UniProtKB - Q9UIG4 (PS1C2_HUMAN)
Protein
Psoriasis susceptibility 1 candidate gene 2 protein
Gene
PSORS1C2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Psoriasis susceptibility 1 candidate gene 2 proteinAlternative name(s): Protein SPR1 |
Gene namesi | Name:PSORS1C2 Synonyms:C6orf17, SPR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17199, PSORS1C2 |
MIMi | 613526, gene |
neXtProti | NX_Q9UIG4 |
VEuPathDBi | HostDB:ENSG00000204538.3 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 170680 |
OpenTargetsi | ENSG00000204538 |
PharmGKBi | PA33920 |
Miscellaneous databases
Pharosi | Q9UIG4, Tbio |
Genetic variation databases
BioMutai | PSORS1C2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000022159 | 23 – 136 | Psoriasis susceptibility 1 candidate gene 2 proteinAdd BLAST | 114 |
Proteomic databases
PaxDbi | Q9UIG4 |
PeptideAtlasi | Q9UIG4 |
PRIDEi | Q9UIG4 |
ProteomicsDBi | 84516 |
PTM databases
iPTMneti | Q9UIG4 |
PhosphoSitePlusi | Q9UIG4 |
Expressioni
Tissue specificityi
Expressed in skin. Also expressed in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000204538, Expressed in skin of leg and 92 other tissues |
ExpressionAtlasi | Q9UIG4, baseline and differential |
Genevisiblei | Q9UIG4, HS |
Organism-specific databases
HPAi | ENSG00000204538, Tissue enhanced (lymphoid tissue, skin, tongue) |
Interactioni
Binary interactionsi
Hide detailsQ9UIG4
Protein-protein interaction databases
BioGRIDi | 128076, 26 interactors |
IntActi | Q9UIG4, 26 interactors |
STRINGi | 9606.ENSP00000259845 |
Miscellaneous databases
RNActi | Q9UIG4, protein |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQEE, Eukaryota |
GeneTreei | ENSGT00390000013322 |
HOGENOMi | CLU_1880263_0_0_1 |
InParanoidi | Q9UIG4 |
OMAi | LPDDPWP |
OrthoDBi | 1622929at2759 |
PhylomeDBi | Q9UIG4 |
TreeFami | TF337801 |
Family and domain databases
InterProi | View protein in InterPro IPR029271, SPR1 |
PANTHERi | PTHR31853, PTHR31853, 1 hit |
Pfami | View protein in Pfam PF15356, SPR1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9UIG4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILNWKLLGI LVLCLHTRGI SGSEGHPSHP PAEDREEAGS PTLPQGPPVP
60 70 80 90 100
GDPWPGAPPL FEDPPPTRPS RPWRDLPETG VWLPEPPRTD PPQPPRPDDP
110 120 130
WPAGPQPPEN PWPPAPEVDN RPQEEPDLDP PREEYR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017395 | 25 | G → D1 PublicationCorresponds to variant dbSNP:rs2233950Ensembl. | 1 | |
Natural variantiVAR_063104 | 83 | L → P4 PublicationsCorresponds to variant dbSNP:rs2233952Ensembl. | 1 | |
Natural variantiVAR_017396 | 84 | P → L1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB031480 mRNA Translation: BAA88131.1 AF484420 mRNA Translation: AAO49377.1 BA000025 Genomic DNA Translation: BAB63315.1 AB088114 Genomic DNA Translation: BAC54949.1 AL662844 Genomic DNA No translation available. |
CCDSi | CCDS4694.1 |
RefSeqi | NP_054788.2, NM_014069.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB031480 mRNA Translation: BAA88131.1 AF484420 mRNA Translation: AAO49377.1 BA000025 Genomic DNA Translation: BAB63315.1 AB088114 Genomic DNA Translation: BAC54949.1 AL662844 Genomic DNA No translation available. |
CCDSi | CCDS4694.1 |
RefSeqi | NP_054788.2, NM_014069.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128076, 26 interactors |
IntActi | Q9UIG4, 26 interactors |
STRINGi | 9606.ENSP00000259845 |
PTM databases
iPTMneti | Q9UIG4 |
PhosphoSitePlusi | Q9UIG4 |
Genetic variation databases
BioMutai | PSORS1C2 |
Proteomic databases
PaxDbi | Q9UIG4 |
PeptideAtlasi | Q9UIG4 |
PRIDEi | Q9UIG4 |
ProteomicsDBi | 84516 |
Protocols and materials databases
Antibodypediai | 53231, 13 antibodies |
DNASUi | 170680 |
Genome annotation databases
Organism-specific databases
CTDi | 170680 |
DisGeNETi | 170680 |
GeneCardsi | PSORS1C2 |
HGNCi | HGNC:17199, PSORS1C2 |
HPAi | ENSG00000204538, Tissue enhanced (lymphoid tissue, skin, tongue) |
MIMi | 613526, gene |
neXtProti | NX_Q9UIG4 |
OpenTargetsi | ENSG00000204538 |
PharmGKBi | PA33920 |
VEuPathDBi | HostDB:ENSG00000204538.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQEE, Eukaryota |
GeneTreei | ENSGT00390000013322 |
HOGENOMi | CLU_1880263_0_0_1 |
InParanoidi | Q9UIG4 |
OMAi | LPDDPWP |
OrthoDBi | 1622929at2759 |
PhylomeDBi | Q9UIG4 |
TreeFami | TF337801 |
Enzyme and pathway databases
PathwayCommonsi | Q9UIG4 |
Miscellaneous databases
BioGRID-ORCSi | 170680, 4 hits in 869 CRISPR screens |
GenomeRNAii | 170680 |
Pharosi | Q9UIG4, Tbio |
PROi | PR:Q9UIG4 |
RNActi | Q9UIG4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204538, Expressed in skin of leg and 92 other tissues |
ExpressionAtlasi | Q9UIG4, baseline and differential |
Genevisiblei | Q9UIG4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029271, SPR1 |
PANTHERi | PTHR31853, PTHR31853, 1 hit |
Pfami | View protein in Pfam PF15356, SPR1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PS1C2_HUMAN | |
Accessioni | Q9UIG4Primary (citable) accession number: Q9UIG4 Secondary accession number(s): Q5STD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 21, 2003 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot