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UniProtKB - Q9UIW2 (PLXA1_HUMAN)

Protein

Plexin-A1

Gene

PLXNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).By similarity

GO - Molecular functioni

  • semaphorin receptor activity Source: GO_Central
  • signaling receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-416700 Other semaphorin interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A1
Alternative name(s):
Semaphorin receptor NOV
Gene namesi
Name:PLXNA1
Synonyms:NOV, PLXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114554.11
HGNCiHGNC:9099 PLXNA1
MIMi601055 gene
neXtProtiNX_Q9UIW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1244ExtracellularSequence analysisAdd BLAST1218
Transmembranei1245 – 1265HelicalSequence analysisAdd BLAST21
Topological domaini1266 – 1896CytoplasmicSequence analysisAdd BLAST631

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5361
OpenTargetsiENSG00000114554

Polymorphism and mutation databases

BioMutaiPLXNA1
DMDMi313104202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000023274527 – 1896Plexin-A1Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Disulfide bondi130 ↔ 138PROSITE-ProRule annotation
Disulfide bondi286 ↔ 407PROSITE-ProRule annotation
Disulfide bondi302 ↔ 358PROSITE-ProRule annotation
Disulfide bondi376 ↔ 395PROSITE-ProRule annotation
Disulfide bondi515 ↔ 532PROSITE-ProRule annotation
Disulfide bondi521 ↔ 563PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi535 ↔ 547PROSITE-ProRule annotation
Disulfide bondi598 ↔ 617PROSITE-ProRule annotation
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1043N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UIW2
MaxQBiQ9UIW2
PaxDbiQ9UIW2
PeptideAtlasiQ9UIW2
PRIDEiQ9UIW2
ProteomicsDBi84573

PTM databases

iPTMnetiQ9UIW2
PhosphoSitePlusiQ9UIW2
SwissPalmiQ9UIW2

Expressioni

Tissue specificityi

Detected in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000114554 Expressed in 219 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_NOV
HS_PLXNA1
GenevisibleiQ9UIW2 HS

Organism-specific databases

HPAiCAB012483
HPA007499

Interactioni

Subunit structurei

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi111375, 24 interactors
CORUMiQ9UIW2
IntActiQ9UIW2, 1 interactor
MINTiQ9UIW2
STRINGi9606.ENSP00000377061

Structurei

3D structure databases

ProteinModelPortaliQ9UIW2
SMRiQ9UIW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini864 – 959IPT/TIG 1Add BLAST96
Domaini961 – 1045IPT/TIG 2Add BLAST85
Domaini1048 – 1147IPT/TIG 3Add BLAST100
Domaini1150 – 1236IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1264 – 1317Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiQ9UIW2
KOiK06820
OMAiQPAFRTF
OrthoDBiEOG091G00EK
PhylomeDBiQ9UIW2
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UIW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG 
        60         70         80         90        100
LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS 
       110        120        130        140        150
VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG 
       160        170        180        190        200
EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT 
       210        220        230        240        250
LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF 
       260        270        280        290        300
RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI 
       310        320        330        340        350
GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK 
       360        370        380        390        400
PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL 
       410        420        430        440        450
QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA 
       460        470        480        490        500
GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY 
       510        520        530        540        550
AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA 
       560        570        580        590        600
DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF 
       610        620        630        640        650
EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK 
       660        670        680        690        700
FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV 
       710        720        730        740        750
NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG 
       760        770        780        790        800
SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ 
       810        820        830        840        850
NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS 
       860        870        880        890        900
WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV 
       910        920        930        940        950
RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA 
       960        970        980        990       1000
LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP 
      1010       1020       1030       1040       1050
CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI 
      1060       1070       1080       1090       1100
LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT 
      1110       1120       1130       1140       1150
TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP 
      1160       1170       1180       1190       1200
VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT 
      1210       1220       1230       1240       1250
VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG 
      1260       1270       1280       1290       1300
GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF 
      1310       1320       1330       1340       1350
AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN 
      1360       1370       1380       1390       1400
VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE 
      1410       1420       1430       1440       1450
MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY 
      1460       1470       1480       1490       1500
KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY 
      1510       1520       1530       1540       1550
KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK 
      1560       1570       1580       1590       1600
AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL 
      1610       1620       1630       1640       1650
VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG 
      1660       1670       1680       1690       1700
TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET 
      1710       1720       1730       1740       1750
IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW 
      1760       1770       1780       1790       1800
VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL 
      1810       1820       1830       1840       1850
LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS 
      1860       1870       1880       1890 
ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Length:1,896
Mass (Da):211,067
Last modified:November 30, 2010 - v3
Checksum:i76E5C9C0710C7FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → G in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti55V → L in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti110S → N in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti140F → S in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti407C → R in CAB57274 (PubMed:8570614).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.
CCDSiCCDS33847.2
RefSeqiNP_115618.3, NM_032242.3
UniGeneiHs.432329

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554
GeneIDi5361
KEGGihsa:5361
UCSCiuc003ejg.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.
CCDSiCCDS33847.2
RefSeqiNP_115618.3, NM_032242.3
UniGeneiHs.432329

3D structure databases

ProteinModelPortaliQ9UIW2
SMRiQ9UIW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111375, 24 interactors
CORUMiQ9UIW2
IntActiQ9UIW2, 1 interactor
MINTiQ9UIW2
STRINGi9606.ENSP00000377061

PTM databases

iPTMnetiQ9UIW2
PhosphoSitePlusiQ9UIW2
SwissPalmiQ9UIW2

Polymorphism and mutation databases

BioMutaiPLXNA1
DMDMi313104202

Proteomic databases

EPDiQ9UIW2
MaxQBiQ9UIW2
PaxDbiQ9UIW2
PeptideAtlasiQ9UIW2
PRIDEiQ9UIW2
ProteomicsDBi84573

Protocols and materials databases

DNASUi5361
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554
GeneIDi5361
KEGGihsa:5361
UCSCiuc003ejg.3 human

Organism-specific databases

CTDi5361
DisGeNETi5361
EuPathDBiHostDB:ENSG00000114554.11
GeneCardsiPLXNA1
H-InvDBiHIX0003640
HIX0030977
HGNCiHGNC:9099 PLXNA1
HPAiCAB012483
HPA007499
MIMi601055 gene
neXtProtiNX_Q9UIW2
OpenTargetsiENSG00000114554
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiQ9UIW2
KOiK06820
OMAiQPAFRTF
OrthoDBiEOG091G00EK
PhylomeDBiQ9UIW2
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRSiPLXNA1 human
GeneWikiiPlexin_A1
GenomeRNAii5361
PROiPR:Q9UIW2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114554 Expressed in 219 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_NOV
HS_PLXNA1
GenevisibleiQ9UIW2 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UIW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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