteomic databases

PaxDbiQ9UJH8
PeptideAtlasiQ9UJH8
PRIDEiQ9UJH8
ProteomicsDBi84625

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000568223; ENSP00000455068; ENSG00000103260
GeneIDi79006
KEGGihsa:79006
UCSCiuc010bra.4 human

Organism-specific databases

CTDi79006
DisGeNETi79006
EuPathDBiHostDB:ENSG00000103260.8
GeneCardsiMETRN
HGNCiHGNC:14151 METRN
HPAiHPA051164
MIMi610998 gene
neXtProtiNX_Q9UJH8
OpenTargetsiENSG00000103260
PharmGKBiPA25537
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKV7 Eukaryota
ENOG4111FCI LUCA
GeneTreeiENSGT00390000001390
HOGENOMiHOG000236301
HOVERGENiHBG052461
InParanoidiQ9UJH8
OMAiGAIEWLY
OrthoDBiEOG091G0FAE
PhylomeDBiQ9UJH8
TreeFamiTF330918

Miscellaneous databases

ChiTaRSiMETRN human
GenomeRNAii79006
PROiPR:Q9UJH8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103260 Expressed in 205 organ(s), highest expression level in substantia nigra
CleanExiHS_METRN
ExpressionAtlasiQ9UJH8 baseline and differential
GenevisibleiQ9UJH8 HS

Family and domain databases

InterProiView protein in InterPro
IPR039229 Meteorin
PANTHERiPTHR28593:SF2 PTHR28593:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMETRN_HUMAN
AccessioniPrimary (citable) accession number: Q9UJH8
Secondary accession number(s): Q9UJH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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