UniProtKB - Q9UJ78 (ZMYM5_HUMAN)
Protein
Zinc finger MYM-type protein 5
Gene
ZMYM5
Organism
Homo sapiens (Human)
Status
Functioni
Functions as a transcriptional regulator.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 265 – 299 | MYM-type 1Add BLAST | 35 | |
Zinc fingeri | 311 – 351 | MYM-type 2Add BLAST | 41 | |
Zinc fingeri | 358 – 393 | MYM-type 3Add BLAST | 36 | |
Zinc fingeri | 404 – 431 | MYM-type 4Add BLAST | 28 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UJ78 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger MYM-type protein 5Alternative name(s): Zinc finger protein 198-like 1 Zinc finger protein 237 |
Gene namesi | Name:ZMYM5 Synonyms:ZNF198L1, ZNF237 ORF Names:HSPC050 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13029, ZMYM5 |
MIMi | 616443, gene |
neXtProti | NX_Q9UJ78 |
VEuPathDBi | HostDB:ENSG00000132950.18 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 112 | N → H: Abolishes interaction with ETV5. Abolished repression activity. 1 Publication | 1 | |
Mutagenesisi | 114 | S → G: Abolishes interaction with ETV5. No effect on repression activity. 1 Publication | 1 | |
Mutagenesisi | 116 | T → A: No effect on repression activity. 1 Publication | 1 | |
Mutagenesisi | 120 | D → G: Increases repression activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9205 |
OpenTargetsi | ENSG00000132950 |
PharmGKBi | PA37607 |
Miscellaneous databases
Pharosi | Q9UJ78, Tdark |
Genetic variation databases
BioMutai | ZMYM5 |
DMDMi | 212288108 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191380 | 1 – 669 | Zinc finger MYM-type protein 5Add BLAST | 669 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 88 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 91 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 134 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 149 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 225 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 443 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 455 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 462 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 552 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9UJ78 |
jPOSTi | Q9UJ78 |
MassIVEi | Q9UJ78 |
MaxQBi | Q9UJ78 |
PaxDbi | Q9UJ78 |
PeptideAtlasi | Q9UJ78 |
PRIDEi | Q9UJ78 |
ProteomicsDBi | 84596 [Q9UJ78-4] 84597 [Q9UJ78-1] 84598 [Q9UJ78-2] 84599 [Q9UJ78-3] 84600 [Q9UJ78-5] |
PTM databases
iPTMneti | Q9UJ78 |
PhosphoSitePlusi | Q9UJ78 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132950, Expressed in buccal mucosa cell and 222 other tissues |
Genevisiblei | Q9UJ78, HS |
Organism-specific databases
HPAi | ENSG00000132950, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal).
1 PublicationBinary interactionsi
Hide detailsQ9UJ78
With | #Exp. | IntAct |
---|---|---|
SUMO1 [P63165] | 3 | EBI-7228860,EBI-80140 |
Isoform 2 [Q9UJ78-2]
Protein-protein interaction databases
BioGRIDi | 114639, 30 interactors |
IntActi | Q9UJ78, 26 interactors |
MINTi | Q9UJ78 |
STRINGi | 9606.ENSP00000372361 |
Miscellaneous databases
RNActi | Q9UJ78, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9UJ78 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UJ78 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 59 | Poly-Asp | 7 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 265 – 299 | MYM-type 1Add BLAST | 35 | |
Zinc fingeri | 311 – 351 | MYM-type 2Add BLAST | 41 | |
Zinc fingeri | 358 – 393 | MYM-type 3Add BLAST | 36 | |
Zinc fingeri | 404 – 431 | MYM-type 4Add BLAST | 28 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502S9U9, Eukaryota |
GeneTreei | ENSGT00940000162379 |
HOGENOMi | CLU_026638_0_1_1 |
InParanoidi | Q9UJ78 |
OMAi | TWPRILN |
OrthoDBi | 537563at2759 |
PhylomeDBi | Q9UJ78 |
Family and domain databases
InterProi | View protein in InterPro IPR011017, TRASH_dom IPR010507, Znf_MYM |
Pfami | View protein in Pfam PF06467, zf-FCS, 3 hits |
SMARTi | View protein in SMART SM00746, TRASH, 3 hits |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 4 (identifier: Q9UJ78-4) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKCSVGGLE LTEQTPALLG NMAMATSLMD IGDSFGHPAC PLVSRSRNSP
60 70 80 90 100
VEDDDDDDDV VFIESIQPPS ISAPAIADQR NFIFASSKNE KPQGNYSVIP
110 120 130 140 150
PSSRDLASQK GNISETIVID DEEDIETNGG AEKKSSCFIE WGLPGTKNKT
160 170 180 190 200
NDLDFSTSSL SRSKTKTGVR PFNPGRMNVA GDLFQNGEFA THHSPDSWIS
210 220 230 240 250
QSASFPSNQK QPGVDSLSPV ALLRKQNFQP TAQQQLTKPA KITCANCKKP
260 270 280 290 300
LQKGQTAYQR KGSAHLFCST TCLSSFSHKR TQNTRSIICK KDASTKKANV
310 320 330 340 350
ILPVESSKSF QEFYSTSCLS PCENNWNLKK GVFNKSRCTI CSKLAEIRHE
360 370 380 390 400
VSVNNVTHKL CSNHCFNKYR LANGLIMNCC EHCGEYMPSK STGNNILVIG
410 420 430 440 450
GQQKRFCCQS CINEYKQMME TKSKKLTASE NRKRNAFREE NEKQLYGSSN
460 470 480 490 500
TLLKKIEGIP EKKEKTSQLQ LSVECGTDTL LIQENVNLPP SSTSTIADTF
510 520 530 540 550
QEQLEEKNFE DSIVPVVLSA DPGTWPRILN IKQRDTLVEN VPPQVRNFNF
560 570 580 590 600
PKDNTGRKFS ETYYTRILPN GEKTTRSWLL YSTSKDSVFC LYCKLFGEGK
610 620 630 640 650
NQLKNENGCK DWQHLSHILS KHEESEMHVN NSVKYSKLKS DLKKNKAIDA
660
AEHRLYENEK NDGVLLLYT
Sequence cautioni
The sequence AAF29022 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 210 | K → R in AAF29022 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 214 | V → M in AAF29022 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 286 | S → A in AAF29022 (PubMed:11042152).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025508 | 125 | I → V2 PublicationsCorresponds to variant dbSNP:rs9579718Ensembl. | 1 | |
Natural variantiVAR_025509 | 137 | C → F2 PublicationsCorresponds to variant dbSNP:rs9579717Ensembl. | 1 | |
Natural variantiVAR_062160 | 231 | T → A. Corresponds to variant dbSNP:rs41292167Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034645 | 1 – 176 | Missing in isoform 5. CuratedAdd BLAST | 176 | |
Alternative sequenceiVSP_011442 | 165 – 213 | TKTGV…QKQPG → VNAGMGNSGITTELTLKYII TNVTTLETGISSVNAGQDVN IIITYKTSL in isoform 3. 2 PublicationsAdd BLAST | 49 | |
Alternative sequenceiVSP_011443 | 196 – 208 | DSWIS…SFPSN → EMHLQRRLMSFFQ in isoform 2. 3 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_011444 | 209 – 669 | Missing in isoform 2. 3 PublicationsAdd BLAST | 461 | |
Alternative sequenceiVSP_011445 | 214 – 669 | Missing in isoform 3. 2 PublicationsAdd BLAST | 456 | |
Alternative sequenceiVSP_034646 | 347 – 382 | IRHEV…NCCEH → VWIFIPKLLFRLTVIILTFK CYYVLFHLHNARVLDV in isoform 1. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_034647 | 383 – 669 | Missing in isoform 1. 1 PublicationAdd BLAST | 287 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ133352 mRNA Translation: CAB57262.1 AJ133353 mRNA Translation: CAB57263.1 AJ133355 mRNA Translation: CAB57265.1 AJ133354 mRNA Translation: CAB57264.1 BT006687 mRNA Translation: AAP35333.1 AK312724 mRNA Translation: BAG35598.1 AL354808 Genomic DNA No translation available. AL355001 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08238.1 CH471075 Genomic DNA Translation: EAX08240.1 BC007048 mRNA Translation: AAH07048.1 AF161535 mRNA Translation: AAF29022.1 Frameshift. |
CCDSi | CCDS31942.1 [Q9UJ78-1] CCDS31943.1 [Q9UJ78-2] |
RefSeqi | NP_001034738.1, NM_001039649.2 [Q9UJ78-2] NP_001034739.1, NM_001039650.2 [Q9UJ78-1] NP_001136156.1, NM_001142684.1 [Q9UJ78-4] XP_005266650.1, XM_005266593.3 [Q9UJ78-4] XP_005266651.1, XM_005266594.2 [Q9UJ78-4] XP_006719957.1, XM_006719894.2 [Q9UJ78-4] |
Genome annotation databases
Ensembli | ENST00000337963; ENSP00000337034; ENSG00000132950 [Q9UJ78-4] ENST00000382905; ENSP00000372361; ENSG00000132950 [Q9UJ78-1] ENST00000382907; ENSP00000372364; ENSG00000132950 [Q9UJ78-2] |
GeneIDi | 9205 |
KEGGi | hsa:9205 |
UCSCi | uc001umn.4, human [Q9UJ78-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ133352 mRNA Translation: CAB57262.1 AJ133353 mRNA Translation: CAB57263.1 AJ133355 mRNA Translation: CAB57265.1 AJ133354 mRNA Translation: CAB57264.1 BT006687 mRNA Translation: AAP35333.1 AK312724 mRNA Translation: BAG35598.1 AL354808 Genomic DNA No translation available. AL355001 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08238.1 CH471075 Genomic DNA Translation: EAX08240.1 BC007048 mRNA Translation: AAH07048.1 AF161535 mRNA Translation: AAF29022.1 Frameshift. |
CCDSi | CCDS31942.1 [Q9UJ78-1] CCDS31943.1 [Q9UJ78-2] |
RefSeqi | NP_001034738.1, NM_001039649.2 [Q9UJ78-2] NP_001034739.1, NM_001039650.2 [Q9UJ78-1] NP_001136156.1, NM_001142684.1 [Q9UJ78-4] XP_005266650.1, XM_005266593.3 [Q9UJ78-4] XP_005266651.1, XM_005266594.2 [Q9UJ78-4] XP_006719957.1, XM_006719894.2 [Q9UJ78-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DAS | NMR | - | A | 229-277 | [»] | |
SMRi | Q9UJ78 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114639, 30 interactors |
IntActi | Q9UJ78, 26 interactors |
MINTi | Q9UJ78 |
STRINGi | 9606.ENSP00000372361 |
PTM databases
iPTMneti | Q9UJ78 |
PhosphoSitePlusi | Q9UJ78 |
Genetic variation databases
BioMutai | ZMYM5 |
DMDMi | 212288108 |
Proteomic databases
EPDi | Q9UJ78 |
jPOSTi | Q9UJ78 |
MassIVEi | Q9UJ78 |
MaxQBi | Q9UJ78 |
PaxDbi | Q9UJ78 |
PeptideAtlasi | Q9UJ78 |
PRIDEi | Q9UJ78 |
ProteomicsDBi | 84596 [Q9UJ78-4] 84597 [Q9UJ78-1] 84598 [Q9UJ78-2] 84599 [Q9UJ78-3] 84600 [Q9UJ78-5] |
Protocols and materials databases
Antibodypediai | 22270, 37 antibodies |
DNASUi | 9205 |
Genome annotation databases
Ensembli | ENST00000337963; ENSP00000337034; ENSG00000132950 [Q9UJ78-4] ENST00000382905; ENSP00000372361; ENSG00000132950 [Q9UJ78-1] ENST00000382907; ENSP00000372364; ENSG00000132950 [Q9UJ78-2] |
GeneIDi | 9205 |
KEGGi | hsa:9205 |
UCSCi | uc001umn.4, human [Q9UJ78-4] |
Organism-specific databases
CTDi | 9205 |
DisGeNETi | 9205 |
GeneCardsi | ZMYM5 |
HGNCi | HGNC:13029, ZMYM5 |
HPAi | ENSG00000132950, Low tissue specificity |
MIMi | 616443, gene |
neXtProti | NX_Q9UJ78 |
OpenTargetsi | ENSG00000132950 |
PharmGKBi | PA37607 |
VEuPathDBi | HostDB:ENSG00000132950.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9U9, Eukaryota |
GeneTreei | ENSGT00940000162379 |
HOGENOMi | CLU_026638_0_1_1 |
InParanoidi | Q9UJ78 |
OMAi | TWPRILN |
OrthoDBi | 537563at2759 |
PhylomeDBi | Q9UJ78 |
Enzyme and pathway databases
PathwayCommonsi | Q9UJ78 |
Miscellaneous databases
BioGRID-ORCSi | 9205, 4 hits in 1000 CRISPR screens |
ChiTaRSi | ZMYM5, human |
EvolutionaryTracei | Q9UJ78 |
GenomeRNAii | 9205 |
Pharosi | Q9UJ78, Tdark |
PROi | PR:Q9UJ78 |
RNActi | Q9UJ78, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132950, Expressed in buccal mucosa cell and 222 other tissues |
Genevisiblei | Q9UJ78, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011017, TRASH_dom IPR010507, Znf_MYM |
Pfami | View protein in Pfam PF06467, zf-FCS, 3 hits |
SMARTi | View protein in SMART SM00746, TRASH, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZMYM5_HUMAN | |
Accessioni | Q9UJ78Primary (citable) accession number: Q9UJ78 Secondary accession number(s): B2R6V1 Q9UJ77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | July 22, 2008 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references