DAPK2

Functionⁱ

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).3 Publications

Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactorⁱ

Mg²⁺3 Publications

Activity regulationⁱ

Activated by Ca²⁺/calmodulin. Regulated by a double locking mechanism, involving autophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 is phosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318, release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain, and generation of the monomeric active form of the kinase.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	52	ATPPROSITE-ProRule annotation2 Publications		1
Active siteⁱ	149	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	29 – 37	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376525
calmodulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376525
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10629061
- 11230133
protein serine/threonine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 16756490

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anoikis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18957423
apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 10629061
intracellular signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 10376525
neutrophil migration Source: Ensembl
peptidyl-serine phosphorylation Source: GO_Central
peptidyl-threonine phosphorylation Source: GO_Central
positive regulation of eosinophil chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24163421
positive regulation of neutrophil chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24163421
protein autophosphorylation
Source: UniProtKB
Traceable author statementⁱ
- 16756490
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 10376525
regulation of apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 16756490
regulation of autophagy
Source: UniProtKB
Traceable author statementⁱ
- 16756490
regulation of intrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10376525

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418889 via Dependence Receptors in the absence of ligand
SignaLinkⁱ	Q9UIK4
SIGNORⁱ	Q9UIK4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Death-associated protein kinase 2 (EC:2.7.11.12 Publications) Short name: DAP kinase 2 Alternative name(s): DAP-kinase-related protein 1 Short name: DRP-1
Gene namesⁱ	Name:DAPK2
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000035664.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2675 DAPK2
MIMⁱ	616567 gene
neXtProtⁱ	NX_Q9UIK4

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	52	K → A: Loss of activity, apoptotic function and of autophosphorylation. 3 Publications	1
Mutagenesisⁱ	299 – 330	Missing : Loss of ca(2+)-calmodulin binding, increase in activity, loss of autophosphorylation. Add BLAST	32
Mutagenesisⁱ	299	S → A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity. 1 Publication	1
Mutagenesisⁱ	318	S → A: Loss of Ca(2+)-calmodulin independent phosphorylation, increase in apoptotic activity. 1 Publication	1
Mutagenesisⁱ	318	S → D: Abolishes apoptotic activity. 1 Publication	1
Mutagenesisⁱ	320	S → A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity. 1 Publication	1
Mutagenesisⁱ	323	S → A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity. 1 Publication	1
Mutagenesisⁱ	329	T → A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity. 1 Publication	1
Mutagenesisⁱ	367	S → A: No effect on interaction with YWHAE. 1 Publication	1
Mutagenesisⁱ	368	S → A: No effect on interaction with YWHAE. 1 Publication	1
Mutagenesisⁱ	369	T → A: Interaction with YWHAE is reduced. 1 Publication	1
Mutagenesisⁱ	370	S → A: Interaction with YWHAE is increased. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23604
Open Targets More...OpenTargetsⁱ	ENSG00000035664
PharmGKBⁱ	PA27143

Chemistry databases

ChEMBLⁱ	CHEMBL3123

ChEMBLⁱ

CHEMBL3123

Polymorphism and mutation databases

BioMutaⁱ	DAPK2
DMDMⁱ	38605084

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085912	1 – 370	Death-associated protein kinase 2Add BLAST		370

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	299	PhosphoserineCombined sources	1
Modified residueⁱ	318	Phosphoserine; by autocatalysis1 Publication	1
Modified residueⁱ	349	PhosphoserineCombined sources	1
Modified residueⁱ	369	Phosphothreonine; by PKB/AKT11 Publication	1

Post-translational modificationⁱ

Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UIK4
PaxDbⁱ	Q9UIK4
PeptideAtlas More...PeptideAtlasⁱ	Q9UIK4
PRIDEⁱ	Q9UIK4
ProteomicsDBⁱ	84537 84538 [Q9UIK4-2]

PTM databases

iPTMnetⁱ	Q9UIK4
PhosphoSitePlusⁱ	Q9UIK4

Expressionⁱ

Tissue specificityⁱ

Expressed in neutrophils and eosinophils (PubMed:24163421). Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle.4 Publications

Inductionⁱ

Up-regulated during granulocytic maturation (PubMed:17347302, PubMed:24163421).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000035664 Expressed in 210 organ(s), highest expression level in right lobe of thyroid gland
CleanExⁱ	HS_DAPK2
ExpressionAtlasⁱ	Q9UIK4 baseline and differential
Genevisibleⁱ	Q9UIK4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071581

HPAⁱ

HPA071581

Interactionⁱ

Subunit structureⁱ

Homodimer in its autoinhibited state. Active as monomer (By similarity). Isoform 2 but not isoform 1 can interact with ATF4. Interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN; the interaction requires DAPK2 phosphorylation at Thr-369 and suppresses DAPK2 kinase activity and DAPK2-induced apoptosis (PubMed:26047703).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-77154,EBI-77154
ATF4	P18848	2	EBI-9693115,EBI-492498
FAM9B	Q8IZU0	3	EBI-77154,EBI-10175124

GO - Molecular functionⁱ

calmodulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376525
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10629061
- 11230133

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117137, 8 interactors
IntActⁱ	Q9UIK4, 8 interactors
STRINGⁱ	9606.ENSP00000261891

Chemistry databases

BindingDBⁱ

Q9UIK4

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	19 – 22	Combined sources	4
Beta strandⁱ	23 – 31	Combined sources	9
Beta strandⁱ	33 – 42	Combined sources	10
Turnⁱ	43 – 45	Combined sources	3
Beta strandⁱ	48 – 56	Combined sources	9
Beta strandⁱ	58 – 61	Combined sources	4
Beta strandⁱ	63 – 66	Combined sources	4
Helixⁱ	68 – 80	Combined sources	13
Beta strandⁱ	89 – 94	Combined sources	6
Beta strandⁱ	96 – 103	Combined sources	8
Helixⁱ	111 – 116	Combined sources	6
Helixⁱ	123 – 142	Combined sources	20
Beta strandⁱ	144 – 146	Combined sources	3
Helixⁱ	152 – 154	Combined sources	3
Beta strandⁱ	155 – 158	Combined sources	4
Beta strandⁱ	162 – 164	Combined sources	3
Beta strandⁱ	167 – 169	Combined sources	3
Helixⁱ	191 – 193	Combined sources	3
Helixⁱ	196 – 199	Combined sources	4
Helixⁱ	207 – 222	Combined sources	16
Helixⁱ	232 – 240	Combined sources	9
Helixⁱ	248 – 251	Combined sources	4
Helixⁱ	256 – 263	Combined sources	8
Turnⁱ	270 – 272	Combined sources	3
Helixⁱ	276 – 281	Combined sources	6
Turnⁱ	283 – 285	Combined sources	3
Helixⁱ	290 – 298	Combined sources	9
Helixⁱ	303 – 312	Combined sources	10
Helixⁱ	314 – 328	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UIK4
SMRⁱ	Q9UIK4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UIK4

EvolutionaryTraceⁱ

Q9UIK4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 285	Protein kinasePROSITE-ProRule annotationAdd BLAST		263

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	277 – 344	Calmodulin-bindingAdd BLAST		68
Regionⁱ	292 – 301	Autoinhibitory domainBy similarity		10

Domainⁱ

The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic and electrostatic contacts with the kinase core.By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118877
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG100551
InParanoidⁱ	Q9UIK4
KEGG Orthology (KO) More...KOⁱ	K08803
OMAⁱ	CNHLSRS
PhylomeDBⁱ	Q9UIK4
TreeFamⁱ	TF314166

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UIK4-1) [UniParc]FASTA Add to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQASMRSPN MEPFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA 
        60         70         80         90        100
AKFIKKRQSR ASRRGVSREE IEREVSILRQ VLHHNVITLH DVYENRTDVV 
       110        120        130        140        150
LILELVSGGE LFDFLAQKES LSEEEATSFI KQILDGVNYL HTKKIAHFDL 
       160        170        180        190        200
KPENIMLLDK NIPIPHIKLI DFGLAHEIED GVEFKNIFGT PEFVAPEIVN 
       210        220        230        240        250
YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT AVSYDFDEEF 
       260        270        280        290        300
FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITPVDN QQAMVRRESV 
       310        320        330        340        350
VNLENFRKQY VRRRWKLSFS IVSLCNHLTR SLMKKVHLRP DEDLRNCESD 
       360        370
TEEDIARRKA LHPRRRSSTS

Length:370

Mass (Da):42,898

Last modified:May 1, 2000 - v1

Checksum:ⁱ035E914BBCD881A2

GO

Isoform 2 (identifier: Q9UIK4-2) [UniParc]FASTA Add to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
287-370: PVDNQQAMVR...LHPRRRSSTS → SKGEGRAPEQ...TEEFLAGWKL

« Hide

        10         20         30         40         50
MFQASMRSPN MEPFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA 
        60         70         80         90        100
AKFIKKRQSR ASRRGVSREE IEREVSILRQ VLHHNVITLH DVYENRTDVV 
       110        120        130        140        150
LILELVSGGE LFDFLAQKES LSEEEATSFI KQILDGVNYL HTKKIAHFDL 
       160        170        180        190        200
KPENIMLLDK NIPIPHIKLI DFGLAHEIED GVEFKNIFGT PEFVAPEIVN 
       210        220        230        240        250
YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT AVSYDFDEEF 
       260        270        280        290        300
FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITSKGE GRAPEQRKTE 
       310        320        330        340        350
PTQLKTKHLR EYTLKCHSSM PPNNSYVNFE RFACVVEDVA RVDLGCRALV 
       360        370        380        390        400
EAHDTIQDDV EALVSIFNEK EAWYREENES ARHDLSQLRY EFRKVESLKK 
       410        420        430        440        450
LLREDIQATG CSLGSMARKL DHLQAQFEIL RQELSADLQW IQELVGSFQL 
       460        470        480 
ESGSSEGLGS TFYQDTSESL SELLSRSCTE EFLAGWKL

Note: Contains a leucine zipper at positions 434-451.

Show »

Length:488

Mass (Da):55,931

Checksum:ⁱ34F716A709C569B8

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YKW8	H0YKW8_HUMAN	Death-associated protein kinase 2 Death-associated protein kinase 2	DAPK2	80	Annotation score:
H0YLP5	H0YLP5_HUMAN	Death-associated protein kinase 2 Death-associated protein kinase 2	DAPK2	88	Annotation score:
H0YMK1	H0YMK1_HUMAN	Death-associated protein kinase 2 Death-associated protein kinase 2	DAPK2	91	Annotation score:
H0YL86	H0YL86_HUMAN	Death-associated protein kinase 2 Death-associated protein kinase 2	DAPK2	48	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	241	A → S in AAC35001 (PubMed:10629061).Curated		1
Sequence conflictⁱ	253	Q → H in AAC35001 (PubMed:10629061).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_040436	60	R → W1 PublicationCorresponds to variant dbSNP:rs56047843Ensembl.		1
Natural variantⁱVAR_040437	271	R → W1 PublicationCorresponds to variant dbSNP:rs34270163Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042057	287 – 370	PVDNQ…RSSTS → SKGEGRAPEQRKTEPTQLKT KHLREYTLKCHSSMPPNNSY VNFERFACVVEDVARVDLGC RALVEAHDTIQDDVEALVSI FNEKEAWYREENESARHDLS QLRYEFRKVESLKKLLREDI QATGCSLGSMARKLDHLQAQ FEILRQELSADLQWIQELVG SFQLESGSSEGLGSTFYQDT SESLSELLSRSCTEEFLAGW KL in isoform 2. 1 PublicationAdd BLAST		84

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018001 mRNA Translation: BAA88063.1 AF052941 mRNA Translation: AAC35001.1 GU056176 mRNA Translation: ADD83109.1 AC015914 Genomic DNA No translation available. AC021541 Genomic DNA No translation available. BC114506 mRNA Translation: AAI14507.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10188.1 [Q9UIK4-1] CCDS86463.1 [Q9UIK4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_055141.2, NM_014326.3 [Q9UIK4-1] XP_011519718.1, XM_011521416.2 [Q9UIK4-2]
UniGeneⁱ	Hs.237886

Genome annotation databases

Ensemblⁱ	ENST00000261891; ENSP00000261891; ENSG00000035664 [Q9UIK4-1] ENST00000457488; ENSP00000408277; ENSG00000035664 [Q9UIK4-1] ENST00000558069; ENSP00000453235; ENSG00000035664 [Q9UIK4-2] ENST00000612884; ENSP00000484390; ENSG00000035664 [Q9UIK4-2]
GeneIDⁱ	23604
KEGGⁱ	hsa:23604
UCSC genome browser More...UCSCⁱ	uc002amr.4 human [Q9UIK4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UIK4	Death-associated protein kinase 2, isoform CRA_b		HUMAN		370	UniRef100_Q9UIK4
DAPK2 isoform 4		PANTR		370
Uncharacterized protein		PANPA		370
Uncharacterized protein		NOMLE		370

Protein	Similar proteins		Species	Score	Length	Source
Q9UIK4	Death-associated protein kinase 2	)	MOUSE		370	UniRef90_Q9UIK4
Death-associated protein kinase 2, isoform CRA_b		HUMAN		370
DAPK2 isoform 4		PANTR		370
Uncharacterized protein		PANPA		370
Uncharacterized protein		NOMLE		370
+84
Q9UIK4-2	Uncharacterized protein		CANLF		488	UniRef90_Q9UIK4-2
Death associated protein kinase 2		CALJA		488
Uncharacterized protein		NOMLE		488
death-associated protein kinase 2 isoform X1		TARSY		488
Uncharacterized protein		SAIBB		488
+40

Protein	Similar proteins		Species	Score	Length	Source
Q9UIK4	Death-associated protein kinase 2	)	MOUSE		370	UniRef50_Q9UIK4
Death-associated protein kinase 2, isoform CRA_b		HUMAN		370
DAPK2 isoform 4		PANTR		370
Uncharacterized protein		PANPA		370
Uncharacterized protein		NOMLE		370
+147
Q9UIK4-2	Death-associated protein kinase 3	)	HUMAN		454	UniRef50_O43293
DAPK3 isoform 1		PANTR		454
DAPK3 isoform 1		PONAB		454
Death-associated protein kinase 3		PIG		454
death-associated protein kinase 3		PHYCD		454
+562

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018001 mRNA Translation: BAA88063.1 AF052941 mRNA Translation: AAC35001.1 GU056176 mRNA Translation: ADD83109.1 AC015914 Genomic DNA No translation available. AC021541 Genomic DNA No translation available. BC114506 mRNA Translation: AAI14507.1
CCDSⁱ	CCDS10188.1 [Q9UIK4-1] CCDS86463.1 [Q9UIK4-2]
RefSeqⁱ	NP_055141.2, NM_014326.3 [Q9UIK4-1] XP_011519718.1, XM_011521416.2 [Q9UIK4-2]
UniGeneⁱ	Hs.237886

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WMK	X-ray	3.60	A/B/C/D/E/F/G/H	11-330	[»]
	1WRZ	X-ray	2.00	B	312-330	[»]
	1Z9X	X-ray	3.93	A/B/C	11-330	[»]
	1ZUZ	X-ray	1.91	B	312-330	[»]
	1ZWS	X-ray	2.90	A/B/C/D/E/F/G/H	11-297	[»]
	2A27	X-ray	3.00	A/B/C/D/E/F/G/H	11-330	[»]
	2A2A	X-ray	1.47	A/B/C/D	11-330	[»]
	2CKE	X-ray	2.80	A/B/C/D	11-330	[»]
ProteinModelPortalⁱ	Q9UIK4
SMRⁱ	Q9UIK4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117137, 8 interactors
IntActⁱ	Q9UIK4, 8 interactors
STRINGⁱ	9606.ENSP00000261891

Chemistry databases

BindingDBⁱ	Q9UIK4
ChEMBLⁱ	CHEMBL3123

PTM databases

iPTMnetⁱ	Q9UIK4
PhosphoSitePlusⁱ	Q9UIK4

Polymorphism and mutation databases

BioMutaⁱ	DAPK2
DMDMⁱ	38605084

Proteomic databases

EPDⁱ	Q9UIK4
PaxDbⁱ	Q9UIK4
PeptideAtlasⁱ	Q9UIK4
PRIDEⁱ	Q9UIK4
ProteomicsDBⁱ	84537 84538 [Q9UIK4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23604
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261891; ENSP00000261891; ENSG00000035664 [Q9UIK4-1] ENST00000457488; ENSP00000408277; ENSG00000035664 [Q9UIK4-1] ENST00000558069; ENSP00000453235; ENSG00000035664 [Q9UIK4-2] ENST00000612884; ENSP00000484390; ENSG00000035664 [Q9UIK4-2]
GeneIDⁱ	23604
KEGGⁱ	hsa:23604
UCSCⁱ	uc002amr.4 human [Q9UIK4-1]

Organism-specific databases

CTDⁱ	23604
DisGeNETⁱ	23604
EuPathDBⁱ	HostDB:ENSG00000035664.11
GeneCardsⁱ	DAPK2
HGNCⁱ	HGNC:2675 DAPK2
HPAⁱ	HPA071581
MIMⁱ	616567 gene
neXtProtⁱ	NX_Q9UIK4
OpenTargetsⁱ	ENSG00000035664
PharmGKBⁱ	PA27143
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
GeneTreeⁱ	ENSGT00760000118877
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG100551
InParanoidⁱ	Q9UIK4
KOⁱ	K08803
OMAⁱ	CNHLSRS
PhylomeDBⁱ	Q9UIK4
TreeFamⁱ	TF314166

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418889 via Dependence Receptors in the absence of ligand
SignaLinkⁱ	Q9UIK4
SIGNORⁱ	Q9UIK4

Miscellaneous databases

ChiTaRSⁱ	DAPK2 human
EvolutionaryTraceⁱ	Q9UIK4
GeneWikiⁱ	DAPK2
GenomeRNAiⁱ	23604
Protein Ontology More...PROⁱ	PR:Q9UIK4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000035664 Expressed in 210 organ(s), highest expression level in right lobe of thyroid gland
CleanExⁱ	HS_DAPK2
ExpressionAtlasⁱ	Q9UIK4 baseline and differential
Genevisibleⁱ	Q9UIK4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DAPK2_HUMAN
Accessionⁱ	Q9UIK4Primary (citable) accession number: Q9UIK4 Secondary accession number(s): E9JGM7, O75892, Q24JS1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	May 1, 2000
	Last modified:	September 12, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9UIK4 (DAPK2_HUMAN)

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Death-associated protein kinase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Keywords - Cellular componenti

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

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Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ