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Entry version 159 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Gene

ST6GALNAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.2 Publications

Miscellaneous

Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=130 µM for CMP-N-acetylneuraminate1 Publication
  2. KM=104 µM for CMP-N-acetylneuraminate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

    This protein is involved in the pathway protein glycosylation, which is part of Protein modification.2 Publications
    View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei156CMP-N-acetylneuraminateCombined sources1 Publication1
    Binding sitei179CMP-N-acetylneuraminateCombined sources1 Publication1
    Binding sitei304CMP-N-acetylneuraminateCombined sources1 Publication1
    Binding sitei336CMP-N-acetylneuraminateCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.99.3, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q9UJ37

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-4085001, Sialic acid metabolism
    R-HSA-9683673, Maturation of protein 3a
    R-HSA-977068, Termination of O-glycan biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00378

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT29, Glycosyltransferase Family 29

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (EC:2.4.99.32 Publications)
    Alternative name(s):
    GalNAc alpha-2,6-sialyltransferase II
    ST6GalNAc II1 Publication
    Short name:
    ST6GalNAcII1 Publication
    SThM
    Sialyltransferase 7B
    Short name:
    SIAT7-B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ST6GALNAC2
    Synonyms:SIAT7B, SIATL1, STHM
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000070731.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10867, ST6GALNAC2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610137, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UJ37

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini29 – 374LumenalSequence analysisAdd BLAST346

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    10610

    Open Targets

    More...
    OpenTargetsi
    ENSG00000070731

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35769

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9UJ37, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ST6GALNAC2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    21759448

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001492721 – 374Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2Add BLAST374

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi66 ↔ 148Combined sources1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi85N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi130N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Disulfide bondi151 ↔ 317Combined sources1 Publication
    Glycosylationi161N-linked (GlcNAc...) asparagineCombined sources1 Publication1

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9UJ37

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9UJ37

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9UJ37

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UJ37

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UJ37

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UJ37

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    84582

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q9UJ37, 4 sites, 1 O-linked glycan (1 site)

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UJ37

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UJ37

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000070731, Expressed in pigmented layer of retina and 215 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UJ37, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UJ37, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000070731, Tissue enhanced (retina)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    115856, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9UJ37, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    Q9UJ37

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000225276

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q9UJ37, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1374
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9UJ37

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2692, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160433

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_032020_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UJ37

    KEGG Orthology (KO)

    More...
    KOi
    K06616

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HKAGILW

    Database of Orthologous Groups

    More...
    OrthoDBi
    891104at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UJ37

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF354325

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1480.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    IPR012163, Sialyl_trans

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00777, Glyco_transf_29, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005557, Sialyl_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    Q9UJ37-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGLPRGSFFW LLLLLTAACS GLLFALYFSA VQRYPGPAAG ARDTTSFEAF
    60 70 80 90 100
    FQSKASNSWT GKGQACRHLL HLAIQRHPHF RGLFNLSIPV LLWGDLFTPA
    110 120 130 140 150
    LWDRLSQHKA PYGWRGLSHQ VIASTLSLLN GSESAKLFAP PRDTPPKCIR
    160 170 180 190 200
    CAVVGNGGIL NGSRQGPNID AHDYVFRLNG AVIKGFERDV GTKTSFYGFT
    210 220 230 240 250
    VNTMKNSLVS YWNLGFTSVP QGQDLQYIFI PSDIRDYVML RSAILGVPVP
    260 270 280 290 300
    EGLDKGDRPH AYFGPEASAS KFKLLHPDFI SYLTERFLKS KLINTHFGDL
    310 320 330 340 350
    YMPSTGALML LTALHTCDQV SAYGFITSNY WKFSDHYFER KMKPLIFYAN
    360 370
    HDLSLEAALW RDLHKAGILQ LYQR
    Length:374
    Mass (Da):41,939
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0BD439E4C6BB427
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7EMM1K7EMM1_HUMAN
    Alpha-N-acetylgalactosaminide alpha...
    ST6GALNAC2
    212Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EKT8K7EKT8_HUMAN
    Alpha-N-acetylgalactosaminide alpha...
    ST6GALNAC2
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EMI2K7EMI2_HUMAN
    Alpha-N-acetylgalactosaminide alpha...
    ST6GALNAC2
    74Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EIW2K7EIW2_HUMAN
    Alpha-N-acetylgalactosaminide alpha...
    ST6GALNAC2
    38Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11L → V in AAA52228 (Ref. 2) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ251053 mRNA Translation: CAB61434.1
    U14550 mRNA Translation: AAA52228.1
    BT019972 mRNA Translation: AAV38775.1
    BC040455 mRNA Translation: AAH40455.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11747.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_006447.2, NM_006456.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000225276; ENSP00000225276; ENSG00000070731

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10610

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:10610

    UCSC genome browser

    More...
    UCSCi
    uc002jsg.5, human

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Functional Glycomics Gateway - GTase

    ST6GalNAc II

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ251053 mRNA Translation: CAB61434.1
    U14550 mRNA Translation: AAA52228.1
    BT019972 mRNA Translation: AAV38775.1
    BC040455 mRNA Translation: AAH40455.1
    CCDSiCCDS11747.1
    RefSeqiNP_006447.2, NM_006456.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6APJX-ray3.10A/B/C/D/E/F1-374[»]
    6APLX-ray2.35A/B/C/D/E/F1-374[»]
    SMRiQ9UJ37
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi115856, 2 interactors
    IntActiQ9UJ37, 1 interactor
    MINTiQ9UJ37
    STRINGi9606.ENSP00000225276

    Protein family/group databases

    CAZyiGT29, Glycosyltransferase Family 29

    PTM databases

    GlyGeniQ9UJ37, 4 sites, 1 O-linked glycan (1 site)
    iPTMnetiQ9UJ37
    PhosphoSitePlusiQ9UJ37

    Polymorphism and mutation databases

    BioMutaiST6GALNAC2
    DMDMi21759448

    Proteomic databases

    EPDiQ9UJ37
    MassIVEiQ9UJ37
    MaxQBiQ9UJ37
    PaxDbiQ9UJ37
    PeptideAtlasiQ9UJ37
    PRIDEiQ9UJ37
    ProteomicsDBi84582

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    32441, 78 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    10610

    Genome annotation databases

    EnsembliENST00000225276; ENSP00000225276; ENSG00000070731
    GeneIDi10610
    KEGGihsa:10610
    UCSCiuc002jsg.5, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10610
    DisGeNETi10610
    EuPathDBiHostDB:ENSG00000070731.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ST6GALNAC2
    HGNCiHGNC:10867, ST6GALNAC2
    HPAiENSG00000070731, Tissue enhanced (retina)
    MIMi610137, gene
    neXtProtiNX_Q9UJ37
    OpenTargetsiENSG00000070731
    PharmGKBiPA35769

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2692, Eukaryota
    GeneTreeiENSGT00940000160433
    HOGENOMiCLU_032020_0_0_1
    InParanoidiQ9UJ37
    KOiK06616
    OMAiHKAGILW
    OrthoDBi891104at2759
    PhylomeDBiQ9UJ37
    TreeFamiTF354325

    Enzyme and pathway databases

    UniPathwayiUPA00378
    BRENDAi2.4.99.3, 2681
    PathwayCommonsiQ9UJ37
    ReactomeiR-HSA-4085001, Sialic acid metabolism
    R-HSA-9683673, Maturation of protein 3a
    R-HSA-977068, Termination of O-glycan biosynthesis

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    10610, 4 hits in 865 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ST6GALNAC2, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ST6GALNAC2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    10610
    PharosiQ9UJ37, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q9UJ37
    RNActiQ9UJ37, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000070731, Expressed in pigmented layer of retina and 215 other tissues
    ExpressionAtlasiQ9UJ37, baseline and differential
    GenevisibleiQ9UJ37, HS

    Family and domain databases

    Gene3Di3.90.1480.20, 1 hit
    InterProiView protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    IPR012163, Sialyl_trans
    PfamiView protein in Pfam
    PF00777, Glyco_transf_29, 1 hit
    PIRSFiPIRSF005557, Sialyl_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIA7B_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJ37
    Secondary accession number(s): Q12971
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: May 1, 2000
    Last modified: October 7, 2020
    This is version 159 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
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