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Entry version 141 (26 Feb 2020)
Sequence version 1 (01 May 2000)
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Protein

Butyrophilin-like protein 2

Gene

BTNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of T-cell proliferation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8851680 Butyrophilin (BTN) family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Butyrophilin-like protein 2
Short name:
BTL-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BTNL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1142 BTNL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606000 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIR0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 23Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini24 – 455ExtracellularSequence analysisAdd BLAST432

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sarcoidosis 2 (SS2)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.
Disease descriptionAn idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
56244

MalaCards human disease database

More...
MalaCardsi
BTNL2
MIMi612387 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000204290

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
797 Sarcoidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25463

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UIR0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BTNL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73921189

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000145371 – 455Butyrophilin-like protein 2Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 124PROSITE-ProRule annotation
Disulfide bondi164 ↔ 218PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi267 ↔ 341PROSITE-ProRule annotation
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UIR0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UIR0

PeptideAtlas

More...
PeptideAtlasi
Q9UIR0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UIR0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84554 [Q9UIR0-1]
84555 [Q9UIR0-2]
84556 [Q9UIR0-3]
84557 [Q9UIR0-4]
84558 [Q9UIR0-5]
84559 [Q9UIR0-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By proinflammatory cytokines such as TNF and IL1B/interleukin-1 beta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204290 Expressed in amygdala and 65 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UIR0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UIR0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000390613

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UIR0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 140Ig-like V-type 1Add BLAST112
Domaini142 – 234Ig-like V-type 2Add BLAST93
Domaini236 – 355Ig-like V-type 3Add BLAST120

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJJG Eukaryota
ENOG410YIB9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162484

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032563_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UIR0

Database of Orthologous Groups

More...
OrthoDBi
522383at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UIR0

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686 V-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00407 IGc1, 1 hit
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UIR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDFPGYNLS GAVASFLFIL LTMKQSEDFR VIGPAHPILA GVGEDALLTC
60 70 80 90 100
QLLPKRTTMH VEVRWYRSEP STPVFVHRDG VEVTEMQMEE YRGWVEWIEN
110 120 130 140 150
GIAKGNVALK IHNIQPSDNG QYWCHFQDGN YCGETSLLLK VAGLGSAPSI
160 170 180 190 200
HMEGPGESGV QLVCTARGWF PEPQVYWEDI RGEKLLAVSE HRIQDKDGLF
210 220 230 240 250
YAEATLVVRN ASAESVSCLV HNPVLTEEKG SVISLPEKLQ TELASLKVNG
260 270 280 290 300
PSQPILVRVG EDIQLTCYLS PKANAQSMEV RWDRSHRYPA VHVYMDGDHV
310 320 330 340 350
AGEQMAEYRG RTVLVSDAID EGRLTLQILS ARPSDDGQYR CLFEKDDVYQ
360 370 380 390 400
EASLDLKVVS LGSSPLITVE GQEDGEMQPM CSSDGWFPQP HVPWRDMEGK
410 420 430 440 450
TIPSSSQALT QGSHGLFHVQ TLLRVTNISA VDVTCSISIP FLGEEKIATF

SLSGW
Length:455
Mass (Da):50,436
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4194025C7416F839
GO
Isoform 2 (identifier: Q9UIR0-2) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     143-236: Missing.
     454-455: GW → ESRMTFLWKTLLVWGLLLAVAVGLPRKRS

Show »
Length:388
Mass (Da):43,373
Checksum:iC7398D15BAF5492D
GO
Isoform 3 (identifier: Q9UIR0-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     143-236: Missing.
     360-364: SLGSS → WVLPH
     365-455: Missing.

Show »
Length:270
Mass (Da):30,568
Checksum:i284B8285EA865323
GO
Isoform 4 (identifier: Q9UIR0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-237: Missing.

Show »
Length:245
Mass (Da):27,086
Checksum:i0141DB697EF1DDD4
GO
Isoform 5 (identifier: Q9UIR0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.

Show »
Length:178
Mass (Da):19,831
Checksum:iBE380AD9588A90C6
GO
Isoform 6 (identifier: Q9UIR0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-259: ASLKVNGPSQPILVRV → GKYEVLAHTCGGSLCP
     260-455: Missing.

Show »
Length:259
Mass (Da):28,660
Checksum:iBF7BA587B9FC4526
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBA1F8WBA1_HUMAN
Butyrophilin-like protein 2
BTNL2
482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UPS5F6UPS5_HUMAN
Butyrophilin-like protein 2
BTNL2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDK6F8WDK6_HUMAN
Butyrophilin-like protein 2
BTNL2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJ84A0A0G2JJ84_HUMAN
Butyrophilin-like protein 2
BTNL2
482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X5D146X5D146_HUMAN
BTNL2
BTNL2
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27Missing in AAV91023 (PubMed:15516930).Curated1
Isoform 5 (identifier: Q9UIR0-5)
Sequence conflicti83S → G in AAI19669 (PubMed:15489334).Curated1
Isoform 4 (identifier: Q9UIR0-4)
Sequence conflicti150S → G in AAI27643 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03360294W → R. Corresponds to variant dbSNP:rs28362682Ensembl.1
Natural variantiVAR_061307181R → Q. Corresponds to variant dbSNP:rs28362681Ensembl.1
Natural variantiVAR_049837188V → M. Corresponds to variant dbSNP:rs9461742Ensembl.1
Natural variantiVAR_021171196K → E1 PublicationCorresponds to variant dbSNP:rs2076523Ensembl.1
Natural variantiVAR_061308202A → V. Corresponds to variant dbSNP:rs28362680Ensembl.1
Natural variantiVAR_033603283D → V. Corresponds to variant dbSNP:rs34423804Ensembl.1
Natural variantiVAR_029128334S → L1 PublicationCorresponds to variant dbSNP:rs28362679Ensembl.1
Natural variantiVAR_033604352A → T. Corresponds to variant dbSNP:rs35037492Ensembl.1
Natural variantiVAR_049838360S → G. Corresponds to variant dbSNP:rs2076530Ensembl.1
Natural variantiVAR_033605379P → L. Corresponds to variant dbSNP:rs28362678Ensembl.1
Natural variantiVAR_033606380M → I. Corresponds to variant dbSNP:rs28362677Ensembl.1
Natural variantiVAR_033607393P → Q. Corresponds to variant dbSNP:rs41521946Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0271841 – 277Missing in isoform 5. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_02718528 – 237Missing in isoform 4. 1 PublicationAdd BLAST210
Alternative sequenceiVSP_027186143 – 236Missing in isoform 2 and isoform 3. CuratedAdd BLAST94
Alternative sequenceiVSP_027187244 – 259ASLKV…ILVRV → GKYEVLAHTCGGSLCP in isoform 6. CuratedAdd BLAST16
Alternative sequenceiVSP_027188260 – 455Missing in isoform 6. CuratedAdd BLAST196
Alternative sequenceiVSP_027189360 – 364SLGSS → WVLPH in isoform 3. Curated5
Alternative sequenceiVSP_027190365 – 455Missing in isoform 3. CuratedAdd BLAST91
Alternative sequenceiVSP_027191454 – 455GW → ESRMTFLWKTLLVWGLLLAV AVGLPRKRS in isoform 2. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF186593 AF186590 Genomic DNA Translation: AAF05530.1
AY881999 Genomic DNA Translation: AAX35330.1
AY881999 Genomic DNA Translation: AAX35331.1
AL034394, Z84814 Genomic DNA Translation: CAI42180.1
Z84814, AL034394 Genomic DNA Translation: CAC69895.2
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
AL935032 Genomic DNA No translation available.
BX255945 Genomic DNA No translation available.
CR753634 Genomic DNA No translation available.
CR759917 Genomic DNA No translation available.
BC119668 mRNA Translation: AAI19669.1
BC127642 mRNA Translation: AAI27643.1
AY684332 mRNA Translation: AAV91022.1
AY684333 mRNA Translation: AAV91023.1

NCBI Reference Sequences

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RefSeqi
NP_001291490.1, NM_001304561.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000374993; ENSP00000364132; ENSG00000204290 [Q9UIR0-1]
ENST00000544175; ENSP00000443364; ENSG00000204290 [Q9UIR0-5]
ENST00000548253; ENSP00000447733; ENSG00000224242
ENST00000548717; ENSP00000449356; ENSG00000225412
ENST00000548832; ENSP00000448852; ENSG00000229741 [Q9UIR0-4]
ENST00000549560; ENSP00000448550; ENSG00000226127 [Q9UIR0-5]
ENST00000549852; ENSP00000446915; ENSG00000225845
ENST00000549943; ENSP00000449578; ENSG00000224770 [Q9UIR0-5]
ENST00000550327; ENSP00000447985; ENSG00000226127 [Q9UIR0-1]
ENST00000550531; ENSP00000448023; ENSG00000229597 [Q9UIR0-1]
ENST00000550698; ENSP00000447616; ENSG00000229597 [Q9UIR0-5]
ENST00000551095; ENSP00000449546; ENSG00000229741 [Q9UIR0-1]
ENST00000551669; ENSP00000446794; ENSG00000224242
ENST00000551686; ENSP00000450139; ENSG00000225412
ENST00000552479; ENSP00000449365; ENSG00000224770 [Q9UIR0-1]
ENST00000553032; ENSP00000447291; ENSG00000229741 [Q9UIR0-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56244

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56244

UCSC genome browser

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UCSCi
uc003obg.1 human [Q9UIR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186593 AF186590 Genomic DNA Translation: AAF05530.1
AY881999 Genomic DNA Translation: AAX35330.1
AY881999 Genomic DNA Translation: AAX35331.1
AL034394, Z84814 Genomic DNA Translation: CAI42180.1
Z84814, AL034394 Genomic DNA Translation: CAC69895.2
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
AL935032 Genomic DNA No translation available.
BX255945 Genomic DNA No translation available.
CR753634 Genomic DNA No translation available.
CR759917 Genomic DNA No translation available.
BC119668 mRNA Translation: AAI19669.1
BC127642 mRNA Translation: AAI27643.1
AY684332 mRNA Translation: AAV91022.1
AY684333 mRNA Translation: AAV91023.1
RefSeqiNP_001291490.1, NM_001304561.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000390613

PTM databases

iPTMnetiQ9UIR0
PhosphoSitePlusiQ9UIR0

Polymorphism and mutation databases

BioMutaiBTNL2
DMDMi73921189

Proteomic databases

EPDiQ9UIR0
PaxDbiQ9UIR0
PeptideAtlasiQ9UIR0
PRIDEiQ9UIR0
ProteomicsDBi84554 [Q9UIR0-1]
84555 [Q9UIR0-2]
84556 [Q9UIR0-3]
84557 [Q9UIR0-4]
84558 [Q9UIR0-5]
84559 [Q9UIR0-6]

Genome annotation databases

EnsembliENST00000374993; ENSP00000364132; ENSG00000204290 [Q9UIR0-1]
ENST00000544175; ENSP00000443364; ENSG00000204290 [Q9UIR0-5]
ENST00000548253; ENSP00000447733; ENSG00000224242
ENST00000548717; ENSP00000449356; ENSG00000225412
ENST00000548832; ENSP00000448852; ENSG00000229741 [Q9UIR0-4]
ENST00000549560; ENSP00000448550; ENSG00000226127 [Q9UIR0-5]
ENST00000549852; ENSP00000446915; ENSG00000225845
ENST00000549943; ENSP00000449578; ENSG00000224770 [Q9UIR0-5]
ENST00000550327; ENSP00000447985; ENSG00000226127 [Q9UIR0-1]
ENST00000550531; ENSP00000448023; ENSG00000229597 [Q9UIR0-1]
ENST00000550698; ENSP00000447616; ENSG00000229597 [Q9UIR0-5]
ENST00000551095; ENSP00000449546; ENSG00000229741 [Q9UIR0-1]
ENST00000551669; ENSP00000446794; ENSG00000224242
ENST00000551686; ENSP00000450139; ENSG00000225412
ENST00000552479; ENSP00000449365; ENSG00000224770 [Q9UIR0-1]
ENST00000553032; ENSP00000447291; ENSG00000229741 [Q9UIR0-5]
GeneIDi56244
KEGGihsa:56244
UCSCiuc003obg.1 human [Q9UIR0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56244
DisGeNETi56244

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BTNL2
HGNCiHGNC:1142 BTNL2
MalaCardsiBTNL2
MIMi606000 gene
612387 phenotype
neXtProtiNX_Q9UIR0
OpenTargetsiENSG00000204290
Orphaneti797 Sarcoidosis
PharmGKBiPA25463

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJJG Eukaryota
ENOG410YIB9 LUCA
GeneTreeiENSGT00940000162484
HOGENOMiCLU_032563_1_0_1
InParanoidiQ9UIR0
OrthoDBi522383at2759
PhylomeDBiQ9UIR0
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BTNL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56244
PharosiQ9UIR0 Tbio

Protein Ontology

More...
PROi
PR:Q9UIR0
RNActiQ9UIR0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204290 Expressed in amygdala and 65 other tissues
ExpressionAtlasiQ9UIR0 baseline and differential
GenevisibleiQ9UIR0 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00407 IGc1, 1 hit
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBTNL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIR0
Secondary accession number(s): A0PJV5
, B0UYW9, B0V0N6, O98261, Q08E96, Q58R22, Q58R23, Q5JYF9, Q5MP42, Q5MP43, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: February 26, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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