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Entry version 166 (22 Apr 2020)
Sequence version 1 (01 May 2000)
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Protein

ATPase inhibitor, mitochondrial

Gene

ATP5IF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endogenous F1F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F1F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F1F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATPase inhibitor, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit epsilonCurated
Inhibitor of F(1)F(o)-ATPase
Short name:
IF(1)
Short name:
IF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP5IF1Imported
Synonyms:ATPI, ATPIF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:871 ATP5IF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614981 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UII2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
93974

Open Targets

More...
OpenTargetsi
ENSG00000130770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25173

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UII2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATPIF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12585262

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 25MitochondrionCombined sources1 PublicationAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000254726 – 106ATPase inhibitor, mitochondrialAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei103N6-succinyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UII2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UII2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UII2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UII2

PeptideAtlas

More...
PeptideAtlasi
Q9UII2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UII2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84524 [Q9UII2-1]
84525 [Q9UII2-2]
84526 [Q9UII2-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9UII2-1 [Q9UII2-1]
Q9UII2-2 [Q9UII2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UII2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UII2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130770 Expressed in testis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UII2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UII2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130770 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125063, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UII2

Protein interaction database and analysis system

More...
IntActi
Q9UII2, 34 interactors

Molecular INTeraction database

More...
MINTi
Q9UII2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000335203

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UII2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UII2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 52N-terminal inhibitory regionBy similarityAdd BLAST27
Regioni74 – 106Antiparallel alpha-helical coiled coil regionBy similarityAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili63 – 106Sequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil composed of residues 74-106, leaving each N-terminal inhibitory region (residues 26-52) accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region (residues 26-52) binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase inhibitor family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2TJ Eukaryota
ENOG41127Z5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006264

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_147479_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UII2

KEGG Orthology (KO)

More...
KOi
K22255

Identification of Orthologs from Complete Genome Data

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OMAi
QIRMASD

Database of Orthologous Groups

More...
OrthoDBi
1566610at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UII2

TreeFam database of animal gene trees

More...
TreeFami
TF320659

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007648 ATPase_inhibitor_mt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04568 IATP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UII2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVTALAART WLGVWGVRTM QARGFGSDQS ENVDRGAGSI REAGGAFGKR
60 70 80 90 100
EQAEEERYFR AQSREQLAAL KKHHEEEIVH HKKEIERLQK EIERHKQKIK

MLKHDD
Length:106
Mass (Da):12,249
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6144431125D5A86
GO
Isoform 2 (identifier: Q9UII2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-106: AQSREQLAALKKHHEEEIVHHKKEIERLQKEIERHKQKIKMLKHDD → HYRLCFEISLG

Show »
Length:71
Mass (Da):7,912
Checksum:iD7E481A83975E005
GO
Isoform 3 (identifier: Q9UII2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-106: Missing.

Show »
Length:60
Mass (Da):6,592
Checksum:i151FBFCD72F13D1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J230A0A0B4J230_HUMAN
ATPase inhibitor, mitochondrial
ATP5IF1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04955 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60R → RR in CAI46227 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04141761 – 106AQSRE…LKHDD → HYRLCFEISLG in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_04141861 – 106Missing in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029042 mRNA Translation: BAA88422.1
AK316600 mRNA Translation: BAG38187.1
DB030607 mRNA No translation available.
AL050386 mRNA Translation: CAI46227.1
AF114836 mRNA Translation: AAP97235.1
AY005470 Genomic DNA Translation: AAF97495.1
AL583540 mRNA No translation available.
BT009849 mRNA Translation: AAP88851.1
CR457097 mRNA Translation: CAG33378.1
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07704.1
BC004955 mRNA Translation: AAH04955.1 Different initiation.
BC009677 mRNA Translation: AAH09677.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS319.1 [Q9UII2-1]
CCDS320.1 [Q9UII2-2]
CCDS44096.1 [Q9UII2-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7175

NCBI Reference Sequences

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RefSeqi
NP_057395.1, NM_016311.4 [Q9UII2-1]
NP_835497.1, NM_178190.2 [Q9UII2-2]
NP_835498.1, NM_178191.2 [Q9UII2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335514; ENSP00000335203; ENSG00000130770 [Q9UII2-1]
ENST00000465645; ENSP00000437337; ENSG00000130770 [Q9UII2-3]
ENST00000497986; ENSP00000435579; ENSG00000130770 [Q9UII2-2]
ENST00000642464; ENSP00000496122; ENSG00000285390 [Q9UII2-2]
ENST00000647074; ENSP00000494248; ENSG00000285390 [Q9UII2-1]
ENST00000647380; ENSP00000496605; ENSG00000285390 [Q9UII2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93974

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93974

UCSC genome browser

More...
UCSCi
uc001bpp.4 human [Q9UII2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029042 mRNA Translation: BAA88422.1
AK316600 mRNA Translation: BAG38187.1
DB030607 mRNA No translation available.
AL050386 mRNA Translation: CAI46227.1
AF114836 mRNA Translation: AAP97235.1
AY005470 Genomic DNA Translation: AAF97495.1
AL583540 mRNA No translation available.
BT009849 mRNA Translation: AAP88851.1
CR457097 mRNA Translation: CAG33378.1
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07704.1
BC004955 mRNA Translation: AAH04955.1 Different initiation.
BC009677 mRNA Translation: AAH09677.1
CCDSiCCDS319.1 [Q9UII2-1]
CCDS320.1 [Q9UII2-2]
CCDS44096.1 [Q9UII2-3]
PIRiJC7175
RefSeqiNP_057395.1, NM_016311.4 [Q9UII2-1]
NP_835497.1, NM_178190.2 [Q9UII2-2]
NP_835498.1, NM_178191.2 [Q9UII2-3]

3D structure databases

SMRiQ9UII2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125063, 26 interactors
CORUMiQ9UII2
IntActiQ9UII2, 34 interactors
MINTiQ9UII2
STRINGi9606.ENSP00000335203

PTM databases

iPTMnetiQ9UII2
PhosphoSitePlusiQ9UII2

Polymorphism and mutation databases

BioMutaiATPIF1
DMDMi12585262

Proteomic databases

EPDiQ9UII2
jPOSTiQ9UII2
MassIVEiQ9UII2
PaxDbiQ9UII2
PeptideAtlasiQ9UII2
PRIDEiQ9UII2
ProteomicsDBi84524 [Q9UII2-1]
84525 [Q9UII2-2]
84526 [Q9UII2-3]
TopDownProteomicsiQ9UII2-1 [Q9UII2-1]
Q9UII2-2 [Q9UII2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30912 217 antibodies

The DNASU plasmid repository

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DNASUi
93974

Genome annotation databases

EnsembliENST00000335514; ENSP00000335203; ENSG00000130770 [Q9UII2-1]
ENST00000465645; ENSP00000437337; ENSG00000130770 [Q9UII2-3]
ENST00000497986; ENSP00000435579; ENSG00000130770 [Q9UII2-2]
ENST00000642464; ENSP00000496122; ENSG00000285390 [Q9UII2-2]
ENST00000647074; ENSP00000494248; ENSG00000285390 [Q9UII2-1]
ENST00000647380; ENSP00000496605; ENSG00000285390 [Q9UII2-3]
GeneIDi93974
KEGGihsa:93974
UCSCiuc001bpp.4 human [Q9UII2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
93974
DisGeNETi93974

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP5IF1
HGNCiHGNC:871 ATP5IF1
HPAiENSG00000130770 Low tissue specificity
MIMi614981 gene
neXtProtiNX_Q9UII2
OpenTargetsiENSG00000130770
PharmGKBiPA25173

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J2TJ Eukaryota
ENOG41127Z5 LUCA
GeneTreeiENSGT00390000006264
HOGENOMiCLU_147479_0_0_1
InParanoidiQ9UII2
KOiK22255
OMAiQIRMASD
OrthoDBi1566610at2759
PhylomeDBiQ9UII2
TreeFamiTF320659

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATP5IF1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATPIF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93974
PharosiQ9UII2 Tbio

Protein Ontology

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PROi
PR:Q9UII2
RNActiQ9UII2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000130770 Expressed in testis and 229 other tissues
ExpressionAtlasiQ9UII2 baseline and differential
GenevisibleiQ9UII2 HS

Family and domain databases

InterProiView protein in InterPro
IPR007648 ATPase_inhibitor_mt
PfamiView protein in Pfam
PF04568 IATP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATIF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UII2
Secondary accession number(s): Q5JXL8, Q6IAQ7, Q9BSL9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: April 22, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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