UniProtKB - Q9UIF9 (BAZ2A_HUMAN)
Bromodomain adjacent to zinc finger domain protein 2A
BAZ2A
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 649 – 661 | A.T hook 1Add BLAST | 13 | |
DNA bindingi | 670 – 682 | A.T hook 2Add BLAST | 13 | |
DNA bindingi | 1186 – 1198 | A.T hook 3Add BLAST | 13 | |
DNA bindingi | 1404 – 1416 | A.T hook 4Add BLAST | 13 | |
Zinc fingeri | 1676 – 1726 | PHD-typePROSITE-ProRule annotationAdd BLAST | 51 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- histone binding Source: UniProtKB
- lysine-acetylated histone binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- nuclear receptor binding Source: BHF-UCL
- RNA binding Source: UniProtKB
GO - Biological processi
- chromatin remodeling Source: UniProtKB
- DNA methylation Source: UniProtKB
- histone deacetylation Source: UniProtKB
- rDNA heterochromatin assembly Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- RNA polymerase I preinitiation complex assembly Source: GOC
- transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Repressor, RNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UIF9 |
Reactomei | R-HSA-427413, NoRC negatively regulates rRNA expression |
Names & Taxonomyi
Protein namesi | Recommended name: Bromodomain adjacent to zinc finger domain protein 2AAlternative name(s): Transcription termination factor I-interacting protein 5 Short name: TTF-I-interacting protein 5 Short name: Tip5 hWALp3 |
Gene namesi | Name:BAZ2A Synonyms:KIAA0314, TIP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:962, BAZ2A |
MIMi | 605682, gene |
neXtProti | NX_Q9UIF9 |
VEuPathDBi | HostDB:ENSG00000076108.11 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Note: Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus.By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- chromatin silencing complex Source: UniProtKB
- nuclear speck Source: HPA
- nucleolus Source: UniProtKB
Other locations
- rDNA heterochromatin Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 11176 |
OpenTargetsi | ENSG00000076108 |
PharmGKBi | PA25272 |
Miscellaneous databases
Pharosi | Q9UIF9, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3108642 |
GuidetoPHARMACOLOGYi | 2721 |
Genetic variation databases
BioMutai | BAZ2A |
DMDMi | 257051081 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211172 | 1 – 1905 | Bromodomain adjacent to zinc finger domain protein 2AAdd BLAST | 1905 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 507 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 509 | PhosphoserineCombined sources | 1 | |
Modified residuei | 548 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 613 | PhosphoserineCombined sources | 1 | |
Modified residuei | 680 | N6-acetyllysine; by KAT81 Publication | 1 | |
Modified residuei | 799 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 866 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1051 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1150 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1172 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1184 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1397 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1559 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1676 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1709 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1747 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1770 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1783 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1785 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UIF9 |
jPOSTi | Q9UIF9 |
MassIVEi | Q9UIF9 |
PaxDbi | Q9UIF9 |
PeptideAtlasi | Q9UIF9 |
PRIDEi | Q9UIF9 |
ProteomicsDBi | 84511 [Q9UIF9-1] 84512 [Q9UIF9-2] 84513 [Q9UIF9-3] |
PTM databases
iPTMneti | Q9UIF9 |
PhosphoSitePlusi | Q9UIF9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000076108, Expressed in sural nerve and 244 other tissues |
ExpressionAtlasi | Q9UIF9, baseline and differential |
Genevisiblei | Q9UIF9, HS |
Organism-specific databases
HPAi | ENSG00000076108, Low tissue specificity |
Interactioni
Subunit structurei
Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5.
Interacts with TTF1; required for recruitment of the NoRC complex to rDNA.
Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By similarity).
Interacts with BEND3 and USP21.
By similarity1 PublicationBinary interactionsi
Hide detailsQ9UIF9
With | #Exp. | IntAct |
---|---|---|
NCK1 [P16333] | 2 | EBI-934890,EBI-389883 |
Ttf1 [Q62187] from Mus musculus. | 3 | EBI-934890,EBI-11705418 |
GO - Molecular functioni
- histone binding Source: UniProtKB
- lysine-acetylated histone binding Source: UniProtKB
- nuclear receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 116346, 37 interactors |
ComplexPortali | CPX-432, NoRC complex |
CORUMi | Q9UIF9 |
IntActi | Q9UIF9, 17 interactors |
MINTi | Q9UIF9 |
STRINGi | 9606.ENSP00000446880 |
Chemistry databases
BindingDBi | Q9UIF9 |
Miscellaneous databases
RNActi | Q9UIF9, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9UIF9 |
SMRi | Q9UIF9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 546 – 617 | MBDPROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 848 – 913 | DDTPROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 1810 – 1880 | BromoPROSITE-ProRule annotationAdd BLAST | 71 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 693 – 792 | Sequence analysisAdd BLAST | 100 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 660 – 799 | Lys-richAdd BLAST | 140 | |
Compositional biasi | 1212 – 1277 | Glu-richAdd BLAST | 66 | |
Compositional biasi | 1290 – 1411 | Pro-richAdd BLAST | 122 | |
Compositional biasi | 1759 – 1762 | Poly-Arg | 4 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1676 – 1726 | PHD-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Bromodomain, Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1245, Eukaryota |
GeneTreei | ENSGT00940000159490 |
InParanoidi | Q9UIF9 |
OMAi | GVEPTLC |
OrthoDBi | 200493at2759 |
PhylomeDBi | Q9UIF9 |
TreeFami | TF329083 |
Family and domain databases
CDDi | cd05503, Bromo_BAZ2A_B_like, 1 hit |
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR017956, AT_hook_DNA-bd_motif IPR037374, BAZ2A/B_Bromo IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR018501, DDT_dom IPR016177, DNA-bd_dom_sf IPR001739, Methyl_CpG_DNA-bd IPR028940, TIP5 IPR028942, WHIM1_dom IPR028941, WHIM2_dom IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45915:SF5, PTHR45915:SF5, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF02791, DDT, 1 hit PF01429, MBD, 1 hit PF00628, PHD, 1 hit PF15612, WHIM1, 1 hit PF15613, WSD, 2 hits |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00384, AT_hook, 4 hits SM00297, BROMO, 1 hit SM00571, DDT, 1 hit SM00391, MBD, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF54171, SSF54171, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 1 hit PS50827, DDT, 1 hit PS50982, MBD, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN
60 70 80 90 100
GDVNVNGLST VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS
110 120 130 140 150
ANPGSNLKDP PLLSQFSGGQ YPLNGILGGS RQPSSPSHNT NLRAGSQEFW
160 170 180 190 200
ANGTQSPMGL NFDSQELYDS FPDQNFEVMP NGPPSFFTSP QTSPMLGSSI
210 220 230 240 250
QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL EEEQPELKMC
260 270 280 290 300
GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE
310 320 330 340 350
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA
360 370 380 390 400
FSLLADDSQT STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ
410 420 430 440 450
SSDFPPSLTQ PAPDQSSTIQ LHPATSPAVS PTTSPAVSLV VSPAASPEIS
460 470 480 490 500
PEVCPAASTV VSPAVFSVVS PASSAVLPAV SLEVPLTASV TSPKASPVTS
510 520 530 540 550
PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD VMRRRIATPE
560 570 580 590 600
EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN
610 620 630 640 650
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG
660 670 680 690 700
KRGRPRNTEK AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE
710 720 730 740 750
TLNEEDKAKI AKSKKKMRQK VQRGECQTTI QGQARNKRKQ ETKSLKQKEA
760 770 780 790 800
KKKSKAEKEK GKTKQEKLKE KVKREKKEKV KMKEKEEVTK AKPACKADKT
810 820 830 840 850
LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR VPGLTLPSGA
860 870 880 890 900
FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL
910 920 930 940 950
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV
960 970 980 990 1000
EPALCDRLRT QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS
1010 1020 1030 1040 1050
SYRKNKWIVE GRLRRLKTVL AKRTGRSEVE MEGPEECLGR RRSSRIMEET
1060 1070 1080 1090 1100
SGMEEEEEEE SIAAVPGRRG RRDGEVDATA SSIPELERQI EKLSKRQLFF
1110 1120 1130 1140 1150
RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE GNLVPEEVIK
1160 1170 1180 1190 1200
KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM
1210 1220 1230 1240 1250
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ
1260 1270 1280 1290 1300
EGSPLSLGQS QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA
1310 1320 1330 1340 1350
PSQPPEEPEP DEAESSPDPQ ALWFNISAQM PCNAAPTPPP AVSEDQPTPS
1360 1370 1380 1390 1400
PQQLASSKPM NRPSAANPCS PVQFSSTPLA GLAPKRRAGD PGEMPQSPTG
1410 1420 1430 1440 1450
LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW WIRDPEMLDA
1460 1470 1480 1490 1500
MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG
1510 1520 1530 1540 1550
IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL
1560 1570 1580 1590 1600
AYCEHLSDSQ EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR
1610 1620 1630 1640 1650
YLREPLWPTH EVVLEKALLS TPNGAPEGTT TEISYEITPR IRVWRQTLER
1660 1670 1680 1690 1700
CRSAAQVCLC LGQLERSIAW EKSVNKVTCL VCRKGDNDEF LLLCDGCDRG
1710 1720 1730 1740 1750
CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK RGQKRKSGYS
1760 1770 1780 1790 1800
LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT
1810 1820 1830 1840 1850
FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG
1860 1870 1880 1890 1900
GYTSSEEFAA DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG
KQANL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VU39 | F8VU39_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 1,903 | Annotation score: | ||
J3KPG5 | J3KPG5_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 1,875 | Annotation score: | ||
A0A0C4DGI9 | A0A0C4DGI9_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 837 | Annotation score: | ||
H0YII3 | H0YII3_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 205 | Annotation score: | ||
H0YHL2 | H0YHL2_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 162 | Annotation score: | ||
H0YHQ7 | H0YHQ7_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 277 | Annotation score: | ||
F8VWQ3 | F8VWQ3_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 131 | Annotation score: | ||
F8W053 | F8W053_HUMAN | Bromodomain adjacent to zinc finger... | BAZ2A | 116 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | N → S in CAH18232 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 148 | E → K in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 155 | Q → H in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 207 | Q → P in CAH18232 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 210 | G → C in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 236 | G → C in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 503 | A → T in CAH18232 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 601 | V → L in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 727 | Q → L in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 747 | Q → H in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 812 | R → K in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 978 | L → P in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1032 – 1033 | EG → GR in BAA89211 (PubMed:10662543).Curated | 2 | |
Sequence conflicti | 1190 | G → S in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1193 | R → L in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1199 | S → F in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1205 | L → F in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1229 | A → V in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1274 | S → N in CAH18232 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1319 | P → L in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1322 | L → F in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1340 | P → L in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1443 | R → P in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1568 | R → P in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1598 | E → K in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1643 | V → I in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1649 | E → Q in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1656 | Q → H in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1663 | Q → H in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1766 | R → K in BAA89211 (PubMed:10662543).Curated | 1 | |
Sequence conflicti | 1781 | G → R in BAA89211 (PubMed:10662543).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055548 | 498 | V → E. Corresponds to variant dbSNP:rs2230579Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037960 | 6 | N → NEAN in isoform 1. 1 Publication | 1 | |
Alternative sequenceiVSP_019111 | 178 – 207 | Missing in isoform 1. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_037961 | 1434 – 1437 | Missing in isoform 3. Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032254 mRNA Translation: BAA89211.1 CR749379 mRNA Translation: CAH18232.1 AC090681 Genomic DNA No translation available. AB002312 mRNA Translation: BAA20773.2 AK023830 mRNA Translation: BAG51228.1 Sequence problems. AF000422 mRNA Translation: AAB60864.1 Sequence problems. BC008965 mRNA Translation: AAH08965.2 |
CCDSi | CCDS44924.1 [Q9UIF9-1] |
RefSeqi | NP_038477.2, NM_013449.3 [Q9UIF9-1] |
Genome annotation databases
Ensembli | ENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1] |
GeneIDi | 11176 |
KEGGi | hsa:11176 |
UCSCi | uc001slq.2, human [Q9UIF9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032254 mRNA Translation: BAA89211.1 CR749379 mRNA Translation: CAH18232.1 AC090681 Genomic DNA No translation available. AB002312 mRNA Translation: BAA20773.2 AK023830 mRNA Translation: BAG51228.1 Sequence problems. AF000422 mRNA Translation: AAB60864.1 Sequence problems. BC008965 mRNA Translation: AAH08965.2 |
CCDSi | CCDS44924.1 [Q9UIF9-1] |
RefSeqi | NP_038477.2, NM_013449.3 [Q9UIF9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4LZ2 | X-ray | 1.76 | A | 1796-1899 | [»] | |
4Q6F | X-ray | 1.91 | A/B/C/D | 1673-1728 | [»] | |
4QBM | X-ray | 1.65 | A/B | 1796-1899 | [»] | |
4QF2 | X-ray | 1.70 | A/B/C/D | 1673-1728 | [»] | |
5AGQ | NMR | - | A | 543-650 | [»] | |
5MGJ | X-ray | 2.10 | A | 1796-1898 | [»] | |
5MGK | X-ray | 2.30 | A | 1796-1898 | [»] | |
5MGL | X-ray | 2.65 | A | 1796-1898 | [»] | |
5MGM | X-ray | 2.80 | A | 1796-1898 | [»] | |
5OR8 | X-ray | 2.40 | A | 1796-1899 | [»] | |
5T8R | X-ray | 2.40 | A/B/C/D | 1673-1728 | [»] | |
6FAP | X-ray | 2.70 | A/B/C/D | 1673-1728 | [»] | |
6FG6 | X-ray | 2.40 | A | 1796-1898 | [»] | |
6FGF | X-ray | 2.80 | A | 1796-1898 | [»] | |
6FGG | X-ray | 1.10 | A | 1796-1899 | [»] | |
6FGH | X-ray | 2.10 | A | 1796-1898 | [»] | |
6FGI | X-ray | 2.55 | A | 1796-1898 | [»] | |
6FGL | X-ray | 2.10 | A | 1796-1898 | [»] | |
6FGV | X-ray | 2.50 | A | 1796-1899 | [»] | |
6FGW | X-ray | 2.73 | A | 1796-1899 | [»] | |
6FHU | X-ray | 2.00 | A/B/C/D | 1673-1728 | [»] | |
6FI0 | X-ray | 1.90 | A/B/C/D | 1673-1728 | [»] | |
6FKP | X-ray | 2.00 | A/B/C/D | 1673-1728 | [»] | |
BMRBi | Q9UIF9 | |||||
SMRi | Q9UIF9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116346, 37 interactors |
ComplexPortali | CPX-432, NoRC complex |
CORUMi | Q9UIF9 |
IntActi | Q9UIF9, 17 interactors |
MINTi | Q9UIF9 |
STRINGi | 9606.ENSP00000446880 |
Chemistry databases
BindingDBi | Q9UIF9 |
ChEMBLi | CHEMBL3108642 |
GuidetoPHARMACOLOGYi | 2721 |
PTM databases
iPTMneti | Q9UIF9 |
PhosphoSitePlusi | Q9UIF9 |
Genetic variation databases
BioMutai | BAZ2A |
DMDMi | 257051081 |
Proteomic databases
EPDi | Q9UIF9 |
jPOSTi | Q9UIF9 |
MassIVEi | Q9UIF9 |
PaxDbi | Q9UIF9 |
PeptideAtlasi | Q9UIF9 |
PRIDEi | Q9UIF9 |
ProteomicsDBi | 84511 [Q9UIF9-1] 84512 [Q9UIF9-2] 84513 [Q9UIF9-3] |
Protocols and materials databases
Antibodypediai | 28282, 84 antibodies |
DNASUi | 11176 |
Genome annotation databases
Ensembli | ENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1] |
GeneIDi | 11176 |
KEGGi | hsa:11176 |
UCSCi | uc001slq.2, human [Q9UIF9-1] |
Organism-specific databases
CTDi | 11176 |
DisGeNETi | 11176 |
GeneCardsi | BAZ2A |
HGNCi | HGNC:962, BAZ2A |
HPAi | ENSG00000076108, Low tissue specificity |
MIMi | 605682, gene |
neXtProti | NX_Q9UIF9 |
OpenTargetsi | ENSG00000076108 |
PharmGKBi | PA25272 |
VEuPathDBi | HostDB:ENSG00000076108.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1245, Eukaryota |
GeneTreei | ENSGT00940000159490 |
InParanoidi | Q9UIF9 |
OMAi | GVEPTLC |
OrthoDBi | 200493at2759 |
PhylomeDBi | Q9UIF9 |
TreeFami | TF329083 |
Enzyme and pathway databases
PathwayCommonsi | Q9UIF9 |
Reactomei | R-HSA-427413, NoRC negatively regulates rRNA expression |
Miscellaneous databases
BioGRID-ORCSi | 11176, 26 hits in 998 CRISPR screens |
ChiTaRSi | BAZ2A, human |
GeneWikii | BAZ2A |
GenomeRNAii | 11176 |
Pharosi | Q9UIF9, Tchem |
PROi | PR:Q9UIF9 |
RNActi | Q9UIF9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000076108, Expressed in sural nerve and 244 other tissues |
ExpressionAtlasi | Q9UIF9, baseline and differential |
Genevisiblei | Q9UIF9, HS |
Family and domain databases
CDDi | cd05503, Bromo_BAZ2A_B_like, 1 hit |
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR017956, AT_hook_DNA-bd_motif IPR037374, BAZ2A/B_Bromo IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR018501, DDT_dom IPR016177, DNA-bd_dom_sf IPR001739, Methyl_CpG_DNA-bd IPR028940, TIP5 IPR028942, WHIM1_dom IPR028941, WHIM2_dom IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45915:SF5, PTHR45915:SF5, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF02791, DDT, 1 hit PF01429, MBD, 1 hit PF00628, PHD, 1 hit PF15612, WHIM1, 1 hit PF15613, WSD, 2 hits |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00384, AT_hook, 4 hits SM00297, BROMO, 1 hit SM00571, DDT, 1 hit SM00391, MBD, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF54171, SSF54171, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 1 hit PS50827, DDT, 1 hit PS50982, MBD, 1 hit PS50016, ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BAZ2A_HUMAN | |
Accessioni | Q9UIF9Primary (citable) accession number: Q9UIF9 Secondary accession number(s): B3KN66 Q96H26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2002 |
Last sequence update: | September 1, 2009 | |
Last modified: | April 7, 2021 | |
This is version 199 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families