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Protein

Serpin B13

Gene

SERPINB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the proliferation or differentiation of keratinocytes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei356 – 357Reactive bondBy similarity2

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  • protease binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of endopeptidase activity Source: UniProtKB
  • negative regulation of keratinocyte apoptotic process Source: UniProtKB
  • regulation of keratinocyte differentiation Source: Reactome
  • regulation of proteolysis Source: UniProtKB
  • response to UV Source: ProtInc

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Protein family/group databases

MEROPSiI04.017

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B13
Alternative name(s):
HaCaT UV-repressible serpin
Short name:
Hurpin
Headpin
Peptidase inhibitor 13
Short name:
PI-13
Proteinase inhibitor 13
Gene namesi
Name:SERPINB13
Synonyms:PI13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000197641.11
HGNCiHGNC:8944 SERPINB13
MIMi604445 gene
neXtProtiNX_Q9UIV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5275
OpenTargetsiENSG00000197641
PharmGKBiPA35512

Polymorphism and mutation databases

BioMutaiSERPINB13
DMDMi12643252

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941211 – 391Serpin B13Add BLAST391

Proteomic databases

EPDiQ9UIV8
PaxDbiQ9UIV8
PeptideAtlasiQ9UIV8
PRIDEiQ9UIV8
ProteomicsDBi84570
84571 [Q9UIV8-2]

PTM databases

iPTMnetiQ9UIV8
PhosphoSitePlusiQ9UIV8

Expressioni

Tissue specificityi

Skin specific.

Gene expression databases

BgeeiENSG00000197641 Expressed in 94 organ(s), highest expression level in vagina
CleanExiHS_SERPINB13
ExpressionAtlasiQ9UIV8 baseline and differential
GenevisibleiQ9UIV8 HS

Organism-specific databases

HPAiHPA052630
HPA057129

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111293, 32 interactors
IntActiQ9UIV8, 2 interactors
STRINGi9606.ENSP00000341584

Structurei

3D structure databases

ProteinModelPortaliQ9UIV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOVERGENiHBG005957
InParanoidiQ9UIV8
KOiK13963
PhylomeDBiQ9UIV8
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UIV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA
60 70 80 90 100
SQLEEVFHSE KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY
110 120 130 140 150
ELNITNRLFG EKTYLFLQKY LDYVEKYYHA SLEPVDFVNA ADESRKKINS
160 170 180 190 200
WVESKTNEKI KDLFPDGSIS SSTKLVLVNM VYFKGQWDRE FKKENTKEEK
210 220 230 240 250
FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN DLSMFVLLPN
260 270 280 290 300
DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL
310 320 330 340 350
AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG
360 370 380 390
IGFTVTSAPG HENVHCNHPF LFFIRHNESN SILFFGRFSS P
Length:391
Mass (Da):44,276
Last modified:December 1, 2000 - v2
Checksum:i2CA88558D4BC2B09
GO
Isoform 2 (identifier: Q9UIV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-257: Missing.

Show »
Length:339
Mass (Da):38,413
Checksum:iEDF2E376FB246068
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQW3A0A0A0MQW3_HUMAN
Serpin B13
SERPINB13
400Annotation score:
C9JL93C9JL93_HUMAN
Serpin B13
SERPINB13
158Annotation score:
F8WE70F8WE70_HUMAN
Serpin B13
SERPINB13
165Annotation score:
H7BZS9H7BZS9_HUMAN
Serpin B13
SERPINB13
124Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → N in CAC03569 (PubMed:11313015).Curated1
Sequence conflicti75Missing in CAA04937 (PubMed:10512713).Curated1
Sequence conflicti297E → Q in CAA04937 (PubMed:10512713).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024356293G → S3 PublicationsCorresponds to variant dbSNP:rs1020694Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006058206 – 257Missing in isoform 2. CuratedAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001696 mRNA Translation: CAA04935.2
AJ001697 mRNA Translation: CAA04936.2
AJ001698 mRNA Translation: CAA04937.1
AF169949 mRNA Translation: AAD55765.1
AF216854 Genomic DNA Translation: AAF72879.1
AJ278717 Genomic DNA Translation: CAC03569.1
AK290323 mRNA Translation: BAF83012.1
AK313486 mRNA Translation: BAG36269.1
CH471096 Genomic DNA Translation: EAW63153.1
BC101821 mRNA Translation: AAI01822.1
CCDSiCCDS11985.1 [Q9UIV8-1]
PIRiJC7118
RefSeqiNP_001294852.1, NM_001307923.1
NP_036529.1, NM_012397.3 [Q9UIV8-1]
UniGeneiHs.241407

Genome annotation databases

EnsembliENST00000344731; ENSP00000341584; ENSG00000197641 [Q9UIV8-1]
GeneIDi5275
KEGGihsa:5275
UCSCiuc002ljc.4 human [Q9UIV8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001696 mRNA Translation: CAA04935.2
AJ001697 mRNA Translation: CAA04936.2
AJ001698 mRNA Translation: CAA04937.1
AF169949 mRNA Translation: AAD55765.1
AF216854 Genomic DNA Translation: AAF72879.1
AJ278717 Genomic DNA Translation: CAC03569.1
AK290323 mRNA Translation: BAF83012.1
AK313486 mRNA Translation: BAG36269.1
CH471096 Genomic DNA Translation: EAW63153.1
BC101821 mRNA Translation: AAI01822.1
CCDSiCCDS11985.1 [Q9UIV8-1]
PIRiJC7118
RefSeqiNP_001294852.1, NM_001307923.1
NP_036529.1, NM_012397.3 [Q9UIV8-1]
UniGeneiHs.241407

3D structure databases

ProteinModelPortaliQ9UIV8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111293, 32 interactors
IntActiQ9UIV8, 2 interactors
STRINGi9606.ENSP00000341584

Protein family/group databases

MEROPSiI04.017

PTM databases

iPTMnetiQ9UIV8
PhosphoSitePlusiQ9UIV8

Polymorphism and mutation databases

BioMutaiSERPINB13
DMDMi12643252

Proteomic databases

EPDiQ9UIV8
PaxDbiQ9UIV8
PeptideAtlasiQ9UIV8
PRIDEiQ9UIV8
ProteomicsDBi84570
84571 [Q9UIV8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344731; ENSP00000341584; ENSG00000197641 [Q9UIV8-1]
GeneIDi5275
KEGGihsa:5275
UCSCiuc002ljc.4 human [Q9UIV8-1]

Organism-specific databases

CTDi5275
DisGeNETi5275
EuPathDBiHostDB:ENSG00000197641.11
GeneCardsiSERPINB13
HGNCiHGNC:8944 SERPINB13
HPAiHPA052630
HPA057129
MIMi604445 gene
neXtProtiNX_Q9UIV8
OpenTargetsiENSG00000197641
PharmGKBiPA35512
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOVERGENiHBG005957
InParanoidiQ9UIV8
KOiK13963
PhylomeDBiQ9UIV8
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Miscellaneous databases

ChiTaRSiSERPINB13 human
GeneWikiiSERPINB13
GenomeRNAii5275
PROiPR:Q9UIV8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197641 Expressed in 94 organ(s), highest expression level in vagina
CleanExiHS_SERPINB13
ExpressionAtlasiQ9UIV8 baseline and differential
GenevisibleiQ9UIV8 HS

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB13_HUMAN
AccessioniPrimary (citable) accession number: Q9UIV8
Secondary accession number(s): A8K2Q8
, Q3MII2, Q9HCX1, Q9UBW1, Q9UKG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 10, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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