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Entry version 156 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

Solute carrier organic anion transporter family member 3A1

Gene

SLCO3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=101 nM for PGE1 (isoform 1)1 Publication
  2. KM=218 nM for PGE1 (isoform 2)1 Publication
  3. KM=219 nM for PGE2 (isoform 1)1 Publication
  4. KM=371 nM for PGE2 (isoform 2)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processIon transport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-879518 Transport of organic anions [Q9UIG8-1]

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.60.1.18 the organo anion transporter (oat) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Short name:
    OATP3A1
    Alternative name(s):
    Organic anion transporter polypeptide-related protein 3
    Short name:
    OATP-RP3
    Short name:
    OATPRP3
    Organic anion-transporting polypeptide D
    Short name:
    OATP-D
    PGE1 transporter
    Sodium-independent organic anion transporter D
    Solute carrier family 21 member 11
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLCO3A1
    Synonyms:OATP3A1, OATPD, SLC21A11
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10952 SLCO3A1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612435 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UIG8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 60Helical; Name=1Sequence analysisAdd BLAST20
    Topological domaini61 – 79ExtracellularSequence analysisAdd BLAST19
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini101 – 106CytoplasmicSequence analysis6
    Transmembranei107 – 131Helical; Name=3Sequence analysisAdd BLAST25
    Topological domaini132 – 174ExtracellularSequence analysisAdd BLAST43
    Transmembranei175 – 203Helical; Name=4Sequence analysisAdd BLAST29
    Topological domaini204 – 222CytoplasmicSequence analysisAdd BLAST19
    Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini244 – 261ExtracellularSequence analysisAdd BLAST18
    Transmembranei262 – 286Helical; Name=6Sequence analysisAdd BLAST25
    Topological domaini287 – 344CytoplasmicSequence analysisAdd BLAST58
    Transmembranei345 – 366Helical; Name=7Sequence analysisAdd BLAST22
    Topological domaini367 – 386ExtracellularSequence analysisAdd BLAST20
    Transmembranei387 – 410Helical; Name=8Sequence analysisAdd BLAST24
    Topological domaini411 – 414CytoplasmicSequence analysis4
    Transmembranei415 – 438Helical; Name=9Sequence analysisAdd BLAST24
    Topological domaini439 – 539ExtracellularSequence analysisAdd BLAST101
    Transmembranei540 – 562Helical; Name=10Sequence analysisAdd BLAST23
    Topological domaini563 – 571CytoplasmicSequence analysis9
    Transmembranei572 – 597Helical; Name=11Sequence analysisAdd BLAST26
    Topological domaini598 – 630ExtracellularSequence analysisAdd BLAST33
    Transmembranei631 – 648Helical; Name=12Sequence analysisAdd BLAST18
    Topological domaini649 – 705CytoplasmicSequence analysisAdd BLAST57

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    28232

    Open Targets

    More...
    OpenTargetsi
    ENSG00000176463

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35837

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9UIG8

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2073685

    Drug and drug target database

    More...
    DrugBanki
    DB00770 Alprostadil
    DB00345 Aminohippuric acid
    DB01053 Benzylpenicillin
    DB00286 Conjugated estrogens
    DB01160 Dinoprost tromethamine
    DB00917 Dinoprostone
    DB01088 Iloprost
    DB09198 Lobeglitazone
    DB00563 Methotrexate
    DB06654 Safinamide
    DB04348 Taurocholic Acid

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLCO3A1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296452954

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910641 – 710Solute carrier organic anion transporter family member 3A1Add BLAST710

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
    Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9UIG8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9UIG8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UIG8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UIG8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UIG8

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    84519 [Q9UIG8-1]
    84520 [Q9UIG8-2]
    84521 [Q9UIG8-3]
    84522 [Q9UIG8-4]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UIG8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UIG8

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9UIG8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000176463 Expressed in 224 organ(s), highest expression level in testis

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UIG8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UIG8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA066327

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    118181, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9UIG8, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000320634

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini465 – 513Kazal-likePROSITE-ProRule annotationAdd BLAST49

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3626 Eukaryota
    ENOG410XRSF LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182739

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UIG8

    KEGG Orthology (KO)

    More...
    KOi
    K14353

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ICVCSMI

    Database of Orthologous Groups

    More...
    OrthoDBi
    1029129at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UIG8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF317540

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR036259 MFS_trans_sf
    IPR004156 OATP

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11388 PTHR11388, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00805 oat, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51465 KAZAL_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UIG8-1) [UniParc]FASTAAdd to basket
    Also known as: OATP3A1-v1

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
    60 70 80 90 100
    LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
    110 120 130 140 150
    ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
    160 170 180 190 200
    AANGSGGDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
    210 220 230 240 250
    YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
    260 270 280 290 300
    LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE
    310 320 330 340 350
    QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
    360 370 380 390 400
    FTCIILAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
    410 420 430 440 450
    LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
    460 470 480 490 500
    VTVPYGNSTA PGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
    510 520 530 540 550
    CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL CVMCICSLIG
    560 570 580 590 600
    AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
    610 620 630 640 650
    CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
    660 670 680 690 700
    NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH
    710
    EWCENMESVL
    Length:710
    Mass (Da):76,553
    Last modified:May 18, 2010 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED56724BA0998553
    GO
    Isoform 2 (identifier: Q9UIG8-2) [UniParc]FASTAAdd to basket
    Also known as: OATP3A1-v2

    The sequence of this isoform differs from the canonical sequence as follows:
         667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESHSPSEDSFVRS
         693-710: Missing.

    Show »
    Length:692
    Mass (Da):74,372
    Checksum:i2C7B72AC4C0E4E88
    GO
    Isoform 3 (identifier: Q9UIG8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.
         59-60: YL → MN
         641-710: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:582
    Mass (Da):62,203
    Checksum:iE653AA86DA1BA276
    GO
    Isoform 4 (identifier: Q9UIG8-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-281: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:429
    Mass (Da):46,411
    Checksum:i822E718765321BC4
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G3V2B7G3V2B7_HUMAN
    Solute carrier organic anion transp...
    SLCO3A1
    130Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YJM0H0YJM0_HUMAN
    Solute carrier organic anion transp...
    SLCO3A1
    109Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V3K4G3V3K4_HUMAN
    Solute carrier organic anion transp...
    SLCO3A1
    87Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40K → R in BAF83561 (PubMed:14702039).Curated1
    Sequence conflicti168R → L in AAH00585 (PubMed:15489334).Curated1
    Sequence conflicti188G → D in BAF83561 (PubMed:14702039).Curated1
    Sequence conflicti202I → Y in BAA89287 (PubMed:10873595).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054853294E → D5 PublicationsCorresponds to variant dbSNP:rs1517618Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368331 – 281Missing in isoform 4. 1 PublicationAdd BLAST281
    Alternative sequenceiVSP_0368341 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
    Alternative sequenceiVSP_03683559 – 60YL → MN in isoform 3. 1 Publication2
    Alternative sequenceiVSP_036836641 – 710Missing in isoform 3. 1 PublicationAdd BLAST70
    Alternative sequenceiVSP_036837667 – 692EFFAS…THRTK → TEYQDIETEKTCPESHSPSE DSFVRS in isoform 2. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_036838693 – 710Missing in isoform 2. 1 PublicationAdd BLAST18

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB031050 mRNA Translation: BAA89287.1
    AF205074 mRNA Translation: AAG42206.1
    AF187816 mRNA Translation: AAG43446.1
    AK290872 mRNA Translation: BAF83561.1
    AK057031 mRNA Translation: BAG51847.1
    AK097797 mRNA Translation: BAG53529.1
    FJ515841 Genomic DNA Translation: ACS13734.1
    AC104020 Genomic DNA No translation available.
    AC104236 Genomic DNA No translation available.
    AC113190 Genomic DNA No translation available.
    AC116903 Genomic DNA No translation available.
    AC135996 Genomic DNA No translation available.
    BC000585 mRNA Translation: AAH00585.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10371.1 [Q9UIG8-1]
    CCDS45354.1 [Q9UIG8-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001138516.1, NM_001145044.1 [Q9UIG8-2]
    NP_037404.2, NM_013272.3 [Q9UIG8-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000318445; ENSP00000320634; ENSG00000176463 [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463 [Q9UIG8-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    28232

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:28232

    UCSC genome browser

    More...
    UCSCi
    uc002bqx.3 human [Q9UIG8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB031050 mRNA Translation: BAA89287.1
    AF205074 mRNA Translation: AAG42206.1
    AF187816 mRNA Translation: AAG43446.1
    AK290872 mRNA Translation: BAF83561.1
    AK057031 mRNA Translation: BAG51847.1
    AK097797 mRNA Translation: BAG53529.1
    FJ515841 Genomic DNA Translation: ACS13734.1
    AC104020 Genomic DNA No translation available.
    AC104236 Genomic DNA No translation available.
    AC113190 Genomic DNA No translation available.
    AC116903 Genomic DNA No translation available.
    AC135996 Genomic DNA No translation available.
    BC000585 mRNA Translation: AAH00585.1
    CCDSiCCDS10371.1 [Q9UIG8-1]
    CCDS45354.1 [Q9UIG8-2]
    RefSeqiNP_001138516.1, NM_001145044.1 [Q9UIG8-2]
    NP_037404.2, NM_013272.3 [Q9UIG8-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi118181, 2 interactors
    IntActiQ9UIG8, 5 interactors
    STRINGi9606.ENSP00000320634

    Chemistry databases

    ChEMBLiCHEMBL2073685
    DrugBankiDB00770 Alprostadil
    DB00345 Aminohippuric acid
    DB01053 Benzylpenicillin
    DB00286 Conjugated estrogens
    DB01160 Dinoprost tromethamine
    DB00917 Dinoprostone
    DB01088 Iloprost
    DB09198 Lobeglitazone
    DB00563 Methotrexate
    DB06654 Safinamide
    DB04348 Taurocholic Acid

    Protein family/group databases

    TCDBi2.A.60.1.18 the organo anion transporter (oat) family

    PTM databases

    iPTMnetiQ9UIG8
    PhosphoSitePlusiQ9UIG8
    SwissPalmiQ9UIG8

    Polymorphism and mutation databases

    BioMutaiSLCO3A1
    DMDMi296452954

    Proteomic databases

    jPOSTiQ9UIG8
    MassIVEiQ9UIG8
    PaxDbiQ9UIG8
    PeptideAtlasiQ9UIG8
    PRIDEiQ9UIG8
    ProteomicsDBi84519 [Q9UIG8-1]
    84520 [Q9UIG8-2]
    84521 [Q9UIG8-3]
    84522 [Q9UIG8-4]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    28232

    Genome annotation databases

    EnsembliENST00000318445; ENSP00000320634; ENSG00000176463 [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463 [Q9UIG8-2]
    GeneIDi28232
    KEGGihsa:28232
    UCSCiuc002bqx.3 human [Q9UIG8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    28232
    DisGeNETi28232

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLCO3A1
    HGNCiHGNC:10952 SLCO3A1
    HPAiHPA066327
    MIMi612435 gene
    neXtProtiNX_Q9UIG8
    OpenTargetsiENSG00000176463
    PharmGKBiPA35837

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3626 Eukaryota
    ENOG410XRSF LUCA
    GeneTreeiENSGT00950000182739
    InParanoidiQ9UIG8
    KOiK14353
    OMAiICVCSMI
    OrthoDBi1029129at2759
    PhylomeDBiQ9UIG8
    TreeFamiTF317540

    Enzyme and pathway databases

    ReactomeiR-HSA-879518 Transport of organic anions [Q9UIG8-1]

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLCO3A1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLCO3A1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    28232
    PharosiQ9UIG8

    Protein Ontology

    More...
    PROi
    PR:Q9UIG8

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000176463 Expressed in 224 organ(s), highest expression level in testis
    ExpressionAtlasiQ9UIG8 baseline and differential
    GenevisibleiQ9UIG8 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR036259 MFS_trans_sf
    IPR004156 OATP
    PANTHERiPTHR11388 PTHR11388, 1 hit
    PfamiView protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit
    SUPFAMiSSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00805 oat, 1 hit
    PROSITEiView protein in PROSITE
    PS51465 KAZAL_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO3A1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIG8
    Secondary accession number(s): A8K4A7
    , B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: May 18, 2010
    Last modified: October 16, 2019
    This is version 156 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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