Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - Q9UIF9 (BAZ2A_HUMAN)

Entry version 199 (07 Apr 2021)
Sequence version 4 (01 Sep 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Bromodomain adjacent to zinc finger domain protein 2A

Gene

BAZ2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi649 – 661A.T hook 1Add BLAST13
DNA bindingi670 – 682A.T hook 2Add BLAST13
DNA bindingi1186 – 1198A.T hook 3Add BLAST13
DNA bindingi1404 – 1416A.T hook 4Add BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1676 – 1726PHD-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UIF9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427413, NoRC negatively regulates rRNA expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 2A
Alternative name(s):
Transcription termination factor I-interacting protein 5
Short name:
TTF-I-interacting protein 5
Short name:
Tip5
hWALp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAZ2A
Synonyms:KIAA0314, TIP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:962, BAZ2A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605682, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UIF9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000076108.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11176

Open Targets

More...OpenTargetsi		ENSG00000076108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UIF9, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3108642

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2721

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BAZ2A

Domain mapping of disease mutations (DMDM)

More...DMDMi		257051081

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111721 – 1905Bromodomain adjacent to zinc finger domain protein 2AAdd BLAST1905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei507PhosphothreonineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei548PhosphothreonineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei680N6-acetyllysine; by KAT81 Publication1
Modified residuei799N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki866Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1051PhosphoserineBy similarity1
Cross-linki1150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1184PhosphoserineBy similarity1
Modified residuei1397PhosphoserineCombined sources1
Modified residuei1559PhosphoserineCombined sources1
Cross-linki1676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1747PhosphoserineCombined sources1
Modified residuei1770PhosphoserineCombined sources1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1785PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in late S phase when the silent copies of rRNA genes are replicated (By similarity).By similarity
Ubiquitinated. Deubiquitinated by USP21 leading to its stabilization.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UIF9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UIF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UIF9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UIF9

PeptideAtlas

More...PeptideAtlasi		Q9UIF9

PRoteomics IDEntifications database

More...PRIDEi		Q9UIF9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84511 [Q9UIF9-1]
84512 [Q9UIF9-2]
84513 [Q9UIF9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UIF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UIF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000076108, Expressed in sural nerve and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UIF9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UIF9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000076108, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5.

Interacts with TTF1; required for recruitment of the NoRC complex to rDNA.

Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By similarity).

Interacts with BEND3 and USP21.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116346, 37 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-432, NoRC complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UIF9

Protein interaction database and analysis system

More...IntActi		Q9UIF9, 17 interactors

Molecular INTeraction database

More...MINTi		Q9UIF9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000446880

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UIF9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UIF9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11905
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9UIF9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UIF9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini546 – 617MBDPROSITE-ProRule annotationAdd BLAST72
Domaini848 – 913DDTPROSITE-ProRule annotationAdd BLAST66
Domaini1810 – 1880BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili693 – 792Sequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi660 – 799Lys-richAdd BLAST140
Compositional biasi1212 – 1277Glu-richAdd BLAST66
Compositional biasi1290 – 1411Pro-richAdd BLAST122
Compositional biasi1759 – 1762Poly-Arg4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac). These 2 domains play a central role in the recruitment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1.
The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WAL family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1676 – 1726PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1245, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159490

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UIF9

Identification of Orthologs from Complete Genome Data

More...OMAi		GVEPTLC

Database of Orthologous Groups

More...OrthoDBi		200493at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UIF9

TreeFam database of animal gene trees

More...TreeFami		TF329083

Family and domain databases

Conserved Domains Database

More...CDDi		cd05503, Bromo_BAZ2A_B_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017956, AT_hook_DNA-bd_motif
IPR037374, BAZ2A/B_Bromo
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR018501, DDT_dom
IPR016177, DNA-bd_dom_sf
IPR001739, Methyl_CpG_DNA-bd
IPR028940, TIP5
IPR028942, WHIM1_dom
IPR028941, WHIM2_dom
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR45915:SF5, PTHR45915:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF01429, MBD, 1 hit
PF00628, PHD, 1 hit
PF15612, WHIM1, 1 hit
PF15613, WSD, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00384, AT_hook, 4 hits
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00391, MBD, 1 hit
SM00249, PHD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370, SSF47370, 1 hit
SSF54171, SSF54171, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS50982, MBD, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9UIF9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN 
        60         70         80         90        100
GDVNVNGLST VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS 
       110        120        130        140        150
ANPGSNLKDP PLLSQFSGGQ YPLNGILGGS RQPSSPSHNT NLRAGSQEFW 
       160        170        180        190        200
ANGTQSPMGL NFDSQELYDS FPDQNFEVMP NGPPSFFTSP QTSPMLGSSI 
       210        220        230        240        250
QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL EEEQPELKMC 
       260        270        280        290        300
GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 
       310        320        330        340        350
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA 
       360        370        380        390        400
FSLLADDSQT STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ 
       410        420        430        440        450
SSDFPPSLTQ PAPDQSSTIQ LHPATSPAVS PTTSPAVSLV VSPAASPEIS 
       460        470        480        490        500
PEVCPAASTV VSPAVFSVVS PASSAVLPAV SLEVPLTASV TSPKASPVTS 
       510        520        530        540        550
PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD VMRRRIATPE 
       560        570        580        590        600
EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 
       610        620        630        640        650
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG 
       660        670        680        690        700
KRGRPRNTEK AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE 
       710        720        730        740        750
TLNEEDKAKI AKSKKKMRQK VQRGECQTTI QGQARNKRKQ ETKSLKQKEA 
       760        770        780        790        800
KKKSKAEKEK GKTKQEKLKE KVKREKKEKV KMKEKEEVTK AKPACKADKT 
       810        820        830        840        850
LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR VPGLTLPSGA 
       860        870        880        890        900
FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 
       910        920        930        940        950
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV 
       960        970        980        990       1000
EPALCDRLRT QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS 
      1010       1020       1030       1040       1050
SYRKNKWIVE GRLRRLKTVL AKRTGRSEVE MEGPEECLGR RRSSRIMEET 
      1060       1070       1080       1090       1100
SGMEEEEEEE SIAAVPGRRG RRDGEVDATA SSIPELERQI EKLSKRQLFF 
      1110       1120       1130       1140       1150
RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE GNLVPEEVIK 
      1160       1170       1180       1190       1200
KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 
      1210       1220       1230       1240       1250
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ 
      1260       1270       1280       1290       1300
EGSPLSLGQS QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA 
      1310       1320       1330       1340       1350
PSQPPEEPEP DEAESSPDPQ ALWFNISAQM PCNAAPTPPP AVSEDQPTPS 
      1360       1370       1380       1390       1400
PQQLASSKPM NRPSAANPCS PVQFSSTPLA GLAPKRRAGD PGEMPQSPTG 
      1410       1420       1430       1440       1450
LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW WIRDPEMLDA 
      1460       1470       1480       1490       1500
MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG 
      1510       1520       1530       1540       1550
IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL 
      1560       1570       1580       1590       1600
AYCEHLSDSQ EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR 
      1610       1620       1630       1640       1650
YLREPLWPTH EVVLEKALLS TPNGAPEGTT TEISYEITPR IRVWRQTLER 
      1660       1670       1680       1690       1700
CRSAAQVCLC LGQLERSIAW EKSVNKVTCL VCRKGDNDEF LLLCDGCDRG 
      1710       1720       1730       1740       1750
CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK RGQKRKSGYS 
      1760       1770       1780       1790       1800
LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT 
      1810       1820       1830       1840       1850
FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG 
      1860       1870       1880       1890       1900
GYTSSEEFAA DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG 

KQANL
Length:1,905
Mass (Da):211,198
Last modified:September 1, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF364E2AC4BF89EA2
GO
Isoform 1 (identifier: Q9UIF9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: N → NEAN
     178-207: Missing.

Show »
Length:1,878
Mass (Da):208,390
Checksum:i8F197C2BE4F4EB4A
GO
Isoform 3 (identifier: Q9UIF9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1437: Missing.

Show »
Length:1,901
Mass (Da):210,747
Checksum:i00A922530275504E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU39F8VU39_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
1,903Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPG5J3KPG5_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
1,875Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGI9A0A0C4DGI9_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YII3H0YII3_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHL2H0YHL2_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHQ7H0YHQ7_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWQ3F8VWQ3_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W053F8W053_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60864 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAG51228 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106N → S in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti148E → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti155Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti207Q → P in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti210G → C in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti236G → C in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti503A → T in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti601V → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti727Q → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti747Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti812R → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti978L → P in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1032 – 1033EG → GR in BAA89211 (PubMed:10662543).Curated2
Sequence conflicti1190G → S in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1193R → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1199S → F in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1205L → F in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1229A → V in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1274S → N in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti1319P → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1322L → F in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1340P → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1443R → P in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1568R → P in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1598E → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1643V → I in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1649E → Q in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1656Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1663Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1766R → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1781G → R in BAA89211 (PubMed:10662543).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055548498V → E. Corresponds to variant dbSNP:rs2230579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0379606N → NEAN in isoform 1. 1 Publication1
Alternative sequenceiVSP_019111178 – 207Missing in isoform 1. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_0379611434 – 1437Missing in isoform 3. Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB032254 mRNA Translation: BAA89211.1
CR749379 mRNA Translation: CAH18232.1
AC090681 Genomic DNA No translation available.
AB002312 mRNA Translation: BAA20773.2
AK023830 mRNA Translation: BAG51228.1 Sequence problems.
AF000422 mRNA Translation: AAB60864.1 Sequence problems.
BC008965 mRNA Translation: AAH08965.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44924.1 [Q9UIF9-1]

NCBI Reference Sequences

More...RefSeqi		NP_038477.2, NM_013449.3 [Q9UIF9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11176

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11176

UCSC genome browser

More...UCSCi		uc001slq.2, human [Q9UIF9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032254 mRNA Translation: BAA89211.1
CR749379 mRNA Translation: CAH18232.1
AC090681 Genomic DNA No translation available.
AB002312 mRNA Translation: BAA20773.2
AK023830 mRNA Translation: BAG51228.1 Sequence problems.
AF000422 mRNA Translation: AAB60864.1 Sequence problems.
BC008965 mRNA Translation: AAH08965.2
CCDSiCCDS44924.1 [Q9UIF9-1]
RefSeqiNP_038477.2, NM_013449.3 [Q9UIF9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LZ2X-ray1.76A1796-1899[»]
4Q6FX-ray1.91A/B/C/D1673-1728[»]
4QBMX-ray1.65A/B1796-1899[»]
4QF2X-ray1.70A/B/C/D1673-1728[»]
5AGQNMR-A543-650[»]
5MGJX-ray2.10A1796-1898[»]
5MGKX-ray2.30A1796-1898[»]
5MGLX-ray2.65A1796-1898[»]
5MGMX-ray2.80A1796-1898[»]
5OR8X-ray2.40A1796-1899[»]
5T8RX-ray2.40A/B/C/D1673-1728[»]
6FAPX-ray2.70A/B/C/D1673-1728[»]
6FG6X-ray2.40A1796-1898[»]
6FGFX-ray2.80A1796-1898[»]
6FGGX-ray1.10A1796-1899[»]
6FGHX-ray2.10A1796-1898[»]
6FGIX-ray2.55A1796-1898[»]
6FGLX-ray2.10A1796-1898[»]
6FGVX-ray2.50A1796-1899[»]
6FGWX-ray2.73A1796-1899[»]
6FHUX-ray2.00A/B/C/D1673-1728[»]
6FI0X-ray1.90A/B/C/D1673-1728[»]
6FKPX-ray2.00A/B/C/D1673-1728[»]
BMRBiQ9UIF9
SMRiQ9UIF9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116346, 37 interactors
ComplexPortaliCPX-432, NoRC complex
CORUMiQ9UIF9
IntActiQ9UIF9, 17 interactors
MINTiQ9UIF9
STRINGi9606.ENSP00000446880

Chemistry databases

BindingDBiQ9UIF9
ChEMBLiCHEMBL3108642
GuidetoPHARMACOLOGYi2721

PTM databases

iPTMnetiQ9UIF9
PhosphoSitePlusiQ9UIF9

Genetic variation databases

BioMutaiBAZ2A
DMDMi257051081

Proteomic databases

EPDiQ9UIF9
jPOSTiQ9UIF9
MassIVEiQ9UIF9
PaxDbiQ9UIF9
PeptideAtlasiQ9UIF9
PRIDEiQ9UIF9
ProteomicsDBi84511 [Q9UIF9-1]
84512 [Q9UIF9-2]
84513 [Q9UIF9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28282, 84 antibodies

The DNASU plasmid repository

More...DNASUi		11176

Genome annotation databases

EnsembliENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1]
GeneIDi11176
KEGGihsa:11176
UCSCiuc001slq.2, human [Q9UIF9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11176
DisGeNETi11176

GeneCards: human genes, protein and diseases

More...GeneCardsi		BAZ2A
HGNCiHGNC:962, BAZ2A
HPAiENSG00000076108, Low tissue specificity
MIMi605682, gene
neXtProtiNX_Q9UIF9
OpenTargetsiENSG00000076108
PharmGKBiPA25272
VEuPathDBiHostDB:ENSG00000076108.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1245, Eukaryota
GeneTreeiENSGT00940000159490
InParanoidiQ9UIF9
OMAiGVEPTLC
OrthoDBi200493at2759
PhylomeDBiQ9UIF9
TreeFamiTF329083

Enzyme and pathway databases

PathwayCommonsiQ9UIF9
ReactomeiR-HSA-427413, NoRC negatively regulates rRNA expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11176, 26 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BAZ2A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BAZ2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11176
PharosiQ9UIF9, Tchem

Protein Ontology

More...PROi		PR:Q9UIF9
RNActiQ9UIF9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000076108, Expressed in sural nerve and 244 other tissues
ExpressionAtlasiQ9UIF9, baseline and differential
GenevisibleiQ9UIF9, HS

Family and domain databases

CDDicd05503, Bromo_BAZ2A_B_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017956, AT_hook_DNA-bd_motif
IPR037374, BAZ2A/B_Bromo
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR018501, DDT_dom
IPR016177, DNA-bd_dom_sf
IPR001739, Methyl_CpG_DNA-bd
IPR028940, TIP5
IPR028942, WHIM1_dom
IPR028941, WHIM2_dom
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45915:SF5, PTHR45915:SF5, 1 hit
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF01429, MBD, 1 hit
PF00628, PHD, 1 hit
PF15612, WHIM1, 1 hit
PF15613, WSD, 2 hits
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00384, AT_hook, 4 hits
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00391, MBD, 1 hit
SM00249, PHD, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF54171, SSF54171, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS50982, MBD, 1 hit
PS50016, ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAZ2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIF9
Secondary accession number(s): B3KN66
, O00536, O15030, Q68DI8, Q96H26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: September 1, 2009
Last modified: April 7, 2021
This is version 199 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again