CD207

Functionⁱ

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.4 Publications

GO - Molecular functionⁱ

carbohydrate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20026605
mannose binding
Source: ProtInc
Traceable author statementⁱ
- 10661407

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
defense response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 17334373
receptor-mediated endocytosis Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Lectin

Ligand

Lectin

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Reactomeⁱ

R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Protein family/group databases

UniLectinⁱ	Q9UJ71

UniLectinⁱ

Q9UJ71

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-type lectin domain family 4 member K Alternative name(s): Langerin CD_antigen: CD207
Gene namesⁱ	Name:CD207 Synonyms:CLEC4K
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116031.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17935 CD207
MIMⁱ	604862 gene
neXtProtⁱ	NX_Q9UJ71

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 43	CytoplasmicSequence analysisAdd BLAST	43
Transmembraneⁱ	44 – 64	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	65 – 328	ExtracellularSequence analysisAdd BLAST	264

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Birbeck granule deficiency (BIRGD)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063828	264	W → R in BIRGD; abolishes mannose-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs200837270EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	285	E → A: Loss of binding to 6'-sulfo-LacNAc and invertase. 1 Publication	1
Mutagenesisⁱ	287	N → A: Loss of binding to 6'-sulfo-LacNAc and invertase. 1 Publication	1
Mutagenesisⁱ	299	K → A: Loss of binding to 6'-sulfo-LacNAc. 1 Publication	1
Mutagenesisⁱ	313	K → A: Loss of binding to 6'-sulfo-LacNAc and 6-sulfo-GlcNAc. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50489
MalaCards human disease database More...MalaCardsⁱ	CD207
MIMⁱ	613393 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000116031
PharmGKBⁱ	PA134986203

Chemistry databases

ChEMBLⁱ	CHEMBL2176853

ChEMBLⁱ

CHEMBL2176853

Polymorphism and mutation databases

BioMutaⁱ	CD207
DMDMⁱ	229784129

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000223693	1 – 328	C-type lectin domain family 4 member KAdd BLAST		328

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	87	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	223 ↔ 319	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	295 ↔ 311	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9UJ71
PeptideAtlas More...PeptideAtlasⁱ	Q9UJ71
PRIDEⁱ	Q9UJ71
ProteomicsDBⁱ	84594

PTM databases

iPTMnetⁱ	Q9UJ71
PhosphoSitePlusⁱ	Q9UJ71

Expressionⁱ

Tissue specificityⁱ

Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000116031
CleanExⁱ	HS_CD207
Genevisibleⁱ	Q9UJ71 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002222 HPA011216

HPAⁱ

CAB002222
HPA011216

Interactionⁱ

Subunit structureⁱ

Homotrimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CREB3	O43889-2	3	EBI-2873235,EBI-625022
GRAMD2B	Q96HH9	5	EBI-2873235,EBI-2832937

Show more details

Protein-protein interaction databases

BioGridⁱ	119076, 7 interactors
IntActⁱ	Q9UJ71, 7 interactors
STRINGⁱ	9606.ENSP00000386378

Chemistry databases

BindingDBⁱ

Q9UJ71

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	160 – 195	Combined sources	36
Turnⁱ	196 – 198	Combined sources	3
Beta strandⁱ	200 – 202	Combined sources	3
Beta strandⁱ	205 – 209	Combined sources	5
Helixⁱ	216 – 225	Combined sources	10
Helixⁱ	236 – 246	Combined sources	11
Beta strandⁱ	251 – 258	Combined sources	8
Turnⁱ	259 – 262	Combined sources	4
Beta strandⁱ	263 – 266	Combined sources	4
Helixⁱ	274 – 277	Combined sources	4
Helixⁱ	278 – 280	Combined sources	3
Helixⁱ	289 – 291	Combined sources	3
Beta strandⁱ	295 – 298	Combined sources	4
Beta strandⁱ	300 – 304	Combined sources	5
Beta strandⁱ	306 – 309	Combined sources	4
Beta strandⁱ	315 – 322	Combined sources	8

3D structure databases

ProteinModelPortalⁱ	Q9UJ71
SMRⁱ	Q9UJ71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9UJ71

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	202 – 320	C-type lectinPROSITE-ProRule annotationAdd BLAST		119

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	145 – 190	Sequence analysisAdd BLAST		46

Domainⁱ

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.1 Publication

Keywords - Domainⁱ

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4297 Eukaryota ENOG410XPJ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118924
HOGENOMⁱ	HOG000064516
HOVERGENⁱ	HBG073250
InParanoidⁱ	Q9UJ71
KEGG Orthology (KO) More...KOⁱ	K06561
OMAⁱ	EVPDAHF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GQS
PhylomeDBⁱ	Q9UJ71
TreeFamⁱ	TF333341

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR018378 C-type_lectin_CS IPR033989 CD209-like_CTLD IPR016187 CTDL_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00615 C_TYPE_LECTIN_1, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UJ71-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTVEKEAPDA HFTVDKQNIS LWPREPPPKS GPSLVPGKTP TVRAALICLT 
        60         70         80         90        100
LVLVASVLLQ AVLYPRFMGT ISDVKTNVQL LKGRVDNIST LDSEIKKNSD 
       110        120        130        140        150
GMEAAGVQIQ MVNESLGYVR SQFLKLKTSV EKANAQIQIL TRSWEEVSTL 
       160        170        180        190        200
NAQIPELKSD LEKASALNTK IRALQGSLEN MSKLLKRQND ILQVVSQGWK 
       210        220        230        240        250
YFKGNFYYFS LIPKTWYSAE QFCVSRNSHL TSVTSESEQE FLYKTAGGLI 
       260        270        280        290        300
YWIGLTKAGM EGDWSWVDDT PFNKVQSVRF WIPGEPNNAG NNEHCGNIKA 
       310        320 
PSLQAWNDAP CDKTFLFICK RPYVPSEP

Length:328

Mass (Da):36,725

Last modified:March 24, 2009 - v2

Checksum:ⁱ83DF432682BF4B62

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054781	55	A → V. Corresponds to variant dbSNP:rs10489990Ensembl.	1
Natural variantⁱVAR_056151	136	Q → E. Corresponds to variant dbSNP:rs17718987Ensembl.	1
Natural variantⁱVAR_054782	213	P → S. Corresponds to variant dbSNP:rs17006436Ensembl.	1
Natural variantⁱVAR_063828	264	W → R in BIRGD; abolishes mannose-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs200837270EnsemblClinVar.	1
Natural variantⁱVAR_054783	278	V → A No effect on mannose-binding ability. 2 PublicationsCorresponds to variant dbSNP:rs741326Ensembl.	1
Natural variantⁱVAR_054784	288	N → D Significant reduction in mannose-binding ability. 1 PublicationCorresponds to variant dbSNP:rs13383830Ensembl.	1
Natural variantⁱVAR_059448	300	A → P Significant reduction in mannose-binding ability; significant decrease in thermal stability; increased sensitivity of sugar binding to pH change. 1 PublicationCorresponds to variant dbSNP:rs2080391Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ242859 mRNA Translation: CAB62403.1 AC007395 Genomic DNA No translation available. BC022278 mRNA Translation: AAH22278.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74520.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056532.4, NM_015717.4 XP_011531176.1, XM_011532874.1
UniGeneⁱ	Hs.199731

Genome annotation databases

Ensemblⁱ	ENST00000410009; ENSP00000386378; ENSG00000116031
GeneIDⁱ	50489
KEGGⁱ	hsa:50489
UCSC genome browser More...UCSCⁱ	uc002shg.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9UJ71	UPI0000208634		HUMAN		261
CD207 isoform 1		PANTR		328
CD207 isoform 1		PONAB		328
CD207 molecule		PANPA		328
CD207 molecule		NOMLE		328
+5

Protein	Similar proteins		Species	Score	Length
Q9UJ71	UPI0000208634		HUMAN		261
CD207 isoform 1		PANTR		328
CD207 molecule		PANPA		328
CD207 isoform 1		PONAB		328
CD207 molecule		GORGO		328
+104

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

Langerin

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ242859 mRNA Translation: CAB62403.1 AC007395 Genomic DNA No translation available. BC022278 mRNA Translation: AAH22278.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74520.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056532.4, NM_015717.4 XP_011531176.1, XM_011532874.1
UniGeneⁱ	Hs.199731

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3C22	X-ray	1.50	A/B/C/D	188-328	[»]
	3KQG	X-ray	2.30	A/B/C/D/E/F	147-328	[»]
	3P5D	X-ray	1.80	A/B/C/D	193-328	[»]
	3P5E	X-ray	1.70	A/B/C/D	193-328	[»]
	3P5F	X-ray	1.75	A/B/C/D	193-328	[»]
	3P5G	X-ray	1.60	A/B/C/D	193-328	[»]
	3P5H	X-ray	1.61	A/B/C/D	193-328	[»]
	3P5I	X-ray	1.80	A/B/C/D	193-328	[»]
	3P7F	X-ray	2.50	A/B/C/D	193-328	[»]
	3P7G	X-ray	1.60	A/B/C/D	193-328	[»]
	3P7H	X-ray	2.30	A/B/C/D	193-328	[»]
	4AK8	X-ray	1.40	A/B/C/D	188-328	[»]
	4N32	X-ray	1.75	A/B/C/D	193-328	[»]
	4N33	X-ray	1.85	A/B/C/D	193-328	[»]
	4N34	X-ray	1.75	A/B/C/D	193-328	[»]
	4N35	X-ray	1.85	A/B/C/D	193-328	[»]
	4N36	X-ray	1.85	A/B/C/D	193-328	[»]
	4N37	X-ray	2.00	A/B/C/D	193-328	[»]
	4N38	X-ray	2.00	A/B/C/D	193-328	[»]
	5G6U	X-ray	1.84	A/B/C/D	68-328	[»]
ProteinModelPortalⁱ	Q9UJ71
SMRⁱ	Q9UJ71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119076, 7 interactors
IntActⁱ	Q9UJ71, 7 interactors
STRINGⁱ	9606.ENSP00000386378

Chemistry databases

BindingDBⁱ	Q9UJ71
ChEMBLⁱ	CHEMBL2176853

Protein family/group databases

UniLectinⁱ	Q9UJ71

UniLectinⁱ

Q9UJ71

PTM databases

iPTMnetⁱ	Q9UJ71
PhosphoSitePlusⁱ	Q9UJ71

Polymorphism and mutation databases

BioMutaⁱ	CD207
DMDMⁱ	229784129

Proteomic databases

PaxDbⁱ	Q9UJ71
PeptideAtlas More...PeptideAtlasⁱ	Q9UJ71
PRIDEⁱ	Q9UJ71
ProteomicsDBⁱ	84594

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50489
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000410009; ENSP00000386378; ENSG00000116031
GeneIDⁱ	50489
KEGGⁱ	hsa:50489
UCSC genome browser More...UCSCⁱ	uc002shg.4 human

Organism-specific databases

CTDⁱ	50489
DisGeNET More...DisGeNETⁱ	50489
EuPathDBⁱ	HostDB:ENSG00000116031.8
GeneCardsⁱ	CD207
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17935 CD207
Human Protein Atlas More...HPAⁱ	CAB002222 HPA011216
MalaCards human disease database More...MalaCardsⁱ	CD207
MIMⁱ	604862 gene 613393 phenotype
neXtProtⁱ	NX_Q9UJ71
Open Targets More...OpenTargetsⁱ	ENSG00000116031
PharmGKBⁱ	PA134986203
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4297 Eukaryota ENOG410XPJ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118924
HOGENOMⁱ	HOG000064516
HOVERGENⁱ	HBG073250
InParanoidⁱ	Q9UJ71
KEGG Orthology (KO) More...KOⁱ	K06561
OMAⁱ	EVPDAHF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GQS
PhylomeDBⁱ	Q9UJ71
TreeFamⁱ	TF333341

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Reactomeⁱ

R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UJ71
GeneWikiⁱ	Langerin
GenomeRNAiⁱ	50489
Protein Ontology More...PROⁱ	PR:Q9UJ71
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116031
CleanExⁱ	HS_CD207
Genevisibleⁱ	Q9UJ71 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR018378 C-type_lectin_CS IPR033989 CD209-like_CTLD IPR016187 CTDL_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00615 C_TYPE_LECTIN_1, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLC4K_HUMAN
Accessionⁱ	Q9UJ71Primary (citable) accession number: Q9UJ71
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
	Last sequence update:	March 24, 2009
	Last modified:	July 18, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9UJ71 (CLC4K_HUMAN)

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C-type lectin domain family 4 member K

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endosome

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ