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Protein

Cadherin-22

Gene

CDH22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-22
Alternative name(s):
Pituitary and brain cadherin
Short name:
PB-cadherin
Gene namesi
Name:CDH22
Synonyms:C20orf25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149654.9
HGNCiHGNC:13251 CDH22
MIMi609920 gene
neXtProtiNX_Q9UJ99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 624ExtracellularSequence analysisAdd BLAST589
Transmembranei625 – 645HelicalSequence analysisAdd BLAST21
Topological domaini646 – 828CytoplasmicSequence analysisAdd BLAST183

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64405
OpenTargetsiENSG00000149654
PharmGKBiPA26295

Polymorphism and mutation databases

DMDMi24211543

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000000382135 – 828Cadherin-22Add BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UJ99
PeptideAtlasiQ9UJ99
PRIDEiQ9UJ99
ProteomicsDBi84607

PTM databases

iPTMnetiQ9UJ99
PhosphoSitePlusiQ9UJ99

Expressioni

Gene expression databases

BgeeiENSG00000149654 Expressed in 147 organ(s), highest expression level in cerebellar vermis
CleanExiHS_CDH22
GenevisibleiQ9UJ99 HS

Organism-specific databases

HPAiHPA012164

Interactioni

Protein-protein interaction databases

BioGridi122159, 1 interactor
STRINGi9606.ENSP00000361336

Structurei

3D structure databases

ProteinModelPortaliQ9UJ99
SMRiQ9UJ99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 168Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini169 – 277Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini278 – 394Cadherin 3PROSITE-ProRule annotationAdd BLAST117
Domaini395 – 498Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini499 – 616Cadherin 5PROSITE-ProRule annotationAdd BLAST118

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ9UJ99
KOiK06812
OMAiNRQEQDV
OrthoDBiEOG091G02GU
PhylomeDBiQ9UJ99
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UJ99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPRPEGRGL RAGVALSPAL LLLLLLPPPP TLLGRLWAAG TPSPSAPGAR
60 70 80 90 100
QDGALGAGRV KRGWVWNQFF VVEEYTGTEP LYVGKIHSDS DEGDGAIKYT
110 120 130 140 150
ISGEGAGTIF LIDELTGDIH AMERLDREQK TFYTLRAQAR DRATNRLLEP
160 170 180 190 200
ESEFIIKVQD INDSEPRFLH GPYIGSVAEL SPTGTSVMQV MASDADDPTY
210 220 230 240 250
GSSARLVYSV LDGEHHFTVD PKTGVIRTAV PDLDRESQER YEVVIQATDM
260 270 280 290 300
AGQLGGLSGS TTVTIVVTDV NDNPPRFPQK MYQFSIQESA PIGTAVGRVK
310 320 330 340 350
AEDSDVGENT DMTYHLKDES SSGGDVFKVT TDSDTQEAII VVQKRLDFES
360 370 380 390 400
QPVHTVILEA LNKFVDPRFA DLGTFRDQAI VRVAVTDVDE PPEFRPPSGL
410 420 430 440 450
LEVQEDAQVG SLVGVVTARD PDAANRPVRY AIDRESDLDQ IFDIDADTGA
460 470 480 490 500
IVTGKGLDRE TAGWHNITVL AMEADNHAQL SRASLRIRIL DVNDNPPELA
510 520 530 540 550
TPYEAAVCED AKPGQLIQTI SVVDRDEPQG GHRFYFRLVP EAPSNPHFSL
560 570 580 590 600
LDIQDNTAAV HTQHVGFNRQ EQDVFFLPIL VVDSGPPTLS STGTLTIRIC
610 620 630 640 650
GCDSSGTIQS CNTTAFVMAA SLSPGALIAL LVCVLILVVL VLLILTLRRH
660 670 680 690 700
HKSHLSSDED EDMRDNVIKY NDEGGGEQDT EAYDMSALRS LYDFGELKGG
710 720 730 740 750
DGGGSAGGGA GGGSGGGAGS PPQAHLPSER HSLPQGPPSP EPDFSVFRDF
760 770 780 790 800
ISRKVALADG DLSVPPYDAF QTYAFEGADS PAASLSSLHS GSSGSEQDFA
810 820
YLSSWGPRFR PLAALYAGHR GDDEAQAS
Length:828
Mass (Da):89,091
Last modified:March 1, 2001 - v2
Checksum:i520F7B1D1F624DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031687 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75755.1
BC136526 mRNA Translation: AAI36527.1
AF035300 mRNA Translation: AAB88183.1
CCDSiCCDS13395.1
RefSeqiNP_067071.1, NM_021248.2
XP_011527296.1, XM_011528994.2
UniGeneiHs.472861

Genome annotation databases

EnsembliENST00000372262; ENSP00000361336; ENSG00000149654
ENST00000537909; ENSP00000437790; ENSG00000149654
GeneIDi64405
KEGGihsa:64405
UCSCiuc010ghk.3 human

Similar proteinsi

Entry informationi

Entry nameiCAD22_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ99
Secondary accession number(s): B9EGK7, O43205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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