UniProtKB - Q9UJC5 (SH3L2_HUMAN)
Protein
SH3 domain-binding glutamic acid-rich-like protein 2
Gene
SH3BGRL2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- SH3 domain binding Source: UniProtKB-KW
Enzyme and pathway databases
PathwayCommonsi | Q9UJC5 |
Names & Taxonomyi
Protein namesi | Recommended name: SH3 domain-binding glutamic acid-rich-like protein 2Alternative name(s): Fovea-associated SH3 domain-binding protein |
Gene namesi | Name:SH3BGRL2 Synonyms:FASH3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15567, SH3BGRL2 |
MIMi | 615678, gene |
neXtProti | NX_Q9UJC5 |
VEuPathDBi | HostDB:ENSG00000198478.7 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 83699 |
OpenTargetsi | ENSG00000198478 |
PharmGKBi | PA37978 |
Miscellaneous databases
Pharosi | Q9UJC5, Tbio |
Genetic variation databases
BioMutai | SH3BGRL2 |
DMDMi | 24638476 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220747 | 1 – 107 | SH3 domain-binding glutamic acid-rich-like protein 2Add BLAST | 107 |
Proteomic databases
EPDi | Q9UJC5 |
jPOSTi | Q9UJC5 |
MassIVEi | Q9UJC5 |
MaxQBi | Q9UJC5 |
PaxDbi | Q9UJC5 |
PeptideAtlasi | Q9UJC5 |
PRIDEi | Q9UJC5 |
ProteomicsDBi | 84618 |
TopDownProteomicsi | Q9UJC5 |
2D gel databases
UCD-2DPAGEi | Q9UJC5 |
PTM databases
iPTMneti | Q9UJC5 |
PhosphoSitePlusi | Q9UJC5 |
Expressioni
Tissue specificityi
Highly expressed in brain, placenta, liver and kidney. Expressed in retina.1 Publication
Gene expression databases
Bgeei | ENSG00000198478, Expressed in parotid gland and 222 other tissues |
Genevisiblei | Q9UJC5, HS |
Organism-specific databases
HPAi | ENSG00000198478, Tissue enhanced (salivary) |
Interactioni
GO - Molecular functioni
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 123733, 8 interactors |
IntActi | Q9UJC5, 5 interactors |
STRINGi | 9606.ENSP00000358853 |
Miscellaneous databases
RNActi | Q9UJC5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9UJC5 |
SMRi | Q9UJC5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UJC5 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 61 – 67 | SH3-bindingSequence analysis | 7 |
Sequence similaritiesi
Belongs to the SH3BGR family.Curated
Keywords - Domaini
SH3-bindingPhylogenomic databases
eggNOGi | KOG4023, Eukaryota |
GeneTreei | ENSGT00940000159157 |
HOGENOMi | CLU_084862_3_0_1 |
InParanoidi | Q9UJC5 |
OMAi | VAVKKHQ |
OrthoDBi | 1508713at2759 |
PhylomeDBi | Q9UJC5 |
TreeFami | TF105574 |
Family and domain databases
CDDi | cd03030, GRX_SH3BGR, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR006993, Glut_rich_SH3-bd IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF04908, SH3BGR, 1 hit |
PIRSFi | PIRSF008142, SH3-bind_E-rich_L, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UJC5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVIRVFIASS SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY
60 70 80 90 100
KNVPPEKKPT QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR
LASKAEP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | I → V in AAH70059 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 39 | I → T in AAH40489 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297972 mRNA Translation: CAC35771.1 AF340151 mRNA Translation: AAK37526.1 AK311757 mRNA Translation: BAG34700.1 AL035700 Genomic DNA No translation available. AL451064 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48703.1 BC040489 mRNA Translation: AAH40489.2 BC052987 mRNA Translation: AAH52987.2 BC060799 mRNA Translation: AAH60799.2 BC070059 mRNA Translation: AAH70059.2 BC109043 mRNA Translation: AAI09044.2 BC109044 mRNA Translation: AAI09045.2 |
CCDSi | CCDS4991.1 |
RefSeqi | NP_113657.1, NM_031469.3 XP_016866833.1, XM_017011344.1 |
Genome annotation databases
Ensembli | ENST00000369838; ENSP00000358853; ENSG00000198478 |
GeneIDi | 83699 |
KEGGi | hsa:83699 |
UCSCi | uc003piz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ297972 mRNA Translation: CAC35771.1 AF340151 mRNA Translation: AAK37526.1 AK311757 mRNA Translation: BAG34700.1 AL035700 Genomic DNA No translation available. AL451064 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48703.1 BC040489 mRNA Translation: AAH40489.2 BC052987 mRNA Translation: AAH52987.2 BC060799 mRNA Translation: AAH60799.2 BC070059 mRNA Translation: AAH70059.2 BC109043 mRNA Translation: AAI09044.2 BC109044 mRNA Translation: AAI09045.2 |
CCDSi | CCDS4991.1 |
RefSeqi | NP_113657.1, NM_031469.3 XP_016866833.1, XM_017011344.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CT6 | NMR | - | A | 1-98 | [»] | |
BMRBi | Q9UJC5 | |||||
SMRi | Q9UJC5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123733, 8 interactors |
IntActi | Q9UJC5, 5 interactors |
STRINGi | 9606.ENSP00000358853 |
PTM databases
iPTMneti | Q9UJC5 |
PhosphoSitePlusi | Q9UJC5 |
Genetic variation databases
BioMutai | SH3BGRL2 |
DMDMi | 24638476 |
2D gel databases
UCD-2DPAGEi | Q9UJC5 |
Proteomic databases
EPDi | Q9UJC5 |
jPOSTi | Q9UJC5 |
MassIVEi | Q9UJC5 |
MaxQBi | Q9UJC5 |
PaxDbi | Q9UJC5 |
PeptideAtlasi | Q9UJC5 |
PRIDEi | Q9UJC5 |
ProteomicsDBi | 84618 |
TopDownProteomicsi | Q9UJC5 |
Protocols and materials databases
Antibodypediai | 64235, 21 antibodies |
Genome annotation databases
Ensembli | ENST00000369838; ENSP00000358853; ENSG00000198478 |
GeneIDi | 83699 |
KEGGi | hsa:83699 |
UCSCi | uc003piz.2, human |
Organism-specific databases
CTDi | 83699 |
DisGeNETi | 83699 |
GeneCardsi | SH3BGRL2 |
HGNCi | HGNC:15567, SH3BGRL2 |
HPAi | ENSG00000198478, Tissue enhanced (salivary) |
MIMi | 615678, gene |
neXtProti | NX_Q9UJC5 |
OpenTargetsi | ENSG00000198478 |
PharmGKBi | PA37978 |
VEuPathDBi | HostDB:ENSG00000198478.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4023, Eukaryota |
GeneTreei | ENSGT00940000159157 |
HOGENOMi | CLU_084862_3_0_1 |
InParanoidi | Q9UJC5 |
OMAi | VAVKKHQ |
OrthoDBi | 1508713at2759 |
PhylomeDBi | Q9UJC5 |
TreeFami | TF105574 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJC5 |
Miscellaneous databases
BioGRID-ORCSi | 83699, 2 hits in 878 CRISPR screens |
ChiTaRSi | SH3BGRL2, human |
EvolutionaryTracei | Q9UJC5 |
GenomeRNAii | 83699 |
Pharosi | Q9UJC5, Tbio |
PROi | PR:Q9UJC5 |
RNActi | Q9UJC5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198478, Expressed in parotid gland and 222 other tissues |
Genevisiblei | Q9UJC5, HS |
Family and domain databases
CDDi | cd03030, GRX_SH3BGR, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR006993, Glut_rich_SH3-bd IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF04908, SH3BGR, 1 hit |
PIRSFi | PIRSF008142, SH3-bind_E-rich_L, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SH3L2_HUMAN | |
Accessioni | Q9UJC5Primary (citable) accession number: Q9UJC5 Secondary accession number(s): A8MQU2 Q9BPY5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | November 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families