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Entry version 167 (29 Sep 2021)
Sequence version 3 (18 May 2010)
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Protein

Solute carrier organic anion transporter family member 3A1

Gene

SLCO3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595).

Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).

2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=101 nM for PGE1 (isoform 1)1 Publication
  2. KM=218 nM for PGE1 (isoform 2)1 Publication
  3. KM=219 nM for PGE2 (isoform 1)1 Publication
  4. KM=371 nM for PGE2 (isoform 2)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UIG8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-879518, Transport of organic anions [Q9UIG8-1]

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.18, the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 3A1
Short name:
OATP3A1
Alternative name(s):
Organic anion transporter polypeptide-related protein 3
Short name:
OATP-RP3
Short name:
OATPRP3
Organic anion-transporting polypeptide D
Short name:
OATP-D
PGE1 transporter
Sodium-independent organic anion transporter D
Solute carrier family 21 member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO3A1
Synonyms:OATP3A1, OATPD, SLC21A11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10952, SLCO3A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612435, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIG8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000176463

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 60Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini61 – 79ExtracellularSequence analysisAdd BLAST19
Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini101 – 106CytoplasmicSequence analysis6
Transmembranei107 – 131Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini132 – 174ExtracellularSequence analysisAdd BLAST43
Transmembranei175 – 203Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini204 – 222CytoplasmicSequence analysisAdd BLAST19
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 261ExtracellularSequence analysisAdd BLAST18
Transmembranei262 – 286Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini287 – 344CytoplasmicSequence analysisAdd BLAST58
Transmembranei345 – 366Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini367 – 386ExtracellularSequence analysisAdd BLAST20
Transmembranei387 – 410Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini411 – 414CytoplasmicSequence analysis4
Transmembranei415 – 438Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini439 – 539ExtracellularSequence analysisAdd BLAST101
Transmembranei540 – 562Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini563 – 571CytoplasmicSequence analysis9
Transmembranei572 – 597Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini598 – 630ExtracellularSequence analysisAdd BLAST33
Transmembranei631 – 648Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini649 – 705CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
28232

Open Targets

More...
OpenTargetsi
ENSG00000176463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35837

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UIG8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073685

Drug and drug target database

More...
DrugBanki
DB00770, Alprostadil
DB00345, Aminohippuric acid
DB01053, Benzylpenicillin
DB00286, Conjugated estrogens
DB01160, Dinoprost tromethamine
DB00917, Dinoprostone
DB01088, Iloprost
DB09198, Lobeglitazone
DB00563, Methotrexate
DB06654, Safinamide
DB04348, Taurocholic acid
DB09100, Thyroid, porcine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO3A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452954

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910641 – 710Solute carrier organic anion transporter family member 3A1Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi471 ↔ 501PROSITE-ProRule annotation
Disulfide bondi477 ↔ 497PROSITE-ProRule annotation
Disulfide bondi486 ↔ 511PROSITE-ProRule annotation
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UIG8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UIG8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UIG8

PeptideAtlas

More...
PeptideAtlasi
Q9UIG8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UIG8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84519 [Q9UIG8-1]
84520 [Q9UIG8-2]
84521 [Q9UIG8-3]
84522 [Q9UIG8-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UIG8, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIG8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIG8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UIG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176463, Expressed in testis and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UIG8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UIG8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176463, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118181, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UIG8, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320634

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UIG8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini465 – 513Kazal-likePROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01040000240378

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008954_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UIG8

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQPHRTK

Database of Orthologous Groups

More...
OrthoDBi
1029129at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UIG8

TreeFam database of animal gene trees

More...
TreeFami
TF317540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR036259, MFS_trans_sf
IPR004156, OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388, PTHR11388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648, Kazal_2, 1 hit
PF03137, OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805, oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465, KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UIG8-1) [UniParc]FASTAAdd to basket
Also known as: OATP3A1-v1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
60 70 80 90 100
LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
110 120 130 140 150
ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
160 170 180 190 200
AANGSGGDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
210 220 230 240 250
YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
260 270 280 290 300
LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE
310 320 330 340 350
QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
360 370 380 390 400
FTCIILAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
410 420 430 440 450
LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
460 470 480 490 500
VTVPYGNSTA PGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
510 520 530 540 550
CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL CVMCICSLIG
560 570 580 590 600
AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
610 620 630 640 650
CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
660 670 680 690 700
NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH
710
EWCENMESVL
Length:710
Mass (Da):76,553
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED56724BA0998553
GO
Isoform 2 (identifier: Q9UIG8-2) [UniParc]FASTAAdd to basket
Also known as: OATP3A1-v2

The sequence of this isoform differs from the canonical sequence as follows:
     667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESHSPSEDSFVRS
     693-710: Missing.

Show »
Length:692
Mass (Da):74,372
Checksum:i2C7B72AC4C0E4E88
GO
Isoform 3 (identifier: Q9UIG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     59-60: YL → MN
     641-710: Missing.

Show »
Length:582
Mass (Da):62,203
Checksum:iE653AA86DA1BA276
GO
Isoform 4 (identifier: Q9UIG8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Show »
Length:429
Mass (Da):46,411
Checksum:i822E718765321BC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2B7G3V2B7_HUMAN
Solute carrier organic anion transp...
SLCO3A1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJM0H0YJM0_HUMAN
Solute carrier organic anion transp...
SLCO3A1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3K4G3V3K4_HUMAN
Solute carrier organic anion transp...
SLCO3A1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40K → R in BAF83561 (PubMed:14702039).Curated1
Sequence conflicti168R → L in AAH00585 (PubMed:15489334).Curated1
Sequence conflicti188G → D in BAF83561 (PubMed:14702039).Curated1
Sequence conflicti202I → Y in BAA89287 (PubMed:10873595).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054853294E → D5 PublicationsCorresponds to variant dbSNP:rs1517618Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368331 – 281Missing in isoform 4. 1 PublicationAdd BLAST281
Alternative sequenceiVSP_0368341 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_03683559 – 60YL → MN in isoform 3. 1 Publication2
Alternative sequenceiVSP_036836641 – 710Missing in isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_036837667 – 692EFFAS…THRTK → TEYQDIETEKTCPESHSPSE DSFVRS in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_036838693 – 710Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB031050 mRNA Translation: BAA89287.1
AF205074 mRNA Translation: AAG42206.1
AF187816 mRNA Translation: AAG43446.1
AK290872 mRNA Translation: BAF83561.1
AK057031 mRNA Translation: BAG51847.1
AK097797 mRNA Translation: BAG53529.1
FJ515841 Genomic DNA Translation: ACS13734.1
AC104020 Genomic DNA No translation available.
AC104236 Genomic DNA No translation available.
AC113190 Genomic DNA No translation available.
AC116903 Genomic DNA No translation available.
AC135996 Genomic DNA No translation available.
BC000585 mRNA Translation: AAH00585.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10371.1 [Q9UIG8-1]
CCDS45354.1 [Q9UIG8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001138516.1, NM_001145044.1 [Q9UIG8-2]
NP_037404.2, NM_013272.3 [Q9UIG8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318445; ENSP00000320634; ENSG00000176463 [Q9UIG8-1]
ENST00000424469; ENSP00000387846; ENSG00000176463 [Q9UIG8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
28232

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:28232

UCSC genome browser

More...
UCSCi
uc002bqx.3, human [Q9UIG8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031050 mRNA Translation: BAA89287.1
AF205074 mRNA Translation: AAG42206.1
AF187816 mRNA Translation: AAG43446.1
AK290872 mRNA Translation: BAF83561.1
AK057031 mRNA Translation: BAG51847.1
AK097797 mRNA Translation: BAG53529.1
FJ515841 Genomic DNA Translation: ACS13734.1
AC104020 Genomic DNA No translation available.
AC104236 Genomic DNA No translation available.
AC113190 Genomic DNA No translation available.
AC116903 Genomic DNA No translation available.
AC135996 Genomic DNA No translation available.
BC000585 mRNA Translation: AAH00585.1
CCDSiCCDS10371.1 [Q9UIG8-1]
CCDS45354.1 [Q9UIG8-2]
RefSeqiNP_001138516.1, NM_001145044.1 [Q9UIG8-2]
NP_037404.2, NM_013272.3 [Q9UIG8-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118181, 7 interactors
IntActiQ9UIG8, 5 interactors
STRINGi9606.ENSP00000320634

Chemistry databases

ChEMBLiCHEMBL2073685
DrugBankiDB00770, Alprostadil
DB00345, Aminohippuric acid
DB01053, Benzylpenicillin
DB00286, Conjugated estrogens
DB01160, Dinoprost tromethamine
DB00917, Dinoprostone
DB01088, Iloprost
DB09198, Lobeglitazone
DB00563, Methotrexate
DB06654, Safinamide
DB04348, Taurocholic acid
DB09100, Thyroid, porcine

Protein family/group databases

TCDBi2.A.60.1.18, the organo anion transporter (oat) family

PTM databases

GlyGeniQ9UIG8, 7 sites
iPTMnetiQ9UIG8
PhosphoSitePlusiQ9UIG8
SwissPalmiQ9UIG8

Genetic variation databases

BioMutaiSLCO3A1
DMDMi296452954

Proteomic databases

jPOSTiQ9UIG8
MassIVEiQ9UIG8
PaxDbiQ9UIG8
PeptideAtlasiQ9UIG8
PRIDEiQ9UIG8
ProteomicsDBi84519 [Q9UIG8-1]
84520 [Q9UIG8-2]
84521 [Q9UIG8-3]
84522 [Q9UIG8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
29012, 76 antibodies

The DNASU plasmid repository

More...
DNASUi
28232

Genome annotation databases

EnsembliENST00000318445; ENSP00000320634; ENSG00000176463 [Q9UIG8-1]
ENST00000424469; ENSP00000387846; ENSG00000176463 [Q9UIG8-2]
GeneIDi28232
KEGGihsa:28232
UCSCiuc002bqx.3, human [Q9UIG8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
28232
DisGeNETi28232

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLCO3A1
HGNCiHGNC:10952, SLCO3A1
HPAiENSG00000176463, Low tissue specificity
MIMi612435, gene
neXtProtiNX_Q9UIG8
OpenTargetsiENSG00000176463
PharmGKBiPA35837
VEuPathDBiHostDB:ENSG00000176463

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3626, Eukaryota
GeneTreeiENSGT01040000240378
HOGENOMiCLU_008954_3_0_1
InParanoidiQ9UIG8
OMAiNQPHRTK
OrthoDBi1029129at2759
PhylomeDBiQ9UIG8
TreeFamiTF317540

Enzyme and pathway databases

PathwayCommonsiQ9UIG8
ReactomeiR-HSA-879518, Transport of organic anions [Q9UIG8-1]

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
28232, 1 hit in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLCO3A1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLCO3A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
28232
PharosiQ9UIG8, Tbio

Protein Ontology

More...
PROi
PR:Q9UIG8
RNActiQ9UIG8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176463, Expressed in testis and 238 other tissues
ExpressionAtlasiQ9UIG8, baseline and differential
GenevisibleiQ9UIG8, HS

Family and domain databases

InterProiView protein in InterPro
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR036259, MFS_trans_sf
IPR004156, OATP
PANTHERiPTHR11388, PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
PF03137, OATP, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00805, oat, 1 hit
PROSITEiView protein in PROSITE
PS51465, KAZAL_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO3A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIG8
Secondary accession number(s): A8K4A7
, B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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