UniProtKB - Q9UIH9 (KLF15_HUMAN)
Krueppel-like factor 15
KLF15
Functioni
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity).
Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity).
Involved in podocyte differentiation (By similarity).
Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
By similarity4 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 321 – 345 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 351 – 375 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 381 – 403 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- cardiac muscle hypertrophy in response to stress Source: Ensembl
- cellular glucose homeostasis Source: Ensembl
- cellular response to peptide Source: Ensembl
- glial cell differentiation Source: Ensembl
- glomerular visceral epithelial cell differentiation Source: UniProtKB
- negative regulation of peptidyl-lysine acetylation Source: UniProtKB
- positive regulation of glucose import Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of Wnt signaling pathway Source: Ensembl
- response to insulin Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UIH9 |
Reactomei | R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression |
SignaLinki | Q9UIH9 |
SIGNORi | Q9UIH9 |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 15Alternative name(s): Kidney-enriched krueppel-like factor |
Gene namesi | Name:KLF15 Synonyms:KKLF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14536, KLF15 |
MIMi | 606465, gene |
neXtProti | NX_Q9UIH9 |
VEuPathDBi | HostDB:ENSG00000163884 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Organism-specific databases
DisGeNETi | 28999 |
OpenTargetsi | ENSG00000163884 |
PharmGKBi | PA30134 |
Miscellaneous databases
Pharosi | Q9UIH9, Tbio |
Genetic variation databases
BioMutai | KLF15 |
DMDMi | 20138787 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047187 | 1 – 416 | Krueppel-like factor 15Add BLAST | 416 |
Proteomic databases
MassIVEi | Q9UIH9 |
PaxDbi | Q9UIH9 |
PeptideAtlasi | Q9UIH9 |
PRIDEi | Q9UIH9 |
ProteomicsDBi | 84523 |
PTM databases
iPTMneti | Q9UIH9 |
PhosphoSitePlusi | Q9UIH9 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000163884, Expressed in parotid gland and 210 other tissues |
Genevisiblei | Q9UIH9, HS |
Organism-specific databases
HPAi | ENSG00000163884, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Interacts with MYOCD and EP300.
2 PublicationsBinary interactionsi
Q9UIH9
Protein-protein interaction databases
BioGRIDi | 118818, 35 interactors |
IntActi | Q9UIH9, 52 interactors |
MINTi | Q9UIH9 |
STRINGi | 9606.ENSP00000296233 |
Miscellaneous databases
RNActi | Q9UIH9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UIH9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UIH9 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 219 | DisorderedSequence analysisAdd BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 75 – 83 | 9aaTAD1 Publication | 9 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 321 – 345 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 351 – 375 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 381 – 403 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156977 |
HOGENOMi | CLU_035818_0_0_1 |
InParanoidi | Q9UIH9 |
OMAi | SGRAYHM |
PhylomeDBi | Q9UIH9 |
TreeFami | TF350556 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC
60 70 80 90 100
SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS
110 120 130 140 150
GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE
160 170 180 190 200
NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS
210 220 230 240 250
AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ
260 270 280 290 300
LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP
310 320 330 340 350
AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP
360 370 380 390 400
FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI
410
KVHRFPRSSR SVRSVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029254 mRNA Translation: BAA88561.1 BC036733 mRNA Translation: AAH36733.1 |
CCDSi | CCDS3036.1 |
RefSeqi | NP_054798.1, NM_014079.3 XP_005247457.1, XM_005247400.3 |
Genome annotation databases
Ensembli | ENST00000296233; ENSP00000296233; ENSG00000163884 |
GeneIDi | 28999 |
KEGGi | hsa:28999 |
MANE-Selecti | ENST00000296233.4; ENSP00000296233.3; NM_014079.4; NP_054798.1 |
UCSCi | uc011bkk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029254 mRNA Translation: BAA88561.1 BC036733 mRNA Translation: AAH36733.1 |
CCDSi | CCDS3036.1 |
RefSeqi | NP_054798.1, NM_014079.3 XP_005247457.1, XM_005247400.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ENT | NMR | - | A | 346-380 | [»] | |
SMRi | Q9UIH9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118818, 35 interactors |
IntActi | Q9UIH9, 52 interactors |
MINTi | Q9UIH9 |
STRINGi | 9606.ENSP00000296233 |
PTM databases
iPTMneti | Q9UIH9 |
PhosphoSitePlusi | Q9UIH9 |
Genetic variation databases
BioMutai | KLF15 |
DMDMi | 20138787 |
Proteomic databases
MassIVEi | Q9UIH9 |
PaxDbi | Q9UIH9 |
PeptideAtlasi | Q9UIH9 |
PRIDEi | Q9UIH9 |
ProteomicsDBi | 84523 |
Protocols and materials databases
Antibodypediai | 17142, 368 antibodies from 36 providers |
DNASUi | 28999 |
Genome annotation databases
Ensembli | ENST00000296233; ENSP00000296233; ENSG00000163884 |
GeneIDi | 28999 |
KEGGi | hsa:28999 |
MANE-Selecti | ENST00000296233.4; ENSP00000296233.3; NM_014079.4; NP_054798.1 |
UCSCi | uc011bkk.2, human |
Organism-specific databases
CTDi | 28999 |
DisGeNETi | 28999 |
GeneCardsi | KLF15 |
HGNCi | HGNC:14536, KLF15 |
HPAi | ENSG00000163884, Tissue enhanced (liver) |
MIMi | 606465, gene |
neXtProti | NX_Q9UIH9 |
OpenTargetsi | ENSG00000163884 |
PharmGKBi | PA30134 |
VEuPathDBi | HostDB:ENSG00000163884 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156977 |
HOGENOMi | CLU_035818_0_0_1 |
InParanoidi | Q9UIH9 |
OMAi | SGRAYHM |
PhylomeDBi | Q9UIH9 |
TreeFami | TF350556 |
Enzyme and pathway databases
PathwayCommonsi | Q9UIH9 |
Reactomei | R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression |
SignaLinki | Q9UIH9 |
SIGNORi | Q9UIH9 |
Miscellaneous databases
BioGRID-ORCSi | 28999, 8 hits in 1065 CRISPR screens |
ChiTaRSi | KLF15, human |
EvolutionaryTracei | Q9UIH9 |
GeneWikii | KLF15 |
GenomeRNAii | 28999 |
Pharosi | Q9UIH9, Tbio |
PROi | PR:Q9UIH9 |
RNActi | Q9UIH9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163884, Expressed in parotid gland and 210 other tissues |
Genevisiblei | Q9UIH9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF15_HUMAN | |
Accessioni | Q9UIH9Primary (citable) accession number: Q9UIH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families