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Entry version 157 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Tomoregulin-2

Gene

TMEFF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I01.969

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tomoregulin-2
Short name:
TR-2
Alternative name(s):
Hyperplastic polyposis protein 1
Transmembrane protein with EGF-like and two follistatin-like domains
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEFF2
Synonyms:HPP1, TENB2, TPEF
ORF Names:UNQ178/PRO204
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11867 TMEFF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605734 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIK5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 320ExtracellularSequence analysisAdd BLAST280
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 374CytoplasmicSequence analysisAdd BLAST33

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23671

Open Targets

More...
OpenTargetsi
ENSG00000144339

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36568

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UIK5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEFF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153590

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 401 PublicationAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001658741 – 374Tomoregulin-2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi91 ↔ 121PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Disulfide bondi103 ↔ 135PROSITE-ProRule annotation
Disulfide bondi182 ↔ 213PROSITE-ProRule annotation
Disulfide bondi186 ↔ 206PROSITE-ProRule annotation
Disulfide bondi195 ↔ 227PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) (complex) asparagine; atypical1 Publication1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 278By similarity
Disulfide bondi273 ↔ 289By similarity
Disulfide bondi291 ↔ 300By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.2 Publications
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UIK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UIK5

PeptideAtlas

More...
PeptideAtlasi
Q9UIK5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UIK5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84539 [Q9UIK5-1]
84540 [Q9UIK5-2]
84541 [Q9UIK5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIK5

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9UIK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.6 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144339 Expressed in 144 organ(s), highest expression level in middle temporal gyrus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UIK5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015587

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050673EBI-11423693,EBI-21194918

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117189, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UIK5, 10 interactors

Molecular INTeraction database

More...
MINTi
Q9UIK5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272771

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 137Kazal-like 1PROSITE-ProRule annotationAdd BLAST53
Domaini176 – 229Kazal-like 2PROSITE-ProRule annotationAdd BLAST54
Domaini261 – 301EGF-likePROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni303 – 320Required for sheddingAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tomoregulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP0A Eukaryota
ENOG4110TEU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156056

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UIK5

KEGG Orthology (KO)

More...
KOi
K23608

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNCSGFD

Database of Orthologous Groups

More...
OrthoDBi
773030at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UIK5

TreeFam database of animal gene trees

More...
TreeFami
TF330868

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648 Kazal_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00280 KAZAL, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS51465 KAZAL_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UIK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT
60 70 80 90 100
PTGWNCSGYD DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV
110 120 130 140 150
PVCGSNGESY QNECYLRQAA CKQQSEILVV SEGSCATDAG SGSGDGVHEG
160 170 180 190 200
SGETSQKETS TCDICQFGAE CDEDAEDVWC VCNIDCSQTN FNPLCASDGK
210 220 230 240 250
SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG HYARTDYAEN
260 270 280 290 300
ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC
310 320 330 340 350
EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR
360 370
IHRQKQNTGH YSSDNTTRAS TRLI
Length:374
Mass (Da):41,428
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44452F680FEBDCDB
GO
Isoform 2 (identifier: Q9UIK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-346: KCP → AKL
     347-374: Missing.

Show »
Length:346
Mass (Da):38,132
Checksum:iA2C7231AD4CD43EA
GO
Isoform 3 (identifier: Q9UIK5-3) [UniParc]FASTAAdd to basket
Also known as: TMEFF2-S

The sequence of this isoform differs from the canonical sequence as follows:
     147-175: VHEGSGETSQKETSTCDICQFGAECDEDA → GRSCLFTYLKIYWWILLCIFTYVCSISDI
     176-374: Missing.

Show »
Length:175
Mass (Da):19,472
Checksum:i8CF92F9D9FB171DF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90820 differs from that shown. Contaminating sequence. Mitochondrial contamination starting in position 361.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28M → V in BAD96411 (Ref. 8) Curated1
Sequence conflicti63E → G in BAC11030 (PubMed:14702039).Curated1
Sequence conflicti222M → T in BAD96411 (Ref. 8) Curated1
Sequence conflicti339L → H in BAD96411 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024973147 – 175VHEGS…CDEDA → GRSCLFTYLKIYWWILLCIF TYVCSISDI in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_024974176 – 374Missing in isoform 3. 1 PublicationAdd BLAST199
Alternative sequenceiVSP_014312344 – 346KCP → AKL in isoform 2. 2 Publications3
Alternative sequenceiVSP_014313347 – 374Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017269 mRNA Translation: BAA87897.1
AF242221 Genomic DNA Translation: AAG49451.1
AF242222 mRNA Translation: AAG49452.1
AF179274 mRNA Translation: AAD55776.2
DQ133599 mRNA Translation: AAZ43216.1
AY358907 mRNA Translation: AAQ89266.1
AK074507 mRNA Translation: BAC11030.1
CR457390 mRNA Translation: CAG33671.1
AK222691 mRNA Translation: BAD96411.1
AL157430 mRNA Translation: CAB75654.1
AC092644 Genomic DNA Translation: AAY14874.1
AC098617 Genomic DNA Translation: AAX88893.1
BC008973 mRNA Translation: AAH08973.1
AB004064 mRNA Translation: BAA90820.1 Different termination.
AF264150 Genomic DNA Translation: AAF91397.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2314.1 [Q9UIK5-1]
CCDS82547.1 [Q9UIK5-3]
CCDS82548.1 [Q9UIK5-2]

Protein sequence database of the Protein Information Resource

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PIRi
T46914

NCBI Reference Sequences

More...
RefSeqi
NP_001292063.1, NM_001305134.1 [Q9UIK5-2]
NP_001292074.1, NM_001305145.1 [Q9UIK5-3]
NP_057276.2, NM_016192.3 [Q9UIK5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272771; ENSP00000272771; ENSG00000144339 [Q9UIK5-1]
ENST00000392314; ENSP00000376128; ENSG00000144339 [Q9UIK5-2]
ENST00000409056; ENSP00000386871; ENSG00000144339 [Q9UIK5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23671

UCSC genome browser

More...
UCSCi
uc002utc.4 human [Q9UIK5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017269 mRNA Translation: BAA87897.1
AF242221 Genomic DNA Translation: AAG49451.1
AF242222 mRNA Translation: AAG49452.1
AF179274 mRNA Translation: AAD55776.2
DQ133599 mRNA Translation: AAZ43216.1
AY358907 mRNA Translation: AAQ89266.1
AK074507 mRNA Translation: BAC11030.1
CR457390 mRNA Translation: CAG33671.1
AK222691 mRNA Translation: BAD96411.1
AL157430 mRNA Translation: CAB75654.1
AC092644 Genomic DNA Translation: AAY14874.1
AC098617 Genomic DNA Translation: AAX88893.1
BC008973 mRNA Translation: AAH08973.1
AB004064 mRNA Translation: BAA90820.1 Different termination.
AF264150 Genomic DNA Translation: AAF91397.1
CCDSiCCDS2314.1 [Q9UIK5-1]
CCDS82547.1 [Q9UIK5-3]
CCDS82548.1 [Q9UIK5-2]
PIRiT46914
RefSeqiNP_001292063.1, NM_001305134.1 [Q9UIK5-2]
NP_001292074.1, NM_001305145.1 [Q9UIK5-3]
NP_057276.2, NM_016192.3 [Q9UIK5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FMWmodel-A264-301[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117189, 2 interactors
IntActiQ9UIK5, 10 interactors
MINTiQ9UIK5
STRINGi9606.ENSP00000272771

Protein family/group databases

MEROPSiI01.969

PTM databases

iPTMnetiQ9UIK5
PhosphoSitePlusiQ9UIK5

Polymorphism and mutation databases

BioMutaiTMEFF2
DMDMi71153590

Proteomic databases

MassIVEiQ9UIK5
PaxDbiQ9UIK5
PeptideAtlasiQ9UIK5
PRIDEiQ9UIK5
ProteomicsDBi84539 [Q9UIK5-1]
84540 [Q9UIK5-2]
84541 [Q9UIK5-3]

Genome annotation databases

EnsembliENST00000272771; ENSP00000272771; ENSG00000144339 [Q9UIK5-1]
ENST00000392314; ENSP00000376128; ENSG00000144339 [Q9UIK5-2]
ENST00000409056; ENSP00000386871; ENSG00000144339 [Q9UIK5-3]
GeneIDi23671
KEGGihsa:23671
UCSCiuc002utc.4 human [Q9UIK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23671
DisGeNETi23671

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEFF2
HGNCiHGNC:11867 TMEFF2
HPAiHPA015587
MIMi605734 gene
neXtProtiNX_Q9UIK5
OpenTargetsiENSG00000144339
PharmGKBiPA36568

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IP0A Eukaryota
ENOG4110TEU LUCA
GeneTreeiENSGT00940000156056
InParanoidiQ9UIK5
KOiK23608
OMAiWNCSGFD
OrthoDBi773030at2759
PhylomeDBiQ9UIK5
TreeFamiTF330868

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEFF2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TMEFF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23671
PharosiQ9UIK5
PMAP-CutDBiQ9UIK5

Protein Ontology

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PROi
PR:Q9UIK5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144339 Expressed in 144 organ(s), highest expression level in middle temporal gyrus
GenevisibleiQ9UIK5 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS51465 KAZAL_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEFF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIK5
Secondary accession number(s): Q2FA44
, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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