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UniProtKB - Q9UIQ6 (LCAP_HUMAN)

Entry version 200 (02 Dec 2020)
Sequence version 3 (17 Apr 2007)
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Protein

Leucyl-cystinyl aminopeptidase

Gene

LNPEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei295SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi464Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei465Proton acceptorPROSITE-ProRule annotation1
Metal bindingi468Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi487Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei549Transition state stabilizerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UIQ6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1236977, Endosomal/Vacuolar pathway
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9UIQ6

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UIQ6

Protein family/group databases

MEROPS protease database

More...MEROPSi		M01.011

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucyl-cystinyl aminopeptidase (EC:3.4.11.3)
Short name:
Cystinyl aminopeptidase
Alternative name(s):
Insulin-regulated membrane aminopeptidase
Insulin-responsive aminopeptidase
Short name:
IRAP
Oxytocinase
Short name:
OTase
Placental leucine aminopeptidase
Short name:
P-LAP
Cleaved into the following chain:
Leucyl-cystinyl aminopeptidase, pregnancy serum form
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LNPEP
Synonyms:OTASE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000113441.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:6656, LNPEP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		151300, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UIQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 110CytoplasmicSequence analysisAdd BLAST110
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini132 – 1025ExtracellularSequence analysisAdd BLAST894

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4012

Open Targets

More...OpenTargetsi		ENSG00000113441

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30418

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UIQ6, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2693

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1570

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LNPEP

Domain mapping of disease mutations (DMDM)

More...DMDMi		145559489

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000951141 – 1025Leucyl-cystinyl aminopeptidaseAdd BLAST1025
ChainiPRO_0000292264155 – 1025Leucyl-cystinyl aminopeptidase, pregnancy serum formAdd BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei70PhosphotyrosineBy similarity1
Modified residuei80PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi682N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi760N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi834N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi850N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154 – 155Cleavage; to produce pregnancy serum form2

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UIQ6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UIQ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UIQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UIQ6

PeptideAtlas

More...PeptideAtlasi		Q9UIQ6

PRoteomics IDEntifications database

More...PRIDEi		Q9UIQ6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84551 [Q9UIQ6-1]
84552 [Q9UIQ6-2]
84553 [Q9UIQ6-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1455, 10 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UIQ6, 18 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UIQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UIQ6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UIQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113441, Expressed in chorionic villus and 232 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UIQ6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113441, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds tankyrases 1 and 2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110196, 82 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9UIQ6

Protein interaction database and analysis system

More...IntActi		Q9UIQ6, 65 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000231368

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UIQ6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UIQ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11025
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UIQ6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 101Tankyrase binding6
Regioni428 – 432Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi53 – 54Dileucine internalization motifSequence analysis2
Motifi76 – 77Dileucine internalization motifSequence analysis2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1046, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157902

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003705_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UIQ6

Identification of Orthologs from Complete Genome Data

More...OMAi		MSSWTSQ

Database of Orthologous Groups

More...OrthoDBi		110058at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UIQ6

TreeFam database of animal gene trees

More...TreeFami		TF300395

Family and domain databases

Conserved Domains Database

More...CDDi		cd09601, M1_APN-Q_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1730, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR034017, Cystinyl_aminopeptidase
IPR024571, ERAP1-like_C_dom
IPR034016, M1_APN-typ
IPR001930, Peptidase_M1
IPR014782, Peptidase_M1_dom

The PANTHER Classification System

More...PANTHERi		PTHR11533:SF42, PTHR11533:SF42, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11838, ERAP1_C, 1 hit
PF01433, Peptidase_M1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00756, ALADIPTASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF63737, SSF63737, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9UIQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG 
        60         70         80         90        100
SRLLVRGLGE HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD 
       110        120        130        140        150
GACSVPSART MVVCAFVIVV AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL 
       160        170        180        190        200
IQPFATNGKL FPWAQIRLPT AVVPLRYELS LHPNLTSMTF RGSVTISVQA 
       210        220        230        240        250
LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH GQIAIVAPEA 
       260        270        280        290        300
LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR 
       310        320        330        340        350
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE 
       360        370        380        390        400
SVKMSTYLVA FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL 
       410        420        430        440        450
LEFFQNYFEI QYPLKKLDLV AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS 
       460        470        480        490        500
SMADRKLVTK IIAHELAHQW FGNLVTMKWW NDLWLNEGFA TFMEYFSLEK 
       510        520        530        540        550
IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI EEMFDSLSYF 
       560        570        580        590        600
KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT 
       610        620        630        640        650
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY 
       660        670        680        690        700
LWHIPLSYVT EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY 
       710        720        730        740        750
IVHYADDDWE ALIHQLKINP YVLSDKDRAN LINNIFELAG LGKVPLKRAF 
       760        770        780        790        800
DLINYLGNEN HTAPITEALF QTDLIYNLLE KLGYMDLASR LVTRVFKLLQ 
       810        820        830        840        850
NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM KLFDDWMASN 
       860        870        880        890        900
GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS 
       910        920        930        940        950
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN 
       960        970        980        990       1000
KLVQKFPLGS YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV 
      1010       1020 
QEALEVIQLN IQWMEKNLKS LTWWL
Length:1,025
Mass (Da):117,349
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF84C0EA9D48DC2C0
GO
Isoform 2 (identifier: Q9UIQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:1,011
Mass (Da):115,636
Checksum:iFBB54EFECFBA8FD9
GO
Isoform 3 (identifier: Q9UIQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:1,006
Mass (Da):115,062
Checksum:iF57E71F1AA3C28E3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA09436 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92120 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66D → V in CAB61646 (PubMed:10759854).Curated1
Sequence conflicti66D → V in CAB94753 (PubMed:10759854).Curated1
Sequence conflicti301S → L AA sequence (PubMed:8119729).Curated1
Sequence conflicti386K → N in AAB66672 (PubMed:9177475).Curated1
Sequence conflicti386K → N in AAB66673 (PubMed:9177475).Curated1
Sequence conflicti386K → N in CAB61646 (PubMed:10759854).Curated1
Sequence conflicti386K → N in CAB94753 (PubMed:10759854).Curated1
Sequence conflicti892K → Q in BAA09436 (PubMed:8550619).Curated1
Sequence conflicti944F → L in BAA09436 (PubMed:8550619).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03161686S → P. Corresponds to variant dbSNP:rs3797799Ensembl.1
Natural variantiVAR_051567594N → I. Corresponds to variant dbSNP:rs12520455Ensembl.1
Natural variantiVAR_012812763A → T. Corresponds to variant dbSNP:rs2303138Ensembl.1
Natural variantiVAR_051568913S → T. Corresponds to variant dbSNP:rs17087233Ensembl.1
Natural variantiVAR_031617963I → V. Corresponds to variant dbSNP:rs11746232Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0054491 – 19Missing in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0054481 – 14Missing in isoform 2. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D50810 mRNA Translation: BAA09436.1 Different initiation.
U62768 mRNA Translation: AAB66672.1
U62769 mRNA Translation: AAB66673.1
AJ131023 AJ131039 Genomic DNA Translation: CAB61646.1
AJ131025 AJ131039 Genomic DNA Translation: CAB94753.1
AB208883 mRNA Translation: BAD92120.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4087.1 [Q9UIQ6-1]
CCDS43346.1 [Q9UIQ6-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A59383
A59384

NCBI Reference Sequences

More...RefSeqi		NP_005566.2, NM_005575.2 [Q9UIQ6-1]
NP_787116.2, NM_175920.3 [Q9UIQ6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000231368; ENSP00000231368; ENSG00000113441 [Q9UIQ6-1]
ENST00000395770; ENSP00000379117; ENSG00000113441 [Q9UIQ6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4012

UCSC genome browser

More...UCSCi		uc003kmv.2, human [Q9UIQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50810 mRNA Translation: BAA09436.1 Different initiation.
U62768 mRNA Translation: AAB66672.1
U62769 mRNA Translation: AAB66673.1
AJ131023 AJ131039 Genomic DNA Translation: CAB61646.1
AJ131025 AJ131039 Genomic DNA Translation: CAB94753.1
AB208883 mRNA Translation: BAD92120.1 Frameshift.
CCDSiCCDS4087.1 [Q9UIQ6-1]
CCDS43346.1 [Q9UIQ6-2]
PIRiA59383
A59384
RefSeqiNP_005566.2, NM_005575.2 [Q9UIQ6-1]
NP_787116.2, NM_175920.3 [Q9UIQ6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P8QX-ray3.02A/B155-1025[»]
4PJ6X-ray2.96A/B155-1025[»]
4Z7IX-ray3.31A/B155-1025[»]
5C97X-ray3.37A/B155-1025[»]
5JHQX-ray3.20E/F/G/H/I/J/K/L92-107[»]
5MJ6X-ray2.53A/B155-1025[»]
SMRiQ9UIQ6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110196, 82 interactors
ELMiQ9UIQ6
IntActiQ9UIQ6, 65 interactors
STRINGi9606.ENSP00000231368

Chemistry databases

BindingDBiQ9UIQ6
ChEMBLiCHEMBL2693
GuidetoPHARMACOLOGYi1570

Protein family/group databases

MEROPSiM01.011

PTM databases

GlyConnecti1455, 10 N-Linked glycans (2 sites)
GlyGeniQ9UIQ6, 18 sites
iPTMnetiQ9UIQ6
PhosphoSitePlusiQ9UIQ6
SwissPalmiQ9UIQ6

Polymorphism and mutation databases

BioMutaiLNPEP
DMDMi145559489

Proteomic databases

EPDiQ9UIQ6
jPOSTiQ9UIQ6
MassIVEiQ9UIQ6
PaxDbiQ9UIQ6
PeptideAtlasiQ9UIQ6
PRIDEiQ9UIQ6
ProteomicsDBi84551 [Q9UIQ6-1]
84552 [Q9UIQ6-2]
84553 [Q9UIQ6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25094, 136 antibodies

The DNASU plasmid repository

More...DNASUi		4012

Genome annotation databases

EnsembliENST00000231368; ENSP00000231368; ENSG00000113441 [Q9UIQ6-1]
ENST00000395770; ENSP00000379117; ENSG00000113441 [Q9UIQ6-2]
GeneIDi4012
KEGGihsa:4012
UCSCiuc003kmv.2, human [Q9UIQ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4012
DisGeNETi4012
EuPathDBiHostDB:ENSG00000113441.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		LNPEP
HGNCiHGNC:6656, LNPEP
HPAiENSG00000113441, Tissue enriched (placenta)
MIMi151300, gene
neXtProtiNX_Q9UIQ6
OpenTargetsiENSG00000113441
PharmGKBiPA30418

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1046, Eukaryota
GeneTreeiENSGT00940000157902
HOGENOMiCLU_003705_2_2_1
InParanoidiQ9UIQ6
OMAiMSSWTSQ
OrthoDBi110058at2759
PhylomeDBiQ9UIQ6
TreeFamiTF300395

Enzyme and pathway databases

PathwayCommonsiQ9UIQ6
ReactomeiR-HSA-1236977, Endosomal/Vacuolar pathway
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SABIO-RKiQ9UIQ6
SIGNORiQ9UIQ6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4012, 4 hits in 848 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LNPEP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cystinyl_aminopeptidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4012
PharosiQ9UIQ6, Tchem

Protein Ontology

More...PROi		PR:Q9UIQ6
RNActiQ9UIQ6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113441, Expressed in chorionic villus and 232 other tissues
GenevisibleiQ9UIQ6, HS

Family and domain databases

CDDicd09601, M1_APN-Q_like, 1 hit
Gene3Di2.60.40.1730, 1 hit
InterProiView protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR034017, Cystinyl_aminopeptidase
IPR024571, ERAP1-like_C_dom
IPR034016, M1_APN-typ
IPR001930, Peptidase_M1
IPR014782, Peptidase_M1_dom
PANTHERiPTHR11533:SF42, PTHR11533:SF42, 1 hit
PfamiView protein in Pfam
PF11838, ERAP1_C, 1 hit
PF01433, Peptidase_M1, 1 hit
PRINTSiPR00756, ALADIPTASE
SUPFAMiSSF63737, SSF63737, 1 hit
PROSITEiView protein in PROSITE
PS00142, ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIQ6
Secondary accession number(s): O00769
, Q15145, Q59H76, Q9TNQ2, Q9TNQ3, Q9UIQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: April 17, 2007
Last modified: December 2, 2020
This is version 200 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Peptidase families
    Classification of peptidase families and list of entries
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