UniProtKB - Q9UIF9 (BAZ2A_HUMAN)

BLAST

>sp|Q9UIF9|BAZ2A_HUMAN Bromodomain adjacent to zinc finger domain protein 2A OS=Homo sapiens OX=9606 GN=BAZ2A PE=1 SV=4
MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLST
VSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQ
YPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMP
NGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLEL
EEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLE
PFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQT
STSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQ
LHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAV
SLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGD
VMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRN
VVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEK
AKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQK
VQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKV
KMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSR
VPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLL
VRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRT
QPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVL
AKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATA
SSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTE
GNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSM
QPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS
QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQ
ALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLA
GLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWW
WIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEG
IMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQ
EDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLS
TPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCL
VCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPK
RGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLT
FCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA
DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL

Align

Format
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History
Entry version 180 (12 Sep 2018)
Sequence version 4 (01 Sep 2009)
Previous versions | rss
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Protein

Bromodomain adjacent to zinc finger domain protein 2A

Gene

BAZ2A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	649 – 661	A.T hook 1Add BLAST	13
DNA bindingⁱ	670 – 682	A.T hook 2Add BLAST	13
DNA bindingⁱ	1186 – 1198	A.T hook 3Add BLAST	13
DNA bindingⁱ	1404 – 1416	A.T hook 4Add BLAST	13
Zinc fingerⁱ	1676 – 1726	PHD-typePROSITE-ProRule annotationAdd BLAST	51

GO - Molecular functionⁱ

histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22368283
lysine-acetylated histone binding Source: UniProtKB
metal ion binding Source: UniProtKB-KW
nuclear receptor binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 10662543
RNA binding Source: UniProtKB
RNA polymerase I CORE element sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22368283

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin remodeling
Source: UniProtKB
Non-traceable author statementⁱ
- 11532953
chromatin silencing at rDNA Source: UniProtKB
DNA methylation Source: UniProtKB
histone deacetylation Source: UniProtKB
regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10662543
transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10662543

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, DNA-binding, Repressor, RNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427413 NoRC negatively regulates rRNA expression

Reactomeⁱ

R-HSA-427413 NoRC negatively regulates rRNA expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bromodomain adjacent to zinc finger domain protein 2A Alternative name(s): Transcription termination factor I-interacting protein 5 Short name: TTF-I-interacting protein 5 Short name: Tip5 hWALp3
Gene namesⁱ	Name:BAZ2A Synonyms:KIAA0314, TIP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000076108.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:962 BAZ2A
MIMⁱ	605682 gene
neXtProtⁱ	NX_Q9UIF9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11176
Open Targets More...OpenTargetsⁱ	ENSG00000076108
PharmGKBⁱ	PA25272

Chemistry databases

ChEMBLⁱ	CHEMBL3108642
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2721

Polymorphism and mutation databases

BioMutaⁱ	BAZ2A
DMDMⁱ	257051081

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211172	1 – 1905	Bromodomain adjacent to zinc finger domain protein 2AAdd BLAST		1905

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	507	PhosphothreonineCombined sources	1
Modified residueⁱ	509	PhosphoserineCombined sources	1
Modified residueⁱ	548	PhosphothreonineCombined sources	1
Modified residueⁱ	613	PhosphoserineCombined sources	1
Modified residueⁱ	680	N6-acetyllysine; by KAT81 Publication	1
Modified residueⁱ	799	N6-acetyllysineBy similarity	1
Cross-linkⁱ	866	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1051	PhosphoserineBy similarity	1
Cross-linkⁱ	1150	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1172	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1184	PhosphoserineBy similarity	1
Modified residueⁱ	1397	PhosphoserineCombined sources	1
Modified residueⁱ	1559	PhosphoserineCombined sources	1
Cross-linkⁱ	1676	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1709	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	1747	PhosphoserineCombined sources	1
Modified residueⁱ	1770	PhosphoserineCombined sources	1
Modified residueⁱ	1783	PhosphoserineCombined sources	1
Modified residueⁱ	1785	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in late S phase when the silent copies of rRNA genes are replicated (By similarity).By similarity

Ubiquitinated. Deubiquitinated by USP21 leading to its stabilization.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UIF9
PaxDbⁱ	Q9UIF9
PeptideAtlas More...PeptideAtlasⁱ	Q9UIF9
PRIDEⁱ	Q9UIF9
ProteomicsDBⁱ	84511 84512 [Q9UIF9-2] 84513 [Q9UIF9-3]

PTM databases

iPTMnetⁱ	Q9UIF9
PhosphoSitePlusⁱ	Q9UIF9

Expressionⁱ

Tissue specificityⁱ

Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000076108 Expressed in 234 organ(s), highest expression level in cingulate cortex
CleanExⁱ	HS_BAZ2A
ExpressionAtlasⁱ	Q9UIF9 baseline and differential
Genevisibleⁱ	Q9UIF9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005782 HPA063806

HPAⁱ

HPA005782
HPA063806

Interactionⁱ

Subunit structureⁱ

Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5. Interacts with TTF1; required for recruitment of the NoRC complex to rDNA. Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By similarity). Interacts with BEND3 and USP21.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	2	EBI-934890,EBI-389883
Ttf1	Q62187	3	EBI-934890,EBI-11705418	From Mus musculus.

GO - Molecular functionⁱ

histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22368283
lysine-acetylated histone binding Source: UniProtKB
nuclear receptor binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 10662543

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116346, 18 interactors
ComplexPortalⁱ	CPX-432 NoRC complex
CORUMⁱ	Q9UIF9
IntActⁱ	Q9UIF9, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9UIF9
STRINGⁱ	9606.ENSP00000446880

Chemistry databases

BindingDBⁱ

Q9UIF9

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	549 – 558	Combined sources	10
Beta strandⁱ	561 – 568	Combined sources	8
Beta strandⁱ	570 – 580	Combined sources	11
Beta strandⁱ	582 – 584	Combined sources	3
Helixⁱ	590 – 599	Combined sources	10
Helixⁱ	607 – 609	Combined sources	3
Beta strandⁱ	618 – 627	Combined sources	10
Beta strandⁱ	630 – 636	Combined sources	7
Turnⁱ	638 – 640	Combined sources	3
Helixⁱ	641 – 648	Combined sources	8
Helixⁱ	1674 – 1676	Combined sources	3
Turnⁱ	1680 – 1682	Combined sources	3
Helixⁱ	1688 – 1690	Combined sources	3
Beta strandⁱ	1691 – 1693	Combined sources	3
Beta strandⁱ	1695 – 1698	Combined sources	4
Beta strandⁱ	1700 – 1702	Combined sources	3
Turnⁱ	1703 – 1705	Combined sources	3
Helixⁱ	1721 – 1724	Combined sources	4
Helixⁱ	1800 – 1810	Combined sources	11
Helixⁱ	1813 – 1815	Combined sources	3
Helixⁱ	1816 – 1818	Combined sources	3
Helixⁱ	1824 – 1826	Combined sources	3
Helixⁱ	1830 – 1833	Combined sources	4
Helixⁱ	1840 – 1848	Combined sources	9
Helixⁱ	1855 – 1872	Combined sources	18
Helixⁱ	1878 – 1897	Combined sources	20

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UIF9
SMRⁱ	Q9UIF9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	546 – 617	MBDPROSITE-ProRule annotationAdd BLAST	72
Domainⁱ	848 – 913	DDTPROSITE-ProRule annotationAdd BLAST	66
Domainⁱ	1810 – 1880	BromoPROSITE-ProRule annotationAdd BLAST	71

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	693 – 792	Sequence analysisAdd BLAST		100

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	660 – 799	Lys-richAdd BLAST	140
Compositional biasⁱ	1212 – 1277	Glu-richAdd BLAST	66
Compositional biasⁱ	1290 – 1411	Pro-richAdd BLAST	122
Compositional biasⁱ	1759 – 1762	Poly-Arg	4

Domainⁱ

The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac). These 2 domains play a central role in the recruitment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1.

The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the WAL family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1676 – 1726	PHD-typePROSITE-ProRule annotationAdd BLAST		51

Keywords - Domainⁱ

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1245 Eukaryota COG5076 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148952
HOGENOMⁱ	HOG000169644
HOVERGENⁱ	HBG107494
InParanoidⁱ	Q9UIF9
KEGG Orthology (KO) More...KOⁱ	K15224
OMAⁱ	NYSQYPS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00WO
PhylomeDBⁱ	Q9UIF9
TreeFamⁱ	TF329083

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05503 Bromo_BAZ2A_B_like, 1 hit
Gene3Dⁱ	1.20.920.10, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR017956 AT_hook_DNA-bd_motif IPR037374 BAZ2A/B_Bromo IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR018501 DDT_dom IPR016177 DNA-bd_dom_sf IPR001739 Methyl_CpG_DNA-bd IPR028940 TIP5 IPR028942 WHIM1_dom IPR028941 WHIM2_dom IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR22880:SF141 PTHR22880:SF141, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00439 Bromodomain, 1 hit PF02791 DDT, 1 hit PF01429 MBD, 1 hit PF00628 PHD, 1 hit PF15612 WHIM1, 1 hit PF15613 WSD, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00384 AT_hook, 4 hits SM00297 BROMO, 1 hit SM00571 DDT, 1 hit SM00391 MBD, 1 hit SM00249 PHD, 1 hit
SUPFAMⁱ	SSF47370 SSF47370, 1 hit SSF54171 SSF54171, 1 hit SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 1 hit PS50014 BROMODOMAIN_2, 1 hit PS50827 DDT, 1 hit PS50982 MBD, 1 hit PS50016 ZF_PHD_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 2 (identifier: Q9UIF9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN 
        60         70         80         90        100
GDVNVNGLST VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS 
       110        120        130        140        150
ANPGSNLKDP PLLSQFSGGQ YPLNGILGGS RQPSSPSHNT NLRAGSQEFW 
       160        170        180        190        200
ANGTQSPMGL NFDSQELYDS FPDQNFEVMP NGPPSFFTSP QTSPMLGSSI 
       210        220        230        240        250
QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL EEEQPELKMC 
       260        270        280        290        300
GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 
       310        320        330        340        350
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA 
       360        370        380        390        400
FSLLADDSQT STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ 
       410        420        430        440        450
SSDFPPSLTQ PAPDQSSTIQ LHPATSPAVS PTTSPAVSLV VSPAASPEIS 
       460        470        480        490        500
PEVCPAASTV VSPAVFSVVS PASSAVLPAV SLEVPLTASV TSPKASPVTS 
       510        520        530        540        550
PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD VMRRRIATPE 
       560        570        580        590        600
EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 
       610        620        630        640        650
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG 
       660        670        680        690        700
KRGRPRNTEK AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE 
       710        720        730        740        750
TLNEEDKAKI AKSKKKMRQK VQRGECQTTI QGQARNKRKQ ETKSLKQKEA 
       760        770        780        790        800
KKKSKAEKEK GKTKQEKLKE KVKREKKEKV KMKEKEEVTK AKPACKADKT 
       810        820        830        840        850
LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR VPGLTLPSGA 
       860        870        880        890        900
FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 
       910        920        930        940        950
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV 
       960        970        980        990       1000
EPALCDRLRT QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS 
      1010       1020       1030       1040       1050
SYRKNKWIVE GRLRRLKTVL AKRTGRSEVE MEGPEECLGR RRSSRIMEET 
      1060       1070       1080       1090       1100
SGMEEEEEEE SIAAVPGRRG RRDGEVDATA SSIPELERQI EKLSKRQLFF 
      1110       1120       1130       1140       1150
RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE GNLVPEEVIK 
      1160       1170       1180       1190       1200
KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 
      1210       1220       1230       1240       1250
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ 
      1260       1270       1280       1290       1300
EGSPLSLGQS QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA 
      1310       1320       1330       1340       1350
PSQPPEEPEP DEAESSPDPQ ALWFNISAQM PCNAAPTPPP AVSEDQPTPS 
      1360       1370       1380       1390       1400
PQQLASSKPM NRPSAANPCS PVQFSSTPLA GLAPKRRAGD PGEMPQSPTG 
      1410       1420       1430       1440       1450
LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW WIRDPEMLDA 
      1460       1470       1480       1490       1500
MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG 
      1510       1520       1530       1540       1550
IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL 
      1560       1570       1580       1590       1600
AYCEHLSDSQ EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR 
      1610       1620       1630       1640       1650
YLREPLWPTH EVVLEKALLS TPNGAPEGTT TEISYEITPR IRVWRQTLER 
      1660       1670       1680       1690       1700
CRSAAQVCLC LGQLERSIAW EKSVNKVTCL VCRKGDNDEF LLLCDGCDRG 
      1710       1720       1730       1740       1750
CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK RGQKRKSGYS 
      1760       1770       1780       1790       1800
LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT 
      1810       1820       1830       1840       1850
FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG 
      1860       1870       1880       1890       1900
GYTSSEEFAA DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG 

KQANL

Length:1,905

Mass (Da):211,198

Last modified:September 1, 2009 - v4

Checksum:ⁱF364E2AC4BF89EA2

Isoform 1 (identifier: Q9UIF9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
6-6: N → NEAN
178-207: Missing.

« Hide

        10         20         30         40         50
MEMEANEAND HFNFTGLPPA PAASGLKPSP SSGEGLYTNG SPMNFPQQGK 
        60         70         80         90        100
SLNGDVNVNG LSTVSHTTTS GILNSAPHSS STSHLHHPSV AYDCLWNYSQ 
       110        120        130        140        150
YPSANPGSNL KDPPLLSQFS GGQYPLNGIL GGSRQPSSPS HNTNLRAGSQ 
       160        170        180        190        200
EFWANGTQSP MGLNFDSQEL YDSFPDQNFE EVGSGIHPDE AAEKEMTSVV 
       210        220        230        240        250
AENGTGLVGS LELEEEQPEL KMCGYNGSVP SVESLHQEVS VLVPDPTVSC 
       260        270        280        290        300
LDDPSHLPDQ LEDTPILSED SLEPFNSLAP EPVSGGLYGI DDTELMGAED 
       310        320        330        340        350
KLPLEDSPVI SALDCPSLNN ATAFSLLADD SQTSTSIFAS PTSPPVLGES 
       360        370        380        390        400
VLQDNSFDLN NGSDAEQEEM ETQSSDFPPS LTQPAPDQSS TIQLHPATSP 
       410        420        430        440        450
AVSPTTSPAV SLVVSPAASP EISPEVCPAA STVVSPAVFS VVSPASSAVL 
       460        470        480        490        500
PAVSLEVPLT ASVTSPKASP VTSPAAAFPT ASPANKDVSS FLETTADVEE 
       510        520        530        540        550
ITGEGLTASG SGDVMRRRIA TPEEVRLPLQ HGWRREVRIK KGSHRWQGET 
       560        570        580        590        600
WYYGPCGKRM KQFPEVIKYL SRNVVHSVRR EHFSFSPRMP VGDFFEERDT 
       610        620        630        640        650
PEGLQWVQLS AEEIPSRIQA ITGKRGRPRN TEKAKTKEVP KVKRGRGRPP 
       660        670        680        690        700
KVKITELLNK TDNRPLKKLE AQETLNEEDK AKIAKSKKKM RQKVQRGECQ 
       710        720        730        740        750
TTIQGQARNK RKQETKSLKQ KEAKKKSKAE KEKGKTKQEK LKEKVKREKK 
       760        770        780        790        800
EKVKMKEKEE VTKAKPACKA DKTLATQRRL EERQRQQMIL EEMKKPTEDM 
       810        820        830        840        850
CLTDHQPLPD FSRVPGLTLP SGAFSDCLTI VEFLHSFGKV LGFDPAKDVP 
       860        870        880        890        900
SLGVLQEGLL CQGDSLGEVQ DLLVRLLKAA LHDPGFPSYC QSLKILGEKV 
       910        920        930        940        950
SEIPLTRDNV SEILRCFLMA YGVEPALCDR LRTQPFQAQP PQQKAAVLAF 
       960        970        980        990       1000
LVHELNGSTL IINEIDKTLE SMSSYRKNKW IVEGRLRRLK TVLAKRTGRS 
      1010       1020       1030       1040       1050
EVEMEGPEEC LGRRRSSRIM EETSGMEEEE EEESIAAVPG RRGRRDGEVD 
      1060       1070       1080       1090       1100
ATASSIPELE RQIEKLSKRQ LFFRKKLLHS SQMLRAVSLG QDRYRRRYWV 
      1110       1120       1130       1140       1150
LPYLAGIFVE GTEGNLVPEE VIKKETDSLK VAAHASLNPA LFSMKMELAG 
      1160       1170       1180       1190       1200
SNTTASSPAR ARGRPRKTKP GSMQPRHLKS PVRGQDSEQP QAQLQPEAQL 
      1210       1220       1230       1240       1250
HAPAQPQPQL QLQLQSHKGF LEQEGSPLSL GQSQHDLSQS AFLSWLSQTQ 
      1260       1270       1280       1290       1300
SHSSLLSSSV LTPDSSPGKL DPAPSQPPEE PEPDEAESSP DPQALWFNIS 
      1310       1320       1330       1340       1350
AQMPCNAAPT PPPAVSEDQP TPSPQQLASS KPMNRPSAAN PCSPVQFSST 
      1360       1370       1380       1390       1400
PLAGLAPKRR AGDPGEMPQS PTGLGQPKRR GRPPSKFFKQ MEQRYLTQLT 
      1410       1420       1430       1440       1450
AQPVPPEMCS GWWWIRDPEM LDAMLKALHP RGIREKALHK HLNKHRDFLQ 
      1460       1470       1480       1490       1500
EVCLRPSADP IFEPRQLPAF QEGIMSWSPK EKTYETDLAV LQWVEELEQR 
      1510       1520       1530       1540       1550
VIMSDLQIRG WTCPSPDSTR EDLAYCEHLS DSQEDITWRG RGREGLAPQR 
      1560       1570       1580       1590       1600
KTTNPLDLAV MRLAALEQNV ERRYLREPLW PTHEVVLEKA LLSTPNGAPE 
      1610       1620       1630       1640       1650
GTTTEISYEI TPRIRVWRQT LERCRSAAQV CLCLGQLERS IAWEKSVNKV 
      1660       1670       1680       1690       1700
TCLVCRKGDN DEFLLLCDGC DRGCHIYCHR PKMEAVPEGD WFCTVCLAQQ 
      1710       1720       1730       1740       1750
VEGEFTQKPG FPKRGQKRKS GYSLNFSEGD GRRRRVLLRG RESPAAGPRY 
      1760       1770       1780       1790       1800
SEEGLSPSKR RRLSMRNHHS DLTFCEIILM EMESHDAAWP FLEPVNPRLV 
      1810       1820       1830       1840       1850
SGYRRIIKNP MDFSTMRERL LRGGYTSSEE FAADALLVFD NCQTFNEDDS 
      1860       1870 
EVGKAGHIMR RFFESRWEEF YQGKQANL

Note: No experimental confirmation available.

Show »

Length:1,878

Mass (Da):208,390

Checksum:ⁱ8F197C2BE4F4EB4A

Isoform 3 (identifier: Q9UIF9-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1434-1437: Missing.

« Hide

        10         20         30         40         50
MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN 
        60         70         80         90        100
GDVNVNGLST VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS 
       110        120        130        140        150
ANPGSNLKDP PLLSQFSGGQ YPLNGILGGS RQPSSPSHNT NLRAGSQEFW 
       160        170        180        190        200
ANGTQSPMGL NFDSQELYDS FPDQNFEVMP NGPPSFFTSP QTSPMLGSSI 
       210        220        230        240        250
QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL EEEQPELKMC 
       260        270        280        290        300
GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 
       310        320        330        340        350
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA 
       360        370        380        390        400
FSLLADDSQT STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ 
       410        420        430        440        450
SSDFPPSLTQ PAPDQSSTIQ LHPATSPAVS PTTSPAVSLV VSPAASPEIS 
       460        470        480        490        500
PEVCPAASTV VSPAVFSVVS PASSAVLPAV SLEVPLTASV TSPKASPVTS 
       510        520        530        540        550
PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD VMRRRIATPE 
       560        570        580        590        600
EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 
       610        620        630        640        650
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG 
       660        670        680        690        700
KRGRPRNTEK AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE 
       710        720        730        740        750
TLNEEDKAKI AKSKKKMRQK VQRGECQTTI QGQARNKRKQ ETKSLKQKEA 
       760        770        780        790        800
KKKSKAEKEK GKTKQEKLKE KVKREKKEKV KMKEKEEVTK AKPACKADKT 
       810        820        830        840        850
LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR VPGLTLPSGA 
       860        870        880        890        900
FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 
       910        920        930        940        950
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV 
       960        970        980        990       1000
EPALCDRLRT QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS 
      1010       1020       1030       1040       1050
SYRKNKWIVE GRLRRLKTVL AKRTGRSEVE MEGPEECLGR RRSSRIMEET 
      1060       1070       1080       1090       1100
SGMEEEEEEE SIAAVPGRRG RRDGEVDATA SSIPELERQI EKLSKRQLFF 
      1110       1120       1130       1140       1150
RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE GNLVPEEVIK 
      1160       1170       1180       1190       1200
KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 
      1210       1220       1230       1240       1250
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ 
      1260       1270       1280       1290       1300
EGSPLSLGQS QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA 
      1310       1320       1330       1340       1350
PSQPPEEPEP DEAESSPDPQ ALWFNISAQM PCNAAPTPPP AVSEDQPTPS 
      1360       1370       1380       1390       1400
PQQLASSKPM NRPSAANPCS PVQFSSTPLA GLAPKRRAGD PGEMPQSPTG 
      1410       1420       1430       1440       1450
LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPGWWWIRD PEMLDAMLKA 
      1460       1470       1480       1490       1500
LHPRGIREKA LHKHLNKHRD FLQEVCLRPS ADPIFEPRQL PAFQEGIMSW 
      1510       1520       1530       1540       1550
SPKEKTYETD LAVLQWVEEL EQRVIMSDLQ IRGWTCPSPD STREDLAYCE 
      1560       1570       1580       1590       1600
HLSDSQEDIT WRGRGREGLA PQRKTTNPLD LAVMRLAALE QNVERRYLRE 
      1610       1620       1630       1640       1650
PLWPTHEVVL EKALLSTPNG APEGTTTEIS YEITPRIRVW RQTLERCRSA 
      1660       1670       1680       1690       1700
AQVCLCLGQL ERSIAWEKSV NKVTCLVCRK GDNDEFLLLC DGCDRGCHIY 
      1710       1720       1730       1740       1750
CHRPKMEAVP EGDWFCTVCL AQQVEGEFTQ KPGFPKRGQK RKSGYSLNFS 
      1760       1770       1780       1790       1800
EGDGRRRRVL LRGRESPAAG PRYSEEGLSP SKRRRLSMRN HHSDLTFCEI 
      1810       1820       1830       1840       1850
ILMEMESHDA AWPFLEPVNP RLVSGYRRII KNPMDFSTMR ERLLRGGYTS 
      1860       1870       1880       1890       1900
SEEFAADALL VFDNCQTFNE DDSEVGKAGH IMRRFFESRW EEFYQGKQAN 

L

Note: No experimental confirmation available.

Show »

Length:1,901

Mass (Da):210,747

Checksum:ⁱ00A922530275504E

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VU39	F8VU39_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	1,903	Annotation score:
J3KPG5	J3KPG5_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	1,875	Annotation score:
H0YII3	H0YII3_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	205	Annotation score:
A0A0C4DGI9	A0A0C4DGI9_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	837	Annotation score:
H0YHQ7	H0YHQ7_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	277	Annotation score:
H0YHL2	H0YHL2_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	162	Annotation score:
F8W053	F8W053_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	116	Annotation score:
F8VWQ3	F8VWQ3_HUMAN	Bromodomain adjacent to zinc finger... Bromodomain adjacent to zinc finger domain protein 2A	BAZ2A	131	Annotation score:

Sequence cautionⁱ

The sequence AAB60864 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence BAG51228 differs from that shown. Reason: Erroneous termination at position 168. Translated as Tyr.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	106	N → S in CAH18232 (PubMed:17974005).Curated	1
Sequence conflictⁱ	148	E → K in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	155	Q → H in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	207	Q → P in CAH18232 (PubMed:17974005).Curated	1
Sequence conflictⁱ	210	G → C in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	236	G → C in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	503	A → T in CAH18232 (PubMed:17974005).Curated	1
Sequence conflictⁱ	601	V → L in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	727	Q → L in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	747	Q → H in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	812	R → K in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	978	L → P in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1032 – 1033	EG → GR in BAA89211 (PubMed:10662543).Curated	2
Sequence conflictⁱ	1190	G → S in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1193	R → L in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1199	S → F in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1205	L → F in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1229	A → V in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1274	S → N in CAH18232 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1319	P → L in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1322	L → F in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1340	P → L in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1443	R → P in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1568	R → P in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1598	E → K in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1643	V → I in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1649	E → Q in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1656	Q → H in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1663	Q → H in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1766	R → K in BAA89211 (PubMed:10662543).Curated	1
Sequence conflictⁱ	1781	G → R in BAA89211 (PubMed:10662543).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055548	498	V → E. Corresponds to variant dbSNP:rs2230579Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_037960	6	N → NEAN in isoform 1. 1 Publication	1
Alternative sequenceⁱVSP_019111	178 – 207	Missing in isoform 1. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_037961	1434 – 1437	Missing in isoform 3. Curated	4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032254 mRNA Translation: BAA89211.1 CR749379 mRNA Translation: CAH18232.1 AC090681 Genomic DNA No translation available. AB002312 mRNA Translation: BAA20773.2 AK023830 mRNA Translation: BAG51228.1 Sequence problems. AF000422 mRNA Translation: AAB60864.1 Sequence problems. BC008965 mRNA Translation: AAH08965.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44924.1 [Q9UIF9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_038477.2, NM_013449.3 [Q9UIF9-1]
UniGeneⁱ	Hs.314263

Genome annotation databases

Ensemblⁱ	ENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1]
GeneIDⁱ	11176
KEGGⁱ	hsa:11176
UCSC genome browser More...UCSCⁱ	uc001slq.2 human [Q9UIF9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A		HUMAN		1903	UniRef100_Q9UIF9
Q9UIF9-3	Bromodomain adjacent to zinc finger domain protein 2A (Fragment)		HUMAN		837	UniRef100_Q9UIF9-3

Protein	Similar proteins		Species	Score	Length	Source
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A		HUMAN		1903	UniRef90_Q9UIF9
Uncharacterized protein		PONAB		1912
Uncharacterized protein		MACMU		1910
Uncharacterized protein		PAPAN		1910
Uncharacterized protein		MANLE		1910
+108
Q9UIF9-2	Bromodomain adjacent to zinc finger domain 2A		AILME		1922	UniRef90_Q9UIF9-2
bromodomain adjacent to zinc finger domain protein 2A isoform X1		Enhydra lutris kenyoni		1914
Bromodomain adjacent to zinc finger domain 2A		CANLF		1911
Bromodomain adjacent to zinc finger domain protein 2A		MYOBR		1910
Transcription termination factor I-interacting protein 5 (Fragment)		MACMU		1908
+101

Protein	Similar proteins		Species	Score	Length	Source
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A		MOUSE		1889	UniRef50_Q91YE5
Uncharacterized protein		NEOLE		1866
bromodomain adjacent to zinc finger domain protein 2A isoform X3		DELLE		1882
bromodomain adjacent to zinc finger domain protein 2A isoform X2		Yangtze finless porpoise		1880
bromodomain adjacent to zinc finger domain protein 2A		TARSY		1888
+408

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032254 mRNA Translation: BAA89211.1 CR749379 mRNA Translation: CAH18232.1 AC090681 Genomic DNA No translation available. AB002312 mRNA Translation: BAA20773.2 AK023830 mRNA Translation: BAG51228.1 Sequence problems. AF000422 mRNA Translation: AAB60864.1 Sequence problems. BC008965 mRNA Translation: AAH08965.2
CCDSⁱ	CCDS44924.1 [Q9UIF9-1]
RefSeqⁱ	NP_038477.2, NM_013449.3 [Q9UIF9-1]
UniGeneⁱ	Hs.314263

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4LZ2	X-ray	1.76	A	1796-1899	[»]
	4Q6F	X-ray	1.91	A/B/C/D	1673-1728	[»]
	4QBM	X-ray	1.65	A/B	1796-1899	[»]
	4QF2	X-ray	1.70	A/B/C/D	1673-1728	[»]
	5AGQ	NMR	-	A	543-650	[»]
	5MGJ	X-ray	2.10	A	1796-1898	[»]
	5MGK	X-ray	2.30	A	1796-1898	[»]
	5MGL	X-ray	2.65	A	1796-1898	[»]
	5MGM	X-ray	2.80	A	1796-1898	[»]
	5OR8	X-ray	2.40	A	1796-1899	[»]
	5T8R	X-ray	2.40	A/B/C/D	1673-1728	[»]
	6FAP	X-ray	2.70	A/B/C/D	1673-1728	[»]
	6FG6	X-ray	2.40	A	1796-1898	[»]
	6FGF	X-ray	2.80	A	1796-1898	[»]
	6FGG	X-ray	1.10	A	1796-1899	[»]
	6FGH	X-ray	2.10	A	1796-1898	[»]
	6FGI	X-ray	2.55	A	1796-1898	[»]
	6FGL	X-ray	2.10	A	1796-1898	[»]
	6FGV	X-ray	2.50	A	1796-1899	[»]
	6FGW	X-ray	2.73	A	1796-1899	[»]
	6FHU	X-ray	2.00	A/B/C/D	1673-1728	[»]
	6FI0	X-ray	1.90	A/B/C/D	1673-1728	[»]
	6FKP	X-ray	2.00	A/B/C/D	1673-1728	[»]
ProteinModelPortalⁱ	Q9UIF9
SMRⁱ	Q9UIF9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116346, 18 interactors
ComplexPortalⁱ	CPX-432 NoRC complex
CORUMⁱ	Q9UIF9
IntActⁱ	Q9UIF9, 9 interactors
MINTⁱ	Q9UIF9
STRINGⁱ	9606.ENSP00000446880

Chemistry databases

BindingDBⁱ	Q9UIF9
ChEMBLⁱ	CHEMBL3108642
GuidetoPHARMACOLOGYⁱ	2721

PTM databases

iPTMnetⁱ	Q9UIF9
PhosphoSitePlusⁱ	Q9UIF9

Polymorphism and mutation databases

BioMutaⁱ	BAZ2A
DMDMⁱ	257051081

Proteomic databases

EPDⁱ	Q9UIF9
PaxDbⁱ	Q9UIF9
PeptideAtlasⁱ	Q9UIF9
PRIDEⁱ	Q9UIF9
ProteomicsDBⁱ	84511 84512 [Q9UIF9-2] 84513 [Q9UIF9-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11176
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000551812; ENSP00000446880; ENSG00000076108 [Q9UIF9-1]
GeneIDⁱ	11176
KEGGⁱ	hsa:11176
UCSCⁱ	uc001slq.2 human [Q9UIF9-1]

Organism-specific databases

CTDⁱ	11176
DisGeNETⁱ	11176
EuPathDBⁱ	HostDB:ENSG00000076108.11
GeneCardsⁱ	BAZ2A
H-InvDBⁱ	HIX0010736
HGNCⁱ	HGNC:962 BAZ2A
HPAⁱ	HPA005782 HPA063806
MIMⁱ	605682 gene
neXtProtⁱ	NX_Q9UIF9
OpenTargetsⁱ	ENSG00000076108
PharmGKBⁱ	PA25272
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1245 Eukaryota COG5076 LUCA
GeneTreeⁱ	ENSGT00920000148952
HOGENOMⁱ	HOG000169644
HOVERGENⁱ	HBG107494
InParanoidⁱ	Q9UIF9
KOⁱ	K15224
OMAⁱ	NYSQYPS
OrthoDBⁱ	EOG091G00WO
PhylomeDBⁱ	Q9UIF9
TreeFamⁱ	TF329083

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427413 NoRC negatively regulates rRNA expression

Reactomeⁱ

R-HSA-427413 NoRC negatively regulates rRNA expression

Miscellaneous databases

ChiTaRSⁱ	BAZ2A human
GeneWikiⁱ	BAZ2A
GenomeRNAiⁱ	11176
Protein Ontology More...PROⁱ	PR:Q9UIF9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000076108 Expressed in 234 organ(s), highest expression level in cingulate cortex
CleanExⁱ	HS_BAZ2A
ExpressionAtlasⁱ	Q9UIF9 baseline and differential
Genevisibleⁱ	Q9UIF9 HS

Family and domain databases

CDDⁱ	cd05503 Bromo_BAZ2A_B_like, 1 hit
Gene3Dⁱ	1.20.920.10, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR017956 AT_hook_DNA-bd_motif IPR037374 BAZ2A/B_Bromo IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR018501 DDT_dom IPR016177 DNA-bd_dom_sf IPR001739 Methyl_CpG_DNA-bd IPR028940 TIP5 IPR028942 WHIM1_dom IPR028941 WHIM2_dom IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR22880:SF141 PTHR22880:SF141, 1 hit
Pfamⁱ	View protein in Pfam PF00439 Bromodomain, 1 hit PF02791 DDT, 1 hit PF01429 MBD, 1 hit PF00628 PHD, 1 hit PF15612 WHIM1, 1 hit PF15613 WSD, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00384 AT_hook, 4 hits SM00297 BROMO, 1 hit SM00571 DDT, 1 hit SM00391 MBD, 1 hit SM00249 PHD, 1 hit
SUPFAMⁱ	SSF47370 SSF47370, 1 hit SSF54171 SSF54171, 1 hit SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 1 hit PS50014 BROMODOMAIN_2, 1 hit PS50827 DDT, 1 hit PS50982 MBD, 1 hit PS50016 ZF_PHD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BAZ2A_HUMAN
Accessionⁱ	Q9UIF9Primary (citable) accession number: Q9UIF9 Secondary accession number(s): B3KN66 , O00536, O15030, Q68DI8, Q96H26
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
	Last sequence update:	September 1, 2009
	Last modified:	September 12, 2018
	This is version 180 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UIF9 (BAZ2A_HUMAN)

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Bromodomain adjacent to zinc finger domain protein 2A

BAZ2A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ