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Protein

Glutathione hydrolase 7

Gene

GGT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processGlutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-174403 Glutathione synthesis and recycling
R-HSA-5423646 Aflatoxin activation and detoxification
UniPathwayi
UPA00204

Protein family/group databases

MEROPSiT03.017

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase 7 (EC:3.4.19.13)
Alternative name(s):
Gamma-glutamyltransferase 7 (EC:2.3.2.2)
Short name:
GGT 7
Gamma-glutamyltransferase-like 3
Gamma-glutamyltransferase-like 5
Gamma-glutamyltranspeptidase 7
Cleaved into the following 2 chains:
Gene namesi
Name:GGT7
Synonyms:GGTL3, GGTL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000131067.16
HGNCiHGNC:4259 GGT7
MIMi612342 gene
neXtProtiNX_Q9UJ14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 127Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini128 – 662ExtracellularSequence analysisAdd BLAST535

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2686
OpenTargetsiENSG00000131067
PharmGKBiPA28669

Polymorphism and mutation databases

BioMutaiGGT7
DMDMi152031612

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000110661 – 472Glutathione hydrolase 7 heavy chainBy similarityAdd BLAST472
ChainiPRO_0000011067473 – 662Glutathione hydrolase 7 light chainBy similarityAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineBy similarity1
Modified residuei72PhosphoserineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

EPDiQ9UJ14
PaxDbiQ9UJ14
PeptideAtlasiQ9UJ14
PRIDEiQ9UJ14
ProteomicsDBi84578
84579 [Q9UJ14-4]
84580 [Q9UJ14-5]
84581 [Q9UJ14-6]

PTM databases

GlyConnecti1258
iPTMnetiQ9UJ14
PhosphoSitePlusiQ9UJ14

Expressioni

Tissue specificityi

Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

Gene expression databases

BgeeiENSG00000131067 Expressed in 184 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_GGT7
ExpressionAtlasiQ9UJ14 baseline and differential
GenevisibleiQ9UJ14 HS

Organism-specific databases

HPAiHPA013204
HPA013339

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi108953, 28 interactors
IntActiQ9UJ14, 26 interactors
MINTiQ9UJ14
STRINGi9606.ENSP00000338964

Structurei

3D structure databases

ProteinModelPortaliQ9UJ14
SMRiQ9UJ14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00550000074591
HOGENOMiHOG000231793
HOVERGENiHBG039468
InParanoidiQ9UJ14
KOiK00681
OMAiNFIIGVK
OrthoDBiEOG091G030G
PhylomeDBiQ9UJ14
TreeFamiTF333329

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJ14-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF
60 70 80 90 100
LGDPDTDPDS FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC
110 120 130 140 150
SCRQDGLTVI VTACLTFATG VTVALVMQIY FGDPQIFQQG AVVTDAARCT
160 170 180 190 200
SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH SSGLGGGGVM LVHDIRRNES
210 220 230 240 250
HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH EAHQLYGRLP
260 270 280 290 300
WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL
310 320 330 340 350
PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED
360 370 380 390 400
FSNYSALVEK PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS
410 420 430 440 450
REQALHWVAE TLKIALALAS RLGDPVYDST ITESMDDMLS KVEAAYLRGH
460 470 480 490 500
INDSQAAPAP LLPVYELDGA PTAAQVLIMG PDDFIVAMVS SLNQPFGSGL
510 520 530 540 550
ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL SFLLPTVVRP
560 570 580 590 600
AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL
610 620 630 640 650
QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIAVKD
660
PRSPDAAGAT IL
Note: Gene prediction confirmed by EST data.
Length:662
Mass (Da):70,467
Last modified:July 10, 2007 - v2
Checksum:i29DDBC719CADD195
GO
Isoform 2 (identifier: Q9UJ14-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     273-289: ARALAEQLPPNMSERFR → GQWGLGIWERHEVDGEG
     290-662: Missing.

Note: No experimental confirmation available.
Show »
Length:213
Mass (Da):22,494
Checksum:i830752C08248C1DA
GO
Isoform 3 (identifier: Q9UJ14-5) [UniParc]FASTAAdd to basket
Also known as: GGTL3B, B

The sequence of this isoform differs from the canonical sequence as follows:
     226-251: PGLLVGVPGMVKGLHEAHQLYGRLPW → VGTLVRRESSGESLFIALLLTQALIC
     252-662: Missing.

Show »
Length:251
Mass (Da):26,578
Checksum:i3A8BBC5A2B81311C
GO
Isoform 4 (identifier: Q9UJ14-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     369-425: HLVLSPPPPH...LALASRLGDP → DLSPGSQGPP...QTRVSPPSEK
     426-662: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):15,236
Checksum:i15B48378E9DCA3A5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2G5A2A2G5_HUMAN
Glutathione hydrolase 7
GGT7
202Annotation score:
A0A0D9SF08A0A0D9SF08_HUMAN
Glutathione hydrolase 7
GGT7
88Annotation score:
A0A0D9SFH0A0A0D9SFH0_HUMAN
Glutathione hydrolase 7
GGT7
151Annotation score:

Sequence cautioni

The sequence BAC03394 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5N → K in AAN15928 (PubMed:12270127).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0081331 – 283Missing in isoform 4. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_0081341 – 76Missing in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_008136226 – 251PGLLV…GRLPW → VGTLVRRESSGESLFIALLL TQALIC in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_008137252 – 662Missing in isoform 3. 1 PublicationAdd BLAST411
Alternative sequenceiVSP_008138273 – 289ARALA…SERFR → GQWGLGIWERHEVDGEG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_008139290 – 662Missing in isoform 2. 1 PublicationAdd BLAST373
Alternative sequenceiVSP_008140369 – 425HLVLS…RLGDP → DLSPGSQGPPSGEASQSMAT SFWPRDSSPFHRRETKAVSY LGSQLLKQTRVSPPSEK in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_008141426 – 662Missing in isoform 4. 1 PublicationAdd BLAST237

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138815 mRNA Translation: AAN15928.1
AK097100 mRNA Translation: BAC04950.1
AK090413 mRNA Translation: BAC03394.1 Different initiation.
AL049709 Genomic DNA No translation available.
CCDSiCCDS13242.2 [Q9UJ14-1]
RefSeqiNP_821158.2, NM_178026.2 [Q9UJ14-1]
UniGeneiHs.433738

Genome annotation databases

EnsembliENST00000336431; ENSP00000338964; ENSG00000131067 [Q9UJ14-1]
GeneIDi2686
KEGGihsa:2686
UCSCiuc002xay.4 human [Q9UJ14-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138815 mRNA Translation: AAN15928.1
AK097100 mRNA Translation: BAC04950.1
AK090413 mRNA Translation: BAC03394.1 Different initiation.
AL049709 Genomic DNA No translation available.
CCDSiCCDS13242.2 [Q9UJ14-1]
RefSeqiNP_821158.2, NM_178026.2 [Q9UJ14-1]
UniGeneiHs.433738

3D structure databases

ProteinModelPortaliQ9UJ14
SMRiQ9UJ14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108953, 28 interactors
IntActiQ9UJ14, 26 interactors
MINTiQ9UJ14
STRINGi9606.ENSP00000338964

Protein family/group databases

MEROPSiT03.017

PTM databases

GlyConnecti1258
iPTMnetiQ9UJ14
PhosphoSitePlusiQ9UJ14

Polymorphism and mutation databases

BioMutaiGGT7
DMDMi152031612

Proteomic databases

EPDiQ9UJ14
PaxDbiQ9UJ14
PeptideAtlasiQ9UJ14
PRIDEiQ9UJ14
ProteomicsDBi84578
84579 [Q9UJ14-4]
84580 [Q9UJ14-5]
84581 [Q9UJ14-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336431; ENSP00000338964; ENSG00000131067 [Q9UJ14-1]
GeneIDi2686
KEGGihsa:2686
UCSCiuc002xay.4 human [Q9UJ14-1]

Organism-specific databases

CTDi2686
DisGeNETi2686
EuPathDBiHostDB:ENSG00000131067.16
GeneCardsiGGT7
H-InvDBiHIX0203047
HGNCiHGNC:4259 GGT7
HPAiHPA013204
HPA013339
MIMi612342 gene
neXtProtiNX_Q9UJ14
OpenTargetsiENSG00000131067
PharmGKBiPA28669
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00550000074591
HOGENOMiHOG000231793
HOVERGENiHBG039468
InParanoidiQ9UJ14
KOiK00681
OMAiNFIIGVK
OrthoDBiEOG091G030G
PhylomeDBiQ9UJ14
TreeFamiTF333329

Enzyme and pathway databases

UniPathwayi
UPA00204

ReactomeiR-HSA-174403 Glutathione synthesis and recycling
R-HSA-5423646 Aflatoxin activation and detoxification

Miscellaneous databases

ChiTaRSiGGT7 human
GeneWikiiGGTL3
GenomeRNAii2686
PROiPR:Q9UJ14
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131067 Expressed in 184 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_GGT7
ExpressionAtlasiQ9UJ14 baseline and differential
GenevisibleiQ9UJ14 HS

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGGT7_HUMAN
AccessioniPrimary (citable) accession number: Q9UJ14
Secondary accession number(s): Q8N899
, Q8NF66, Q9BYP5, Q9BYP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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