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UniProtKB - Q9UIW2 (PLXA1_HUMAN)

Entry version 161 (29 Sep 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

Plexin-A1

Gene

PLXNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UIW2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956, CRMPs in Sema3A signaling
R-HSA-416700, Other semaphorin interactions
R-HSA-9696273, RND1 GTPase cycle

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UIW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-A1
Alternative name(s):
Semaphorin receptor NOV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXNA1
Synonyms:NOV, PLXN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9099, PLXNA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601055, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UIW2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114554

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 1244ExtracellularSequence analysisAdd BLAST1218
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1245 – 1265HelicalSequence analysisAdd BLAST21
Topological domaini1266 – 1896CytoplasmicSequence analysisAdd BLAST631

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5361

Open Targets

More...OpenTargetsi		ENSG00000114554

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UIW2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLXNA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023274527 – 1896Plexin-A1Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi77N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Disulfide bondi130 ↔ 138PROSITE-ProRule annotation
Disulfide bondi286 ↔ 407PROSITE-ProRule annotation
Disulfide bondi302 ↔ 358PROSITE-ProRule annotation
Disulfide bondi376 ↔ 395PROSITE-ProRule annotation
Disulfide bondi515 ↔ 532PROSITE-ProRule annotation
Disulfide bondi521 ↔ 563PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi535 ↔ 547PROSITE-ProRule annotation
Disulfide bondi598 ↔ 617PROSITE-ProRule annotation
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1043N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UIW2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UIW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UIW2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UIW2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UIW2

PeptideAtlas

More...PeptideAtlasi		Q9UIW2

PRoteomics IDEntifications database

More...PRIDEi		Q9UIW2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84573

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UIW2, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UIW2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UIW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UIW2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UIW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114554, Expressed in middle temporal gyrus and 232 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UIW2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114554, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with NRP1 and NRP2.

Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111375, 39 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UIW2

Protein interaction database and analysis system

More...IntActi		Q9UIW2, 12 interactors

Molecular INTeraction database

More...MINTi		Q9UIW2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377061

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UIW2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UIW2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini864 – 959IPT/TIG 1Add BLAST96
Domaini961 – 1045IPT/TIG 2Add BLAST85
Domaini1048 – 1147IPT/TIG 3Add BLAST100
Domaini1150 – 1236IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1264 – 1317Sequence analysisAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3610, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001436_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UIW2

Identification of Orthologs from Complete Genome Data

More...OMAi		PCAFSWR

Database of Orthologous Groups

More...OrthoDBi		90434at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UIW2

TreeFam database of animal gene trees

More...TreeFami		TF312962

Family and domain databases

Conserved Domains Database

More...CDDi		cd11271, Sema_plexin_A1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.506.10, 2 hits
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR042744, Plexin-A1_Sema
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UIW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG 
        60         70         80         90        100
LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS 
       110        120        130        140        150
VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG 
       160        170        180        190        200
EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT 
       210        220        230        240        250
LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF 
       260        270        280        290        300
RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI 
       310        320        330        340        350
GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK 
       360        370        380        390        400
PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL 
       410        420        430        440        450
QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA 
       460        470        480        490        500
GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY 
       510        520        530        540        550
AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA 
       560        570        580        590        600
DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF 
       610        620        630        640        650
EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK 
       660        670        680        690        700
FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV 
       710        720        730        740        750
NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG 
       760        770        780        790        800
SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ 
       810        820        830        840        850
NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS 
       860        870        880        890        900
WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV 
       910        920        930        940        950
RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA 
       960        970        980        990       1000
LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP 
      1010       1020       1030       1040       1050
CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI 
      1060       1070       1080       1090       1100
LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT 
      1110       1120       1130       1140       1150
TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP 
      1160       1170       1180       1190       1200
VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT 
      1210       1220       1230       1240       1250
VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG 
      1260       1270       1280       1290       1300
GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF 
      1310       1320       1330       1340       1350
AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN 
      1360       1370       1380       1390       1400
VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE 
      1410       1420       1430       1440       1450
MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY 
      1460       1470       1480       1490       1500
KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY 
      1510       1520       1530       1540       1550
KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK 
      1560       1570       1580       1590       1600
AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL 
      1610       1620       1630       1640       1650
VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG 
      1660       1670       1680       1690       1700
TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET 
      1710       1720       1730       1740       1750
IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW 
      1760       1770       1780       1790       1800
VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL 
      1810       1820       1830       1840       1850
LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS 
      1860       1870       1880       1890 
ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Length:1,896
Mass (Da):211,067
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76E5C9C0710C7FC1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A804HKL4A0A804HKL4_HUMAN
Plexin-A1
PLXNA1
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46A → G in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti55V → L in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti110S → N in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti140F → S in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti407C → R in CAB57274 (PubMed:8570614).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33847.2

NCBI Reference Sequences

More...RefSeqi		NP_115618.3, NM_032242.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393409; ENSP00000377061; ENSG00000114554

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5361

UCSC genome browser

More...UCSCi		uc003ejg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.
CCDSiCCDS33847.2
RefSeqiNP_115618.3, NM_032242.3

3D structure databases

SMRiQ9UIW2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111375, 39 interactors
CORUMiQ9UIW2
IntActiQ9UIW2, 12 interactors
MINTiQ9UIW2
STRINGi9606.ENSP00000377061

PTM databases

GlyGeniQ9UIW2, 8 sites
iPTMnetiQ9UIW2
MetOSiteiQ9UIW2
PhosphoSitePlusiQ9UIW2
SwissPalmiQ9UIW2

Genetic variation databases

BioMutaiPLXNA1
DMDMi313104202

Proteomic databases

EPDiQ9UIW2
jPOSTiQ9UIW2
MassIVEiQ9UIW2
MaxQBiQ9UIW2
PaxDbiQ9UIW2
PeptideAtlasiQ9UIW2
PRIDEiQ9UIW2
ProteomicsDBi84573

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9UIW2, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2368, 184 antibodies

The DNASU plasmid repository

More...DNASUi		5361

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554
GeneIDi5361
KEGGihsa:5361
UCSCiuc003ejg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5361
DisGeNETi5361

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLXNA1
HGNCiHGNC:9099, PLXNA1
HPAiENSG00000114554, Low tissue specificity
MIMi601055, gene
neXtProtiNX_Q9UIW2
OpenTargetsiENSG00000114554
VEuPathDBiHostDB:ENSG00000114554

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
GeneTreeiENSGT01020000230384
HOGENOMiCLU_001436_2_0_1
InParanoidiQ9UIW2
OMAiPCAFSWR
OrthoDBi90434at2759
PhylomeDBiQ9UIW2
TreeFamiTF312962

Enzyme and pathway databases

PathwayCommonsiQ9UIW2
ReactomeiR-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956, CRMPs in Sema3A signaling
R-HSA-416700, Other semaphorin interactions
R-HSA-9696273, RND1 GTPase cycle
SIGNORiQ9UIW2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5361, 8 hits in 1028 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLXNA1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Plexin_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5361
PharosiQ9UIW2, Tbio

Protein Ontology

More...PROi		PR:Q9UIW2
RNActiQ9UIW2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114554, Expressed in middle temporal gyrus and 232 other tissues
GenevisibleiQ9UIW2, HS

Family and domain databases

CDDicd11271, Sema_plexin_A1, 1 hit
Gene3Di1.10.506.10, 2 hits
2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR042744, Plexin-A1_Sema
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR041362, TIG2_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 2 hits
PF01403, Sema, 1 hit
PF01833, TIG, 4 hits
PF18020, TIG_2, 1 hit
PF17960, TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 30, 2010
Last modified: September 29, 2021
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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