UniProtKB - Q9UIQ6 (LCAP_HUMAN)
Protein
Leucyl-cystinyl aminopeptidase
Gene
LNPEP
Organism
Homo sapiens (Human)
Status
Functioni
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.3 Publications
Catalytic activityi
- Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.2 Publications EC:3.4.11.3
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 295 | SubstrateBy similarity | 1 | |
Metal bindingi | 464 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 465 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 468 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 487 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Sitei | 549 | Transition state stabilizerBy similarity | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: Reactome
- metalloaminopeptidase activity Source: GO_Central
- metallopeptidase activity Source: ProtInc
- peptide binding Source: GO_Central
- zinc ion binding Source: GO_Central
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
- cell-cell signaling Source: ProtInc
- female pregnancy Source: ProtInc
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- peptide catabolic process Source: GO_Central
- protein catabolic process Source: Ensembl
- protein polyubiquitination Source: Reactome
- proteolysis Source: GO_Central
- SMAD protein signal transduction Source: Ensembl
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SABIO-RKi | Q9UIQ6 |
SIGNORi | Q9UIQ6 |
Protein family/group databases
MEROPSi | M01.011 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucyl-cystinyl aminopeptidase (EC:3.4.11.3)Short name: Cystinyl aminopeptidase Alternative name(s): Insulin-regulated membrane aminopeptidase Insulin-responsive aminopeptidase Short name: IRAP Oxytocinase Short name: OTase Placental leucine aminopeptidase Short name: P-LAP Cleaved into the following chain: |
Gene namesi | Name:LNPEP Synonyms:OTASE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000113441.15 |
HGNCi | HGNC:6656 LNPEP |
MIMi | 151300 gene |
neXtProti | NX_Q9UIQ6 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Note: In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Leucyl-cystinyl aminopeptidase, pregnancy serum form :
Extracellular region or secreted
Note: During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
Cytosol
- cytosol Source: Reactome
Endosome
- early endosome lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: HGNC
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic vesicle membrane Source: Ensembl
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 110 | CytoplasmicSequence analysisAdd BLAST | 110 | |
Transmembranei | 111 – 131 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 132 – 1025 | ExtracellularSequence analysisAdd BLAST | 894 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 4012 |
OpenTargetsi | ENSG00000113441 |
PharmGKBi | PA30418 |
Chemistry databases
ChEMBLi | CHEMBL2693 |
GuidetoPHARMACOLOGYi | 1570 |
Polymorphism and mutation databases
BioMutai | LNPEP |
DMDMi | 145559489 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095114 | 1 – 1025 | Leucyl-cystinyl aminopeptidaseAdd BLAST | 1025 | |
ChainiPRO_0000292264 | 155 – 1025 | Leucyl-cystinyl aminopeptidase, pregnancy serum formAdd BLAST | 871 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 70 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 80 | PhosphoserineCombined sources | 1 | |
Modified residuei | 91 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 184 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 368 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 374 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 448 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 525 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 578 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 598 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 664 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 682 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 760 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 834 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 850 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 989 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
N-glycosylated.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 154 – 155 | Cleavage; to produce pregnancy serum form | 2 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9UIQ6 |
jPOSTi | Q9UIQ6 |
PaxDbi | Q9UIQ6 |
PeptideAtlasi | Q9UIQ6 |
PRIDEi | Q9UIQ6 |
ProteomicsDBi | 84551 84552 [Q9UIQ6-2] 84553 [Q9UIQ6-3] |
PTM databases
GlyConnecti | 1455 |
iPTMneti | Q9UIQ6 |
PhosphoSitePlusi | Q9UIQ6 |
SwissPalmi | Q9UIQ6 |
Miscellaneous databases
PMAP-CutDBi | Q9UIQ6 |
Expressioni
Tissue specificityi
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.3 Publications
Gene expression databases
Bgeei | ENSG00000113441 Expressed in 219 organ(s), highest expression level in placenta |
Genevisiblei | Q9UIQ6 HS |
Organism-specific databases
HPAi | HPA043642 |
Interactioni
Subunit structurei
Homodimer. Binds tankyrases 1 and 2.
Binary interactionsi
Protein-protein interaction databases
BioGridi | 110196, 46 interactors |
ELMi | Q9UIQ6 |
IntActi | Q9UIQ6, 42 interactors |
STRINGi | 9606.ENSP00000231368 |
Chemistry databases
BindingDBi | Q9UIQ6 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4P8Q | X-ray | 3.02 | A/B | 155-1025 | [»] | |
4PJ6 | X-ray | 2.96 | A/B | 155-1025 | [»] | |
4Z7I | X-ray | 3.31 | A/B | 155-1025 | [»] | |
5C97 | X-ray | 3.37 | A/B | 155-1025 | [»] | |
5JHQ | X-ray | 3.20 | E/F/G/H/I/J/K/L | 92-107 | [»] | |
5MJ6 | X-ray | 2.53 | A/B | 155-1025 | [»] | |
ProteinModelPortali | Q9UIQ6 | |||||
SMRi | Q9UIQ6 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 96 – 101 | Tankyrase binding | 6 | |
Regioni | 428 – 432 | Substrate bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 53 – 54 | Dileucine internalization motifSequence analysis | 2 | |
Motifi | 76 – 77 | Dileucine internalization motifSequence analysis | 2 |
Sequence similaritiesi
Belongs to the peptidase M1 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1046 Eukaryota COG0308 LUCA |
GeneTreei | ENSGT00940000157902 |
HOVERGENi | HBG108296 |
InParanoidi | Q9UIQ6 |
KOi | K01257 |
OMAi | LEGHNYT |
OrthoDBi | 110058at2759 |
PhylomeDBi | Q9UIQ6 |
TreeFami | TF300395 |
Family and domain databases
CDDi | cd09601 M1_APN_2, 1 hit |
InterProi | View protein in InterPro IPR034017 Cystinyl_aminopeptidase IPR024571 ERAP1-like_C_dom IPR034016 M1_APN-typ IPR001930 Peptidase_M1 IPR014782 Peptidase_M1_dom |
PANTHERi | PTHR11533 PTHR11533, 1 hit PTHR11533:SF42 PTHR11533:SF42, 1 hit |
Pfami | View protein in Pfam PF11838 ERAP1_C, 1 hit PF01433 Peptidase_M1, 1 hit |
PRINTSi | PR00756 ALADIPTASE |
PROSITEi | View protein in PROSITE PS00142 ZINC_PROTEASE, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketNote: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9UIQ6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG
60 70 80 90 100
SRLLVRGLGE HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD
110 120 130 140 150
GACSVPSART MVVCAFVIVV AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL
160 170 180 190 200
IQPFATNGKL FPWAQIRLPT AVVPLRYELS LHPNLTSMTF RGSVTISVQA
210 220 230 240 250
LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH GQIAIVAPEA
260 270 280 290 300
LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR
310 320 330 340 350
SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE
360 370 380 390 400
SVKMSTYLVA FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL
410 420 430 440 450
LEFFQNYFEI QYPLKKLDLV AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS
460 470 480 490 500
SMADRKLVTK IIAHELAHQW FGNLVTMKWW NDLWLNEGFA TFMEYFSLEK
510 520 530 540 550
IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI EEMFDSLSYF
560 570 580 590 600
KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT
610 620 630 640 650
LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY
660 670 680 690 700
LWHIPLSYVT EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY
710 720 730 740 750
IVHYADDDWE ALIHQLKINP YVLSDKDRAN LINNIFELAG LGKVPLKRAF
760 770 780 790 800
DLINYLGNEN HTAPITEALF QTDLIYNLLE KLGYMDLASR LVTRVFKLLQ
810 820 830 840 850
NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM KLFDDWMASN
860 870 880 890 900
GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS
910 920 930 940 950
EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN
960 970 980 990 1000
KLVQKFPLGS YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV
1010 1020
QEALEVIQLN IQWMEKNLKS LTWWL
Sequence cautioni
The sequence BAA09436 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | D → V in CAB61646 (PubMed:10759854).Curated | 1 | |
Sequence conflicti | 66 | D → V in CAB94753 (PubMed:10759854).Curated | 1 | |
Sequence conflicti | 301 | S → L AA sequence (PubMed:8119729).Curated | 1 | |
Sequence conflicti | 386 | K → N in AAB66672 (PubMed:9177475).Curated | 1 | |
Sequence conflicti | 386 | K → N in AAB66673 (PubMed:9177475).Curated | 1 | |
Sequence conflicti | 386 | K → N in CAB61646 (PubMed:10759854).Curated | 1 | |
Sequence conflicti | 386 | K → N in CAB94753 (PubMed:10759854).Curated | 1 | |
Sequence conflicti | 892 | K → Q in BAA09436 (PubMed:8550619).Curated | 1 | |
Sequence conflicti | 944 | F → L in BAA09436 (PubMed:8550619).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031616 | 86 | S → P. Corresponds to variant dbSNP:rs3797799Ensembl. | 1 | |
Natural variantiVAR_051567 | 594 | N → I. Corresponds to variant dbSNP:rs12520455Ensembl. | 1 | |
Natural variantiVAR_012812 | 763 | A → T. Corresponds to variant dbSNP:rs2303138Ensembl. | 1 | |
Natural variantiVAR_051568 | 913 | S → T. Corresponds to variant dbSNP:rs17087233Ensembl. | 1 | |
Natural variantiVAR_031617 | 963 | I → V. Corresponds to variant dbSNP:rs11746232Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005449 | 1 – 19 | Missing in isoform 3. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_005448 | 1 – 14 | Missing in isoform 2. 2 PublicationsAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50810 mRNA Translation: BAA09436.1 Different initiation. U62768 mRNA Translation: AAB66672.1 U62769 mRNA Translation: AAB66673.1 AJ131023 AJ131039 Genomic DNA Translation: CAB61646.1 AJ131025 AJ131039 Genomic DNA Translation: CAB94753.1 AB208883 mRNA Translation: BAD92120.1 Frameshift. |
CCDSi | CCDS4087.1 [Q9UIQ6-1] CCDS43346.1 [Q9UIQ6-2] |
PIRi | A59383 A59384 |
RefSeqi | NP_005566.2, NM_005575.2 [Q9UIQ6-1] NP_787116.2, NM_175920.3 [Q9UIQ6-2] |
UniGenei | Hs.527199 Hs.656905 |
Genome annotation databases
Ensembli | ENST00000231368; ENSP00000231368; ENSG00000113441 [Q9UIQ6-1] ENST00000395770; ENSP00000379117; ENSG00000113441 [Q9UIQ6-2] |
GeneIDi | 4012 |
KEGGi | hsa:4012 |
UCSCi | uc003kmv.2 human [Q9UIQ6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50810 mRNA Translation: BAA09436.1 Different initiation. U62768 mRNA Translation: AAB66672.1 U62769 mRNA Translation: AAB66673.1 AJ131023 AJ131039 Genomic DNA Translation: CAB61646.1 AJ131025 AJ131039 Genomic DNA Translation: CAB94753.1 AB208883 mRNA Translation: BAD92120.1 Frameshift. |
CCDSi | CCDS4087.1 [Q9UIQ6-1] CCDS43346.1 [Q9UIQ6-2] |
PIRi | A59383 A59384 |
RefSeqi | NP_005566.2, NM_005575.2 [Q9UIQ6-1] NP_787116.2, NM_175920.3 [Q9UIQ6-2] |
UniGenei | Hs.527199 Hs.656905 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4P8Q | X-ray | 3.02 | A/B | 155-1025 | [»] | |
4PJ6 | X-ray | 2.96 | A/B | 155-1025 | [»] | |
4Z7I | X-ray | 3.31 | A/B | 155-1025 | [»] | |
5C97 | X-ray | 3.37 | A/B | 155-1025 | [»] | |
5JHQ | X-ray | 3.20 | E/F/G/H/I/J/K/L | 92-107 | [»] | |
5MJ6 | X-ray | 2.53 | A/B | 155-1025 | [»] | |
ProteinModelPortali | Q9UIQ6 | |||||
SMRi | Q9UIQ6 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 110196, 46 interactors |
ELMi | Q9UIQ6 |
IntActi | Q9UIQ6, 42 interactors |
STRINGi | 9606.ENSP00000231368 |
Chemistry databases
BindingDBi | Q9UIQ6 |
ChEMBLi | CHEMBL2693 |
GuidetoPHARMACOLOGYi | 1570 |
Protein family/group databases
MEROPSi | M01.011 |
PTM databases
GlyConnecti | 1455 |
iPTMneti | Q9UIQ6 |
PhosphoSitePlusi | Q9UIQ6 |
SwissPalmi | Q9UIQ6 |
Polymorphism and mutation databases
BioMutai | LNPEP |
DMDMi | 145559489 |
Proteomic databases
EPDi | Q9UIQ6 |
jPOSTi | Q9UIQ6 |
PaxDbi | Q9UIQ6 |
PeptideAtlasi | Q9UIQ6 |
PRIDEi | Q9UIQ6 |
ProteomicsDBi | 84551 84552 [Q9UIQ6-2] 84553 [Q9UIQ6-3] |
Protocols and materials databases
DNASUi | 4012 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000231368; ENSP00000231368; ENSG00000113441 [Q9UIQ6-1] ENST00000395770; ENSP00000379117; ENSG00000113441 [Q9UIQ6-2] |
GeneIDi | 4012 |
KEGGi | hsa:4012 |
UCSCi | uc003kmv.2 human [Q9UIQ6-1] |
Organism-specific databases
CTDi | 4012 |
DisGeNETi | 4012 |
EuPathDBi | HostDB:ENSG00000113441.15 |
GeneCardsi | LNPEP |
H-InvDBi | HIX0005054 |
HGNCi | HGNC:6656 LNPEP |
HPAi | HPA043642 |
MIMi | 151300 gene |
neXtProti | NX_Q9UIQ6 |
OpenTargetsi | ENSG00000113441 |
PharmGKBi | PA30418 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1046 Eukaryota COG0308 LUCA |
GeneTreei | ENSGT00940000157902 |
HOVERGENi | HBG108296 |
InParanoidi | Q9UIQ6 |
KOi | K01257 |
OMAi | LEGHNYT |
OrthoDBi | 110058at2759 |
PhylomeDBi | Q9UIQ6 |
TreeFami | TF300395 |
Enzyme and pathway databases
Reactomei | R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SABIO-RKi | Q9UIQ6 |
SIGNORi | Q9UIQ6 |
Miscellaneous databases
ChiTaRSi | LNPEP human |
GeneWikii | Cystinyl_aminopeptidase |
GenomeRNAii | 4012 |
PMAP-CutDBi | Q9UIQ6 |
PROi | PR:Q9UIQ6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113441 Expressed in 219 organ(s), highest expression level in placenta |
Genevisiblei | Q9UIQ6 HS |
Family and domain databases
CDDi | cd09601 M1_APN_2, 1 hit |
InterProi | View protein in InterPro IPR034017 Cystinyl_aminopeptidase IPR024571 ERAP1-like_C_dom IPR034016 M1_APN-typ IPR001930 Peptidase_M1 IPR014782 Peptidase_M1_dom |
PANTHERi | PTHR11533 PTHR11533, 1 hit PTHR11533:SF42 PTHR11533:SF42, 1 hit |
Pfami | View protein in Pfam PF11838 ERAP1_C, 1 hit PF01433 Peptidase_M1, 1 hit |
PRINTSi | PR00756 ALADIPTASE |
PROSITEi | View protein in PROSITE PS00142 ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | LCAP_HUMAN | |
Accessioni | Q9UIQ6Primary (citable) accession number: Q9UIQ6 Secondary accession number(s): O00769 Q9UIQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | April 17, 2007 | |
Last modified: | February 13, 2019 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations