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Entry version 150 (18 Sep 2019)
Sequence version 2 (05 Jul 2005)
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Protein

Cohesin subunit SA-3

Gene

STAG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Chromosome partition, Meiosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1221632 Meiotic synapsis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cohesin subunit SA-3
Alternative name(s):
SCC3 homolog 3
Stromal antigen 3
Stromalin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11356 STAG3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608489 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UJ98

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Premature ovarian failure 8 (POF8)1 Publication1 Publication
The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in STAG3 predicted to result in frameshift and premature truncation, has been shown to be the cause of premature ovarian failure in a large consanguineous family.1 Publication
Disease descriptionAn ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Related information in OMIM

Keywords - Diseasei

Premature ovarian failure

Organism-specific databases

DisGeNET

More...
DisGeNETi
10734

MalaCards human disease database

More...
MalaCardsi
STAG3
MIMi615723 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000066923

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
619 NON RARE IN EUROPE: Primary ovarian failure

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36178

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UJ98

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAG3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68847235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001201881 – 1225Cohesin subunit SA-3Add BLAST1225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1203PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UJ98

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UJ98

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UJ98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UJ98

PeptideAtlas

More...
PeptideAtlasi
Q9UJ98

PRoteomics IDEntifications database

More...
PRIDEi
Q9UJ98

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
43653
84605 [Q9UJ98-1]
84606 [Q9UJ98-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UJ98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UJ98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066923 Expressed in 125 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UJ98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UJ98 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049106
HPA058330

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the meiosis-specific cohesin complex, which also contains the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer. Such complex likely contains RAD21, or the meiosis-specific related protein REC8.

Interacts with CCDC79/TERB1; recruiting cohesin to telomeres to develop structural rigidity (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115957, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UJ98, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000477973

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UJ98

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 394SCDPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 25Poly-Ser9
Compositional biasi1177 – 1185Poly-Glu9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCC3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2011 Eukaryota
COG5537 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231375

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UJ98

KEGG Orthology (KO)

More...
KOi
K13055

Database of Orthologous Groups

More...
OrthoDBi
167826at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UJ98

TreeFam database of animal gene trees

More...
TreeFami
TF314604

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG

The PANTHER Classification System

More...
PANTHERi
PTHR11199 PTHR11199, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08514 STAG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51425 SCD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJ98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSPLQRAVG DTKRALSASS SSSASLPFDD RDSNHTSEGN GDSLLADEDT
60 70 80 90 100
DFEDSLNRNV KKRAAKRPPK TTPVAKHPKK GSRVVHRHSR KQSEPPANDL
110 120 130 140 150
FNAVKAAKSD MQSLVDEWLD SYKQDQDAGF LELVNFFIQS CGCKGIVTPE
160 170 180 190 200
MFKKMSNSEI IQHLTEQFNE DSGDYPLIAP GPSWKKFQGS FCEFVRTLVC
210 220 230 240 250
QCQYSLLYDG FPMDDLISLL TGLSDSQVRA FRHTSTLAAM KLMTSLVKVA
260 270 280 290 300
LQLSVHQDNN QRQYEAERNK GPGQRAPERL ESLLEKRKEL QEHQEEIEGM
310 320 330 340 350
MNALFRGVFV HRYRDVLPEI RAICIEEIGC WMQSYSTSFL TDSYLKYIGW
360 370 380 390 400
TLHDKHREVR LKCVKALKGL YGNRDLTTRL ELFTSRFKDR MVSMVMDREY
410 420 430 440 450
DVAVEAVRLL ILILKNMEGV LTDADCESVY PVVYASHRGL ASAAGEFLYW
460 470 480 490 500
KLFYPECEIR MMGGREQRQS PGAQRTFFQL LLSFFVESEL HDHAAYLVDS
510 520 530 540 550
LWDCAGARLK DWEGLTSLLL EKDQNLGDVQ ESTLIEILVS SARQASEGHP
560 570 580 590 600
PVGRVTGRKG LTSKERKTQA DDRVKLTEHL IPLLPQLLAK FSADAEKVTP
610 620 630 640 650
LLQLLSCFDL HIYCTGRLEK HLELFLQQLQ EVVVKHAEPA VLEAGAHALY
660 670 680 690 700
LLCNPEFTFF SRADFARSQL VDLLTDRFQQ ELEELLQSSF LDEDEVYNLA
710 720 730 740 750
ATLKRLSAFY NTHDLTRWEL YEPCCQLLQK AVDTGEVPHQ VILPALTLVY
760 770 780 790 800
FSILWTLTHI SKSDASQKQL SSLRDRMVAF CELCQSCLSD VDTEIQEQAF
810 820 830 840 850
VLLSDLLLIF SPQMIVGGRD FLRPLVFFPE ATLQSELASF LMDHVFIQPG
860 870 880 890 900
DLGSGDSQED HLQIERLHQR RRLLAGFCKL LLYGVLEMDA ASDVFKHYNK
910 920 930 940 950
FYNDYGDIIK ETLTRARQID RSHCSRILLL SLKQLYTELL QEHGPQGLNE
960 970 980 990 1000
LPAFIEMRDL ARRFALSFGP QQLQNRDLVV MLHKEGIQFS LSELPPAGSS
1010 1020 1030 1040 1050
NQPPNLAFLE LLSEFSPRLF HQDKQLLLSY LEKCLQHVSQ APGHPWGPVT
1060 1070 1080 1090 1100
TYCHSLSPVE NTAETSPQVL PSSKRRRVEG PAKPNREDVS SSQEESLQLN
1110 1120 1130 1140 1150
SIPPTPTLTS TAVKSRQPLW GLKEMEEEDG SELDFAQGQP VAGTERSRFL
1160 1170 1180 1190 1200
GPQYFQTPHN PSGPGLGNQL MRLSLMEEDE EEELEIQDES NEERQDTDMQ
1210 1220
ASSYSSTSER GLDLLDSTEL DIEDF
Length:1,225
Mass (Da):139,034
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA29B2FC0C3CCE83D
GO
Isoform 2 (identifier: Q9UJ98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-212: Missing.
     759-1053: Missing.

Note: No experimental confirmation available.
Show »
Length:888
Mass (Da):100,644
Checksum:i2E4A0BA4CEE32E37
GO
Isoform 3 (identifier: Q9UJ98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-170: Missing.

Show »
Length:1,167
Mass (Da):132,319
Checksum:i6DD6702344B7304B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6W5U7D6W5U7_HUMAN
Cohesin subunit SA-3
STAG3 hCG_2024106
1,226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3T3C9J3T3_HUMAN
Cohesin subunit SA-3
STAG3
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTG4C9JTG4_HUMAN
Cohesin subunit SA-3
STAG3
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYW5C9JYW5_HUMAN
Cohesin subunit SA-3
STAG3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4S6H0Y4S6_HUMAN
Cohesin subunit SA-3
STAG3
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0H6H7C0H6_HUMAN
Cohesin subunit SA-3
STAG3
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti309F → S in BAG63922 (PubMed:14702039).Curated1
Sequence conflicti361L → V in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti378T → A in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti395V → I in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti401D → S in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti420V → L in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti435 – 437ASH → PSN in CAB59367 (PubMed:10698974).Curated3
Sequence conflicti457C → Y in BAG63922 (PubMed:14702039).Curated1
Sequence conflicti461M → T in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti771S → W in BAG63922 (PubMed:14702039).Curated1
Sequence conflicti1076R → K in CAB59367 (PubMed:10698974).Curated1
Sequence conflicti1138G → GS in CAD38679 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054742113 – 170Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_006996171 – 212Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_006997759 – 1053Missing in isoform 2. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ007798 mRNA Translation: CAB59367.1
AL833816 mRNA Translation: CAD38679.2
AK302693 mRNA Translation: BAG63922.1
AC005071 Genomic DNA No translation available.
AC073842 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76568.1
CH471091 Genomic DNA Translation: EAW76570.1
BC146806 mRNA Translation: AAI46807.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34703.1 [Q9UJ98-1]
CCDS64730.1 [Q9UJ98-3]

NCBI Reference Sequences

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RefSeqi
NP_001269645.1, NM_001282716.1 [Q9UJ98-1]
NP_001269646.1, NM_001282717.1
NP_001269647.1, NM_001282718.1 [Q9UJ98-3]
NP_036579.2, NM_012447.3 [Q9UJ98-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000317296; ENSP00000319318; ENSG00000066923 [Q9UJ98-1]
ENST00000394018; ENSP00000377586; ENSG00000066923 [Q9UJ98-3]
ENST00000426455; ENSP00000400359; ENSG00000066923 [Q9UJ98-1]
ENST00000620100; ENSP00000484098; ENSG00000066923 [Q9UJ98-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10734

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10734

UCSC genome browser

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UCSCi
uc003utx.3 human [Q9UJ98-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007798 mRNA Translation: CAB59367.1
AL833816 mRNA Translation: CAD38679.2
AK302693 mRNA Translation: BAG63922.1
AC005071 Genomic DNA No translation available.
AC073842 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76568.1
CH471091 Genomic DNA Translation: EAW76570.1
BC146806 mRNA Translation: AAI46807.1
CCDSiCCDS34703.1 [Q9UJ98-1]
CCDS64730.1 [Q9UJ98-3]
RefSeqiNP_001269645.1, NM_001282716.1 [Q9UJ98-1]
NP_001269646.1, NM_001282717.1
NP_001269647.1, NM_001282718.1 [Q9UJ98-3]
NP_036579.2, NM_012447.3 [Q9UJ98-1]

3D structure databases

SMRiQ9UJ98
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115957, 2 interactors
IntActiQ9UJ98, 1 interactor
STRINGi9606.ENSP00000477973

PTM databases

iPTMnetiQ9UJ98
PhosphoSitePlusiQ9UJ98

Polymorphism and mutation databases

BioMutaiSTAG3
DMDMi68847235

Proteomic databases

EPDiQ9UJ98
jPOSTiQ9UJ98
MassIVEiQ9UJ98
PaxDbiQ9UJ98
PeptideAtlasiQ9UJ98
PRIDEiQ9UJ98
ProteomicsDBi43653
84605 [Q9UJ98-1]
84606 [Q9UJ98-2]

Genome annotation databases

EnsembliENST00000317296; ENSP00000319318; ENSG00000066923 [Q9UJ98-1]
ENST00000394018; ENSP00000377586; ENSG00000066923 [Q9UJ98-3]
ENST00000426455; ENSP00000400359; ENSG00000066923 [Q9UJ98-1]
ENST00000620100; ENSP00000484098; ENSG00000066923 [Q9UJ98-3]
GeneIDi10734
KEGGihsa:10734
UCSCiuc003utx.3 human [Q9UJ98-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10734
DisGeNETi10734

GeneCards: human genes, protein and diseases

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GeneCardsi
STAG3
HGNCiHGNC:11356 STAG3
HPAiHPA049106
HPA058330
MalaCardsiSTAG3
MIMi608489 gene
615723 phenotype
neXtProtiNX_Q9UJ98
OpenTargetsiENSG00000066923
Orphaneti619 NON RARE IN EUROPE: Primary ovarian failure
PharmGKBiPA36178

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00950000182972
HOGENOMiHOG000231375
InParanoidiQ9UJ98
KOiK13055
OrthoDBi167826at2759
PhylomeDBiQ9UJ98
TreeFamiTF314604

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STAG3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10734
PharosiQ9UJ98

Protein Ontology

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PROi
PR:Q9UJ98

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000066923 Expressed in 125 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9UJ98 baseline and differential
GenevisibleiQ9UJ98 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039662 Cohesin_Scc3/SA
IPR020839 SCD
IPR013721 STAG
PANTHERiPTHR11199 PTHR11199, 1 hit
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJ98
Secondary accession number(s): A6H8Z1
, B4DZ10, D6W5U8, H7BYK9, Q8NDP3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: July 5, 2005
Last modified: September 18, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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