Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 149 (18 Sep 2019)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Plexin-A1

Gene

PLXNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-A1
Alternative name(s):
Semaphorin receptor NOV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXNA1
Synonyms:NOV, PLXN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9099 PLXNA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601055 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 1244ExtracellularSequence analysisAdd BLAST1218
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1245 – 1265HelicalSequence analysisAdd BLAST21
Topological domaini1266 – 1896CytoplasmicSequence analysisAdd BLAST631

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5361

Open Targets

More...
OpenTargetsi
ENSG00000114554

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UIW2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLXNA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023274527 – 1896Plexin-A1Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi77N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Disulfide bondi130 ↔ 138PROSITE-ProRule annotation
Disulfide bondi286 ↔ 407PROSITE-ProRule annotation
Disulfide bondi302 ↔ 358PROSITE-ProRule annotation
Disulfide bondi376 ↔ 395PROSITE-ProRule annotation
Disulfide bondi515 ↔ 532PROSITE-ProRule annotation
Disulfide bondi521 ↔ 563PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi535 ↔ 547PROSITE-ProRule annotation
Disulfide bondi598 ↔ 617PROSITE-ProRule annotation
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1043N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UIW2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UIW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UIW2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UIW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UIW2

PeptideAtlas

More...
PeptideAtlasi
Q9UIW2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UIW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84573

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIW2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UIW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114554 Expressed in 219 organ(s), highest expression level in middle temporal gyrus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UIW2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012483
HPA007499

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with NRP1 and NRP2.

Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111375, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UIW2

Protein interaction database and analysis system

More...
IntActi
Q9UIW2, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9UIW2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377061

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UIW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini864 – 959IPT/TIG 1Add BLAST96
Domaini961 – 1045IPT/TIG 2Add BLAST85
Domaini1048 – 1147IPT/TIG 3Add BLAST100
Domaini1150 – 1236IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1264 – 1317Sequence analysisAdd BLAST54

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610 Eukaryota
ENOG410XR88 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231377

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UIW2

KEGG Orthology (KO)

More...
KOi
K06820

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPAFRTF

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UIW2

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UIW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG
60 70 80 90 100
LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS
110 120 130 140 150
VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG
160 170 180 190 200
EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT
210 220 230 240 250
LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF
260 270 280 290 300
RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI
310 320 330 340 350
GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK
360 370 380 390 400
PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL
410 420 430 440 450
QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA
460 470 480 490 500
GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY
510 520 530 540 550
AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA
560 570 580 590 600
DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF
610 620 630 640 650
EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK
660 670 680 690 700
FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV
710 720 730 740 750
NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG
760 770 780 790 800
SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ
810 820 830 840 850
NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS
860 870 880 890 900
WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV
910 920 930 940 950
RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA
960 970 980 990 1000
LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP
1010 1020 1030 1040 1050
CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI
1060 1070 1080 1090 1100
LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT
1110 1120 1130 1140 1150
TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP
1160 1170 1180 1190 1200
VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT
1210 1220 1230 1240 1250
VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG
1260 1270 1280 1290 1300
GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF
1310 1320 1330 1340 1350
AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN
1360 1370 1380 1390 1400
VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE
1410 1420 1430 1440 1450
MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY
1460 1470 1480 1490 1500
KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY
1510 1520 1530 1540 1550
KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK
1560 1570 1580 1590 1600
AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL
1610 1620 1630 1640 1650
VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG
1660 1670 1680 1690 1700
TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET
1710 1720 1730 1740 1750
IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW
1760 1770 1780 1790 1800
VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL
1810 1820 1830 1840 1850
LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS
1860 1870 1880 1890
ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Length:1,896
Mass (Da):211,067
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76E5C9C0710C7FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46A → G in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti55V → L in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti110S → N in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti140F → S in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti407C → R in CAB57274 (PubMed:8570614).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33847.2

NCBI Reference Sequences

More...
RefSeqi
NP_115618.3, NM_032242.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393409; ENSP00000377061; ENSG00000114554

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5361

UCSC genome browser

More...
UCSCi
uc003ejg.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.
CCDSiCCDS33847.2
RefSeqiNP_115618.3, NM_032242.3

3D structure databases

SMRiQ9UIW2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111375, 29 interactors
CORUMiQ9UIW2
IntActiQ9UIW2, 11 interactors
MINTiQ9UIW2
STRINGi9606.ENSP00000377061

PTM databases

iPTMnetiQ9UIW2
PhosphoSitePlusiQ9UIW2
SwissPalmiQ9UIW2

Polymorphism and mutation databases

BioMutaiPLXNA1
DMDMi313104202

Proteomic databases

EPDiQ9UIW2
jPOSTiQ9UIW2
MassIVEiQ9UIW2
MaxQBiQ9UIW2
PaxDbiQ9UIW2
PeptideAtlasiQ9UIW2
PRIDEiQ9UIW2
ProteomicsDBi84573

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5361

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554
GeneIDi5361
KEGGihsa:5361
UCSCiuc003ejg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5361
DisGeNETi5361

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLXNA1
HGNCiHGNC:9099 PLXNA1
HPAiCAB012483
HPA007499
MIMi601055 gene
neXtProtiNX_Q9UIW2
OpenTargetsiENSG00000114554

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00950000182738
HOGENOMiHOG000231377
InParanoidiQ9UIW2
KOiK06820
OMAiQPAFRTF
OrthoDBi90434at2759
PhylomeDBiQ9UIW2
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLXNA1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Plexin_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5361
PharosiQ9UIW2

Protein Ontology

More...
PROi
PR:Q9UIW2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114554 Expressed in 219 organ(s), highest expression level in middle temporal gyrus
GenevisibleiQ9UIW2 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 30, 2010
Last modified: September 18, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again