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Protein

FK506-binding protein-like

Gene

FKBPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.1 Publication

GO - Biological processi

  • protein stabilization Source: Reactome
  • regulation of blood vessel branching Source: Ensembl
  • response to radiation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:FKBPL
Synonyms:DIR1, NG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204315.3
HGNCiHGNC:13949 FKBPL
neXtProtiNX_Q9UIM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi287K → A: Abolishes HSP90AB1 binding; when associated with A-291. 1 Publication1
Mutagenesisi291R → A: Abolishes HSP90AB1 binding; when associated with A-287. 1 Publication1

Organism-specific databases

DisGeNETi63943
OpenTargetsiENSG00000204315
PharmGKBiPA28167

Polymorphism and mutation databases

BioMutaiFKBPL
DMDMi74762773

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898781 – 349FK506-binding protein-likeAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UIM3
MaxQBiQ9UIM3
PaxDbiQ9UIM3
PeptideAtlasiQ9UIM3
PRIDEiQ9UIM3
ProteomicsDBi84550

PTM databases

iPTMnetiQ9UIM3
PhosphoSitePlusiQ9UIM3

Expressioni

Tissue specificityi

Ubiquitously expressed with higher levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000204315 Expressed in 186 organ(s), highest expression level in body of stomach
CleanExiHS_FKBPL
ExpressionAtlasiQ9UIM3 baseline and differential
GenevisibleiQ9UIM3 HS

Organism-specific databases

HPAiHPA043478
HPA060158

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.

Binary interactionsi

Protein-protein interaction databases

BioGridi122007, 24 interactors
CORUMiQ9UIM3
IntActiQ9UIM3, 55 interactors
STRINGi9606.ENSP00000364298

Structurei

3D structure databases

ProteinModelPortaliQ9UIM3
SMRiQ9UIM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati210 – 243TPR 1Add BLAST34
Repeati252 – 285TPR 2Add BLAST34
Repeati286 – 319TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00920000149187
HOGENOMiHOG000272638
HOVERGENiHBG099465
InParanoidiQ9UIM3
KOiK20097
OMAiDSWELEA
OrthoDBiEOG091G0G4G
PhylomeDBiQ9UIM3
TreeFamiTF105297

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UIM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE
60 70 80 90 100
VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP
110 120 130 140 150
DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP
160 170 180 190 200
WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE
210 220 230 240 250
LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE
260 270 280 290 300
RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG
310 320 330 340
NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG
Length:349
Mass (Da):38,176
Last modified:May 1, 2000 - v1
Checksum:i428EDD70FD9C807C
GO

Sequence cautioni

The sequence BAB15663 differs from that shown. Reason: Frameshift at positions 201, 205 and 319.Curated
The sequence CAG33655 differs from that shown. Reason: Frameshift at position 201.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203T → I in CAG33655 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06154690A → T1 PublicationCorresponds to variant dbSNP:rs28732176Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139374 Genomic DNA Translation: AAF67785.1
AK027119 mRNA Translation: BAB15663.1 Frameshift.
AK291418 mRNA Translation: BAF84107.1
U89337 Genomic DNA Translation: AAF04864.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
CR753803 Genomic DNA No translation available.
CR925796 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03586.1
BC004168 mRNA Translation: AAH04168.1
BC011966 mRNA Translation: AAH11966.1
CR457374 mRNA Translation: CAG33655.1 Frameshift.
CCDSiCCDS4738.1
RefSeqiNP_071393.2, NM_022110.3
UniGeneiHs.520042

Genome annotation databases

EnsembliENST00000375156; ENSP00000364298; ENSG00000204315
ENST00000425378; ENSP00000397530; ENSG00000230907
ENST00000443350; ENSP00000398812; ENSG00000223666
ENST00000456854; ENSP00000412439; ENSG00000224200
GeneIDi63943
KEGGihsa:63943
UCSCiuc003nzr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139374 Genomic DNA Translation: AAF67785.1
AK027119 mRNA Translation: BAB15663.1 Frameshift.
AK291418 mRNA Translation: BAF84107.1
U89337 Genomic DNA Translation: AAF04864.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
CR753803 Genomic DNA No translation available.
CR925796 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03586.1
BC004168 mRNA Translation: AAH04168.1
BC011966 mRNA Translation: AAH11966.1
CR457374 mRNA Translation: CAG33655.1 Frameshift.
CCDSiCCDS4738.1
RefSeqiNP_071393.2, NM_022110.3
UniGeneiHs.520042

3D structure databases

ProteinModelPortaliQ9UIM3
SMRiQ9UIM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122007, 24 interactors
CORUMiQ9UIM3
IntActiQ9UIM3, 55 interactors
STRINGi9606.ENSP00000364298

PTM databases

iPTMnetiQ9UIM3
PhosphoSitePlusiQ9UIM3

Polymorphism and mutation databases

BioMutaiFKBPL
DMDMi74762773

Proteomic databases

EPDiQ9UIM3
MaxQBiQ9UIM3
PaxDbiQ9UIM3
PeptideAtlasiQ9UIM3
PRIDEiQ9UIM3
ProteomicsDBi84550

Protocols and materials databases

DNASUi63943
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375156; ENSP00000364298; ENSG00000204315
ENST00000425378; ENSP00000397530; ENSG00000230907
ENST00000443350; ENSP00000398812; ENSG00000223666
ENST00000456854; ENSP00000412439; ENSG00000224200
GeneIDi63943
KEGGihsa:63943
UCSCiuc003nzr.4 human

Organism-specific databases

CTDi63943
DisGeNETi63943
EuPathDBiHostDB:ENSG00000204315.3
GeneCardsiFKBPL
HGNCiHGNC:13949 FKBPL
HPAiHPA043478
HPA060158
neXtProtiNX_Q9UIM3
OpenTargetsiENSG00000204315
PharmGKBiPA28167
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00920000149187
HOGENOMiHOG000272638
HOVERGENiHBG099465
InParanoidiQ9UIM3
KOiK20097
OMAiDSWELEA
OrthoDBiEOG091G0G4G
PhylomeDBiQ9UIM3
TreeFamiTF105297

Enzyme and pathway databases

ReactomeiR-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

Miscellaneous databases

ChiTaRSiFKBPL human
GeneWikiiFKBPL
GenomeRNAii63943
PROiPR:Q9UIM3

Gene expression databases

BgeeiENSG00000204315 Expressed in 186 organ(s), highest expression level in body of stomach
CleanExiHS_FKBPL
ExpressionAtlasiQ9UIM3 baseline and differential
GenevisibleiQ9UIM3 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBPL_HUMAN
AccessioniPrimary (citable) accession number: Q9UIM3
Secondary accession number(s): A8K5V3, B0UYX8, Q9H5G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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