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Protein

Plexin-A1

Gene

PLXNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).By similarity

GO - Molecular functioni

  • semaphorin receptor activity Source: GO_Central
  • signaling receptor activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-416700 Other semaphorin interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A1
Alternative name(s):
Semaphorin receptor NOV
Gene namesi
Name:PLXNA1
Synonyms:NOV, PLXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114554.11
HGNCiHGNC:9099 PLXNA1
MIMi601055 gene
neXtProtiNX_Q9UIW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1244ExtracellularSequence analysisAdd BLAST1218
Transmembranei1245 – 1265HelicalSequence analysisAdd BLAST21
Topological domaini1266 – 1896CytoplasmicSequence analysisAdd BLAST631

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5361
OpenTargetsiENSG00000114554

Polymorphism and mutation databases

BioMutaiPLXNA1
DMDMi313104202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000023274527 – 1896Plexin-A1Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Disulfide bondi130 ↔ 138PROSITE-ProRule annotation
Disulfide bondi286 ↔ 407PROSITE-ProRule annotation
Disulfide bondi302 ↔ 358PROSITE-ProRule annotation
Disulfide bondi376 ↔ 395PROSITE-ProRule annotation
Disulfide bondi515 ↔ 532PROSITE-ProRule annotation
Disulfide bondi521 ↔ 563PROSITE-ProRule annotation
Disulfide bondi524 ↔ 541PROSITE-ProRule annotation
Disulfide bondi535 ↔ 547PROSITE-ProRule annotation
Disulfide bondi598 ↔ 617PROSITE-ProRule annotation
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi701N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1043N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1212N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UIW2
MaxQBiQ9UIW2
PaxDbiQ9UIW2
PeptideAtlasiQ9UIW2
PRIDEiQ9UIW2
ProteomicsDBi84573

PTM databases

iPTMnetiQ9UIW2
PhosphoSitePlusiQ9UIW2
SwissPalmiQ9UIW2

Expressioni

Tissue specificityi

Detected in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000114554 Expressed in 219 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_NOV
HS_PLXNA1
GenevisibleiQ9UIW2 HS

Organism-specific databases

HPAiCAB012483
HPA007499

Interactioni

Subunit structurei

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi111375, 24 interactors
CORUMiQ9UIW2
IntActiQ9UIW2, 1 interactor
MINTiQ9UIW2
STRINGi9606.ENSP00000377061

Structurei

3D structure databases

ProteinModelPortaliQ9UIW2
SMRiQ9UIW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini864 – 959IPT/TIG 1Add BLAST96
Domaini961 – 1045IPT/TIG 2Add BLAST85
Domaini1048 – 1147IPT/TIG 3Add BLAST100
Domaini1150 – 1236IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1264 – 1317Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiQ9UIW2
KOiK06820
OMAiQPAFRTF
OrthoDBiEOG091G00EK
PhylomeDBiQ9UIW2
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UIW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG
60 70 80 90 100
LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS
110 120 130 140 150
VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG
160 170 180 190 200
EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT
210 220 230 240 250
LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF
260 270 280 290 300
RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI
310 320 330 340 350
GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK
360 370 380 390 400
PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL
410 420 430 440 450
QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA
460 470 480 490 500
GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY
510 520 530 540 550
AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA
560 570 580 590 600
DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF
610 620 630 640 650
EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK
660 670 680 690 700
FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV
710 720 730 740 750
NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG
760 770 780 790 800
SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ
810 820 830 840 850
NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS
860 870 880 890 900
WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV
910 920 930 940 950
RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA
960 970 980 990 1000
LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP
1010 1020 1030 1040 1050
CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI
1060 1070 1080 1090 1100
LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT
1110 1120 1130 1140 1150
TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP
1160 1170 1180 1190 1200
VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT
1210 1220 1230 1240 1250
VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG
1260 1270 1280 1290 1300
GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF
1310 1320 1330 1340 1350
AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN
1360 1370 1380 1390 1400
VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE
1410 1420 1430 1440 1450
MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY
1460 1470 1480 1490 1500
KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY
1510 1520 1530 1540 1550
KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK
1560 1570 1580 1590 1600
AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL
1610 1620 1630 1640 1650
VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG
1660 1670 1680 1690 1700
TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET
1710 1720 1730 1740 1750
IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW
1760 1770 1780 1790 1800
VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL
1810 1820 1830 1840 1850
LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS
1860 1870 1880 1890
ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Length:1,896
Mass (Da):211,067
Last modified:November 30, 2010 - v3
Checksum:i76E5C9C0710C7FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46A → G in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti55V → L in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti110S → N in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti140F → S in CAB57274 (PubMed:8570614).Curated1
Sequence conflicti407C → R in CAB57274 (PubMed:8570614).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.
CCDSiCCDS33847.2
RefSeqiNP_115618.3, NM_032242.3
UniGeneiHs.432329

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554
GeneIDi5361
KEGGihsa:5361
UCSCiuc003ejg.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011199 Genomic DNA No translation available.
X87832 mRNA Translation: CAB57274.1
AK128612 mRNA No translation available.
CCDSiCCDS33847.2
RefSeqiNP_115618.3, NM_032242.3
UniGeneiHs.432329

3D structure databases

ProteinModelPortaliQ9UIW2
SMRiQ9UIW2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111375, 24 interactors
CORUMiQ9UIW2
IntActiQ9UIW2, 1 interactor
MINTiQ9UIW2
STRINGi9606.ENSP00000377061

PTM databases

iPTMnetiQ9UIW2
PhosphoSitePlusiQ9UIW2
SwissPalmiQ9UIW2

Polymorphism and mutation databases

BioMutaiPLXNA1
DMDMi313104202

Proteomic databases

EPDiQ9UIW2
MaxQBiQ9UIW2
PaxDbiQ9UIW2
PeptideAtlasiQ9UIW2
PRIDEiQ9UIW2
ProteomicsDBi84573

Protocols and materials databases

DNASUi5361
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393409; ENSP00000377061; ENSG00000114554
GeneIDi5361
KEGGihsa:5361
UCSCiuc003ejg.3 human

Organism-specific databases

CTDi5361
DisGeNETi5361
EuPathDBiHostDB:ENSG00000114554.11
GeneCardsiPLXNA1
H-InvDBiHIX0003640
HIX0030977
HGNCiHGNC:9099 PLXNA1
HPAiCAB012483
HPA007499
MIMi601055 gene
neXtProtiNX_Q9UIW2
OpenTargetsiENSG00000114554
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiQ9UIW2
KOiK06820
OMAiQPAFRTF
OrthoDBiEOG091G00EK
PhylomeDBiQ9UIW2
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRSiPLXNA1 human
GeneWikiiPlexin_A1
GenomeRNAii5361
PROiPR:Q9UIW2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114554 Expressed in 219 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_NOV
HS_PLXNA1
GenevisibleiQ9UIW2 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UIW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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