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Entry version 129 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

Psoriasis susceptibility 1 candidate gene 2 protein

Gene

PSORS1C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Psoriasis susceptibility 1 candidate gene 2 protein
Alternative name(s):
Protein SPR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSORS1C2
Synonyms:C6orf17, SPR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17199 PSORS1C2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613526 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIG4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
170680

Open Targets

More...
OpenTargetsi
ENSG00000204538

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33920

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UIG4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSORS1C2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002215923 – 136Psoriasis susceptibility 1 candidate gene 2 proteinAdd BLAST114

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UIG4

PRoteomics IDEntifications database

More...
PRIDEi
Q9UIG4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84516

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIG4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin. Also expressed in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204538 Expressed in 77 organ(s), highest expression level in skin of leg

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UIG4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UIG4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061228

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9UIG4, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259845

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JE1P Eukaryota
ENOG41118CT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133055

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UIG4

Identification of Orthologs from Complete Genome Data

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OMAi
PGPNRPW

Database of Orthologous Groups

More...
OrthoDBi
1622929at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UIG4

TreeFam database of animal gene trees

More...
TreeFami
TF337801

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029271 SPR1

The PANTHER Classification System

More...
PANTHERi
PTHR31853 PTHR31853, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15356 SPR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UIG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILNWKLLGI LVLCLHTRGI SGSEGHPSHP PAEDREEAGS PTLPQGPPVP
60 70 80 90 100
GDPWPGAPPL FEDPPPTRPS RPWRDLPETG VWLPEPPRTD PPQPPRPDDP
110 120 130
WPAGPQPPEN PWPPAPEVDN RPQEEPDLDP PREEYR
Length:136
Mass (Da):15,101
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BD5C2F378F1DAE1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01739525G → D1 PublicationCorresponds to variant dbSNP:rs2233950Ensembl.1
Natural variantiVAR_06310483L → P4 PublicationsCorresponds to variant dbSNP:rs2233952Ensembl.1
Natural variantiVAR_01739684P → L1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB031480 mRNA Translation: BAA88131.1
AF484420 mRNA Translation: AAO49377.1
BA000025 Genomic DNA Translation: BAB63315.1
AB088114 Genomic DNA Translation: BAC54949.1
AL662844 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4694.1

NCBI Reference Sequences

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RefSeqi
NP_054788.2, NM_014069.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259845; ENSP00000259845; ENSG00000204538
ENST00000383530; ENSP00000373022; ENSG00000206459
ENST00000413924; ENSP00000398734; ENSG00000227246
ENST00000416027; ENSP00000390931; ENSG00000232127
ENST00000422316; ENSP00000403456; ENSG00000234605
ENST00000458589; ENSP00000414952; ENSG00000224544

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:170680

UCSC genome browser

More...
UCSCi
uc003nso.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031480 mRNA Translation: BAA88131.1
AF484420 mRNA Translation: AAO49377.1
BA000025 Genomic DNA Translation: BAB63315.1
AB088114 Genomic DNA Translation: BAC54949.1
AL662844 Genomic DNA No translation available.
CCDSiCCDS4694.1
RefSeqiNP_054788.2, NM_014069.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9UIG4, 25 interactors
STRINGi9606.ENSP00000259845

PTM databases

iPTMnetiQ9UIG4
PhosphoSitePlusiQ9UIG4

Polymorphism and mutation databases

BioMutaiPSORS1C2

Proteomic databases

PaxDbiQ9UIG4
PRIDEiQ9UIG4
ProteomicsDBi84516

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
170680

Genome annotation databases

EnsembliENST00000259845; ENSP00000259845; ENSG00000204538
ENST00000383530; ENSP00000373022; ENSG00000206459
ENST00000413924; ENSP00000398734; ENSG00000227246
ENST00000416027; ENSP00000390931; ENSG00000232127
ENST00000422316; ENSP00000403456; ENSG00000234605
ENST00000458589; ENSP00000414952; ENSG00000224544
GeneIDi170680
KEGGihsa:170680
UCSCiuc003nso.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170680
DisGeNETi170680

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSORS1C2
HGNCiHGNC:17199 PSORS1C2
HPAiHPA061228
MIMi613526 gene
neXtProtiNX_Q9UIG4
OpenTargetsiENSG00000204538
PharmGKBiPA33920

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JE1P Eukaryota
ENOG41118CT LUCA
GeneTreeiENSGT00390000013322
HOGENOMiHOG000133055
InParanoidiQ9UIG4
OMAiPGPNRPW
OrthoDBi1622929at2759
PhylomeDBiQ9UIG4
TreeFamiTF337801

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170680
PharosiQ9UIG4

Protein Ontology

More...
PROi
PR:Q9UIG4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204538 Expressed in 77 organ(s), highest expression level in skin of leg
ExpressionAtlasiQ9UIG4 baseline and differential
GenevisibleiQ9UIG4 HS

Family and domain databases

InterProiView protein in InterPro
IPR029271 SPR1
PANTHERiPTHR31853 PTHR31853, 1 hit
PfamiView protein in Pfam
PF15356 SPR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPS1C2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIG4
Secondary accession number(s): Q5STD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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