UniProtKB - Q9UIQ6 (LCAP_HUMAN)

>sp|Q9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVV
AVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELS
LHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYH
GQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAAR
SAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWW
NDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQT
LDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT
EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE
KLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAM
KLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASS
EDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGS
YTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWL

Entry version 188 (13 Feb 2019)
Sequence version 3 (17 Apr 2007)
Previous versions | rss

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Protein

Leucyl-cystinyl aminopeptidase

Gene

LNPEP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.3 Publications

Catalytic activityⁱ

Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
2 Publications
Manual assertion based on experiment inⁱ
- Ref.4
  "Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides."
  Matsumoto H., Nagasaka T., Hattori A., Rogi T., Tsuruoka N., Mizutani S., Tsujimoto M.
  Eur. J. Biochem. 268:3259-3266(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
- Ref.7
  "Identification of human placental leucine aminopeptidase as oxytocinase."
  Tsujimoto M., Mizutani S., Adachi H., Kimura M., Nakazato H., Tomoda Y.
  Arch. Biochem. Biophys. 292:388-392(1992) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
EC:3.4.11.3

Cofactorⁱ

Zn²⁺By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	295	SubstrateBy similarity	1
Metal bindingⁱ	464	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	465	Proton acceptorPROSITE-ProRule annotation	1
Metal bindingⁱ	468	Zinc; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	487	Zinc; catalyticPROSITE-ProRule annotation	1
Siteⁱ	549	Transition state stabilizerBy similarity	1

GO - Molecular functionⁱ

aminopeptidase activity
Source: Reactome
Inferred from experimentⁱ
metalloaminopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metallopeptidase activity
Source: ProtInc
Traceable author statementⁱ
- 9177475
peptide binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 8550619
female pregnancy
Source: ProtInc
Traceable author statementⁱ
- 8550619
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 25534853
peptide catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein catabolic process Source: Ensembl
protein polyubiquitination Source: Reactome
proteolysis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SMAD protein signal transduction Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminopeptidase, Hydrolase, Metalloprotease, Protease
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SABIO-RKⁱ	Q9UIQ6
SIGNORⁱ	Q9UIQ6

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M01.011

MEROPSⁱ

M01.011

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucyl-cystinyl aminopeptidase (EC:3.4.11.3) Short name: Cystinyl aminopeptidase Alternative name(s): Insulin-regulated membrane aminopeptidase Insulin-responsive aminopeptidase Short name: IRAP Oxytocinase Short name: OTase Placental leucine aminopeptidase Short name: P-LAP Cleaved into the following chain: Leucyl-cystinyl aminopeptidase, pregnancy serum form
Gene namesⁱ	Name:LNPEP Synonyms:OTASE
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113441.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6656 LNPEP
MIMⁱ	151300 gene
neXtProtⁱ	NX_Q9UIQ6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 110	CytoplasmicSequence analysisAdd BLAST	110
Transmembraneⁱ	111 – 131	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	132 – 1025	ExtracellularSequence analysisAdd BLAST	894

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4012
Open Targets More...OpenTargetsⁱ	ENSG00000113441
PharmGKBⁱ	PA30418

Chemistry databases

ChEMBLⁱ	CHEMBL2693
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1570

Polymorphism and mutation databases

BioMutaⁱ	LNPEP
DMDMⁱ	145559489

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000095114	1 – 1025	Leucyl-cystinyl aminopeptidaseAdd BLAST		1025
ChainⁱPRO_0000292264	155 – 1025	Leucyl-cystinyl aminopeptidase, pregnancy serum formAdd BLAST		871

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	70	PhosphotyrosineBy similarity	1
Modified residueⁱ	80	PhosphoserineCombined sources	1
Modified residueⁱ	91	PhosphoserineCombined sources	1
Glycosylationⁱ	145	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	215	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	256	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	266	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	368	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	374	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	448	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	525	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	578	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	598	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	664	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	682	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	760	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	834	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	850	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	989	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.

N-glycosylated.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	154 – 155	Cleavage; to produce pregnancy serum form		2

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UIQ6
jPOSTⁱ	Q9UIQ6
PaxDbⁱ	Q9UIQ6
PeptideAtlas More...PeptideAtlasⁱ	Q9UIQ6
PRIDEⁱ	Q9UIQ6
ProteomicsDBⁱ	84551 84552 [Q9UIQ6-2] 84553 [Q9UIQ6-3]

PTM databases

GlyConnectⁱ	1455
iPTMnetⁱ	Q9UIQ6
PhosphoSitePlusⁱ	Q9UIQ6
SwissPalmⁱ	Q9UIQ6

Miscellaneous databases

PMAP-CutDBⁱ	Q9UIQ6

PMAP-CutDBⁱ

Q9UIQ6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000113441 Expressed in 219 organ(s), highest expression level in placenta
Genevisibleⁱ	Q9UIQ6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043642

HPAⁱ

HPA043642

Interactionⁱ

Subunit structureⁱ

Homodimer. Binds tankyrases 1 and 2.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FATE1	Q969F0	3	EBI-2805360,EBI-743099
REL	Q04864	3	EBI-2805360,EBI-307352
TCF4	P15884	3	EBI-2805360,EBI-533224

Protein-protein interaction databases

BioGridⁱ	110196, 46 interactors
ELMⁱ	Q9UIQ6
IntActⁱ	Q9UIQ6, 42 interactors
STRINGⁱ	9606.ENSP00000231368

Chemistry databases

BindingDBⁱ

Q9UIQ6

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	165 – 167	Combined sources	3
Beta strandⁱ	170 – 184	Combined sources	15
Turnⁱ	185 – 188	Combined sources	4
Beta strandⁱ	189 – 202	Combined sources	14
Beta strandⁱ	204 – 210	Combined sources	7
Beta strandⁱ	215 – 223	Combined sources	9
Turnⁱ	224 – 226	Combined sources	3
Beta strandⁱ	233 – 237	Combined sources	5
Helixⁱ	238 – 240	Combined sources	3
Beta strandⁱ	242 – 251	Combined sources	10
Beta strandⁱ	256 – 266	Combined sources	11
Beta strandⁱ	268 – 280	Combined sources	13
Beta strandⁱ	282 – 284	Combined sources	3
Beta strandⁱ	286 – 293	Combined sources	8
Turnⁱ	295 – 298	Combined sources	4
Helixⁱ	299 – 302	Combined sources	4
Beta strandⁱ	308 – 310	Combined sources	3
Beta strandⁱ	313 – 322	Combined sources	10
Beta strandⁱ	325 – 331	Combined sources	7
Beta strandⁱ	333 – 338	Combined sources	6
Beta strandⁱ	343 – 348	Combined sources	6
Beta strandⁱ	353 – 355	Combined sources	3
Helixⁱ	356 – 358	Combined sources	3
Beta strandⁱ	361 – 364	Combined sources	4
Beta strandⁱ	367 – 373	Combined sources	7
Beta strandⁱ	376 – 382	Combined sources	7
Helixⁱ	384 – 390	Combined sources	7
Helixⁱ	391 – 408	Combined sources	18
Beta strandⁱ	415 – 424	Combined sources	10
Beta strandⁱ	426 – 430	Combined sources	5
Beta strandⁱ	435 – 439	Combined sources	5
Helixⁱ	440 – 442	Combined sources	3
Turnⁱ	447 – 449	Combined sources	3
Helixⁱ	452 – 468	Combined sources	17
Turnⁱ	472 – 474	Combined sources	3
Beta strandⁱ	475 – 479	Combined sources	5
Helixⁱ	480 – 483	Combined sources	4
Helixⁱ	484 – 501	Combined sources	18
Helixⁱ	503 – 505	Combined sources	3
Helixⁱ	508 – 522	Combined sources	15
Beta strandⁱ	523 – 526	Combined sources	4
Helixⁱ	537 – 542	Combined sources	6
Helixⁱ	546 – 562	Combined sources	17
Helixⁱ	565 – 579	Combined sources	15
Beta strandⁱ	582 – 584	Combined sources	3
Helixⁱ	586 – 597	Combined sources	12
Beta strandⁱ	600 – 602	Combined sources	3
Helixⁱ	603 – 612	Combined sources	10
Beta strandⁱ	613 – 615	Combined sources	3
Beta strandⁱ	617 – 624	Combined sources	8
Beta strandⁱ	627 – 634	Combined sources	8
Beta strandⁱ	654 – 662	Combined sources	9
Beta strandⁱ	663 – 665	Combined sources	3
Beta strandⁱ	667 – 674	Combined sources	8
Beta strandⁱ	676 – 682	Combined sources	7
Beta strandⁱ	687 – 693	Combined sources	7
Helixⁱ	694 – 696	Combined sources	3
Beta strandⁱ	698 – 704	Combined sources	7
Helixⁱ	706 – 718	Combined sources	13
Helixⁱ	720 – 722	Combined sources	3
Helixⁱ	725 – 741	Combined sources	17
Beta strandⁱ	742 – 744	Combined sources	3
Helixⁱ	746 – 753	Combined sources	8
Helixⁱ	754 – 758	Combined sources	5
Helixⁱ	762 – 782	Combined sources	21
Helixⁱ	785 – 804	Combined sources	20
Beta strandⁱ	808 – 810	Combined sources	3
Helixⁱ	814 – 829	Combined sources	16
Helixⁱ	835 – 847	Combined sources	13
Turnⁱ	848 – 850	Combined sources	3
Turnⁱ	857 – 859	Combined sources	3
Helixⁱ	860 – 867	Combined sources	8
Helixⁱ	871 – 881	Combined sources	11
Helixⁱ	887 – 897	Combined sources	11
Helixⁱ	903 – 915	Combined sources	13
Beta strandⁱ	917 – 919	Combined sources	3
Helixⁱ	921 – 923	Combined sources	3
Helixⁱ	924 – 933	Combined sources	10
Helixⁱ	935 – 947	Combined sources	13
Helixⁱ	949 – 955	Combined sources	7
Helixⁱ	961 – 969	Combined sources	9
Turnⁱ	970 – 973	Combined sources	4
Helixⁱ	977 – 988	Combined sources	12
Helixⁱ	992 – 995	Combined sources	4
Helixⁱ	998 – 1024	Combined sources	27

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4P8Q	X-ray	3.02	A/B	155-1025	[»]
	4PJ6	X-ray	2.96	A/B	155-1025	[»]
	4Z7I	X-ray	3.31	A/B	155-1025	[»]
	5C97	X-ray	3.37	A/B	155-1025	[»]
	5JHQ	X-ray	3.20	E/F/G/H/I/J/K/L	92-107	[»]
	5MJ6	X-ray	2.53	A/B	155-1025	[»]
ProteinModelPortalⁱ	Q9UIQ6
SMRⁱ	Q9UIQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	96 – 101	Tankyrase binding		6
Regionⁱ	428 – 432	Substrate bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	53 – 54	Dileucine internalization motifSequence analysis		2
Motifⁱ	76 – 77	Dileucine internalization motifSequence analysis		2

Sequence similaritiesⁱ

Belongs to the peptidase M1 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1046 Eukaryota COG0308 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157902
HOVERGENⁱ	HBG108296
InParanoidⁱ	Q9UIQ6
KEGG Orthology (KO) More...KOⁱ	K01257
OMAⁱ	LEGHNYT
Database of Orthologous Groups More...OrthoDBⁱ	110058at2759
PhylomeDBⁱ	Q9UIQ6
TreeFamⁱ	TF300395

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09601 M1_APN_2, 1 hit
InterProⁱ	View protein in InterPro IPR034017 Cystinyl_aminopeptidase IPR024571 ERAP1-like_C_dom IPR034016 M1_APN-typ IPR001930 Peptidase_M1 IPR014782 Peptidase_M1_dom
PANTHERⁱ	PTHR11533 PTHR11533, 1 hit PTHR11533:SF42 PTHR11533:SF42, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11838 ERAP1_C, 1 hit PF01433 Peptidase_M1, 1 hit
PRINTSⁱ	PR00756 ALADIPTASE
PROSITEⁱ	View protein in PROSITE PS00142 ZINC_PROTEASE, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9UIQ6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG 
        60         70         80         90        100
SRLLVRGLGE HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD 
       110        120        130        140        150
GACSVPSART MVVCAFVIVV AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL 
       160        170        180        190        200
IQPFATNGKL FPWAQIRLPT AVVPLRYELS LHPNLTSMTF RGSVTISVQA 
       210        220        230        240        250
LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH GQIAIVAPEA 
       260        270        280        290        300
LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR 
       310        320        330        340        350
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE 
       360        370        380        390        400
SVKMSTYLVA FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL 
       410        420        430        440        450
LEFFQNYFEI QYPLKKLDLV AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS 
       460        470        480        490        500
SMADRKLVTK IIAHELAHQW FGNLVTMKWW NDLWLNEGFA TFMEYFSLEK 
       510        520        530        540        550
IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI EEMFDSLSYF 
       560        570        580        590        600
KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT 
       610        620        630        640        650
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY 
       660        670        680        690        700
LWHIPLSYVT EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY 
       710        720        730        740        750
IVHYADDDWE ALIHQLKINP YVLSDKDRAN LINNIFELAG LGKVPLKRAF 
       760        770        780        790        800
DLINYLGNEN HTAPITEALF QTDLIYNLLE KLGYMDLASR LVTRVFKLLQ 
       810        820        830        840        850
NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM KLFDDWMASN 
       860        870        880        890        900
GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS 
       910        920        930        940        950
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN 
       960        970        980        990       1000
KLVQKFPLGS YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV 
      1010       1020 
QEALEVIQLN IQWMEKNLKS LTWWL

Length:1,025

Mass (Da):117,349

Last modified:April 17, 2007 - v3

Checksum:ⁱF84C0EA9D48DC2C0

Isoform 2 (identifier: Q9UIQ6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-14: Missing.

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        10         20         30         40         50
MIENSMFEEE PDVVDLAKEP CLHPLEPDEV EYEPRGSRLL VRGLGEHEME 
        60         70         80         90        100
EDEEDYESSA KLLGMSFMNR SSGLRNSATG YRQSPDGACS VPSARTMVVC 
       110        120        130        140        150
AFVIVVAVSV IMVIYLLPRC TFTKEGCHKK NQSIGLIQPF ATNGKLFPWA 
       160        170        180        190        200
QIRLPTAVVP LRYELSLHPN LTSMTFRGSV TISVQALQVT WNIILHSTGH 
       210        220        230        240        250
NISRVTFMSA VSSQEKQAEI LEYAYHGQIA IVAPEALLAG HNYTLKIEYS 
       260        270        280        290        300
ANISSSYYGF YGFSYTDESN EKKYFAATQF EPLAARSAFP CFDEPAFKAT 
       310        320        330        340        350
FIIKIIRDEQ YTALSNMPKK SSVVLDDGLV QDEFSESVKM STYLVAFIVG 
       360        370        380        390        400
EMKNLSQDVN GTLVSIYAVP EKIGQVHYAL ETTVKLLEFF QNYFEIQYPL 
       410        420        430        440        450
KKLDLVAIPD FEAGAMENWG LLTFREETLL YDSNTSSMAD RKLVTKIIAH 
       460        470        480        490        500
ELAHQWFGNL VTMKWWNDLW LNEGFATFME YFSLEKIFKE LSSYEDFLDA 
       510        520        530        540        550
RFKTMKKDSL NSSHPISSSV QSSEQIEEMF DSLSYFKGSS LLLMLKTYLS 
       560        570        580        590        600
EDVFQHAVVL YLHNHSYASI QSDDLWDSFN EVTNQTLDVK RMMKTWTLQK 
       610        620        630        640        650
GFPLVTVQKK GKELFIQQER FFLNMKPEIQ PSDTSYLWHI PLSYVTEGRN 
       660        670        680        690        700
YSKYQSVSLL DKKSGVINLT EEVLWVKVNI NMNGYYIVHY ADDDWEALIH 
       710        720        730        740        750
QLKINPYVLS DKDRANLINN IFELAGLGKV PLKRAFDLIN YLGNENHTAP 
       760        770        780        790        800
ITEALFQTDL IYNLLEKLGY MDLASRLVTR VFKLLQNQIQ QQTWTDEGTP 
       810        820        830        840        850
SMRELRSALL EFACTHNLGN CSTTAMKLFD DWMASNGTQS LPTDVMTTVF 
       860        870        880        890        900
KVGAKTDKGW SFLLGKYISI GSEAEKNKIL EALASSEDVR KLYWLMKSSL 
       910        920        930        940        950
NGDNFRTQKL SFIIRTVGRH FPGHLLAWDF VKENWNKLVQ KFPLGSYTIQ 
       960        970        980        990       1000
NIVAGSTYLF STKTHLSEVQ AFFENQSEAT FRLRCVQEAL EVIQLNIQWM 
      1010 
EKNLKSLTWW L

Show »

Length:1,011

Mass (Da):115,636

Checksum:ⁱFBB54EFECFBA8FD9

Isoform 3 (identifier: Q9UIQ6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-19: Missing.

« Hide

        10         20         30         40         50
MFEEEPDVVD LAKEPCLHPL EPDEVEYEPR GSRLLVRGLG EHEMEEDEED 
        60         70         80         90        100
YESSAKLLGM SFMNRSSGLR NSATGYRQSP DGACSVPSAR TMVVCAFVIV 
       110        120        130        140        150
VAVSVIMVIY LLPRCTFTKE GCHKKNQSIG LIQPFATNGK LFPWAQIRLP 
       160        170        180        190        200
TAVVPLRYEL SLHPNLTSMT FRGSVTISVQ ALQVTWNIIL HSTGHNISRV 
       210        220        230        240        250
TFMSAVSSQE KQAEILEYAY HGQIAIVAPE ALLAGHNYTL KIEYSANISS 
       260        270        280        290        300
SYYGFYGFSY TDESNEKKYF AATQFEPLAA RSAFPCFDEP AFKATFIIKI 
       310        320        330        340        350
IRDEQYTALS NMPKKSSVVL DDGLVQDEFS ESVKMSTYLV AFIVGEMKNL 
       360        370        380        390        400
SQDVNGTLVS IYAVPEKIGQ VHYALETTVK LLEFFQNYFE IQYPLKKLDL 
       410        420        430        440        450
VAIPDFEAGA MENWGLLTFR EETLLYDSNT SSMADRKLVT KIIAHELAHQ 
       460        470        480        490        500
WFGNLVTMKW WNDLWLNEGF ATFMEYFSLE KIFKELSSYE DFLDARFKTM 
       510        520        530        540        550
KKDSLNSSHP ISSSVQSSEQ IEEMFDSLSY FKGSSLLLML KTYLSEDVFQ 
       560        570        580        590        600
HAVVLYLHNH SYASIQSDDL WDSFNEVTNQ TLDVKRMMKT WTLQKGFPLV 
       610        620        630        640        650
TVQKKGKELF IQQERFFLNM KPEIQPSDTS YLWHIPLSYV TEGRNYSKYQ 
       660        670        680        690        700
SVSLLDKKSG VINLTEEVLW VKVNINMNGY YIVHYADDDW EALIHQLKIN 
       710        720        730        740        750
PYVLSDKDRA NLINNIFELA GLGKVPLKRA FDLINYLGNE NHTAPITEAL 
       760        770        780        790        800
FQTDLIYNLL EKLGYMDLAS RLVTRVFKLL QNQIQQQTWT DEGTPSMREL 
       810        820        830        840        850
RSALLEFACT HNLGNCSTTA MKLFDDWMAS NGTQSLPTDV MTTVFKVGAK 
       860        870        880        890        900
TDKGWSFLLG KYISIGSEAE KNKILEALAS SEDVRKLYWL MKSSLNGDNF 
       910        920        930        940        950
RTQKLSFIIR TVGRHFPGHL LAWDFVKENW NKLVQKFPLG SYTIQNIVAG 
       960        970        980        990       1000
STYLFSTKTH LSEVQAFFEN QSEATFRLRC VQEALEVIQL NIQWMEKNLK 

SLTWWL

Show »

Length:1,006

Mass (Da):115,062

Checksum:ⁱF57E71F1AA3C28E3

Sequence cautionⁱ

The sequence BAA09436 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAD92120 differs from that shown. Reason: Frameshift at position 405.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	66	D → V in CAB61646 (PubMed:10759854).Curated	1
Sequence conflictⁱ	66	D → V in CAB94753 (PubMed:10759854).Curated	1
Sequence conflictⁱ	301	S → L AA sequence (PubMed:8119729).Curated	1
Sequence conflictⁱ	386	K → N in AAB66672 (PubMed:9177475).Curated	1
Sequence conflictⁱ	386	K → N in AAB66673 (PubMed:9177475).Curated	1
Sequence conflictⁱ	386	K → N in CAB61646 (PubMed:10759854).Curated	1
Sequence conflictⁱ	386	K → N in CAB94753 (PubMed:10759854).Curated	1
Sequence conflictⁱ	892	K → Q in BAA09436 (PubMed:8550619).Curated	1
Sequence conflictⁱ	944	F → L in BAA09436 (PubMed:8550619).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031616	86	S → P. Corresponds to variant dbSNP:rs3797799Ensembl.	1
Natural variantⁱVAR_051567	594	N → I. Corresponds to variant dbSNP:rs12520455Ensembl.	1
Natural variantⁱVAR_012812	763	A → T. Corresponds to variant dbSNP:rs2303138Ensembl.	1
Natural variantⁱVAR_051568	913	S → T. Corresponds to variant dbSNP:rs17087233Ensembl.	1
Natural variantⁱVAR_031617	963	I → V. Corresponds to variant dbSNP:rs11746232Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005449	1 – 19	Missing in isoform 3. 1 PublicationAdd BLAST		19
Alternative sequenceⁱVSP_005448	1 – 14	Missing in isoform 2. 2 PublicationsAdd BLAST		14

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50810 mRNA Translation: BAA09436.1 Different initiation. U62768 mRNA Translation: AAB66672.1 U62769 mRNA Translation: AAB66673.1 AJ131023 AJ131039 Genomic DNA Translation: CAB61646.1 AJ131025 AJ131039 Genomic DNA Translation: CAB94753.1 AB208883 mRNA Translation: BAD92120.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4087.1 [Q9UIQ6-1] CCDS43346.1 [Q9UIQ6-2]
PIRⁱ	A59383 A59384
NCBI Reference Sequences More...RefSeqⁱ	NP_005566.2, NM_005575.2 [Q9UIQ6-1] NP_787116.2, NM_175920.3 [Q9UIQ6-2]
UniGeneⁱ	Hs.527199 Hs.656905

Genome annotation databases

Ensemblⁱ	ENST00000231368; ENSP00000231368; ENSG00000113441 [Q9UIQ6-1] ENST00000395770; ENSP00000379117; ENSG00000113441 [Q9UIQ6-2]
GeneIDⁱ	4012
KEGGⁱ	hsa:4012
UCSC genome browser More...UCSCⁱ	uc003kmv.2 human [Q9UIQ6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UIQ6	Isoform 2 of Leucyl-cystinyl aminopeptidase		HUMAN		1011	UniRef100_Q9UIQ6
Isoform 3 of Leucyl-cystinyl aminopeptidase		HUMAN		1006

Protein	Similar proteins		Species	Score	Length	Source
Q9UIQ6	Isoform 2 of Leucyl-cystinyl aminopeptidase		HUMAN		1011	UniRef90_Q9UIQ6
leucyl-cystinyl aminopeptidase isoform X1		URSMA		1147
Leucyl and cystinyl aminopeptidase		CANLF		1037
Leucyl and cystinyl aminopeptidase		FELCA		1029
Leucyl and cystinyl aminopeptidase		CERAT		1027
+101

Protein	Similar proteins		Species	Score	Length	Source
Q9UIQ6	Isoform 2 of Leucyl-cystinyl aminopeptidase		HUMAN		1011	UniRef50_Q9UIQ6
leucyl-cystinyl aminopeptidase isoform X1		URSMA		1147
Leucyl and cystinyl aminopeptidase		CANLF		1037
Leucyl and cystinyl aminopeptidase		FELCA		1029
Leucyl and cystinyl aminopeptidase		PAPAN		1027
+294

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D50810 mRNA Translation: BAA09436.1 Different initiation. U62768 mRNA Translation: AAB66672.1 U62769 mRNA Translation: AAB66673.1 AJ131023 AJ131039 Genomic DNA Translation: CAB61646.1 AJ131025 AJ131039 Genomic DNA Translation: CAB94753.1 AB208883 mRNA Translation: BAD92120.1 Frameshift.
CCDSⁱ	CCDS4087.1 [Q9UIQ6-1] CCDS43346.1 [Q9UIQ6-2]
PIRⁱ	A59383 A59384
RefSeqⁱ	NP_005566.2, NM_005575.2 [Q9UIQ6-1] NP_787116.2, NM_175920.3 [Q9UIQ6-2]
UniGeneⁱ	Hs.527199 Hs.656905

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4P8Q	X-ray	3.02	A/B	155-1025	[»]
	4PJ6	X-ray	2.96	A/B	155-1025	[»]
	4Z7I	X-ray	3.31	A/B	155-1025	[»]
	5C97	X-ray	3.37	A/B	155-1025	[»]
	5JHQ	X-ray	3.20	E/F/G/H/I/J/K/L	92-107	[»]
	5MJ6	X-ray	2.53	A/B	155-1025	[»]
ProteinModelPortalⁱ	Q9UIQ6
SMRⁱ	Q9UIQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110196, 46 interactors
ELMⁱ	Q9UIQ6
IntActⁱ	Q9UIQ6, 42 interactors
STRINGⁱ	9606.ENSP00000231368

Chemistry databases

BindingDBⁱ	Q9UIQ6
ChEMBLⁱ	CHEMBL2693
GuidetoPHARMACOLOGYⁱ	1570

Protein family/group databases

MEROPSⁱ	M01.011

MEROPSⁱ

M01.011

PTM databases

GlyConnectⁱ	1455
iPTMnetⁱ	Q9UIQ6
PhosphoSitePlusⁱ	Q9UIQ6
SwissPalmⁱ	Q9UIQ6

Polymorphism and mutation databases

BioMutaⁱ	LNPEP
DMDMⁱ	145559489

Proteomic databases

EPDⁱ	Q9UIQ6
jPOSTⁱ	Q9UIQ6
PaxDbⁱ	Q9UIQ6
PeptideAtlasⁱ	Q9UIQ6
PRIDEⁱ	Q9UIQ6
ProteomicsDBⁱ	84551 84552 [Q9UIQ6-2] 84553 [Q9UIQ6-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4012
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000231368; ENSP00000231368; ENSG00000113441 [Q9UIQ6-1] ENST00000395770; ENSP00000379117; ENSG00000113441 [Q9UIQ6-2]
GeneIDⁱ	4012
KEGGⁱ	hsa:4012
UCSCⁱ	uc003kmv.2 human [Q9UIQ6-1]

Organism-specific databases

CTDⁱ	4012
DisGeNETⁱ	4012
EuPathDBⁱ	HostDB:ENSG00000113441.15
GeneCardsⁱ	LNPEP
H-InvDBⁱ	HIX0005054
HGNCⁱ	HGNC:6656 LNPEP
HPAⁱ	HPA043642
MIMⁱ	151300 gene
neXtProtⁱ	NX_Q9UIQ6
OpenTargetsⁱ	ENSG00000113441
PharmGKBⁱ	PA30418
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1046 Eukaryota COG0308 LUCA
GeneTreeⁱ	ENSGT00940000157902
HOVERGENⁱ	HBG108296
InParanoidⁱ	Q9UIQ6
KOⁱ	K01257
OMAⁱ	LEGHNYT
OrthoDBⁱ	110058at2759
PhylomeDBⁱ	Q9UIQ6
TreeFamⁱ	TF300395

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SABIO-RKⁱ	Q9UIQ6
SIGNORⁱ	Q9UIQ6

Miscellaneous databases

ChiTaRSⁱ	LNPEP human
GeneWikiⁱ	Cystinyl_aminopeptidase
GenomeRNAiⁱ	4012
PMAP-CutDBⁱ	Q9UIQ6
Protein Ontology More...PROⁱ	PR:Q9UIQ6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113441 Expressed in 219 organ(s), highest expression level in placenta
Genevisibleⁱ	Q9UIQ6 HS

Family and domain databases

CDDⁱ	cd09601 M1_APN_2, 1 hit
InterProⁱ	View protein in InterPro IPR034017 Cystinyl_aminopeptidase IPR024571 ERAP1-like_C_dom IPR034016 M1_APN-typ IPR001930 Peptidase_M1 IPR014782 Peptidase_M1_dom
PANTHERⁱ	PTHR11533 PTHR11533, 1 hit PTHR11533:SF42 PTHR11533:SF42, 1 hit
Pfamⁱ	View protein in Pfam PF11838 ERAP1_C, 1 hit PF01433 Peptidase_M1, 1 hit
PRINTSⁱ	PR00756 ALADIPTASE
PROSITEⁱ	View protein in PROSITE PS00142 ZINC_PROTEASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LCAP_HUMAN
Accessionⁱ	Q9UIQ6Primary (citable) accession number: Q9UIQ6 Secondary accession number(s): O00769 , Q15145, Q59H76, Q9TNQ2, Q9TNQ3, Q9UIQ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	April 17, 2007
	Last modified:	February 13, 2019
	This is version 188 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - Q9UIQ6 (LCAP_HUMAN)

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Leucyl-cystinyl aminopeptidase

LNPEP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Cytosol

Endosome

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ