UniProtKB - Q9UIW2 (PLXA1_HUMAN)
Protein
Plexin-A1
Gene
PLXNA1
Organism
Homo sapiens (Human)
Status
Functioni
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).By similarity
GO - Molecular functioni
- semaphorin receptor activity Source: GO_Central
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
- multicellular organism development Source: UniProtKB
- negative regulation of cell adhesion Source: GO_Central
- neuron projection extension Source: Ensembl
- positive regulation of axonogenesis Source: GO_Central
- regulation of cell migration Source: GO_Central
- regulation of cell shape Source: GO_Central
- regulation of GTPase activity Source: GO_Central
- regulation of smooth muscle cell migration Source: Ensembl
- semaphorin-plexin signaling pathway involved in axon guidance Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9UIW2 |
Reactomei | R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956, CRMPs in Sema3A signaling R-HSA-416700, Other semaphorin interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Plexin-A1Alternative name(s): Semaphorin receptor NOV |
Gene namesi | Name:PLXNA1 Synonyms:NOV, PLXN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000114554.11 |
HGNCi | HGNC:9099, PLXNA1 |
MIMi | 601055, gene |
neXtProti | NX_Q9UIW2 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein By similarity
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- semaphorin receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 1244 | ExtracellularSequence analysisAdd BLAST | 1218 | |
Transmembranei | 1245 – 1265 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1266 – 1896 | CytoplasmicSequence analysisAdd BLAST | 631 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5361 |
OpenTargetsi | ENSG00000114554 |
Miscellaneous databases
Pharosi | Q9UIW2, Tbio |
Polymorphism and mutation databases
BioMutai | PLXNA1 |
DMDMi | 313104202 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000232745 | 27 – 1896 | Plexin-A1Add BLAST | 1870 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 77 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 95 ↔ 104 | PROSITE-ProRule annotation | ||
Disulfide bondi | 130 ↔ 138 | PROSITE-ProRule annotation | ||
Disulfide bondi | 286 ↔ 407 | PROSITE-ProRule annotation | ||
Disulfide bondi | 302 ↔ 358 | PROSITE-ProRule annotation | ||
Disulfide bondi | 376 ↔ 395 | PROSITE-ProRule annotation | ||
Disulfide bondi | 515 ↔ 532 | PROSITE-ProRule annotation | ||
Disulfide bondi | 521 ↔ 563 | PROSITE-ProRule annotation | ||
Disulfide bondi | 524 ↔ 541 | PROSITE-ProRule annotation | ||
Disulfide bondi | 535 ↔ 547 | PROSITE-ProRule annotation | ||
Disulfide bondi | 598 ↔ 617 | PROSITE-ProRule annotation | ||
Glycosylationi | 660 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 672 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 701 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1043 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q9UIW2 |
jPOSTi | Q9UIW2 |
MassIVEi | Q9UIW2 |
MaxQBi | Q9UIW2 |
PaxDbi | Q9UIW2 |
PeptideAtlasi | Q9UIW2 |
PRIDEi | Q9UIW2 |
ProteomicsDBi | 84573 |
PTM databases
GlyGeni | Q9UIW2, 8 sites |
iPTMneti | Q9UIW2 |
MetOSitei | Q9UIW2 |
PhosphoSitePlusi | Q9UIW2 |
SwissPalmi | Q9UIW2 |
Expressioni
Tissue specificityi
Detected in fetal brain, lung, liver and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000114554, Expressed in middle temporal gyrus and 231 other tissues |
Genevisiblei | Q9UIW2, HS |
Organism-specific databases
HPAi | ENSG00000114554, Low tissue specificity |
Interactioni
Subunit structurei
Interacts directly with NRP1 and NRP2.
Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 111375, 33 interactors |
CORUMi | Q9UIW2 |
IntActi | Q9UIW2, 12 interactors |
MINTi | Q9UIW2 |
STRINGi | 9606.ENSP00000377061 |
Miscellaneous databases
RNActi | Q9UIW2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 512 | SemaPROSITE-ProRule annotationAdd BLAST | 486 | |
Domaini | 864 – 959 | IPT/TIG 1Add BLAST | 96 | |
Domaini | 961 – 1045 | IPT/TIG 2Add BLAST | 85 | |
Domaini | 1048 – 1147 | IPT/TIG 3Add BLAST | 100 | |
Domaini | 1150 – 1236 | IPT/TIG 4Add BLAST | 87 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1264 – 1317 | Sequence analysisAdd BLAST | 54 |
Sequence similaritiesi
Belongs to the plexin family.Curated
Keywords - Domaini
Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01010000222248 |
HOGENOMi | CLU_001436_2_0_1 |
InParanoidi | Q9UIW2 |
OMAi | QPAFRTF |
OrthoDBi | 90434at2759 |
PhylomeDBi | Q9UIW2 |
TreeFami | TF312962 |
Family and domain databases
CDDi | cd11271, Sema_plexin_A1, 1 hit |
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR031148, Plexin IPR042744, Plexin-A1_Sema IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR041019, TIG1_plexin IPR041362, TIG2_plexin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 2 hits PF01403, Sema, 1 hit PF01833, TIG, 4 hits PF18020, TIG_2, 1 hit PF17960, TIG_plexin, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 3 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit SSF81296, SSF81296, 4 hits |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9UIW2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG
60 70 80 90 100
LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS
110 120 130 140 150
VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG
160 170 180 190 200
EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT
210 220 230 240 250
LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF
260 270 280 290 300
RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI
310 320 330 340 350
GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK
360 370 380 390 400
PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL
410 420 430 440 450
QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA
460 470 480 490 500
GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY
510 520 530 540 550
AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA
560 570 580 590 600
DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF
610 620 630 640 650
EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK
660 670 680 690 700
FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV
710 720 730 740 750
NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG
760 770 780 790 800
SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ
810 820 830 840 850
NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS
860 870 880 890 900
WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV
910 920 930 940 950
RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA
960 970 980 990 1000
LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP
1010 1020 1030 1040 1050
CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI
1060 1070 1080 1090 1100
LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT
1110 1120 1130 1140 1150
TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP
1160 1170 1180 1190 1200
VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT
1210 1220 1230 1240 1250
VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG
1260 1270 1280 1290 1300
GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF
1310 1320 1330 1340 1350
AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN
1360 1370 1380 1390 1400
VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE
1410 1420 1430 1440 1450
MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY
1460 1470 1480 1490 1500
KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY
1510 1520 1530 1540 1550
KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK
1560 1570 1580 1590 1600
AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL
1610 1620 1630 1640 1650
VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG
1660 1670 1680 1690 1700
TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET
1710 1720 1730 1740 1750
IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW
1760 1770 1780 1790 1800
VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL
1810 1820 1830 1840 1850
LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS
1860 1870 1880 1890
ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | A → G in CAB57274 (PubMed:8570614).Curated | 1 | |
Sequence conflicti | 55 | V → L in CAB57274 (PubMed:8570614).Curated | 1 | |
Sequence conflicti | 110 | S → N in CAB57274 (PubMed:8570614).Curated | 1 | |
Sequence conflicti | 140 | F → S in CAB57274 (PubMed:8570614).Curated | 1 | |
Sequence conflicti | 407 | C → R in CAB57274 (PubMed:8570614).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011199 Genomic DNA No translation available. X87832 mRNA Translation: CAB57274.1 AK128612 mRNA No translation available. |
CCDSi | CCDS33847.2 |
RefSeqi | NP_115618.3, NM_032242.3 |
Genome annotation databases
Ensembli | ENST00000393409; ENSP00000377061; ENSG00000114554 |
GeneIDi | 5361 |
KEGGi | hsa:5361 |
UCSCi | uc003ejg.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011199 Genomic DNA No translation available. X87832 mRNA Translation: CAB57274.1 AK128612 mRNA No translation available. |
CCDSi | CCDS33847.2 |
RefSeqi | NP_115618.3, NM_032242.3 |
3D structure databases
SMRi | Q9UIW2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111375, 33 interactors |
CORUMi | Q9UIW2 |
IntActi | Q9UIW2, 12 interactors |
MINTi | Q9UIW2 |
STRINGi | 9606.ENSP00000377061 |
PTM databases
GlyGeni | Q9UIW2, 8 sites |
iPTMneti | Q9UIW2 |
MetOSitei | Q9UIW2 |
PhosphoSitePlusi | Q9UIW2 |
SwissPalmi | Q9UIW2 |
Polymorphism and mutation databases
BioMutai | PLXNA1 |
DMDMi | 313104202 |
Proteomic databases
EPDi | Q9UIW2 |
jPOSTi | Q9UIW2 |
MassIVEi | Q9UIW2 |
MaxQBi | Q9UIW2 |
PaxDbi | Q9UIW2 |
PeptideAtlasi | Q9UIW2 |
PRIDEi | Q9UIW2 |
ProteomicsDBi | 84573 |
Protocols and materials databases
ABCDi | Q9UIW2, 2 sequenced antibodies |
Antibodypediai | 2368, 174 antibodies |
DNASUi | 5361 |
Genome annotation databases
Ensembli | ENST00000393409; ENSP00000377061; ENSG00000114554 |
GeneIDi | 5361 |
KEGGi | hsa:5361 |
UCSCi | uc003ejg.3, human |
Organism-specific databases
CTDi | 5361 |
DisGeNETi | 5361 |
EuPathDBi | HostDB:ENSG00000114554.11 |
GeneCardsi | PLXNA1 |
HGNCi | HGNC:9099, PLXNA1 |
HPAi | ENSG00000114554, Low tissue specificity |
MIMi | 601055, gene |
neXtProti | NX_Q9UIW2 |
OpenTargetsi | ENSG00000114554 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01010000222248 |
HOGENOMi | CLU_001436_2_0_1 |
InParanoidi | Q9UIW2 |
OMAi | QPAFRTF |
OrthoDBi | 90434at2759 |
PhylomeDBi | Q9UIW2 |
TreeFami | TF312962 |
Enzyme and pathway databases
PathwayCommonsi | Q9UIW2 |
Reactomei | R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956, CRMPs in Sema3A signaling R-HSA-416700, Other semaphorin interactions |
Miscellaneous databases
BioGRID-ORCSi | 5361, 4 hits in 854 CRISPR screens |
ChiTaRSi | PLXNA1, human |
GeneWikii | Plexin_A1 |
GenomeRNAii | 5361 |
Pharosi | Q9UIW2, Tbio |
PROi | PR:Q9UIW2 |
RNActi | Q9UIW2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114554, Expressed in middle temporal gyrus and 231 other tissues |
Genevisiblei | Q9UIW2, HS |
Family and domain databases
CDDi | cd11271, Sema_plexin_A1, 1 hit |
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR031148, Plexin IPR042744, Plexin-A1_Sema IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR041019, TIG1_plexin IPR041362, TIG2_plexin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 2 hits PF01403, Sema, 1 hit PF01833, TIG, 4 hits PF18020, TIG_2, 1 hit PF17960, TIG_plexin, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 3 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit SSF81296, SSF81296, 4 hits |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLXA1_HUMAN | |
Accessioni | Q9UIW2Primary (citable) accession number: Q9UIW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families