UniProtKB - Q9UJA9 (ENPP5_HUMAN)
Protein
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Gene
ENPP5
Organism
Homo sapiens (Human)
Status
Functioni
Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication.By similarity
Cofactori
Zn2+1 PublicationNote: Binds 2 Zn2+ ions per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 36 | Zinc 1; catalyticCombined sources1 Publication | 1 | |
Active sitei | 72 | NucleophileCombined sources1 Publication | 1 | |
Metal bindingi | 72 | Zinc 1; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 191 | Zinc 2; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 195 | Zinc 2; via tele nitrogen; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 238 | Zinc 1; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 239 | Zinc 1; via tele nitrogen; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 339 | Zinc 2; via tele nitrogen; catalyticCombined sources1 Publication | 1 |
GO - Molecular functioni
- NAD+ diphosphatase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cell communication Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UJA9 |
Names & Taxonomyi
Protein namesi | Recommended name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (EC:3.1.-.-)Short name: E-NPP 5 Short name: NPP-5 |
Gene namesi | Name:ENPP5Imported ORF Names:UNQ550/PRO1107 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13717, ENPP5 |
MIMi | 617001, gene |
neXtProti | NX_Q9UJA9 |
VEuPathDBi | HostDB:ENSG00000112796.9 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 432 – 452 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 59084 |
OpenTargetsi | ENSG00000112796 |
PharmGKBi | PA27795 |
Miscellaneous databases
Pharosi | Q9UJA9, Tdark |
Genetic variation databases
BioMutai | ENPP5 |
DMDMi | 50401201 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000036401 | 25 – 477 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 5Add BLAST | 453 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 292 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 329 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 362 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 369 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 382 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9UJA9 |
jPOSTi | Q9UJA9 |
MassIVEi | Q9UJA9 |
MaxQBi | Q9UJA9 |
PaxDbi | Q9UJA9 |
PeptideAtlasi | Q9UJA9 |
PRIDEi | Q9UJA9 |
ProteomicsDBi | 84616 |
PTM databases
GlyGeni | Q9UJA9, 8 sites |
iPTMneti | Q9UJA9 |
PhosphoSitePlusi | Q9UJA9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112796, Expressed in caput epididymis and 193 other tissues |
Genevisiblei | Q9UJA9, HS |
Organism-specific databases
HPAi | ENSG00000112796, Tissue enriched (epididymis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121860, 2 interactors |
STRINGi | 9606.ENSP00000360436 |
Miscellaneous databases
RNActi | Q9UJA9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UJA9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2645, Eukaryota |
GeneTreei | ENSGT00940000160562 |
HOGENOMi | CLU_017594_1_2_1 |
InParanoidi | Q9UJA9 |
OMAi | TWVDKSP |
OrthoDBi | 999163at2759 |
PhylomeDBi | Q9UJA9 |
TreeFami | TF330032 |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR002591, Phosphodiest/P_Trfase |
Pfami | View protein in Pfam PF01663, Phosphodiest, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9UJA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSKFLLVSF ILAALSLSTT FSLQPDQQKV LLVSFDGFRW DYLYKVPTPH
60 70 80 90 100
FHYIMKYGVH VKQVTNVFIT KTYPNHYTLV TGLFAENHGI VANDMFDPIR
110 120 130 140 150
NKSFSLDHMN IYDSKFWEEA TPIWITNQRA GHTSGAAMWP GTDVKIHKRF
160 170 180 190 200
PTHYMPYNES VSFEDRVAKI IEWFTSKEPI NLGLLYWEDP DDMGHHLGPD
210 220 230 240 250
SPLMGPVISD IDKKLGYLIQ MLKKAKLWNT LNLIITSDHG MTQCSEERLI
260 270 280 290 300
ELDQYLDKDH YTLIDQSPVA AILPKEGKFD EVYEALTHAH PNLTVYKKED
310 320 330 340 350
VPERWHYKYN SRIQPIIAVA DEGWHILQNK SDDFLLGNHG YDNALADMHP
360 370 380 390 400
IFLAHGPAFR KNFSKEAMNS TDLYPLLCHL LNITAMPHNG SFWNVQDLLN
410 420 430 440 450
SAMPRVVPYT QSTILLPGSV KPAEYDQEGS YPYFIGVSLG SIIVIVFFVI
460 470
FIKHLIHSQI PALQDMHAEI AQPLLQA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | P → L in AAQ88878 (PubMed:12975309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020248 | 6 | L → I1 PublicationCorresponds to variant dbSNP:rs3806995Ensembl. | 1 | |
Natural variantiVAR_033918 | 39 | R → P. Corresponds to variant dbSNP:rs34109856Ensembl. | 1 | |
Natural variantiVAR_052940 | 69 | I → V. Corresponds to variant dbSNP:rs34432940Ensembl. | 1 | |
Natural variantiVAR_024693 | 171 | I → V1 PublicationCorresponds to variant dbSNP:rs6926570Ensembl. | 1 | |
Natural variantiVAR_052941 | 283 | Y → C. Corresponds to variant dbSNP:rs16874326Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358514 mRNA Translation: AAQ88878.1 AL035701 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04293.1 BC027615 mRNA Translation: AAH27615.1 |
CCDSi | CCDS4915.1 |
PIRi | A59391 |
RefSeqi | NP_001277001.1, NM_001290072.1 NP_001277002.1, NM_001290073.1 NP_067547.1, NM_021572.5 XP_005249317.1, XM_005249260.3 XP_011513088.1, XM_011514786.2 |
Genome annotation databases
Ensembli | ENST00000230565; ENSP00000230565; ENSG00000112796 ENST00000371383; ENSP00000360436; ENSG00000112796 |
GeneIDi | 59084 |
KEGGi | hsa:59084 |
UCSCi | uc003oxz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358514 mRNA Translation: AAQ88878.1 AL035701 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04293.1 BC027615 mRNA Translation: AAH27615.1 |
CCDSi | CCDS4915.1 |
PIRi | A59391 |
RefSeqi | NP_001277001.1, NM_001290072.1 NP_001277002.1, NM_001290073.1 NP_067547.1, NM_021572.5 XP_005249317.1, XM_005249260.3 XP_011513088.1, XM_011514786.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5VEM | X-ray | 2.60 | A/B/C | 25-430 | [»] | |
SMRi | Q9UJA9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121860, 2 interactors |
STRINGi | 9606.ENSP00000360436 |
PTM databases
GlyGeni | Q9UJA9, 8 sites |
iPTMneti | Q9UJA9 |
PhosphoSitePlusi | Q9UJA9 |
Genetic variation databases
BioMutai | ENPP5 |
DMDMi | 50401201 |
Proteomic databases
EPDi | Q9UJA9 |
jPOSTi | Q9UJA9 |
MassIVEi | Q9UJA9 |
MaxQBi | Q9UJA9 |
PaxDbi | Q9UJA9 |
PeptideAtlasi | Q9UJA9 |
PRIDEi | Q9UJA9 |
ProteomicsDBi | 84616 |
Protocols and materials databases
Antibodypediai | 2350, 154 antibodies |
DNASUi | 59084 |
Genome annotation databases
Ensembli | ENST00000230565; ENSP00000230565; ENSG00000112796 ENST00000371383; ENSP00000360436; ENSG00000112796 |
GeneIDi | 59084 |
KEGGi | hsa:59084 |
UCSCi | uc003oxz.2, human |
Organism-specific databases
CTDi | 59084 |
DisGeNETi | 59084 |
GeneCardsi | ENPP5 |
HGNCi | HGNC:13717, ENPP5 |
HPAi | ENSG00000112796, Tissue enriched (epididymis) |
MIMi | 617001, gene |
neXtProti | NX_Q9UJA9 |
OpenTargetsi | ENSG00000112796 |
PharmGKBi | PA27795 |
VEuPathDBi | HostDB:ENSG00000112796.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2645, Eukaryota |
GeneTreei | ENSGT00940000160562 |
HOGENOMi | CLU_017594_1_2_1 |
InParanoidi | Q9UJA9 |
OMAi | TWVDKSP |
OrthoDBi | 999163at2759 |
PhylomeDBi | Q9UJA9 |
TreeFami | TF330032 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJA9 |
Miscellaneous databases
BioGRID-ORCSi | 59084, 4 hits in 871 CRISPR screens |
GenomeRNAii | 59084 |
Pharosi | Q9UJA9, Tdark |
PROi | PR:Q9UJA9 |
RNActi | Q9UJA9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112796, Expressed in caput epididymis and 193 other tissues |
Genevisiblei | Q9UJA9, HS |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR002591, Phosphodiest/P_Trfase |
Pfami | View protein in Pfam PF01663, Phosphodiest, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENPP5_HUMAN | |
Accessioni | Q9UJA9Primary (citable) accession number: Q9UJA9 Secondary accession number(s): Q5TFV2, Q6UX49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families