UniProtKB - Q9UJ78 (ZMYM5_HUMAN)

BLAST

>sp|Q9UJ78|ZMYM5_HUMAN Zinc finger MYM-type protein 5 OS=Homo sapiens OX=9606 GN=ZMYM5 PE=1 SV=4
MEKCSVGGLELTEQTPALLGNMAMATSLMDIGDSFGHPACPLVSRSRNSPVEDDDDDDDV
VFIESIQPPSISAPAIADQRNFIFASSKNEKPQGNYSVIPPSSRDLASQKGNISETIVID
DEEDIETNGGAEKKSSCFIEWGLPGTKNKTNDLDFSTSSLSRSKTKTGVRPFNPGRMNVA
GDLFQNGEFATHHSPDSWISQSASFPSNQKQPGVDSLSPVALLRKQNFQPTAQQQLTKPA
KITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTQNTRSIICKKDASTKKANV
ILPVESSKSFQEFYSTSCLSPCENNWNLKKGVFNKSRCTICSKLAEIRHEVSVNNVTHKL
CSNHCFNKYRLANGLIMNCCEHCGEYMPSKSTGNNILVIGGQQKRFCCQSCINEYKQMME
TKSKKLTASENRKRNAFREENEKQLYGSSNTLLKKIEGIPEKKEKTSQLQLSVECGTDTL
LIQENVNLPPSSTSTIADTFQEQLEEKNFEDSIVPVVLSADPGTWPRILNIKQRDTLVEN
VPPQVRNFNFPKDNTGRKFSETYYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLFGEGK
NQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKLKSDLKKNKAIDAAEHRLYENEK
NDGVLLLYT

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History
Entry version 131 (07 Nov 2018)
Sequence version 4 (22 Jul 2008)
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Protein

Zinc finger MYM-type protein 5

Gene

ZMYM5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Functions as a transcriptional regulator.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	265 – 299	MYM-type 1Add BLAST	35
Zinc fingerⁱ	311 – 351	MYM-type 2Add BLAST	41
Zinc fingerⁱ	358 – 393	MYM-type 3Add BLAST	36
Zinc fingerⁱ	404 – 431	MYM-type 4Add BLAST	28

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: UniProtKB
Inferred from direct assayⁱ
- 17126306
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoskeleton organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger MYM-type protein 5 Alternative name(s): Zinc finger protein 198-like 1 Zinc finger protein 237
Gene namesⁱ	Name:ZMYM5 Synonyms:ZNF198L1, ZNF237 ORF Names:HSPC050
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132950.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13029 ZMYM5
MIMⁱ	616443 gene
neXtProtⁱ	NX_Q9UJ78

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	112	N → H: Abolishes interaction with ETV5. Abolished repression activity. 1 Publication	1
Mutagenesisⁱ	114	S → G: Abolishes interaction with ETV5. No effect on repression activity. 1 Publication	1
Mutagenesisⁱ	116	T → A: No effect on repression activity. 1 Publication	1
Mutagenesisⁱ	120	D → G: Increases repression activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9205
Open Targets More...OpenTargetsⁱ	ENSG00000132950
PharmGKBⁱ	PA37607

Polymorphism and mutation databases

BioMutaⁱ	ZMYM5
DMDMⁱ	212288108

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191380	1 – 669	Zinc finger MYM-type protein 5Add BLAST		669

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Cross-linkⁱ	88	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	91	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	134	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	149	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	166	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	225	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	443	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	455	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	462	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	552	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UJ78
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UJ78
PaxDbⁱ	Q9UJ78
PeptideAtlas More...PeptideAtlasⁱ	Q9UJ78
PRIDEⁱ	Q9UJ78
ProteomicsDBⁱ	84596 84597 [Q9UJ78-1] 84598 [Q9UJ78-2] 84599 [Q9UJ78-3] 84600 [Q9UJ78-5]

PTM databases

iPTMnetⁱ	Q9UJ78
PhosphoSitePlusⁱ	Q9UJ78

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132950 Expressed in 211 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_ZMYM5
ExpressionAtlasⁱ	Q9UJ78 baseline and differential
Genevisibleⁱ	Q9UJ78 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020879

HPAⁱ

HPA020879

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SUMO1	P63165	3	EBI-7228860,EBI-80140

With

Entry

#Exp.

IntAct

Notes

SUMO1

P63165

EBI-7228860,EBI-80140

Protein-protein interaction databases

BioGridⁱ	114639, 8 interactors
IntActⁱ	Q9UJ78, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q9UJ78
STRINGⁱ	9606.ENSP00000372361

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	245 – 247	Combined sources	3
Beta strandⁱ	266 – 269	Combined sources	4
Helixⁱ	270 – 276	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UJ78
SMRⁱ	Q9UJ78
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UJ78

EvolutionaryTraceⁱ

Q9UJ78

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	53 – 59	Poly-Asp		7

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	265 – 299	MYM-type 1Add BLAST	35
Zinc fingerⁱ	311 – 351	MYM-type 2Add BLAST	41
Zinc fingerⁱ	358 – 393	MYM-type 3Add BLAST	36
Zinc fingerⁱ	404 – 431	MYM-type 4Add BLAST	28

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410JNGQ Eukaryota ENOG41113IZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074408
HOVERGENⁱ	HBG108767
InParanoidⁱ	Q9UJ78
OMAⁱ	GTWPRIL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00KQ
PhylomeDBⁱ	Q9UJ78

Family and domain databases

InterProⁱ	View protein in InterPro IPR026625 TFII-I-rel IPR011017 TRASH_dom IPR010507 Znf_MYM
PANTHERⁱ	PTHR11697 PTHR11697, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06467 zf-FCS, 3 hits
SMARTⁱ	View protein in SMART SM00746 TRASH, 3 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 4 (identifier: Q9UJ78-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP 
        60         70         80         90        100
VEDDDDDDDV VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP 
       110        120        130        140        150
PSSRDLASQK GNISETIVID DEEDIETNGG AEKKSSCFIE WGLPGTKNKT 
       160        170        180        190        200
NDLDFSTSSL SRSKTKTGVR PFNPGRMNVA GDLFQNGEFA THHSPDSWIS 
       210        220        230        240        250
QSASFPSNQK QPGVDSLSPV ALLRKQNFQP TAQQQLTKPA KITCANCKKP 
       260        270        280        290        300
LQKGQTAYQR KGSAHLFCST TCLSSFSHKR TQNTRSIICK KDASTKKANV 
       310        320        330        340        350
ILPVESSKSF QEFYSTSCLS PCENNWNLKK GVFNKSRCTI CSKLAEIRHE 
       360        370        380        390        400
VSVNNVTHKL CSNHCFNKYR LANGLIMNCC EHCGEYMPSK STGNNILVIG 
       410        420        430        440        450
GQQKRFCCQS CINEYKQMME TKSKKLTASE NRKRNAFREE NEKQLYGSSN 
       460        470        480        490        500
TLLKKIEGIP EKKEKTSQLQ LSVECGTDTL LIQENVNLPP SSTSTIADTF 
       510        520        530        540        550
QEQLEEKNFE DSIVPVVLSA DPGTWPRILN IKQRDTLVEN VPPQVRNFNF 
       560        570        580        590        600
PKDNTGRKFS ETYYTRILPN GEKTTRSWLL YSTSKDSVFC LYCKLFGEGK 
       610        620        630        640        650
NQLKNENGCK DWQHLSHILS KHEESEMHVN NSVKYSKLKS DLKKNKAIDA 
       660 
AEHRLYENEK NDGVLLLYT

Note: No experimental confirmation available.

Length:669

Mass (Da):74,817

Last modified:July 22, 2008 - v4

Checksum:ⁱ3365CE4EFB8D73A9

Isoform 1 (identifier: Q9UJ78-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
347-382: IRHEVSVNNVTHKLCSNHCFNKYRLANGLIMNCCEH → VWIFIPKLLFRLTVIILTFKCYYVLFHLHNARVLDV
383-669: Missing.

« Hide

        10         20         30         40         50
MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP 
        60         70         80         90        100
VEDDDDDDDV VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP 
       110        120        130        140        150
PSSRDLASQK GNISETIVID DEEDIETNGG AEKKSSCFIE WGLPGTKNKT 
       160        170        180        190        200
NDLDFSTSSL SRSKTKTGVR PFNPGRMNVA GDLFQNGEFA THHSPDSWIS 
       210        220        230        240        250
QSASFPSNQK QPGVDSLSPV ALLRKQNFQP TAQQQLTKPA KITCANCKKP 
       260        270        280        290        300
LQKGQTAYQR KGSAHLFCST TCLSSFSHKR TQNTRSIICK KDASTKKANV 
       310        320        330        340        350
ILPVESSKSF QEFYSTSCLS PCENNWNLKK GVFNKSRCTI CSKLAEVWIF 
       360        370        380 
IPKLLFRLTV IILTFKCYYV LFHLHNARVL DV

Show »

Length:382

Mass (Da):42,107

Checksum:ⁱCF8644A504028104

Isoform 2 (identifier: Q9UJ78-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
196-208: DSWISQSASFPSN → EMHLQRRLMSFFQ
209-669: Missing.

« Hide

        10         20         30         40         50
MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP 
        60         70         80         90        100
VEDDDDDDDV VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP 
       110        120        130        140        150
PSSRDLASQK GNISETIVID DEEDIETNGG AEKKSSCFIE WGLPGTKNKT 
       160        170        180        190        200
NDLDFSTSSL SRSKTKTGVR PFNPGRMNVA GDLFQNGEFA THHSPEMHLQ 

RRLMSFFQ

Show »

Length:208

Mass (Da):22,687

Checksum:ⁱ5387088CD2113459

Isoform 3 (identifier: Q9UJ78-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
165-213: TKTGVRPFNP...SFPSNQKQPG → VNAGMGNSGI...NIIITYKTSL
214-669: Missing.

« Hide

        10         20         30         40         50
MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP 
        60         70         80         90        100
VEDDDDDDDV VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP 
       110        120        130        140        150
PSSRDLASQK GNISETIVID DEEDIETNGG AEKKSSCFIE WGLPGTKNKT 
       160        170        180        190        200
NDLDFSTSSL SRSKVNAGMG NSGITTELTL KYIITNVTTL ETGISSVNAG 
       210 
QDVNIIITYK TSL

Show »

Length:213

Mass (Da):22,729

Checksum:ⁱ2CC415998C9BB23E

Isoform 5 (identifier: Q9UJ78-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-176: Missing.

« Hide

        10         20         30         40         50
MNVAGDLFQN GEFATHHSPD SWISQSASFP SNQKQPGVDS LSPVALLRKQ 
        60         70         80         90        100
NFQPTAQQQL TKPAKITCAN CKKPLQKGQT AYQRKGSAHL FCSTTCLSSF 
       110        120        130        140        150
SHKRTQNTRS IICKKDASTK KANVILPVES SKSFQEFYST SCLSPCENNW 
       160        170        180        190        200
NLKKGVFNKS RCTICSKLAE IRHEVSVNNV THKLCSNHCF NKYRLANGLI 
       210        220        230        240        250
MNCCEHCGEY MPSKSTGNNI LVIGGQQKRF CCQSCINEYK QMMETKSKKL 
       260        270        280        290        300
TASENRKRNA FREENEKQLY GSSNTLLKKI EGIPEKKEKT SQLQLSVECG 
       310        320        330        340        350
TDTLLIQENV NLPPSSTSTI ADTFQEQLEE KNFEDSIVPV VLSADPGTWP 
       360        370        380        390        400
RILNIKQRDT LVENVPPQVR NFNFPKDNTG RKFSETYYTR ILPNGEKTTR 
       410        420        430        440        450
SWLLYSTSKD SVFCLYCKLF GEGKNQLKNE NGCKDWQHLS HILSKHEESE 
       460        470        480        490 
MHVNNSVKYS KLKSDLKKNK AIDAAEHRLY ENEKNDGVLL LYT

Note: No experimental confirmation available.

Show »

Length:493

Mass (Da):55,907

Checksum:ⁱC718F90BCFD74646

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YH25	H0YH25_HUMAN		Zinc finger MYM-type protein 5 Zinc finger MYM-type protein 5	ZMYM5	659	Annotation score:

Sequence cautionⁱ

The sequence AAF29022 differs from that shown. Reason: Frameshift at positions 286, 322 and 337.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	210	K → R in AAF29022 (PubMed:11042152).Curated	1
Sequence conflictⁱ	214	V → M in AAF29022 (PubMed:11042152).Curated	1
Sequence conflictⁱ	286	S → A in AAF29022 (PubMed:11042152).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025508	125	I → V2 PublicationsCorresponds to variant dbSNP:rs9579718Ensembl.	1
Natural variantⁱVAR_025509	137	C → F2 PublicationsCorresponds to variant dbSNP:rs9579717Ensembl.	1
Natural variantⁱVAR_062160	231	T → A. Corresponds to variant dbSNP:rs41292167Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_034645	1 – 176	Missing in isoform 5. CuratedAdd BLAST	176
Alternative sequenceⁱVSP_011442	165 – 213	TKTGV…QKQPG → VNAGMGNSGITTELTLKYII TNVTTLETGISSVNAGQDVN IIITYKTSL in isoform 3. 2 PublicationsAdd BLAST	49
Alternative sequenceⁱVSP_011443	196 – 208	DSWIS…SFPSN → EMHLQRRLMSFFQ in isoform 2. 3 PublicationsAdd BLAST	13
Alternative sequenceⁱVSP_011444	209 – 669	Missing in isoform 2. 3 PublicationsAdd BLAST	461
Alternative sequenceⁱVSP_011445	214 – 669	Missing in isoform 3. 2 PublicationsAdd BLAST	456
Alternative sequenceⁱVSP_034646	347 – 382	IRHEV…NCCEH → VWIFIPKLLFRLTVIILTFK CYYVLFHLHNARVLDV in isoform 1. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_034647	383 – 669	Missing in isoform 1. 1 PublicationAdd BLAST	287

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133352 mRNA Translation: CAB57262.1 AJ133353 mRNA Translation: CAB57263.1 AJ133355 mRNA Translation: CAB57265.1 AJ133354 mRNA Translation: CAB57264.1 BT006687 mRNA Translation: AAP35333.1 AK312724 mRNA Translation: BAG35598.1 AL354808 Genomic DNA No translation available. AL355001 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08238.1 CH471075 Genomic DNA Translation: EAX08240.1 BC007048 mRNA Translation: AAH07048.1 AF161535 mRNA Translation: AAF29022.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31942.1 [Q9UJ78-1] CCDS31943.1 [Q9UJ78-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001034738.1, NM_001039649.2 [Q9UJ78-2] NP_001034739.1, NM_001039650.2 [Q9UJ78-1] NP_001136156.1, NM_001142684.1 [Q9UJ78-4] XP_005266650.1, XM_005266593.3 [Q9UJ78-4] XP_005266651.1, XM_005266594.2 [Q9UJ78-4] XP_006719957.1, XM_006719894.2 [Q9UJ78-4]
UniGeneⁱ	Hs.530988

Genome annotation databases

Ensemblⁱ	ENST00000337963; ENSP00000337034; ENSG00000132950 [Q9UJ78-4] ENST00000382905; ENSP00000372361; ENSG00000132950 [Q9UJ78-1] ENST00000382907; ENSP00000372364; ENSG00000132950 [Q9UJ78-2]
GeneIDⁱ	9205
KEGGⁱ	hsa:9205
UCSC genome browser More...UCSCⁱ	uc001umn.4 human [Q9UJ78-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UJ78	Zinc finger MYM-type protein 5 (Fragment)		HUMAN		659	UniRef100_Q9UJ78
Isoform 5 of Zinc finger MYM-type protein 5		HUMAN		493
UPI0005CFFA61		HUMAN		696
Q9UJ78-3	Zinc finger, MYM-type 5, isoform CRA_f		HUMAN		213	UniRef100_A0A024RDQ2

Protein	Similar proteins		Species	Score	Length	Source
Q9UJ78	Zinc finger MYM-type protein 5		MACFA		666	UniRef90_Q9UJ78
Zinc finger MYM-type protein 5 (Fragment)		HUMAN		659
Zinc finger MYM-type containing 5		PANTR		668
ZMYM5 isoform 3		PONAB		668
Uncharacterized protein		PANPA		668
+30
Q9UJ78-1	ZMYM5 isoform 6		PONAB		381	UniRef90_Q9UJ78-1
Zinc finger MYM-type containing 5		PANTR		381
Uncharacterized protein		PANPA		381
Uncharacterized protein		MACMU		378
Uncharacterized protein		MANLE		378
+5
Q9UJ78-2	ZMYM5 isoform 9		PANTR		224	UniRef90_Q9UJ78-2
Uncharacterized protein		PANPA		207
ZMYM5 isoform 5		PONAB		207
Uncharacterized protein		NOMLE		207
Uncharacterized protein		GORGO		206
+21
Q9UJ78-3	Uncharacterized protein DKFZp459N1826		PONAB		212	UniRef90_Q5REB2
Zinc finger, MYM-type 5, isoform CRA_f		HUMAN		213

Protein	Similar proteins		Species	Score	Length	Source
Q9UJ78	Zinc finger MYM-type protein 5		MACFA		666	UniRef50_Q9UJ78
Zinc finger MYM-type protein 5 (Fragment)		HUMAN		659
Zinc finger, MYM-type 5		PANTR		668
Uncharacterized protein		PANPA		668
ZMYM5 isoform 3		PONAB		668
+42
Q9UJ78-1	Isoform 2 of Zinc finger MYM-type protein 2		HUMAN		462	UniRef50_Q9UBW7-2
zinc finger MYM-type protein 2 isoform X9		TURTR		459
Uncharacterized protein		CAVPO		396
Uncharacterized protein (Fragment)		Macqueen's bustard		419
Zinc finger MYM-type protein 5 isoform D		ALLMI		465
+54
Q9UJ78-2	ZMYM5 isoform 9		PANTR		224	UniRef50_Q9UJ78-2
ZMYM5 isoform 5		PONAB		207
Uncharacterized protein		NOMLE		207
Uncharacterized protein		PANPA		207
Uncharacterized protein		GORGO		206
+58
Q9UJ78-3	Isoform 2 of Zinc finger MYM-type protein 5		HUMAN		208	UniRef50_Q9UJ78-2
ZMYM5 isoform 9		PANTR		224
ZMYM5 isoform 5		PONAB		207
Uncharacterized protein		NOMLE		207
Uncharacterized protein		PANPA		207
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133352 mRNA Translation: CAB57262.1 AJ133353 mRNA Translation: CAB57263.1 AJ133355 mRNA Translation: CAB57265.1 AJ133354 mRNA Translation: CAB57264.1 BT006687 mRNA Translation: AAP35333.1 AK312724 mRNA Translation: BAG35598.1 AL354808 Genomic DNA No translation available. AL355001 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08238.1 CH471075 Genomic DNA Translation: EAX08240.1 BC007048 mRNA Translation: AAH07048.1 AF161535 mRNA Translation: AAF29022.1 Frameshift.
CCDSⁱ	CCDS31942.1 [Q9UJ78-1] CCDS31943.1 [Q9UJ78-2]
RefSeqⁱ	NP_001034738.1, NM_001039649.2 [Q9UJ78-2] NP_001034739.1, NM_001039650.2 [Q9UJ78-1] NP_001136156.1, NM_001142684.1 [Q9UJ78-4] XP_005266650.1, XM_005266593.3 [Q9UJ78-4] XP_005266651.1, XM_005266594.2 [Q9UJ78-4] XP_006719957.1, XM_006719894.2 [Q9UJ78-4]
UniGeneⁱ	Hs.530988

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DAS	NMR	-	A	229-277	[»]
ProteinModelPortalⁱ	Q9UJ78
SMRⁱ	Q9UJ78
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114639, 8 interactors
IntActⁱ	Q9UJ78, 10 interactors
MINTⁱ	Q9UJ78
STRINGⁱ	9606.ENSP00000372361

PTM databases

iPTMnetⁱ	Q9UJ78
PhosphoSitePlusⁱ	Q9UJ78

Polymorphism and mutation databases

BioMutaⁱ	ZMYM5
DMDMⁱ	212288108

Proteomic databases

EPDⁱ	Q9UJ78
MaxQBⁱ	Q9UJ78
PaxDbⁱ	Q9UJ78
PeptideAtlasⁱ	Q9UJ78
PRIDEⁱ	Q9UJ78
ProteomicsDBⁱ	84596 84597 [Q9UJ78-1] 84598 [Q9UJ78-2] 84599 [Q9UJ78-3] 84600 [Q9UJ78-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9205
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337963; ENSP00000337034; ENSG00000132950 [Q9UJ78-4] ENST00000382905; ENSP00000372361; ENSG00000132950 [Q9UJ78-1] ENST00000382907; ENSP00000372364; ENSG00000132950 [Q9UJ78-2]
GeneIDⁱ	9205
KEGGⁱ	hsa:9205
UCSCⁱ	uc001umn.4 human [Q9UJ78-4]

Organism-specific databases

CTDⁱ	9205
DisGeNETⁱ	9205
EuPathDBⁱ	HostDB:ENSG00000132950.18
GeneCardsⁱ	ZMYM5
HGNCⁱ	HGNC:13029 ZMYM5
HPAⁱ	HPA020879
MIMⁱ	616443 gene
neXtProtⁱ	NX_Q9UJ78
OpenTargetsⁱ	ENSG00000132950
PharmGKBⁱ	PA37607
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JNGQ Eukaryota ENOG41113IZ LUCA
GeneTreeⁱ	ENSGT00550000074408
HOVERGENⁱ	HBG108767
InParanoidⁱ	Q9UJ78
OMAⁱ	GTWPRIL
OrthoDBⁱ	EOG091G00KQ
PhylomeDBⁱ	Q9UJ78

Miscellaneous databases

ChiTaRSⁱ	ZMYM5 human
EvolutionaryTraceⁱ	Q9UJ78
GenomeRNAiⁱ	9205
Protein Ontology More...PROⁱ	PR:Q9UJ78
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132950 Expressed in 211 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_ZMYM5
ExpressionAtlasⁱ	Q9UJ78 baseline and differential
Genevisibleⁱ	Q9UJ78 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026625 TFII-I-rel IPR011017 TRASH_dom IPR010507 Znf_MYM
PANTHERⁱ	PTHR11697 PTHR11697, 1 hit
Pfamⁱ	View protein in Pfam PF06467 zf-FCS, 3 hits
SMARTⁱ	View protein in SMART SM00746 TRASH, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZMYM5_HUMAN
Accessionⁱ	Q9UJ78Primary (citable) accession number: Q9UJ78 Secondary accession number(s): B2R6V1 Q9UJ77
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	July 22, 2008
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - Q9UJ78 (ZMYM5_HUMAN)

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Zinc finger MYM-type protein 5

ZMYM5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ