Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9UJA5 (TRM6_HUMAN)

Entry version 152 (10 Feb 2021)
Sequence version 1 (01 May 2000)
Previous versions | rss
Add a publicationFeedback
Protein

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Gene

TRMT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N1-methyltransferase complex that mediates methylation of adenosine residues at the N1 position of a small subset of mRNAs: N1 methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei349SubstrateCombined sources1 Publication1
Binding sitei377SubstrateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.220, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UJA5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6782315, tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Alternative name(s):
mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM61 Publication
tRNA(m1A58)-methyltransferase subunit TRM6
Short name:
tRNA(m1A58)MTase subunit TRM6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT6
Synonyms:KIAA1153, TRM6
ORF Names:CGI-09
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20900, TRMT6

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UJA5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000089195.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51605

Open Targets

More...OpenTargetsi		ENSG00000089195

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162407063

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UJA5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRMT6

Domain mapping of disease mutations (DMDM)

More...DMDMi		74753354

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002330981 – 497tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107PhosphothreonineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UJA5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UJA5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UJA5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UJA5

PeptideAtlas

More...PeptideAtlasi		Q9UJA5

PRoteomics IDEntifications database

More...PRIDEi		Q9UJA5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5222
84613 [Q9UJA5-1]
84614 [Q9UJA5-2]
84615 [Q9UJA5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UJA5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UJA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, liver, testis and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089195, Expressed in secondary oocyte and 218 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UJA5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000089195, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.

1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119634, 58 interactors

Protein interaction database and analysis system

More...IntActi		Q9UJA5, 28 interactors

Molecular INTeraction database

More...MINTi		Q9UJA5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000203001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UJA5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1497
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UJA5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 104Substrate bindingCombined sources1 PublicationAdd BLAST11
Regioni145 – 154Substrate bindingCombined sources1 Publication10
Regioni175 – 182Substrate bindingCombined sources1 Publication8
Regioni415 – 423Substrate bindingCombined sources1 Publication9
Regioni434 – 441Substrate bindingCombined sources1 Publication8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRM6/GCD10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1416, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008327

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010916_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UJA5

Identification of Orthologs from Complete Genome Data

More...OMAi		ETCSGLV

Database of Orthologous Groups

More...OrthoDBi		543764at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UJA5

TreeFam database of animal gene trees

More...TreeFami		TF314835

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017423, TRM6

The PANTHER Classification System

More...PANTHERi		PTHR12945, PTHR12945, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04189, Gcd10p, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038170, tRNA_m1A_mtfrase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UJA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ 
        60         70         80         90        100
WFYLDNVIGH SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD 
       110        120        130        140        150
GKSQKLTQDD IKALKDKGIK GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK 
       160        170        180        190        200
KKKYEAIITV VKPSTRILSI MYYAREPGKI NHMRYDTLAQ MLTLGNIRAG 
       210        220        230        240        250
NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA TACFGFPKSF 
       260        270        280        290        300
LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ 
       310        320        330        340        350
ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYIQEKQRRQ 
       360        370        380        390        400
EEQRKRHLEA AALLSERNAD GLIVASRFHP TPLLLSLLDF VAPSRPFVVY 
       410        420        430        440        450
CQYKEPLLEC YTKLRERGGV INLRLSETWL RNYQVLPDRS HPKLLMSGGG 
       460        470        480        490 
GYLLSGFTVA MDNLKADTSL KSNASTLESH ETEEPAAKKR KCPESDS
Length:497
Mass (Da):55,799
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i920800D0722A6CBB
GO
Isoform 2 (identifier: Q9UJA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-497: LIVASRFHPT...KKRKCPESDS → CVDGRRQETPQCMWALLQTDWHSLSPCL

Show »
Length:399
Mass (Da):44,963
Checksum:i28C0FB314555F56C
GO
Isoform 3 (identifier: Q9UJA5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-365: QEKQRRQEEQRKRHLEAAALLS → SGKNRGRQGRSSGKDFWGCRFA
     366-497: Missing.

Show »
Length:365
Mass (Da):40,816
Checksum:i15B0559642D8D087
GO
Isoform 4 (identifier: Q9UJA5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Show »
Length:327
Mass (Da):36,439
Checksum:iF01F65B739562EE6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86467 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86467 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053789293E → K. Corresponds to variant dbSNP:rs6139876Ensembl.1
Natural variantiVAR_053790299E → G2 PublicationsCorresponds to variant dbSNP:rs451571Ensembl.1
Natural variantiVAR_053791333P → L. Corresponds to variant dbSNP:rs35203742Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547401 – 170Missing in isoform 4. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_031100344 – 365QEKQR…AALLS → SGKNRGRQGRSSGKDFWGCR FA in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_031101366 – 497Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_018025372 – 497LIVAS…PESDS → CVDGRRQETPQCMWALLQTD WHSLSPCL in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB032979 mRNA Translation: BAA86467.1 Different initiation.
AF132943 mRNA Translation: AAD27718.1 Frameshift.
AK000613 mRNA No translation available.
AK300812 mRNA Translation: BAG62468.1
AL035461 Genomic DNA No translation available.
BC001262 mRNA Translation: AAH01262.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13093.1 [Q9UJA5-1]
CCDS63225.1 [Q9UJA5-4]

NCBI Reference Sequences

More...RefSeqi		NP_001268396.1, NM_001281467.1 [Q9UJA5-4]
NP_057023.2, NM_015939.4 [Q9UJA5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000203001; ENSP00000203001; ENSG00000089195 [Q9UJA5-1]
ENST00000453074; ENSP00000392070; ENSG00000089195 [Q9UJA5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51605

UCSC genome browser

More...UCSCi		uc002wmh.3, human [Q9UJA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032979 mRNA Translation: BAA86467.1 Different initiation.
AF132943 mRNA Translation: AAD27718.1 Frameshift.
AK000613 mRNA No translation available.
AK300812 mRNA Translation: BAG62468.1
AL035461 Genomic DNA No translation available.
BC001262 mRNA Translation: AAH01262.1
CCDSiCCDS13093.1 [Q9UJA5-1]
CCDS63225.1 [Q9UJA5-4]
RefSeqiNP_001268396.1, NM_001281467.1 [Q9UJA5-4]
NP_057023.2, NM_015939.4 [Q9UJA5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CCBX-ray2.00B1-497[»]
5CCXX-ray2.10B1-497[»]
5CD1X-ray3.60B/E1-497[»]
SMRiQ9UJA5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119634, 58 interactors
IntActiQ9UJA5, 28 interactors
MINTiQ9UJA5
STRINGi9606.ENSP00000203001

PTM databases

iPTMnetiQ9UJA5
PhosphoSitePlusiQ9UJA5

Genetic variation databases

BioMutaiTRMT6
DMDMi74753354

Proteomic databases

EPDiQ9UJA5
jPOSTiQ9UJA5
MassIVEiQ9UJA5
PaxDbiQ9UJA5
PeptideAtlasiQ9UJA5
PRIDEiQ9UJA5
ProteomicsDBi5222
84613 [Q9UJA5-1]
84614 [Q9UJA5-2]
84615 [Q9UJA5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23943, 78 antibodies

The DNASU plasmid repository

More...DNASUi		51605

Genome annotation databases

EnsembliENST00000203001; ENSP00000203001; ENSG00000089195 [Q9UJA5-1]
ENST00000453074; ENSP00000392070; ENSG00000089195 [Q9UJA5-4]
GeneIDi51605
KEGGihsa:51605
UCSCiuc002wmh.3, human [Q9UJA5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51605
DisGeNETi51605

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRMT6
HGNCiHGNC:20900, TRMT6
HPAiENSG00000089195, Low tissue specificity
neXtProtiNX_Q9UJA5
OpenTargetsiENSG00000089195
PharmGKBiPA162407063
VEuPathDBiHostDB:ENSG00000089195.14

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1416, Eukaryota
GeneTreeiENSGT00390000008327
HOGENOMiCLU_010916_0_1_1
InParanoidiQ9UJA5
OMAiETCSGLV
OrthoDBi543764at2759
PhylomeDBiQ9UJA5
TreeFamiTF314835

Enzyme and pathway databases

BRENDAi2.1.1.220, 2681
PathwayCommonsiQ9UJA5
ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51605, 267 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRMT6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51605
PharosiQ9UJA5, Tdark

Protein Ontology

More...PROi		PR:Q9UJA5
RNActiQ9UJA5, protein

Gene expression databases

BgeeiENSG00000089195, Expressed in secondary oocyte and 218 other tissues
GenevisibleiQ9UJA5, HS

Family and domain databases

InterProiView protein in InterPro
IPR017423, TRM6
PANTHERiPTHR12945, PTHR12945, 1 hit
PfamiView protein in Pfam
PF04189, Gcd10p, 1 hit
PIRSFiPIRSF038170, tRNA_m1A_mtfrase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRM6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJA5
Secondary accession number(s): B4DUV6
, Q76P92, Q9BQV5, Q9ULR7, Q9Y2Z8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again