UniProtKB - Q9UJA5 (TRM6_HUMAN)

BLAST

>sp|Q9UJA5|TRM6_HUMAN tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1
MEGSGEQPGPQPQHPGDHRIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNVIGH
SYGTAFEVTSGGSLQPKKKREEPTAETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIK
GEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITVVKPSTRILSIMYYAREPGKI
NHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAA
TACFGFPKSFLSGLYEFPLNKVDSLLHGTFSAKMLSSEPKDSALVEESNGTLEEKQASEQ
ENEDSMAEAPESNHPEDQETMETISQDPEHKGPKERGSKKDYIQEKQRRQEEQRKRHLEA
AALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGV
INLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADTSLKSNASTLESH
ETEEPAAKKRKCPESDS

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History
Entry version 138 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Gene

TRMT6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Substrate-binding subunit of tRNA (adenine-N₁-)-methyltransferase, which catalyzes the formation of N₁-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N₁-methyltransferase complex that mediates methylation of adenosine residues at the N₁ position of a small subset of mRNAs: N₁ methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	349	SubstrateCombined sources1 Publication		1
Binding siteⁱ	377	SubstrateCombined sources1 Publication		1

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA methylation
Source: UniProtKB
Inferred from direct assayⁱ
- 29072297
- 29107537
tRNA methylation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	tRNA processing

Biological process

tRNA processing

Enzyme and pathway databases

BRENDAⁱ	2.1.1.220 2681
Reactomeⁱ	R-HSA-6782315 tRNA modification in the nucleus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 Alternative name(s): mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM61 Publication tRNA(m1A58)-methyltransferase subunit TRM6 Short name: tRNA(m1A58)MTase subunit TRM6
Gene namesⁱ	Name:TRMT6 Synonyms:KIAA1153, TRM6 ORF Names:CGI-09
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089195.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20900 TRMT6
neXtProtⁱ	NX_Q9UJA5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51605
Open Targets More...OpenTargetsⁱ	ENSG00000089195
PharmGKBⁱ	PA162407063

Polymorphism and mutation databases

DMDMⁱ	74753354

DMDMⁱ

74753354

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000233098	1 – 497	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6Add BLAST		497

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	107	PhosphothreonineCombined sources	1
Modified residueⁱ	298	PhosphoserineCombined sources	1
Modified residueⁱ	305	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UJA5
PaxDbⁱ	Q9UJA5
PeptideAtlas More...PeptideAtlasⁱ	Q9UJA5
PRIDEⁱ	Q9UJA5
ProteomicsDBⁱ	84613 84614 [Q9UJA5-2] 84615 [Q9UJA5-3]

PTM databases

iPTMnetⁱ	Q9UJA5
PhosphoSitePlusⁱ	Q9UJA5

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, liver, testis and ovary.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000089195 Expressed in 205 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_TRMT6
Genevisibleⁱ	Q9UJA5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047032 HPA050408

HPAⁱ

HPA047032
HPA050408

Interactionⁱ

Subunit structureⁱ

Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.1 Publication1 Publication

Protein-protein interaction databases

BioGridⁱ	119634, 54 interactors
IntActⁱ	Q9UJA5, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q9UJA5
STRINGⁱ	9606.ENSP00000203001

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	25 – 30	Combined sources	6
Beta strandⁱ	33 – 38	Combined sources	6
Beta strandⁱ	44 – 46	Combined sources	3
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	54 – 56	Combined sources	3
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	64 – 74	Combined sources	11
Helixⁱ	108 – 116	Combined sources	9
Helixⁱ	122 – 130	Combined sources	9
Beta strandⁱ	132 – 134	Combined sources	3
Helixⁱ	135 – 137	Combined sources	3
Helixⁱ	140 – 154	Combined sources	15
Beta strandⁱ	159 – 161	Combined sources	3
Helixⁱ	165 – 175	Combined sources	11
Helixⁱ	177 – 180	Combined sources	4
Helixⁱ	185 – 194	Combined sources	10
Beta strandⁱ	202 – 207	Combined sources	6
Helixⁱ	212 – 221	Combined sources	10
Beta strandⁱ	225 – 232	Combined sources	8
Helixⁱ	239 – 243	Combined sources	5
Helixⁱ	248 – 251	Combined sources	4
Beta strandⁱ	254 – 258	Combined sources	5
Helixⁱ	259 – 261	Combined sources	3
Helixⁱ	262 – 267	Combined sources	6
Helixⁱ	342 – 365	Combined sources	24
Beta strandⁱ	369 – 375	Combined sources	7
Helixⁱ	380 – 387	Combined sources	8
Helixⁱ	388 – 390	Combined sources	3
Beta strandⁱ	396 – 404	Combined sources	9
Helixⁱ	405 – 417	Combined sources	13
Beta strandⁱ	420 – 434	Combined sources	15
Beta strandⁱ	441 – 446	Combined sources	6
Beta strandⁱ	448 – 450	Combined sources	3
Beta strandⁱ	452 – 458	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UJA5
SMRⁱ	Q9UJA5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	94 – 104	SubstrateCombined sources1 PublicationAdd BLAST	11
Regionⁱ	145 – 154	SubstrateCombined sources1 Publication	10
Regionⁱ	175 – 182	SubstrateCombined sources1 Publication	8
Regionⁱ	415 – 423	SubstrateCombined sources1 Publication	9
Regionⁱ	434 – 441	SubstrateCombined sources1 Publication	8

Sequence similaritiesⁱ

Belongs to the TRM6/GCD10 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1416 Eukaryota ENOG410XSXD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008327
HOGENOMⁱ	HOG000232007
HOVERGENⁱ	HBG061231
InParanoidⁱ	Q9UJA5
KEGG Orthology (KO) More...KOⁱ	K03256
OMAⁱ	REPGKIC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G095O
PhylomeDBⁱ	Q9UJA5
TreeFamⁱ	TF314835

Family and domain databases

InterProⁱ	View protein in InterPro IPR017423 TRM6
PANTHERⁱ	PTHR12945 PTHR12945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04189 Gcd10p, 1 hit
PIRSFⁱ	PIRSF038170 tRNA_m1A_mtfrase, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9UJA5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ 
        60         70         80         90        100
WFYLDNVIGH SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD 
       110        120        130        140        150
GKSQKLTQDD IKALKDKGIK GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK 
       160        170        180        190        200
KKKYEAIITV VKPSTRILSI MYYAREPGKI NHMRYDTLAQ MLTLGNIRAG 
       210        220        230        240        250
NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA TACFGFPKSF 
       260        270        280        290        300
LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ 
       310        320        330        340        350
ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYIQEKQRRQ 
       360        370        380        390        400
EEQRKRHLEA AALLSERNAD GLIVASRFHP TPLLLSLLDF VAPSRPFVVY 
       410        420        430        440        450
CQYKEPLLEC YTKLRERGGV INLRLSETWL RNYQVLPDRS HPKLLMSGGG 
       460        470        480        490 
GYLLSGFTVA MDNLKADTSL KSNASTLESH ETEEPAAKKR KCPESDS

Length:497

Mass (Da):55,799

Last modified:May 1, 2000 - v1

Checksum:ⁱ920800D0722A6CBB

Isoform 2 (identifier: Q9UJA5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
372-497: LIVASRFHPT...KKRKCPESDS → CVDGRRQETPQCMWALLQTDWHSLSPCL

« Hide

        10         20         30         40         50
MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ 
        60         70         80         90        100
WFYLDNVIGH SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD 
       110        120        130        140        150
GKSQKLTQDD IKALKDKGIK GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK 
       160        170        180        190        200
KKKYEAIITV VKPSTRILSI MYYAREPGKI NHMRYDTLAQ MLTLGNIRAG 
       210        220        230        240        250
NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA TACFGFPKSF 
       260        270        280        290        300
LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ 
       310        320        330        340        350
ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYIQEKQRRQ 
       360        370        380        390 
EEQRKRHLEA AALLSERNAD GCVDGRRQET PQCMWALLQT DWHSLSPCL

Show »

Length:399

Mass (Da):44,963

Checksum:ⁱ28C0FB314555F56C

Isoform 3 (identifier: Q9UJA5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
344-365: QEKQRRQEEQRKRHLEAAALLS → SGKNRGRQGRSSGKDFWGCRFA
366-497: Missing.

« Hide

        10         20         30         40         50
MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ 
        60         70         80         90        100
WFYLDNVIGH SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD 
       110        120        130        140        150
GKSQKLTQDD IKALKDKGIK GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK 
       160        170        180        190        200
KKKYEAIITV VKPSTRILSI MYYAREPGKI NHMRYDTLAQ MLTLGNIRAG 
       210        220        230        240        250
NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA TACFGFPKSF 
       260        270        280        290        300
LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ 
       310        320        330        340        350
ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYISGKNRGR 
       360 
QGRSSGKDFW GCRFA

Note: No experimental confirmation available.

Show »

Length:365

Mass (Da):40,816

Checksum:ⁱ15B0559642D8D087

Isoform 4 (identifier: Q9UJA5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-170: Missing.

« Hide

        10         20         30         40         50
MYYAREPGKI NHMRYDTLAQ MLTLGNIRAG NKMIVMETCA GLVLGAMMER 
        60         70         80         90        100
MGGFGSIIQL YPGGGPVRAA TACFGFPKSF LSGLYEFPLN KVDSLLHGTF 
       110        120        130        140        150
SAKMLSSEPK DSALVEESNG TLEEKQASEQ ENEDSMAEAP ESNHPEDQET 
       160        170        180        190        200
METISQDPEH KGPKERGSKK DYIQEKQRRQ EEQRKRHLEA AALLSERNAD 
       210        220        230        240        250
GLIVASRFHP TPLLLSLLDF VAPSRPFVVY CQYKEPLLEC YTKLRERGGV 
       260        270        280        290        300
INLRLSETWL RNYQVLPDRS HPKLLMSGGG GYLLSGFTVA MDNLKADTSL 
       310        320 
KSNASTLESH ETEEPAAKKR KCPESDS

Show »

Length:327

Mass (Da):36,439

Checksum:ⁱF01F65B739562EE6

Sequence cautionⁱ

The sequence BAA86467 differs from that shown. Reason: Frameshift at position 319.Curated

The sequence BAA86467 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053789	293	E → K. Corresponds to variant dbSNP:rs6139876Ensembl.	1
Natural variantⁱVAR_053790	299	E → G2 PublicationsCorresponds to variant dbSNP:rs451571Ensembl.	1
Natural variantⁱVAR_053791	333	P → L. Corresponds to variant dbSNP:rs35203742Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_054740	1 – 170	Missing in isoform 4. 1 PublicationAdd BLAST	170
Alternative sequenceⁱVSP_031100	344 – 365	QEKQR…AALLS → SGKNRGRQGRSSGKDFWGCR FA in isoform 3. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_031101	366 – 497	Missing in isoform 3. 1 PublicationAdd BLAST	132
Alternative sequenceⁱVSP_018025	372 – 497	LIVAS…PESDS → CVDGRRQETPQCMWALLQTD WHSLSPCL in isoform 2. 1 PublicationAdd BLAST	126

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032979 mRNA Translation: BAA86467.1 Different initiation. AF132943 mRNA Translation: AAD27718.1 Frameshift. AK000613 mRNA No translation available. AK300812 mRNA Translation: BAG62468.1 AL035461 Genomic DNA No translation available. BC001262 mRNA Translation: AAH01262.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13093.1 [Q9UJA5-1] CCDS63225.1 [Q9UJA5-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001268396.1, NM_001281467.1 [Q9UJA5-4] NP_057023.2, NM_015939.4 [Q9UJA5-1]
UniGeneⁱ	Hs.128791

Genome annotation databases

Ensemblⁱ	ENST00000203001; ENSP00000203001; ENSG00000089195 [Q9UJA5-1] ENST00000453074; ENSP00000392070; ENSG00000089195 [Q9UJA5-4]
GeneIDⁱ	51605
KEGGⁱ	hsa:51605
UCSC genome browser More...UCSCⁱ	uc002wmh.3 human [Q9UJA5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UJA5	Isoform 4 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		HUMAN		327	UniRef100_Q9UJA5
UPI000387CFED		HUMAN		315

Protein	Similar proteins		Species	Score	Length	Source
Q9UJA5	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		BOVIN		497	UniRef90_Q9UJA5
Isoform 4 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		HUMAN		327
tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6		MYOBR		536
tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (Fragment)		ESCRO		503
tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1		Yangtze finless porpoise		503
+116
Q9UJA5-2	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		COLAP		481	UniRef90_Q9UJA5-2

Protein	Similar proteins		Species	Score	Length	Source
Q9UJA5	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		BOVIN		497	UniRef50_Q9UJA5
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		MOUSE		497
Isoform 4 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		HUMAN		327
tRNA (Adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6		MYOBR		536
tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		TURTR		503
+316
Q9UJA5-3	tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6		CAMFR		434	UniRef50_Q9UJA5-3
tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2		ODORO		391
tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2		LEPWE		391
UPI00072F9EF0		OVIMU		398
UPI00045DD516		Orycteropus afer afer		391
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032979 mRNA Translation: BAA86467.1 Different initiation. AF132943 mRNA Translation: AAD27718.1 Frameshift. AK000613 mRNA No translation available. AK300812 mRNA Translation: BAG62468.1 AL035461 Genomic DNA No translation available. BC001262 mRNA Translation: AAH01262.1
CCDSⁱ	CCDS13093.1 [Q9UJA5-1] CCDS63225.1 [Q9UJA5-4]
RefSeqⁱ	NP_001268396.1, NM_001281467.1 [Q9UJA5-4] NP_057023.2, NM_015939.4 [Q9UJA5-1]
UniGeneⁱ	Hs.128791

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CCB	X-ray	2.00	B	1-497	[»]
	5CCX	X-ray	2.10	B	1-497	[»]
	5CD1	X-ray	3.60	B/E	1-497	[»]
ProteinModelPortalⁱ	Q9UJA5
SMRⁱ	Q9UJA5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119634, 54 interactors
IntActⁱ	Q9UJA5, 14 interactors
MINTⁱ	Q9UJA5
STRINGⁱ	9606.ENSP00000203001

PTM databases

iPTMnetⁱ	Q9UJA5
PhosphoSitePlusⁱ	Q9UJA5

Polymorphism and mutation databases

DMDMⁱ	74753354

DMDMⁱ

74753354

Proteomic databases

EPDⁱ	Q9UJA5
PaxDbⁱ	Q9UJA5
PeptideAtlasⁱ	Q9UJA5
PRIDEⁱ	Q9UJA5
ProteomicsDBⁱ	84613 84614 [Q9UJA5-2] 84615 [Q9UJA5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51605
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000203001; ENSP00000203001; ENSG00000089195 [Q9UJA5-1] ENST00000453074; ENSP00000392070; ENSG00000089195 [Q9UJA5-4]
GeneIDⁱ	51605
KEGGⁱ	hsa:51605
UCSCⁱ	uc002wmh.3 human [Q9UJA5-1]

Organism-specific databases

CTDⁱ	51605
DisGeNETⁱ	51605
EuPathDBⁱ	HostDB:ENSG00000089195.14
GeneCardsⁱ	TRMT6
HGNCⁱ	HGNC:20900 TRMT6
HPAⁱ	HPA047032 HPA050408
neXtProtⁱ	NX_Q9UJA5
OpenTargetsⁱ	ENSG00000089195
PharmGKBⁱ	PA162407063
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1416 Eukaryota ENOG410XSXD LUCA
GeneTreeⁱ	ENSGT00390000008327
HOGENOMⁱ	HOG000232007
HOVERGENⁱ	HBG061231
InParanoidⁱ	Q9UJA5
KOⁱ	K03256
OMAⁱ	REPGKIC
OrthoDBⁱ	EOG091G095O
PhylomeDBⁱ	Q9UJA5
TreeFamⁱ	TF314835

Enzyme and pathway databases

BRENDAⁱ	2.1.1.220 2681
Reactomeⁱ	R-HSA-6782315 tRNA modification in the nucleus and cytosol

Miscellaneous databases

GenomeRNAiⁱ	51605
Protein Ontology More...PROⁱ	PR:Q9UJA5

Gene expression databases

Bgeeⁱ	ENSG00000089195 Expressed in 205 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_TRMT6
Genevisibleⁱ	Q9UJA5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017423 TRM6
PANTHERⁱ	PTHR12945 PTHR12945, 1 hit
Pfamⁱ	View protein in Pfam PF04189 Gcd10p, 1 hit
PIRSFⁱ	PIRSF038170 tRNA_m1A_mtfrase, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRM6_HUMAN
Accessionⁱ	Q9UJA5Primary (citable) accession number: Q9UJA5 Secondary accession number(s): B4DUV6 , Q76P92, Q9BQV5, Q9ULR7, Q9Y2Z8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q9UJA5 (TRM6_HUMAN)

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tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

TRMT6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ