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Protein

Bromodomain adjacent to zinc finger domain protein 2B

Gene

BAZ2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in transcriptional regulation interacting with ISWI.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1931 – 1981PHD-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: BHF-UCL
  • regulation of transcription by RNA polymerase II Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain adjacent to zinc finger domain protein 2B
Alternative name(s):
hWALp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAZ2B
Synonyms:KIAA1476
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000123636.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:963 BAZ2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605683 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UIF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000123636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25273

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1741220

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2722

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BAZ2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462995

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111741 – 2168Bromodomain adjacent to zinc finger domain protein 2BAdd BLAST2168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1425Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1462N6-acetyllysineCombined sources1
Modified residuei1465PhosphoserineCombined sources1
Modified residuei1467PhosphoserineCombined sources1
Modified residuei1680PhosphoserineCombined sources1
Modified residuei2014PhosphothreonineCombined sources1
Modified residuei2019PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UIF8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UIF8

PeptideAtlas

More...
PeptideAtlasi
Q9UIF8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UIF8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84506
84507 [Q9UIF8-2]
84508 [Q9UIF8-3]
84509 [Q9UIF8-4]
84510 [Q9UIF8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UIF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UIF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123636 Expressed in 227 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_BAZ2B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UIF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UIF8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019819
HPA059292

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with acetylated lysine residues on histone H1.4, H2A, H2B, H3 and H4 (in vitro).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119019, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UIF8, 10 interactors

Molecular INTeraction database

More...
MINTi
Q9UIF8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376534

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UIF8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UIF8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UIF8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UIF8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini739 – 810MBDPROSITE-ProRule annotationAdd BLAST72
Domaini1087 – 1152DDTPROSITE-ProRule annotationAdd BLAST66
Domaini2077 – 2147BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili883 – 1061Sequence analysisAdd BLAST179
Coiled coili1334 – 1375Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi149 – 265Ser-richAdd BLAST117
Compositional biasi269 – 275Poly-Glu7
Compositional biasi595 – 666Asp/Glu-rich (acidic)Add BLAST72
Compositional biasi837 – 868Arg-richAdd BLAST32
Compositional biasi902 – 1061Lys-richAdd BLAST160
Compositional biasi1296 – 1339Asp-richAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WAL family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1931 – 1981PHD-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Bromodomain, Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1245 Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155359

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231981

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050670

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UIF8

Identification of Orthologs from Complete Genome Data

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OMAi
KSGVSMM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00WO

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UIF8

TreeFam database of animal gene trees

More...
TreeFami
TF329083

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05503 Bromo_BAZ2A_B_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037374 BAZ2A/B_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR016177 DNA-bd_dom_sf
IPR001739 Methyl_CpG_DNA-bd
IPR028941 WHIM2_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF01429 MBD, 1 hit
PF00628 PHD, 1 hit
PF15613 WSD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00391 MBD, 1 hit
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF54171 SSF54171, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS50982 MBD, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UIF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH
60 70 80 90 100
LFRTAGDQPF NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA
110 120 130 140 150
LAAHPQLASF PGAEWWRTTD AHTRTGATFF PPLLGIPPLF APPAQNHDSS
160 170 180 190 200
SFHSRTSGKS NRNGPEKGVN GSINGSNTSS VIGINTSVLS TTASSSMGQT
210 220 230 240 250
KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME SSSNSDSDSG
260 270 280 290 300
TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ
310 320 330 340 350
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LASESQTHSF QSQQKQPQVL
360 370 380 390 400
SQQLPFIFQS SQAKEESVNK HTSVIQSTGL VSNVKPLSLV NQAKKETYMK
410 420 430 440 450
LIVPSPDVLK AGNKNTSEES SLLTSELRSK REQYKQAFPS QLKKQESSKS
460 470 480 490 500
LKKVIAALSN PKATSSSPAH PKQTLENNHP NPFLTNALLG NHQPNGVIQS
510 520 530 540 550
VIQEAPLALT TKTKMQSKIN ENIAAASSTP FSSPVNLSTS GRRTPGNQTP
560 570 580 590 600
VMPSASPILH SQGKEKAVSN NVNPVKTQHH SHPAKSLVEQ FRGTDSDIPS
610 620 630 640 650
SKDSEDSNED EEEDDEEEDE EDDEDDESDD SQSESDSNSE SDTEGSEEED
660 670 680 690 700
DDDKDQDESD SDTEGEKTSM KLNKTTSSVK SPSMSLTGHS TPRNLHIAKA
710 720 730 740 750
PGSAPAALCS ESQSPAFLGT SSSTLTSSPH SGTSKRRRVT DERELRIPLE
760 770 780 790 800
YGWQRETRIR NFGGRLQGEV AYYAPCGKKL RQYPEVIKYL SRNGIMDISR
810 820 830 840 850
DNFSFSAKIR VGDFYEARDG PQGMQWCLLK EEDVIPRIRA MEGRRGRPPN
860 870 880 890 900
PDRQRAREES RMRRRKGRPP NVGNAEFLDN ADAKLLRKLQ AQEIARQAAQ
910 920 930 940 950
IKLLRKLQKQ EQARVAKEAK KQQAIMAAEE KRKQKEQIKI MKQQEKIKRI
960 970 980 990 1000
QQIRMEKELR AQQILEAKKK KKEEAANAKL LEAEKRIKEK EMRRQQAVLL
1010 1020 1030 1040 1050
KHQERERRRQ HMMLMKAMEA RKKAEEKERL KQEKRDEKRL NKERKLEQRR
1060 1070 1080 1090 1100
LELEMAKELK KPNEDMCLAD QKPLPELPRI PGLVLSGSTF SDCLMVVQFL
1110 1120 1130 1140 1150
RNFGKVLGFD VNIDVPNLSV LQEGLLNIGD SMGEVQDLLV RLLSAAVCDP
1160 1170 1180 1190 1200
GLITGYKAKT ALGEHLLNVG VNRDNVSEIL QIFMEAHCGQ TELTESLKTK
1210 1220 1230 1240 1250
AFQAHTPAQK ASVLAFLINE LACSKSVVSE IDKNIDYMSN LRRDKWVVEG
1260 1270 1280 1290 1300
KLRKLRIIHA KKTGKRDTSG GIDLGEEQHP LGTPTPGRKR RRKGGDSDYD
1310 1320 1330 1340 1350
DDDDDDSDDQ GDEDDEDEED KEDKKGKKTD ICEDEDEGDQ AASVEELEKQ
1360 1370 1380 1390 1400
IEKLSKQQSQ YRRKLFDASH SLRSVMFGQD RYRRRYWILP QCGGIFVEGM
1410 1420 1430 1440 1450
ESGEGLEEIA KEREKLKKAE SVQIKEEMFE TSGDSLNCSN TDHCEQKEDL
1460 1470 1480 1490 1500
KEKDNTNLFL QKPGSFSKLS KLLEVAKMPP ESEVMTPKPN AGANGCTLSY
1510 1520 1530 1540 1550
QNSGKHSLGS VQSTATQSNV EKADSNNLFN TGSSGPGKFY SPLPNDQLLK
1560 1570 1580 1590 1600
TLTEKNRQWF SLLPRTPCDD TSLTHADMST ASLVTPQSQP PSKSPSPTPA
1610 1620 1630 1640 1650
PLGSSAQNPV GLNPFALSPL QVKGGVSMMG LQFCGWPTGV VTSNIPFTSS
1660 1670 1680 1690 1700
VPSLGSGLGL SEGNGNSFLT SNVASSKSES PVPQNEKATS AQPAAVEVAK
1710 1720 1730 1740 1750
PVDFPSPKPI PEEMQFGWWR IIDPEDLKAL LKVLHLRGIR EKALQKQIQK
1760 1770 1780 1790 1800
HLDYITQACL KNKDVAIIEL NENEENQVTR DIVENWSVEE QAMEMDLSVL
1810 1820 1830 1840 1850
QQVEDLERRV ASASLQVKGW MCPEPASERE DLVYFEHKSF TKLCKEHDGE
1860 1870 1880 1890 1900
FTGEDESSAH ALERKSDNPL DIAVTRLADL ERNIERRIEE DIAPGLRVWR
1910 1920 1930 1940 1950
RALSEARSAA QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD
1960 1970 1980 1990 2000
GCDKGCHTYC HRPKITTIPD GDWFCPACIA KASGQTLKIK KLHVKGKKTN
2010 2020 2030 2040 2050
ESKKGKKVTL TGDTEDEDSA STSSSLKRGN KDLKKRKMEE NTSINLSKQE
2060 2070 2080 2090 2100
SFTSVKKPKR DDSKDLALCS MILTEMETHE DAWPFLLPVN LKLVPGYKKV
2110 2120 2130 2140 2150
IKKPMDFSTI REKLSSGQYP NLETFALDVR LVFDNCETFN EDDSDIGRAG
2160
HNMRKYFEKK WTDTFKVS
Length:2,168
Mass (Da):240,459
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC64EEEE6243CF779
GO
Isoform 2 (identifier: Q9UIF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     633-730: Missing.

Show »
Length:2,068
Mass (Da):230,154
Checksum:i324018D11EF97BAD
GO
Isoform 3 (identifier: Q9UIF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     789-822: Missing.

Show »
Length:2,134
Mass (Da):236,551
Checksum:i6320F9BC6B744581
GO
Isoform 4 (identifier: Q9UIF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Show »
Length:1,972
Mass (Da):220,710
Checksum:iB3BA3FD40027174C
GO
Isoform 5 (identifier: Q9UIF8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-113: Missing.
     789-822: Missing.

Show »
Length:2,132
Mass (Da):236,423
Checksum:i28286671FC56180F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR97A0A0A0MR97_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2B
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C092H7C092_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2B
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXK5H7BXK5_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2B
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1I6H7C1I6_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2B
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VJC3F6VJC3_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2B
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCA6C9JCA6_HUMAN
Bromodomain adjacent to zinc finger...
BAZ2B
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH12576 differs from that shown. contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH12576 differs from that shown. Reason: Frameshift at position 927.Curated
The sequence BAA96000 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55231 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95L → G in AAH12576 (PubMed:15489334).Curated1
Sequence conflicti333S → F in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti823G → E in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti918E → K in AAH12576 (PubMed:15489334).Curated1
Sequence conflicti986R → Q in AAH12576 (PubMed:15489334).Curated1
Sequence conflicti1324K → Q in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti1379Q → P in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti1391Q → R in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti1649S → L in BAA89212 (PubMed:10662543).Curated1
Sequence conflicti2034K → Q in BAA89212 (PubMed:10662543).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05554971M → T1 PublicationCorresponds to variant dbSNP:rs10202670Ensembl.1
Natural variantiVAR_055550422L → S2 PublicationsCorresponds to variant dbSNP:rs3213790Ensembl.1
Natural variantiVAR_055551530P → L. Corresponds to variant dbSNP:rs3732287Ensembl.1
Natural variantiVAR_055552702G → V. Corresponds to variant dbSNP:rs2302924Ensembl.1
Natural variantiVAR_0555532024S → N. Corresponds to variant dbSNP:rs415793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371141 – 196Missing in isoform 4. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_037115112 – 113Missing in isoform 2 and isoform 5. 2 Publications2
Alternative sequenceiVSP_000553633 – 730Missing in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_000554789 – 822Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032255 mRNA Translation: BAA89212.1
AB040909 mRNA Translation: BAA96000.2 Different initiation.
AL080173 mRNA Translation: CAB45759.1
AL834381 mRNA Translation: CAD39044.2
CH471058 Genomic DNA Translation: EAX11404.1
CH471058 Genomic DNA Translation: EAX11405.1
CH471058 Genomic DNA Translation: EAX11407.1
BC012576 mRNA Translation: AAH12576.1 Sequence problems.
AK027612 mRNA Translation: BAB55231.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2209.2 [Q9UIF8-1]
CCDS74594.1 [Q9UIF8-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12495

NCBI Reference Sequences

More...
RefSeqi
NP_001276904.1, NM_001289975.1 [Q9UIF8-5]
NP_038478.2, NM_013450.3 [Q9UIF8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.470369
Hs.731786

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392782; ENSP00000376533; ENSG00000123636 [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636 [Q9UIF8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29994

UCSC genome browser

More...
UCSCi
uc002uao.4 human [Q9UIF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032255 mRNA Translation: BAA89212.1
AB040909 mRNA Translation: BAA96000.2 Different initiation.
AL080173 mRNA Translation: CAB45759.1
AL834381 mRNA Translation: CAD39044.2
CH471058 Genomic DNA Translation: EAX11404.1
CH471058 Genomic DNA Translation: EAX11405.1
CH471058 Genomic DNA Translation: EAX11407.1
BC012576 mRNA Translation: AAH12576.1 Sequence problems.
AK027612 mRNA Translation: BAB55231.1 Different initiation.
CCDSiCCDS2209.2 [Q9UIF8-1]
CCDS74594.1 [Q9UIF8-5]
PIRiT12495
RefSeqiNP_001276904.1, NM_001289975.1 [Q9UIF8-5]
NP_038478.2, NM_013450.3 [Q9UIF8-1]
UniGeneiHs.470369
Hs.731786

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7ONMR-A2062-2166[»]
3G0LX-ray2.03A2054-2168[»]
3Q2FX-ray2.06A2054-2168[»]
4CUPX-ray1.88A2054-2168[»]
4CUQX-ray2.11A2054-2168[»]
4CURX-ray1.84A2054-2168[»]
4CUSX-ray1.78A2054-2168[»]
4CUTX-ray1.84A2054-2168[»]
4CUUX-ray1.80A2054-2168[»]
4IR3X-ray2.00A2054-2168[»]
4IR4X-ray2.05A2054-2168[»]
4IR5X-ray1.70A2054-2168[»]
4IR6X-ray1.80A2054-2168[»]
4NR9X-ray1.98A2054-2168[»]
4NRAX-ray1.85A2054-2168[»]
4NRBX-ray2.08A2054-2168[»]
4NRCX-ray1.86A2054-2168[»]
4QC1X-ray1.99A/B2062-2166[»]
4QC3X-ray1.60A/B2062-2166[»]
4QF3X-ray1.60A/B1928-1983[»]
4RVRX-ray1.98A2054-2168[»]
4XUAX-ray1.75A2054-2168[»]
4XUBX-ray1.98A2054-2168[»]
5CQ3X-ray1.93A2054-2168[»]
5CQ4X-ray1.78A2054-2168[»]
5CQ5X-ray1.96A2054-2168[»]
5CQ6X-ray1.97A2054-2168[»]
5CQ7X-ray1.86A2054-2166[»]
5CQ8X-ray1.65A2054-2168[»]
5CQAX-ray2.13A2054-2166[»]
5CU8X-ray2.05A2054-2166[»]
5CUAX-ray1.89A2054-2168[»]
5CUBX-ray2.10A2054-2166[»]
5CUCX-ray1.85A2054-2166[»]
5CUDX-ray1.75A2054-2168[»]
5CUEX-ray2.08A2054-2166[»]
5CUGX-ray1.78A2054-2168[»]
5DYUX-ray1.65A2054-2167[»]
5DYXX-ray1.85A2054-2167[»]
5E73X-ray1.71A2054-2167[»]
5E74X-ray1.78A2054-2167[»]
5E9IX-ray1.96A2054-2167[»]
5E9KX-ray2.07A2054-2167[»]
5E9LX-ray1.90A2054-2167[»]
5E9MX-ray1.78A2054-2167[»]
5E9YX-ray1.65A2054-2167[»]
5L8TX-ray1.85A2054-2167[»]
5L8UX-ray1.85A2054-2167[»]
5L96X-ray2.15A2054-2167[»]
5L97X-ray2.05A2054-2167[»]
5L98X-ray2.26A2054-2167[»]
5L99X-ray2.00A2054-2167[»]
5MGEX-ray1.95A2054-2167[»]
5MGFX-ray1.90A2054-2167[»]
5MGGX-ray2.10A2054-2167[»]
5OR9X-ray2.00A2054-2168[»]
5ORBX-ray2.10A2054-2168[»]
5PB7X-ray1.66A2054-2168[»]
5PB8X-ray1.65A2054-2168[»]
5PB9X-ray1.78A2054-2168[»]
5PBAX-ray1.93A2054-2168[»]
5PBBX-ray1.78A2054-2168[»]
5PBCX-ray1.77A2054-2168[»]
5PBDX-ray1.78A2054-2168[»]
5PBEX-ray1.83A2054-2168[»]
5PBFX-ray1.80A2054-2168[»]
5PBGX-ray1.72A2054-2168[»]
5PBHX-ray1.69A2054-2168[»]
5PBIX-ray1.78A2054-2168[»]
5PBJX-ray1.79A2054-2168[»]
5PBKX-ray1.77A2054-2168[»]
5PBLX-ray1.84A2054-2168[»]
5PBMX-ray1.67A2054-2168[»]
5PBNX-ray1.86A2054-2168[»]
5PBOX-ray1.95A2054-2168[»]
5PBPX-ray1.88A2054-2168[»]
5PBQX-ray1.93A2054-2168[»]
5PBRX-ray1.81A2054-2168[»]
5PBSX-ray1.77A2054-2168[»]
5PBTX-ray1.79A2054-2168[»]
5PBUX-ray1.88A2054-2168[»]
5PBVX-ray1.74A2054-2168[»]
5PBWX-ray1.84A2054-2168[»]
5PBXX-ray1.65A2054-2168[»]
5PBYX-ray1.75A2054-2168[»]
5PBZX-ray1.70A2054-2168[»]
5PC0X-ray1.79A2054-2168[»]
5PC1X-ray1.72A2054-2168[»]
5PC2X-ray1.79A2054-2168[»]
5PC3X-ray1.80A2054-2168[»]
5PC4X-ray1.86A2054-2168[»]
5PC5X-ray1.85A2054-2168[»]
5PC6X-ray1.74A2054-2168[»]
5PC7X-ray1.72A2054-2168[»]
5PC8X-ray1.85A2054-2168[»]
5PC9X-ray1.76A2054-2168[»]
5PCAX-ray1.84A2054-2168[»]
5PCBX-ray1.80A2054-2168[»]
5PCCX-ray1.83A2054-2168[»]
5PCDX-ray1.76A2054-2168[»]
5PCEX-ray2.16A2054-2168[»]
5PCFX-ray2.02A2054-2168[»]
5PCGX-ray1.98A2054-2168[»]
5PCHX-ray1.75A2054-2168[»]
5PCIX-ray1.88A2054-2168[»]
5PCJX-ray1.97A2054-2168[»]
5PCKX-ray1.75A2054-2168[»]
5PCLX-ray2.19A2054-2168[»]
5PCMX-ray1.69A2054-2168[»]
5PCNX-ray1.84A2054-2168[»]
5PCOX-ray1.77A2054-2168[»]
5PCPX-ray1.69A2054-2168[»]
5PCQX-ray2.29A2054-2168[»]
5PCRX-ray1.90A2054-2168[»]
5PCSX-ray1.83A2054-2168[»]
5PCTX-ray1.78A2054-2168[»]
5PCUX-ray1.75A2054-2168[»]
5PCVX-ray1.65A2054-2168[»]
5PCWX-ray1.70A2054-2168[»]
5PCXX-ray1.79A2054-2168[»]
5PCZX-ray1.84A2054-2168[»]
5PD0X-ray1.84A2054-2168[»]
5PD1X-ray1.79A2054-2168[»]
5PD2X-ray1.79A2054-2168[»]
5PD3X-ray1.69A2054-2168[»]
5PD4X-ray1.80A2054-2168[»]
5PD5X-ray1.89A2054-2168[»]
5PD6X-ray2.01A2054-2168[»]
5PD7X-ray1.69A2054-2168[»]
5PD8X-ray1.71A2054-2168[»]
5PD9X-ray1.86A2054-2168[»]
5PDAX-ray1.77A2054-2168[»]
5PDBX-ray1.80A2054-2168[»]
5PDCX-ray1.74A2054-2168[»]
5PDDX-ray1.77A2054-2168[»]
5PDEX-ray1.88A2054-2168[»]
5PDFX-ray1.68A2054-2168[»]
5PDGX-ray1.63A2054-2168[»]
5PDHX-ray1.78A2054-2168[»]
5PDIX-ray1.70A2054-2168[»]
5PDJX-ray1.84A2054-2168[»]
5PDKX-ray1.74A2054-2168[»]
5PDLX-ray1.80A2054-2168[»]
5PDMX-ray1.71A2054-2168[»]
5PDNX-ray1.71A2054-2168[»]
5PDOX-ray1.78A2054-2168[»]
5PDPX-ray1.70A2054-2168[»]
5PDQX-ray2.26A2054-2168[»]
5PDRX-ray1.70A2054-2168[»]
5PDSX-ray1.78A2054-2168[»]
5PDTX-ray1.79A2054-2168[»]
5PDUX-ray1.70A2054-2168[»]
5PDVX-ray1.69A2054-2168[»]
5PDWX-ray1.88A2054-2168[»]
5PDXX-ray1.69A2054-2168[»]
5PDYX-ray1.93A2054-2168[»]
5PDZX-ray1.90A2054-2168[»]
5PE0X-ray1.76A2054-2168[»]
5PE1X-ray1.91A2054-2168[»]
5PE2X-ray1.71A2054-2168[»]
5PE3X-ray1.76A2054-2168[»]
5PE4X-ray1.74A2054-2168[»]
5PE5X-ray1.65A2054-2168[»]
5PE6X-ray1.67A2054-2168[»]
5PE7X-ray1.81A2054-2168[»]
5PE8X-ray1.65A2054-2168[»]
5PE9X-ray1.72A2054-2168[»]
5PEAX-ray1.65A2054-2168[»]
5PEBX-ray2.11A2054-2168[»]
5PECX-ray1.85A2054-2168[»]
5PEDX-ray1.80A2054-2168[»]
5PEEX-ray1.75A2054-2168[»]
5PEFX-ray1.73A2054-2168[»]
5PEGX-ray1.69A2054-2168[»]
5PEHX-ray1.71A2054-2168[»]
5PEIX-ray1.66A2054-2168[»]
5PEJX-ray1.71A2054-2168[»]
5PEKX-ray1.79A2054-2168[»]
5PELX-ray1.70A2054-2168[»]
5PEMX-ray1.97A2054-2168[»]
5PENX-ray1.72A2054-2168[»]
5PEOX-ray1.70A2054-2168[»]
5PEQX-ray1.75A2054-2168[»]
5PERX-ray2.00A2054-2168[»]
5PESX-ray1.80A2054-2168[»]
5PETX-ray1.72A2054-2168[»]
5PEUX-ray1.90A2054-2168[»]
5PEVX-ray1.81A2054-2168[»]
5PEWX-ray1.77A2054-2168[»]
5PEXX-ray1.79A2054-2168[»]
5PEYX-ray1.80A2054-2168[»]
5PEZX-ray1.70A2054-2168[»]
5PF0X-ray1.95A2054-2168[»]
5PF1X-ray1.78A2054-2168[»]
5PF2X-ray1.89A2054-2168[»]
5PF3X-ray1.83A2054-2168[»]
5PF4X-ray2.01A2054-2168[»]
5PF5X-ray1.71A2054-2168[»]
5PF6X-ray1.75A2054-2168[»]
5PF7X-ray1.79A2054-2168[»]
5PF8X-ray1.78A2054-2168[»]
5PF9X-ray1.91A2054-2168[»]
5PFAX-ray1.65A2054-2168[»]
5PFBX-ray1.80A2054-2168[»]
5PFCX-ray1.75A2054-2168[»]
5PFDX-ray1.88A2054-2168[»]
5PFEX-ray1.79A2054-2168[»]
5PFFX-ray1.96A2054-2168[»]
5PFGX-ray1.68A2054-2168[»]
5PFHX-ray1.66A2054-2168[»]
5PFIX-ray1.66A2054-2168[»]
5PFJX-ray2.07A2054-2168[»]
5PFLX-ray1.71A2054-2168[»]
5PFMX-ray1.54A2054-2168[»]
5PFNX-ray1.72A2054-2168[»]
5PFOX-ray1.82A2054-2168[»]
5PFPX-ray1.65A2054-2168[»]
5PFQX-ray1.78A2054-2168[»]
5PFRX-ray1.89A2054-2168[»]
5PFSX-ray2.00A2054-2168[»]
5PFTX-ray2.02A2054-2168[»]
5PFUX-ray1.75A2054-2168[»]
5PFVX-ray1.72A2054-2168[»]
5PFWX-ray1.64A2054-2168[»]
5PFXX-ray1.90A2054-2168[»]
5PFYX-ray1.65A2054-2168[»]
5PFZX-ray1.72A2054-2168[»]
5PG0X-ray1.71A2054-2168[»]
5PG1X-ray1.49A2054-2168[»]
5PG2X-ray1.68A2054-2168[»]
5PG3X-ray1.66A2054-2168[»]
5PG4X-ray2.49A2054-2168[»]
5PG5X-ray1.75A2054-2168[»]
5PG6X-ray1.65A2054-2168[»]
5PG7X-ray1.96A2054-2168[»]
5PG8X-ray1.69A2054-2168[»]
5PG9X-ray1.62A2054-2168[»]
5PGAX-ray1.59A2054-2168[»]
5PGBX-ray1.57A2054-2168[»]
5PGCX-ray1.61A2054-2168[»]
5PGDX-ray1.79A2054-2168[»]
5PGEX-ray1.70A2054-2168[»]
5PGFX-ray1.82A2054-2168[»]
5PGGX-ray1.68A2054-2168[»]
5PGHX-ray1.93A2054-2168[»]
5PGIX-ray1.88A2054-2168[»]
5PGJX-ray1.58A2054-2168[»]
5PGKX-ray1.83A2054-2168[»]
5PGLX-ray2.23A2054-2168[»]
5PGNX-ray1.79A2054-2168[»]
5PGOX-ray1.88A2054-2168[»]
5PGPX-ray1.76A2054-2168[»]
5PGQX-ray1.71A2054-2168[»]
5PGRX-ray2.00A2054-2168[»]
5PGSX-ray1.64A2054-2168[»]
5PGTX-ray1.72A2054-2168[»]
6FGTX-ray2.00A2054-2168[»]
6FGUX-ray2.05A2054-2168[»]
6FH6X-ray2.08A2054-2168[»]
6FH7X-ray2.10A2054-2168[»]
6FHQX-ray1.95A/B1928-1983[»]
6FI1X-ray2.70A/B1928-1983[»]
ProteinModelPortaliQ9UIF8
SMRiQ9UIF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119019, 13 interactors
IntActiQ9UIF8, 10 interactors
MINTiQ9UIF8
STRINGi9606.ENSP00000376534

Chemistry databases

BindingDBiQ9UIF8
ChEMBLiCHEMBL1741220
GuidetoPHARMACOLOGYi2722

PTM databases

iPTMnetiQ9UIF8
PhosphoSitePlusiQ9UIF8

Polymorphism and mutation databases

BioMutaiBAZ2B
DMDMi229462995

Proteomic databases

EPDiQ9UIF8
PaxDbiQ9UIF8
PeptideAtlasiQ9UIF8
PRIDEiQ9UIF8
ProteomicsDBi84506
84507 [Q9UIF8-2]
84508 [Q9UIF8-3]
84509 [Q9UIF8-4]
84510 [Q9UIF8-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392782; ENSP00000376533; ENSG00000123636 [Q9UIF8-5]
ENST00000392783; ENSP00000376534; ENSG00000123636 [Q9UIF8-1]
GeneIDi29994
KEGGihsa:29994
UCSCiuc002uao.4 human [Q9UIF8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29994
EuPathDBiHostDB:ENSG00000123636.17

GeneCards: human genes, protein and diseases

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GeneCardsi
BAZ2B

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002531
HGNCiHGNC:963 BAZ2B
HPAiHPA019819
HPA059292
MIMi605683 gene
neXtProtiNX_Q9UIF8
OpenTargetsiENSG00000123636
PharmGKBiPA25273

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1245 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000155359
HOGENOMiHOG000231981
HOVERGENiHBG050670
InParanoidiQ9UIF8
OMAiKSGVSMM
OrthoDBiEOG091G00WO
PhylomeDBiQ9UIF8
TreeFamiTF329083

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BAZ2B human
EvolutionaryTraceiQ9UIF8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29994

Protein Ontology

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PROi
PR:Q9UIF8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123636 Expressed in 227 organ(s), highest expression level in corpus callosum
CleanExiHS_BAZ2B
ExpressionAtlasiQ9UIF8 baseline and differential
GenevisibleiQ9UIF8 HS

Family and domain databases

CDDicd05503 Bromo_BAZ2A_B_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR037374 BAZ2A/B_Bromo
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR016177 DNA-bd_dom_sf
IPR001739 Methyl_CpG_DNA-bd
IPR028941 WHIM2_dom
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF01429 MBD, 1 hit
PF00628 PHD, 1 hit
PF15613 WSD, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00391 MBD, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF54171 SSF54171, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS50982 MBD, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAZ2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UIF8
Secondary accession number(s): D3DPA8
, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 5, 2009
Last modified: December 5, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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