Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier organic anion transporter family member 3A1

Gene

SLCO3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491).2 Publications

Kineticsi

  1. KM=101 nM for PGE1 (isoform 1)1 Publication
  2. KM=218 nM for PGE1 (isoform 2)1 Publication
  3. KM=219 nM for PGE2 (isoform 1)1 Publication
  4. KM=371 nM for PGE2 (isoform 2)1 Publication

    GO - Molecular functioni

    • sodium-independent organic anion transmembrane transporter activity Source: GO_Central

    GO - Biological processi

    Keywordsi

    Biological processIon transport, Transport

    Enzyme and pathway databases

    ReactomeiR-HSA-879518 Transport of organic anions

    Protein family/group databases

    TCDBi2.A.60.1.18 the organo anion transporter (oat) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 3A1
    Short name:
    OATP3A1
    Alternative name(s):
    Organic anion transporter polypeptide-related protein 3
    Short name:
    OATP-RP3
    Short name:
    OATPRP3
    Organic anion-transporting polypeptide D
    Short name:
    OATP-D
    PGE1 transporter
    Sodium-independent organic anion transporter D
    Solute carrier family 21 member 11
    Gene namesi
    Name:SLCO3A1
    Synonyms:OATP3A1, OATPD, SLC21A11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 15

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000176463.13
    HGNCiHGNC:10952 SLCO3A1
    MIMi612435 gene
    neXtProtiNX_Q9UIG8

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
    Transmembranei41 – 60Helical; Name=1Sequence analysisAdd BLAST20
    Topological domaini61 – 79ExtracellularSequence analysisAdd BLAST19
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini101 – 106CytoplasmicSequence analysis6
    Transmembranei107 – 131Helical; Name=3Sequence analysisAdd BLAST25
    Topological domaini132 – 174ExtracellularSequence analysisAdd BLAST43
    Transmembranei175 – 203Helical; Name=4Sequence analysisAdd BLAST29
    Topological domaini204 – 222CytoplasmicSequence analysisAdd BLAST19
    Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini244 – 261ExtracellularSequence analysisAdd BLAST18
    Transmembranei262 – 286Helical; Name=6Sequence analysisAdd BLAST25
    Topological domaini287 – 344CytoplasmicSequence analysisAdd BLAST58
    Transmembranei345 – 366Helical; Name=7Sequence analysisAdd BLAST22
    Topological domaini367 – 386ExtracellularSequence analysisAdd BLAST20
    Transmembranei387 – 410Helical; Name=8Sequence analysisAdd BLAST24
    Topological domaini411 – 414CytoplasmicSequence analysis4
    Transmembranei415 – 438Helical; Name=9Sequence analysisAdd BLAST24
    Topological domaini439 – 539ExtracellularSequence analysisAdd BLAST101
    Transmembranei540 – 562Helical; Name=10Sequence analysisAdd BLAST23
    Topological domaini563 – 571CytoplasmicSequence analysis9
    Transmembranei572 – 597Helical; Name=11Sequence analysisAdd BLAST26
    Topological domaini598 – 630ExtracellularSequence analysisAdd BLAST33
    Transmembranei631 – 648Helical; Name=12Sequence analysisAdd BLAST18
    Topological domaini649 – 705CytoplasmicSequence analysisAdd BLAST57

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi28232
    OpenTargetsiENSG00000176463
    PharmGKBiPA35837

    Chemistry databases

    ChEMBLiCHEMBL2073685
    DrugBankiDB00770 Alprostadil
    DB00345 Aminohippuric acid
    DB01053 Benzylpenicillin
    DB00286 Conjugated Equine Estrogens
    DB01160 Dinoprost Tromethamine
    DB00917 Dinoprostone
    DB01088 Iloprost
    DB00563 Methotrexate
    DB06654 Safinamide
    DB04348 Taurocholic Acid

    Polymorphism and mutation databases

    BioMutaiSLCO3A1
    DMDMi296452954

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001910641 – 710Solute carrier organic anion transporter family member 3A1Add BLAST710

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei1N-acetylmethionine1 Publication1
    Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi471 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 486PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 501PROSITE-ProRule annotation
    Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UIG8
    PeptideAtlasiQ9UIG8
    PRIDEiQ9UIG8
    ProteomicsDBi84519
    84520 [Q9UIG8-2]
    84521 [Q9UIG8-3]
    84522 [Q9UIG8-4]

    PTM databases

    iPTMnetiQ9UIG8
    PhosphoSitePlusiQ9UIG8
    SwissPalmiQ9UIG8

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex.1 Publication

    Gene expression databases

    BgeeiENSG00000176463 Expressed in 224 organ(s), highest expression level in testis
    CleanExiHS_SLCO3A1
    ExpressionAtlasiQ9UIG8 baseline and differential
    GenevisibleiQ9UIG8 HS

    Organism-specific databases

    HPAiHPA066327

    Interactioni

    Protein-protein interaction databases

    BioGridi118181, 2 interactors
    IntActiQ9UIG8, 5 interactors
    STRINGi9606.ENSP00000320634

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UIG8
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini465 – 513Kazal-likePROSITE-ProRule annotationAdd BLAST49

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3626 Eukaryota
    ENOG410XRSF LUCA
    GeneTreeiENSGT00760000119014
    HOVERGENiHBG098539
    InParanoidiQ9UIG8
    KOiK14353
    OMAiAYRYLYV
    OrthoDBiEOG091G03A9
    PhylomeDBiQ9UIG8
    TreeFamiTF317540

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004156 OATP
    PANTHERiPTHR11388 PTHR11388, 1 hit
    PfamiView protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit
    SUPFAMiSSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00805 oat, 1 hit
    PROSITEiView protein in PROSITE
    PS51465 KAZAL_2, 1 hit

    Sequences (4+)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UIG8-1) [UniParc]FASTAAdd to basket
    Also known as: OATP3A1-v1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM
    60 70 80 90 100
    LAQGTVGAYL VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG
    110 120 130 140 150
    ARGHRPRLIG CGGIVMALGA LLSALPEFLT HQYKYEAGEI RWGAEGRDVC
    160 170 180 190 200
    AANGSGGDEG PDPDLICRNR TATNMMYLLL IGAQVLLGIG ATPVQPLGVS
    210 220 230 240 250
    YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY VDAVFIDTSN
    260 270 280 290 300
    LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE
    310 320 330 340 350
    QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV
    360 370 380 390 400
    FTCIILAACM EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC
    410 420 430 440 450
    LGIFLGGLLV KKLSLSALGA IRMAMLVNLV STACYVSFLF LGCDTGPVAG
    460 470 480 490 500
    VTVPYGNSTA PGSALDPYSP CNNNCECQTD SFTPVCGADG ITYLSACFAG
    510 520 530 540 550
    CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL CVMCICSLIG
    560 570 580 590 600
    AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST
    610 620 630 640 650
    CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK
    660 670 680 690 700
    NYKRYIKNHE GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH
    710
    EWCENMESVL
    Length:710
    Mass (Da):76,553
    Last modified:May 18, 2010 - v3
    Checksum:iED56724BA0998553
    GO
    Isoform 2 (identifier: Q9UIG8-2) [UniParc]FASTAAdd to basket
    Also known as: OATP3A1-v2

    The sequence of this isoform differs from the canonical sequence as follows:
         667-692: EFFASTLTLDNLGRDPVPANQTHRTK → TEYQDIETEKTCPESHSPSEDSFVRS
         693-710: Missing.

    Show »
    Length:692
    Mass (Da):74,372
    Checksum:i2C7B72AC4C0E4E88
    GO
    Isoform 3 (identifier: Q9UIG8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.
         59-60: YL → MN
         641-710: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:582
    Mass (Da):62,203
    Checksum:iE653AA86DA1BA276
    GO
    Isoform 4 (identifier: Q9UIG8-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-281: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:429
    Mass (Da):46,411
    Checksum:i822E718765321BC4
    GO

    Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G3V2B7G3V2B7_HUMAN
    Solute carrier organic anion transp...
    SLCO3A1
    130Annotation score:
    H0YJM0H0YJM0_HUMAN
    Solute carrier organic anion transp...
    SLCO3A1
    109Annotation score:
    G3V3K4G3V3K4_HUMAN
    Solute carrier organic anion transp...
    SLCO3A1
    87Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti40K → R in BAF83561 (PubMed:14702039).Curated1
    Sequence conflicti168R → L in AAH00585 (PubMed:15489334).Curated1
    Sequence conflicti188G → D in BAF83561 (PubMed:14702039).Curated1
    Sequence conflicti202I → Y in BAA89287 (PubMed:10873595).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_054853294E → D5 PublicationsCorresponds to variant dbSNP:rs1517618Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0368331 – 281Missing in isoform 4. 1 PublicationAdd BLAST281
    Alternative sequenceiVSP_0368341 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
    Alternative sequenceiVSP_03683559 – 60YL → MN in isoform 3. 1 Publication2
    Alternative sequenceiVSP_036836641 – 710Missing in isoform 3. 1 PublicationAdd BLAST70
    Alternative sequenceiVSP_036837667 – 692EFFAS…THRTK → TEYQDIETEKTCPESHSPSE DSFVRS in isoform 2. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_036838693 – 710Missing in isoform 2. 1 PublicationAdd BLAST18

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB031050 mRNA Translation: BAA89287.1
    AF205074 mRNA Translation: AAG42206.1
    AF187816 mRNA Translation: AAG43446.1
    AK290872 mRNA Translation: BAF83561.1
    AK057031 mRNA Translation: BAG51847.1
    AK097797 mRNA Translation: BAG53529.1
    FJ515841 Genomic DNA Translation: ACS13734.1
    AC104020 Genomic DNA No translation available.
    AC104236 Genomic DNA No translation available.
    AC113190 Genomic DNA No translation available.
    AC116903 Genomic DNA No translation available.
    AC135996 Genomic DNA No translation available.
    BC000585 mRNA Translation: AAH00585.1
    CCDSiCCDS10371.1 [Q9UIG8-1]
    CCDS45354.1 [Q9UIG8-2]
    RefSeqiNP_001138516.1, NM_001145044.1 [Q9UIG8-2]
    NP_037404.2, NM_013272.3 [Q9UIG8-1]
    UniGeneiHs.311187
    Hs.707541

    Genome annotation databases

    EnsembliENST00000318445; ENSP00000320634; ENSG00000176463 [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463 [Q9UIG8-2]
    GeneIDi28232
    KEGGihsa:28232
    UCSCiuc002bqx.3 human [Q9UIG8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB031050 mRNA Translation: BAA89287.1
    AF205074 mRNA Translation: AAG42206.1
    AF187816 mRNA Translation: AAG43446.1
    AK290872 mRNA Translation: BAF83561.1
    AK057031 mRNA Translation: BAG51847.1
    AK097797 mRNA Translation: BAG53529.1
    FJ515841 Genomic DNA Translation: ACS13734.1
    AC104020 Genomic DNA No translation available.
    AC104236 Genomic DNA No translation available.
    AC113190 Genomic DNA No translation available.
    AC116903 Genomic DNA No translation available.
    AC135996 Genomic DNA No translation available.
    BC000585 mRNA Translation: AAH00585.1
    CCDSiCCDS10371.1 [Q9UIG8-1]
    CCDS45354.1 [Q9UIG8-2]
    RefSeqiNP_001138516.1, NM_001145044.1 [Q9UIG8-2]
    NP_037404.2, NM_013272.3 [Q9UIG8-1]
    UniGeneiHs.311187
    Hs.707541

    3D structure databases

    ProteinModelPortaliQ9UIG8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi118181, 2 interactors
    IntActiQ9UIG8, 5 interactors
    STRINGi9606.ENSP00000320634

    Chemistry databases

    ChEMBLiCHEMBL2073685
    DrugBankiDB00770 Alprostadil
    DB00345 Aminohippuric acid
    DB01053 Benzylpenicillin
    DB00286 Conjugated Equine Estrogens
    DB01160 Dinoprost Tromethamine
    DB00917 Dinoprostone
    DB01088 Iloprost
    DB00563 Methotrexate
    DB06654 Safinamide
    DB04348 Taurocholic Acid

    Protein family/group databases

    TCDBi2.A.60.1.18 the organo anion transporter (oat) family

    PTM databases

    iPTMnetiQ9UIG8
    PhosphoSitePlusiQ9UIG8
    SwissPalmiQ9UIG8

    Polymorphism and mutation databases

    BioMutaiSLCO3A1
    DMDMi296452954

    Proteomic databases

    PaxDbiQ9UIG8
    PeptideAtlasiQ9UIG8
    PRIDEiQ9UIG8
    ProteomicsDBi84519
    84520 [Q9UIG8-2]
    84521 [Q9UIG8-3]
    84522 [Q9UIG8-4]

    Protocols and materials databases

    DNASUi28232
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000318445; ENSP00000320634; ENSG00000176463 [Q9UIG8-1]
    ENST00000424469; ENSP00000387846; ENSG00000176463 [Q9UIG8-2]
    GeneIDi28232
    KEGGihsa:28232
    UCSCiuc002bqx.3 human [Q9UIG8-1]

    Organism-specific databases

    CTDi28232
    DisGeNETi28232
    EuPathDBiHostDB:ENSG00000176463.13
    GeneCardsiSLCO3A1
    H-InvDBiHIX0018979
    HGNCiHGNC:10952 SLCO3A1
    HPAiHPA066327
    MIMi612435 gene
    neXtProtiNX_Q9UIG8
    OpenTargetsiENSG00000176463
    PharmGKBiPA35837
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3626 Eukaryota
    ENOG410XRSF LUCA
    GeneTreeiENSGT00760000119014
    HOVERGENiHBG098539
    InParanoidiQ9UIG8
    KOiK14353
    OMAiAYRYLYV
    OrthoDBiEOG091G03A9
    PhylomeDBiQ9UIG8
    TreeFamiTF317540

    Enzyme and pathway databases

    ReactomeiR-HSA-879518 Transport of organic anions

    Miscellaneous databases

    ChiTaRSiSLCO3A1 human
    GeneWikiiSLCO3A1
    GenomeRNAii28232
    PROiPR:Q9UIG8
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000176463 Expressed in 224 organ(s), highest expression level in testis
    CleanExiHS_SLCO3A1
    ExpressionAtlasiQ9UIG8 baseline and differential
    GenevisibleiQ9UIG8 HS

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR002350 Kazal_dom
    IPR036058 Kazal_dom_sf
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004156 OATP
    PANTHERiPTHR11388 PTHR11388, 1 hit
    PfamiView protein in Pfam
    PF07648 Kazal_2, 1 hit
    PF03137 OATP, 1 hit
    SUPFAMiSSF100895 SSF100895, 1 hit
    SSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00805 oat, 1 hit
    PROSITEiView protein in PROSITE
    PS51465 KAZAL_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSO3A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UIG8
    Secondary accession number(s): A8K4A7
    , B3KPY5, B3KUR7, C6G486, Q9BW73, Q9GZV2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: May 18, 2010
    Last modified: November 7, 2018
    This is version 148 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again