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Entry version 193 (22 Apr 2020)
Sequence version 4 (01 Sep 2009)
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Protein

Bromodomain adjacent to zinc finger domain protein 2A

Gene

BAZ2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi649 – 661A.T hook 1Add BLAST13
DNA bindingi670 – 682A.T hook 2Add BLAST13
DNA bindingi1186 – 1198A.T hook 3Add BLAST13
DNA bindingi1404 – 1416A.T hook 4Add BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1676 – 1726PHD-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427413 NoRC negatively regulates rRNA expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 2A
Alternative name(s):
Transcription termination factor I-interacting protein 5
Short name:
TTF-I-interacting protein 5
Short name:
Tip5
hWALp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAZ2A
Synonyms:KIAA0314, TIP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:962 BAZ2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605682 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIF9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11176

Open Targets

More...
OpenTargetsi
ENSG00000076108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UIF9 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3108642

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2721

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BAZ2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257051081

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111721 – 1905Bromodomain adjacent to zinc finger domain protein 2AAdd BLAST1905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei507PhosphothreonineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei548PhosphothreonineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei680N6-acetyllysine; by KAT81 Publication1
Modified residuei799N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki866Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1051PhosphoserineBy similarity1
Cross-linki1150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1184PhosphoserineBy similarity1
Modified residuei1397PhosphoserineCombined sources1
Modified residuei1559PhosphoserineCombined sources1
Cross-linki1676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1747PhosphoserineCombined sources1
Modified residuei1770PhosphoserineCombined sources1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1785PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in late S phase when the silent copies of rRNA genes are replicated (By similarity).By similarity
Ubiquitinated. Deubiquitinated by USP21 leading to its stabilization.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UIF9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UIF9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UIF9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UIF9

PeptideAtlas

More...
PeptideAtlasi
Q9UIF9

PRoteomics IDEntifications database

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PRIDEi
Q9UIF9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84511 [Q9UIF9-1]
84512 [Q9UIF9-2]
84513 [Q9UIF9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIF9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000076108 Expressed in cingulate cortex and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UIF9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UIF9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000076108 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5.

Interacts with TTF1; required for recruitment of the NoRC complex to rDNA.

Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By similarity).

Interacts with BEND3 and USP21.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116346, 27 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-432 NoRC complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UIF9

Protein interaction database and analysis system

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IntActi
Q9UIF9, 13 interactors

Molecular INTeraction database

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MINTi
Q9UIF9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000446880

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9UIF9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UIF9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11905
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UIF9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini546 – 617MBDPROSITE-ProRule annotationAdd BLAST72
Domaini848 – 913DDTPROSITE-ProRule annotationAdd BLAST66
Domaini1810 – 1880BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili693 – 792Sequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi660 – 799Lys-richAdd BLAST140
Compositional biasi1212 – 1277Glu-richAdd BLAST66
Compositional biasi1290 – 1411Pro-richAdd BLAST122
Compositional biasi1759 – 1762Poly-Arg4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac). These 2 domains play a central role in the recruitment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1.
The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WAL family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1676 – 1726PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1245 Eukaryota
COG5076 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159490

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UIF9

KEGG Orthology (KO)

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KOi
K15224

Identification of Orthologs from Complete Genome Data

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OMAi
RPEVEMQ

Database of Orthologous Groups

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OrthoDBi
200493at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UIF9

TreeFam database of animal gene trees

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TreeFami
TF329083

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05503 Bromo_BAZ2A_B_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR037374 BAZ2A/B_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR016177 DNA-bd_dom_sf
IPR001739 Methyl_CpG_DNA-bd
IPR028940 TIP5
IPR028942 WHIM1_dom
IPR028941 WHIM2_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR45915:SF5 PTHR45915:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF01429 MBD, 1 hit
PF00628 PHD, 1 hit
PF15612 WHIM1, 1 hit
PF15613 WSD, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00384 AT_hook, 4 hits
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00391 MBD, 1 hit
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF54171 SSF54171, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS50982 MBD, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9UIF9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN
60 70 80 90 100
GDVNVNGLST VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS
110 120 130 140 150
ANPGSNLKDP PLLSQFSGGQ YPLNGILGGS RQPSSPSHNT NLRAGSQEFW
160 170 180 190 200
ANGTQSPMGL NFDSQELYDS FPDQNFEVMP NGPPSFFTSP QTSPMLGSSI
210 220 230 240 250
QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL EEEQPELKMC
260 270 280 290 300
GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE
310 320 330 340 350
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA
360 370 380 390 400
FSLLADDSQT STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ
410 420 430 440 450
SSDFPPSLTQ PAPDQSSTIQ LHPATSPAVS PTTSPAVSLV VSPAASPEIS
460 470 480 490 500
PEVCPAASTV VSPAVFSVVS PASSAVLPAV SLEVPLTASV TSPKASPVTS
510 520 530 540 550
PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD VMRRRIATPE
560 570 580 590 600
EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN
610 620 630 640 650
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG
660 670 680 690 700
KRGRPRNTEK AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE
710 720 730 740 750
TLNEEDKAKI AKSKKKMRQK VQRGECQTTI QGQARNKRKQ ETKSLKQKEA
760 770 780 790 800
KKKSKAEKEK GKTKQEKLKE KVKREKKEKV KMKEKEEVTK AKPACKADKT
810 820 830 840 850
LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR VPGLTLPSGA
860 870 880 890 900
FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL
910 920 930 940 950
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV
960 970 980 990 1000
EPALCDRLRT QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS
1010 1020 1030 1040 1050
SYRKNKWIVE GRLRRLKTVL AKRTGRSEVE MEGPEECLGR RRSSRIMEET
1060 1070 1080 1090 1100
SGMEEEEEEE SIAAVPGRRG RRDGEVDATA SSIPELERQI EKLSKRQLFF
1110 1120 1130 1140 1150
RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE GNLVPEEVIK
1160 1170 1180 1190 1200
KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM
1210 1220 1230 1240 1250
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ
1260 1270 1280 1290 1300
EGSPLSLGQS QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA
1310 1320 1330 1340 1350
PSQPPEEPEP DEAESSPDPQ ALWFNISAQM PCNAAPTPPP AVSEDQPTPS
1360 1370 1380 1390 1400
PQQLASSKPM NRPSAANPCS PVQFSSTPLA GLAPKRRAGD PGEMPQSPTG
1410 1420 1430 1440 1450
LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW WIRDPEMLDA
1460 1470 1480 1490 1500
MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG
1510 1520 1530 1540 1550
IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL
1560 1570 1580 1590 1600
AYCEHLSDSQ EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR
1610 1620 1630 1640 1650
YLREPLWPTH EVVLEKALLS TPNGAPEGTT TEISYEITPR IRVWRQTLER
1660 1670 1680 1690 1700
CRSAAQVCLC LGQLERSIAW EKSVNKVTCL VCRKGDNDEF LLLCDGCDRG
1710 1720 1730 1740 1750
CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK RGQKRKSGYS
1760 1770 1780 1790 1800
LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT
1810 1820 1830 1840 1850
FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG
1860 1870 1880 1890 1900
GYTSSEEFAA DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG

KQANL
Length:1,905
Mass (Da):211,198
Last modified:September 1, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF364E2AC4BF89EA2
GO
Isoform 1 (identifier: Q9UIF9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: N → NEAN
     178-207: Missing.

Show »
Length:1,878
Mass (Da):208,390
Checksum:i8F197C2BE4F4EB4A
GO
Isoform 3 (identifier: Q9UIF9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1437: Missing.

Show »
Length:1,901
Mass (Da):210,747
Checksum:i00A922530275504E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU39F8VU39_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
1,903Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPG5J3KPG5_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
1,875Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGI9A0A0C4DGI9_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YII3H0YII3_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHQ7H0YHQ7_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHL2H0YHL2_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWQ3F8VWQ3_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W053F8W053_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2A
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB60864 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAG51228 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106N → S in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti148E → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti155Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti207Q → P in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti210G → C in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti236G → C in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti503A → T in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti601V → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti727Q → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti747Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti812R → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti978L → P in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1032 – 1033EG → GR in BAA89211 (PubMed:10662543).Curated2
Sequence conflicti1190G → S in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1193R → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1199S → F in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1205L → F in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1229A → V in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1274S → N in CAH18232 (PubMed:17974005).Curated1
Sequence conflicti1319P → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1322L → F in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1340P → L in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1443R → P in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1568R → P in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1598E → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1643V → I in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1649E → Q in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1656Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1663Q → H in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1766R → K in BAA89211 (PubMed:10662543).Curated1
Sequence conflicti1781G → R in BAA89211 (PubMed:10662543).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055548498V → E. Corresponds to variant dbSNP:rs2230579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0379606N → NEAN in isoform 1. 1 Publication1
Alternative sequenceiVSP_019111178 – 207Missing in isoform 1. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_0379611434 – 1437Missing in isoform 3. Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032254 mRNA Translation: BAA89211.1
CR749379 mRNA Translation: CAH18232.1
AC090681 Genomic DNA No translation available.
AB002312 mRNA Translation: BAA20773.2
AK023830 mRNA Translation: BAG51228.1 Sequence problems.
AF000422 mRNA Translation: AAB60864.1 Sequence problems.
BC008965 mRNA Translation: AAH08965.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44924.1 [Q9UIF9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_038477.2, NM_013449.3 [Q9UIF9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11176

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11176

UCSC genome browser

More...
UCSCi
uc001slq.2 human [Q9UIF9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032254 mRNA Translation: BAA89211.1
CR749379 mRNA Translation: CAH18232.1
AC090681 Genomic DNA No translation available.
AB002312 mRNA Translation: BAA20773.2
AK023830 mRNA Translation: BAG51228.1 Sequence problems.
AF000422 mRNA Translation: AAB60864.1 Sequence problems.
BC008965 mRNA Translation: AAH08965.2
CCDSiCCDS44924.1 [Q9UIF9-1]
RefSeqiNP_038477.2, NM_013449.3 [Q9UIF9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LZ2X-ray1.76A1796-1899[»]
4Q6FX-ray1.91A/B/C/D1673-1728[»]
4QBMX-ray1.65A/B1796-1899[»]
4QF2X-ray1.70A/B/C/D1673-1728[»]
5AGQNMR-A543-650[»]
5MGJX-ray2.10A1796-1898[»]
5MGKX-ray2.30A1796-1898[»]
5MGLX-ray2.65A1796-1898[»]
5MGMX-ray2.80A1796-1898[»]
5OR8X-ray2.40A1796-1899[»]
5T8RX-ray2.40A/B/C/D1673-1728[»]
6FAPX-ray2.70A/B/C/D1673-1728[»]
6FG6X-ray2.40A1796-1898[»]
6FGFX-ray2.80A1796-1898[»]
6FGGX-ray1.10A1796-1899[»]
6FGHX-ray2.10A1796-1898[»]
6FGIX-ray2.55A1796-1898[»]
6FGLX-ray2.10A1796-1898[»]
6FGVX-ray2.50A1796-1899[»]
6FGWX-ray2.73A1796-1899[»]
6FHUX-ray2.00A/B/C/D1673-1728[»]
6FI0X-ray1.90A/B/C/D1673-1728[»]
6FKPX-ray2.00A/B/C/D1673-1728[»]
SMRiQ9UIF9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116346, 27 interactors
ComplexPortaliCPX-432 NoRC complex
CORUMiQ9UIF9
IntActiQ9UIF9, 13 interactors
MINTiQ9UIF9
STRINGi9606.ENSP00000446880

Chemistry databases

BindingDBiQ9UIF9
ChEMBLiCHEMBL3108642
GuidetoPHARMACOLOGYi2721

PTM databases

iPTMnetiQ9UIF9
PhosphoSitePlusiQ9UIF9

Polymorphism and mutation databases

BioMutaiBAZ2A
DMDMi257051081

Proteomic databases

EPDiQ9UIF9
jPOSTiQ9UIF9
MassIVEiQ9UIF9
PaxDbiQ9UIF9
PeptideAtlasiQ9UIF9
PRIDEiQ9UIF9
ProteomicsDBi84511 [Q9UIF9-1]
84512 [Q9UIF9-2]
84513 [Q9UIF9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28282 79 antibodies

The DNASU plasmid repository

More...
DNASUi
11176

Genome annotation databases

EnsembliENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1]
GeneIDi11176
KEGGihsa:11176
UCSCiuc001slq.2 human [Q9UIF9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11176
DisGeNETi11176

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BAZ2A
HGNCiHGNC:962 BAZ2A
HPAiENSG00000076108 Low tissue specificity
MIMi605682 gene
neXtProtiNX_Q9UIF9
OpenTargetsiENSG00000076108
PharmGKBiPA25272

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1245 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000159490
InParanoidiQ9UIF9
KOiK15224
OMAiRPEVEMQ
OrthoDBi200493at2759
PhylomeDBiQ9UIF9
TreeFamiTF329083

Enzyme and pathway databases

ReactomeiR-HSA-427413 NoRC negatively regulates rRNA expression

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BAZ2A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BAZ2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11176
PharosiQ9UIF9 Tchem

Protein Ontology

More...
PROi
PR:Q9UIF9
RNActiQ9UIF9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000076108 Expressed in cingulate cortex and 233 other tissues
ExpressionAtlasiQ9UIF9 baseline and differential
GenevisibleiQ9UIF9 HS

Family and domain databases

CDDicd05503 Bromo_BAZ2A_B_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR037374 BAZ2A/B_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR016177 DNA-bd_dom_sf
IPR001739 Methyl_CpG_DNA-bd
IPR028940 TIP5
IPR028942 WHIM1_dom
IPR028941 WHIM2_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45915:SF5 PTHR45915:SF5, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF01429 MBD, 1 hit
PF00628 PHD, 1 hit
PF15612 WHIM1, 1 hit
PF15613 WSD, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00384 AT_hook, 4 hits
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00391 MBD, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF54171 SSF54171, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS50982 MBD, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAZ2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIF9
Secondary accession number(s): B3KN66
, O00536, O15030, Q68DI8, Q96H26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: September 1, 2009
Last modified: April 22, 2020
This is version 193 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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